Projekte mit Shared Expertise 2014

Titel Antragsteller Shared Expertise Anbieter
Serotonin in vascular calcificationZouhair Aherrahrou, Jeanette Erdmann (Hamburg/Kiel/Lübeck)Michael Bader (Berlin)
Role of CAD risk genes in strokeZouhair Aherrahrou, Jeanette Erdmann (Hamburg/Kiel/Lübeck)Karen Gertz, Matthias Endres (Berlin)
Effects of conditioned carcinoma cell culture medium on engineered heart tissueJohannes Backs, Christian Oeing (Heidelberg/Mannheim)Ingke Braren, Thomas Eschenhagen (Hamburg/Kiel/Lübeck)
Functional relevance of redox-activated PKA for reactive oxygen species-mediated inhibition of cardiac IK1 currentJohannes Backs, Edgar Zitron (Heidelberg/Mannheim)Lars S. Maier (Göttingen)
Order: PRAS 40 in hypertrophic cardiomyopathyJohannes Backs (Heidelberg/Mannheim)Norbert Hübner (Berlin)
Serotonin in vascular calcificationMichael Bader (Berlin)Zouhair Aherrahrou, Jeanette Erdmann (Hamburg/Kiel/Lübeck)
Pilot Omics of Postoperative Atrial FibrillationStefan Blankenberg (Hamburg/Kiel/Lübeck)Thomas Meitinger (München)
Isoprostanes and NADPH oxidases in hypoxic pulmonary hypertension: Role of thromboxane receptorRainer H. Böger (Hamburg/Kiel/Lübeck)Agnes Görlach (München)
Identification of CRTC1-regulated genes in isoprenaline-induced cardiac hypertrophy in miceLucie Carrier, Elke Oetjen (Hamburg/Kiel/Lübeck)Norbert Hübner (Berlin)
Screening of MYBPC3 mutations in individuals with diastolic dysfunction.Lucie Carrier (Hamburg/Kiel/Lübeck)Norbert Hübner (Berlin)
Evaluation of the effect of HCM mutants on the extent of hypertrophy in response to phenylephrine or endothelin-1 in cardiac myocytes Lucie Carrier (Hamburg/Kiel/Lübeck)Stefan Engelhardt (München)
Deep sequencing to identify flow-regulated non-coding RNAsStefanie Dimmeler, Reinier Boon (RheinMain)Nikolaus Rajewsky, Wei Chen (Berlin)
Integration of Comprehensive Transcriptomes to Decipher Processes Controlling CardiogenesisStefanie Dimmeler, Shizuka Uchida (RheinMain)Edgar Wingender (Göttingen)
Determination of arginine derivatives in the SHIP-TREND and GANI_MED studyMarcus Dörr, Henri Wallaschofski (Greifswald)Dorothee Atzler (Hamburg/Kiel/Lübeck)
Exome array genotyping and whole blood expression of heart failure patients from GANI_MED Marcus Dörr, Uwe Völker, Matthias Nauck, Stephan Felix (Greifswald)Thomas Meitinger (München)
Cardiac long-term gene transfer C by adeno-associated viral vectors for the purpose of modulating Phosphodiesteraseexpression in experimental heart failure modelsAli El-Armouche, Christiane Vettel, Gerd Hasenfuss (Göttingen)Oliver Müller (Heidelberg/Mannheim)
Impact of the cardiovascular risk gene Adamts7 on stroke outcomeMatthias Endres, Karen Gertz (Berlin)Zouhair Aherrahrou, Jeanette Erdmann (Hamburg/Kiel/Lübeck)
RNA deep sequencing of murine blood platelets and cardiac biopsiesStefan Engelhardt (München)Norbert Hübner (Berlin)
Functional Analysis of BMPR1A in its Role in the Development of Cardiac Cushion DefectsJeanette Erdmann (Hamburg/Kiel/Lübeck)Salim Seyfried (Berlin)
Transcript analysis of electrically and epigenetically mature artificial myocardial tissueThomas Eschenhagen, Marc Hirt, Justus Stenzig (Hamburg/Kiel/Lübeck)Norbert Hübner (Berlin)
Cardiac overexpression of miR-223 using AAV vectorsIngrid Fleming, Beate Fisslthaler (RheinMain)Salim Seyfried (Berlin)
Generation of AAV9 for heart-specific gene transfer in mice.Norbert Frey, Derk Frank (Hamburg/Kiel/Lübeck)Oliver Müller (Heidelberg/Mannheim)
NADPH oxidases, isoprostanes and NO in hypoxic pulmonary remodelling: Role of HIF transcription factorsAgnes Görlach, Andreas Petry (München)Dorothee Atzler (Hamburg/Kiel/Lübeck)
