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CULPRIT-Shock

Culprit Lesion Only PCI Versus Multivessel PCI in Cardiogenic Shock (CULPRIT-SHOCK)

Prospective randomized multicenter study comparing immediate multivessel revascularization by PCI versus culprit lesion PCI with staged non-culprit lesion revascularization in patients with acute myocardial infarction complicated by cardiogenic shock (CULPRIT-Shock).

When a large area of the heart is affected by myocardial infarction cardiogenic shock can develop. As a result of the damage caused to the heart muscle, the heart is no longer able to maintain sufficient cardiovascular function. These patients have a very poor prognosis. Cardiogenic shock is the second most frequent cause of death in the setting of acute myocardial infarction. This study includes patients in cardiogenic shock who have damage in multiple coronary arteries. In the acute treatment of arterial blockages by percutaneous coronary intervention (PCI) there are essentially two options: one can treat the ‘culprit’ lesion only or treat additional non-culprit coronary lesions at the same time. The study compares the two approaches and determines which treatment is most appropriate for patients who develop cardiogenic shock following myocardial infarction.

Principal Investigators

Principal investigator: Holger Thiele (Lübeck und Leipzig)

Medical institution

Universität zu Lübeck

Keywords

infarction, multivessel coronary artery disease, cardiogenic shock, angioplasty

Recruitment start

04/2013

Patients (planned)

706

Patients (recruited)

706 (completed)

ClinicalTrials.gov

NCT01927549