Study information

Recruiting status

Recruiting complete, follow-up continuing

Recruitment start





Clinical Trials Registration

ClinicalTrials.gov Identifier: NCT04727073

EudraCT Nr.: 2017-000697-11


Guideline relevant study

DZHK Funding

EUR 7.068.795



Operative contact:
Friederike Fenske
Johannes Petutschnigg

Studienzentren/Kontakt (PDF)

SPIRonolactone In the Treatment for Heart Failure (SPIRIT-HF-DZHK8)

The SPIRIT-HF-DZHK8 study investigates whether the drug spironolactone can reduce the number of people with preserved ejection fraction who end up in hospital and the number of people who die from heart failure. Currently, there is no cure for this type of heart failure.

Previous studies with spironolactone have not yet given any clear results for people affected by preserved ejection fraction. The SPIRIT-HF study will differ to previous research because there will be only patients included conclusively diagnosed with poor dilation of the heart chambers.

When someone has heart failure, they overproduce the hormone aldosterone. Excess aldosterone causes heart remodelling. Vital, flexible heart muscle cells are replaced with more rigid connective tissue cells, with no useful function. As a result, the heart’s performance is greatly reduced. Spironolactone blocks the effect of aldosterone and could slow down or stop the remodelling processes that weaken the heart in heart failure.

SPIRIT-HF-DZHK8 is a double-blind phase III study. 35 study sites in Germany, as well as participants and hospitals in Austria, France, the Netherlands and Serbia are involved in the study.

More information: https://spirit-hf.dzhk.de/


There are no publications available yet.

Principal Investigators

Principal investigator: Frank Edelmann (Berlin) (vormals Burkert Pieske)

Press releases and news

New DZHK study offers hope for people with heart failure

A new study from the German Centre for Cardiovascular Research (DZHK) is investigating whether a...

Study recruitment is available in these cities

The map only displays recruitment locations within Germany.