Metabolic consequences related to NADPH oxidases in response to hypoxic and pro-atherosclerotic challengingAgnes Görlach (München)Ulrich Kintscher (Berlin)
Influence of redox stress on the ubiquitin-proteasome systemAgnes Görlach, Andreas Petry (München)Verena Stangl (Berlin)
Developmental regulation of cardiac splicing in zebrafish versus mouse.Michael Gotthardt (Berlin)Benjamin Meder (Heidelberg/Mannheim)
Alternative splicing in cardiomyocytes derived from human ES vs. iPS cellsMichael Gotthardt (Berlin)Kaomei Guan (Göttingen)
Gene expression analysis of human iPS cell-derived cardiomyocytes in Engineered heart tissue constructsArne Hansen (Hamburg/Kiel/Lübeck)Norbert Hübner (Berlin)
Production of an ES cell with gefloxtem titin N2B exonGerd Hasenfuss, Karl Toischer (Göttingen)Michael Bader (Berlin)
Exploring transcriptional differences between iPSCs derived cardiomyocytes obtained from patients with genetic cardiac diseases and healthy donorsGerd Hasenfuss, Kaomei Guan-Schmidt (Göttingen)Benjamin Meder (Heidelberg/Mannheim)
Role of HDAC expression and phosphorylation in hypertrophic obstructive cardiomyopathy compared to afterload-induced cardiac hypertrophy in humansGerd Hasenfuss, Lars S. Maier (Göttingen)Johannes Backs (Heidelberg/Mannheim)
Producing a myomegalin-transgenic mouse with overexpression in cardiomyocytesGerd Hasenfuss, Karl Toischer (Göttingen)Michael Bader (Berlin)
2-Photon intravital microscopy of platelet-endothelial cell interaction in miceMarkus Hecker (Heidelberg/Mannheim)Ulrich Pohl (München)
Blood pressure, stress level, subjective feeling and risk behavior among German adults of working ageChristoph Herrmann-Lingen, Thomas Meyer (Göttingen)Christa Scheidt-Nave (Berlin)
Identification of weaning-specific biomarkers in pediatric and adult DCMP-patientsRoland Hetzer, Felix Berger, Joachim Photiadis, Boris Schmitt, Michael Dande, Christoph Knosalla, Thomas Krabatsch, Henrike Liptau, Judith Kikhney (Berlin)Marcus Krüger (RheinMain)
Generation of Adeno-associated virus (AAV) for viral gene transfer of MLP and its disease associated mutants into mouse MLP-/- cardiomyocytesNorbert Hübner, Christian Geier (Berlin)Ingke Braren (Hamburg/Kiel/Lübeck)
The role of the mechanosensitive ion channel Piezo-1/-2 in cardiac myocytesStefan Kääb, Thomas Gudermann, Michael Mederos y Schnitzler (München)Christian Kuhn, Derk Frank (Hamburg/Kiel/Lübeck)
ISAmiR - mircoRNAs in restenosis after coronary stenting (Discovery study)Adnan Kastrati, Thorsten Kessler (München)Jeanette Erdmann (Hamburg/Kiel/Lübeck)
Regulation of Proteostasis by the Ubiquitin-Proteasom-SystemHugo A. Katus, Ziya Kaya (Heidelberg/Mannheim)Antje Voigt (Berlin)
K2P2.1 K+ channel-associated mechanoelectrical dysfunction in atrial fibrillationHugo A. Katus, Dierk Thomas (Heidelberg/Mannheim)Derk Frank (Hamburg/Kiel/Lübeck)
Adipose tissue lipolysis and pathological cardiac hypertrophyUlrich Kintscher, Anna Foryst-Ludwig (Berlin)Markus Schwaiger, Stephan G. Nekolla (München)
MicroRNA profile of postnatal Nkx2.5 cardiac enhancer positive progenitor cellsHeribert Schunkert, Markus Krane, Rüdiger Lange (München)Zouhair Aherrahrou, Jeanette Erdmann (Hamburg/Kiel/Lübeck)
Role of HO-1 in ischemia/reperfusion injury in miceChristian Kupatt, Rabea Hinkel (München)Philip Wenzel (RheinMain)
Spatial-temporal mathematical modeling of cytosolic and sarcoplasmic Ca2+ concentrations in ventricular cardiac myocytesStefan Luther, Ulrich Parlitz, Gerd Hasenfuss, (Göttingen)Martin Falcke (Berlin)
