Paper of the Month

In vivo model with targeted cAMP biosensor reveals changes in receptor–microdomain communication in cardiac disease, NATURE COMMUNICATIONS | 6:6965, DZHK-Autoren: Lehnart, Hasenfuß, Nikolaev

Sensing Cardiac Electrical Activity with a Cardiomyocyte Targeted Optogenetic Voltage Indicator. Circulation Research. 2015; 117: 401-412, DZHK-Autoren: Chang Liao, Raad, Wagner, Streckfuss-Bömeke, Luther, Guan, Lehnart, Stühmer, Zimmermann

A background Ca21 entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling. European Heart Journal, doi:10.1093/eurheartj/ehv250; DZHK-Autoren: Camacho Londono, Mathar, Freichel

Differential Inhibition of Human Atherosclerotic Plaque–Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies, J Am Coll Cardiol. 2015;65(22):2404-2415, DZHK-Autoren: Weber, Siess

Upregulation of K2P3.1 K+ Current Causes Action Potential Shortening in Patients with Chronic Atrial Fibrillation, Circulation, doi: 10.1161/CIRCULATIONAHA.114.012657, DZHK-Autoren: Schmidt, Zhou, Lang, Borggrefe, Schweizer, Katus, Thomas

High Sensitivity Cardiac Troponin I and B-Type Natriuretic Peptide as Predictors of Vascular Events in Primary Prevention: Impact of Statin Therapy, Circulation 2015, doi: 10.1161/CIRCULATIONAHA.114.014522 (DZHK-Autoren: Zeller, Blankenberg)

Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy, EMBO Molecular Medicine, (2015), DOI: 10.15252/emmm.201505047 (DZHK-Autoren: Pane, Chen, Labeit, Laugwitz, Moretti)

ADAMTS-7 Inhibits Re-Endothelialization of Injured Arteries and Promotes Vascular Remodeling Via Cleavage of Thrombospondin-1 (DZHK-Autoren: Kessler, de Wit, Erdmann, Schunkert, Aherrahrou), Circulation (2015).

Maternal Treatment of Spontaneously Hypertensive Rats With Pentaerythritol Tetranitrate Reduces Blood Pressure in Female Offspring. (DZHK-Autoren: Siuda, D., Daiber, A., Münzel, T., Li, H.) Hypertension 65:232-237 (2015).

Mybpc3 Gene Therapy for Neonatal Cardiomyopathy Enables Long-Term Disease Prevention in Mice. (DZHK-Autoren: Mearini, G., Stimpel, D., B., Weinberger, F., Kramer, E., Schlossarek, S., Braren, I., Katus, H. A., Muller, O. J., Eschenhagen, T. & Carrier, L.) Nature communications...