Study information

Recruiting status

Study completed

Recruitment start





Clinical Trials Registration



Guideline relevant study

DZHK Funding

DZHK-assoziierte Studie (keine finanzielle Förderung)

Operative contact: Roza Meyer-Saraei, MD

Culprit Lesion Only PCI Versus Multivessel PCI in Cardiogenic Shock (CULPRIT-SHOCK)

Prospective randomized multicenter study comparing immediate multivessel revascularization by PCI versus culprit lesion PCI with staged non-culprit lesion revascularization in patients with acute myocardial infarction complicated by cardiogenic shock (CULPRIT-Shock).

When a large area of the heart is affected by myocardial infarction cardiogenic shock can develop. As a result of the damage caused to the heart muscle, the heart is no longer able to maintain sufficient cardiovascular function. These patients have a very poor prognosis. Cardiogenic shock is the second most frequent cause of death in the setting of acute myocardial infarction. This study includes patients in cardiogenic shock who have damage in multiple coronary arteries. In the acute treatment of arterial blockages by percutaneous coronary intervention (PCI) there are essentially two options: one can treat the ‘culprit’ lesion only or treat additional non-culprit coronary lesions at the same time. The study compares the two approaches and determines which treatment is most appropriate for patients who develop cardiogenic shock following myocardial infarction.


One-Year Outcomes after Pci Strategies in Cardiogenic Shock. Thiele, H. et al. The New England journal of medicine, (2018).

CULPRIT-SHOCK (Culprit Lesion Only PCI Versus Multivessel Percutaneous Coronary Intervention in Cardiogenic Shock): Implications on Guideline Recommendations. Thiele H et al. Circulation. 2018 Mar 27;137(13):1314-1316. doi: 10.1161/CIRCULATIONAHA.117.032907. 

Check out all publications of CULPRIT-SHOCK.

Principal Investigators

Principal investigator: Holger Thiele (Lübeck und Leipzig)