DZHKomics - 1,200 Genomes


Project coordinators:
Prof. Tanja Zeller
Prof. Jeanette Erdmann
Prof. Heribert Schunkert

Science administration:
Alexandra Klatt
Science Administration/Use and Access Office:
phone: +4930 3465 52910

About the Project

OMICs technologies have become essential tools and resources in cardiovascular diseases and system medicine pathogenetic investigation. As part of the "DZHKomics" co-operation project, the DZHK provided funds for DNA and RNA sequencing, transport costs for samples and storage media, and data storage for sequence data.

This DNA sequencing project has generated a healthy control resource that will broaden our understanding of how genes contribute to disease occurrence.

Browse Resource

Search for data with our genome browser.

Application for Data

The processed DNA sequencing data of our resource is available to all DZHK members and internationally upon request. Researchers can submit requests for use at any time. Please submit them to omics.resource(at) using the respective form. The DZHKomics Use and Access Committee will decide on any user query.

Co-operation Partner of DZHKomics

Participating cohorts:
For the generation of this resource, a total of 1,200 whole-genome DNA samples and 600 RNA samples were sequenced. The sample material was selected from six already existing epidemiological cohort studies at various DZHK member institutions:
  • Gutenberg-Gesundheitsstudie (GHS) - Universitätsmedizin der Johannes Gutenberg-Universität Mainz
  • Hamburg City Health Study (HCHS) - Universitätsklinikum Hamburg-Eppendorf
  • Heidelberg Normal Kontrollen (NOKO) - Universitätsklinikum Heidelberg
  • Kooperative Gesundheitsforschung in der Region Augsburg (KORA) - Helmholtz Zentrum München
  • Study of Health in Pomerania (SHIP) - Universitätsmedizin Greifswald
  • Instituts für Klinische Molekularbiologie Kiel (IKMB) - Universitätsklinikum Schleswig-Holstein

Sample preparation and quality control:
In the run-up to whole-genome and RNA sequencing, SOPs for a harmonic sample preparation were developed specifically for the DZHKomics project. This procedure was intended to minimize potential interferences on the sequencing of samples from different cohorts and to achieve a high comparability of the generated sequence data.

Sequencing, processing, data management:
DNA samples were sequenced on HiSeq X machines in the 'High Throughput Sequencing Unit' at the German Cancer Research Center (DKFZ) located in Heidelberg. Data were analyzed at the Institute of Human Genetics (Helmholtz Zentrum München), the Institute for Cardiogenetics (Universität zu Lübeck), and the Institute of Medical Biometry and Statistics (Universität zu Lübeck).

In addition, both the RNA sequencing on the HiSeq Sequencers and the processing of the data were performed at the Max Delbrück Center for Molecular Medicine in Berlin (MDC) and the processing was made in Munich, Lübeck and Hamburg.