Establishment of an in vitro splice reporter system for the functional validation of direct or indirect effect of the splicing factor KF243Benjamin Meder (Heidelberg/Mannheim)Michael Gotthardt (Berlin)
Importance of endothelial p53 expression for angiogenesis and regeneration after focal cerebral ischaemiaThomas Münzel, Katrin Schäfer (RheinMain)Matthias Endres, Ulrich Dirnagl, Karen Gertz (Berlin)
Measurement of IL18 levels in blood serum of a KORA F3 subsampleAnnette Peters, Barbara Thorand (München)Tanja Zeller (Hamburg/Kiel/Lübeck)
Effect of Ang (1-7) after intrazerebroventrikulärer application to the weight regulationWalter Raasch, Jeanette Erdmann (Hamburg/Kiel/Lübeck)Michael Bader (Berlin)
Clarifying the role of SHOX2 in ES cell-derived cardiomyocytesGudrun Rappold, Sandra Hoffmann (Heidelberg/Mannheim)Wolfgang-Michael Franz (München)
Characterization and phenotyping of SHOX2-deficient ES cell-derived cardiomyocytesGudrun Rappold, Sandra Hoffmann (Heidelberg/Mannheim)Lars S. Maier, Wolfram H. Zimmermann (Göttingen)
Identification of sex-specific protein phosphorylation in physiological myocardial hypertrophy Vera Regitz-Zagrosek (Berlin)Marcus Krüger (RheinMain)
Role of the Ubiquitin-Proteasome-System in Autoimmune Inflammatory Heart DiseaseVera Regitz-Zagrosek, Antje Voigt (Berlin)Ziya Kaya (Heidelberg/Mannheim)
Evaluation and Analysis of Whole-body Magnetic Resonance Imaging in Patients with Diabetes, Prediabetes, and Normal ControlsMaximilian Reiser, Fabian Bamberg, Annette Peters (München)Henry Völzke (Greifswald)
Generation of a MD-2 transgenic mice modelAlexander Riad (Greifswald)Michael Bader (Berlin)
BMP signaling in genetics of cardiac cushion defectsHeribert Schunkert, Teresa Trenkwalder, Katharina Koch-Büttner, Markus Krane (München)Frank Kaiser (Hamburg/Kiel/Lübeck)
Gender differences in the proteome of human umbilical endothelial cellsVerena Stangl, Mario Lorenz (Berlin)Marcus Krüger (RheinMain)
The role of HIF-1α in vasculoprotective effects in human endothelial cells by proteasome inhibitorsVerena Stangl, Antje Ludwig (Berlin)Agnes Görlach (München)
In vivo expression dynamics of histone modifying enzymes in smooth muscle cell plasticity in the context of vascular diseaseVerena Stangl, Till F. Althoff (Berlin)Marcus Krüger (RheinMain)
Role of microRNA-147 on macrophage function during atherosclerosisChristian Weber, Andreas Schober (München)Marcus Krüger (RheinMain)
HO‐1 induction in a large animal model of ischemia/reperfusion injuryPhilipp Wenzel, Thomas Münzel (RheinMain)Rabea Hinkel, Christian Kupatt (München)
Intravital microscopy imaging of angiotensin II‐induced (peri)vascular inflammationPhilipp Wenzel, Thomas Münzel (RheinMain)Konstantin Stark, Marie-Luise von Brühl, Steffen Massberg (München)
RGS3L-induced covalent modifications of contractile proteins in cardiac myocytesThomas Wieland (Heidelberg/Mannheim)Friederike Cuello (Hamburg/Kiel/Lübeck)
Association analysis of 38 genetic loci and cardiovascular disease in patients having diabetes mellitus type 2 or impaired fasting plasma glucose: the Gutenberg Health StudyPhilipp Wild, Vera Grossmann (RheinMain)Melanie Waldenberger, Annette Peters (München)
Inflammation in atrial fibrillation - studies in sheepStephan Willems, Niklas Klatt (Hamburg/Kiel/Lübeck)Katharina Wassilew (Berlin)
LncRNA RIP-Chip-/Sequencing with Data AnalysisEdgar Wingender, Wolfram H. Zimmermann (Göttingen)Shizuka Uchida (RheinMain)
Analyses of miRNA Expression in Brain and Heart in a genetic AGAT deletion mouse modelTanja Zeller, Edzard Schwedhelm (Hamburg/Kiel/Lübeck)Norbert Hübner (Berlin)