Facilitating international clinical trials

Supporting multinational clinical trials is a focus of the newly established Global Cardiovascular Research Funders Forum (GCRFF). The Initiative is a sub-group of 7 of the 12 national funders.

It aims to facilitate multinational clinical trials by bringing all potential funders to the table right from the start. Scientists simply submit an "Expression of Interest" (EOI) - the initiative coordinates the matching of national funders.

The process has clear advantages for scientists and funders:

  • All funding organisations can get involved in the study design from the beginning. Until now, it has usually been the case that other funding organisations are only brought on board once the study has already been started with one funding organisation.
  • The study can be coordinated and started simultaneously in different countries: this increases the chances of success.
  • Reduce the risk to the funder(s) because there is greater assurance that the trial will be deliverable and costs are spread.

Want to submit an expression of interest (EOI)?

How it works

The EOI is submitted via the Grants Management System of the British Heart Foundation (BHF).

You can find detailed instructions on how to submit an EOI in this document: How it works

The first call for Expressions of Interest is now open - the deadline to submit by is Friday 1st October 2021.

Please note

The GCRFF Multinational Clinical Trials Initiative provides a mechanism to support better coordination of consideration of multinational trial funding. It does not fund trials directly, nor does it guarantee funding by individual funders.

Global Cardiovascular Research Funders Forum (GCRFF)

We've joined forces with leading cardiovascular research funders in a new global partnership. The Global Cardiovascular Research Funders Forum (GCRFF) aims to accelerate the pace of progress by creating opportunities for cross-border coordination and collaboration between world-leading cardiovascular researchers and organisations. Its members will initially collaborate by sharing information on research funding priorities, strategic initiatives, and clinical trials.

The Forum includes many of the biggest independent funders of cardiovascular research in the world, which together support more than US$600 million in research annually.

The 12 members are:

Australia - National Heart Foundation of Australia
Canada - The Heart and Stroke Foundation of Canada; Institute of Circulatory and Respiratory Health, Canadian Institutes of Health Research, Canada
Denmark - Danish Heart Foundation (Hjerteforeningen)
France - Leducq Foundation
Germany - German Centre for Cardiovascular Research
Great Britain - British Heart Foundation
Netherlands - Dutch Heart Foundation (Hartstichting)
New Zealand - National Heart Foundation of New Zealand
Sweden - Swedish Heart Lung Foundation (Hjärt-Lungfonden)
USA - American Heart Association; National Heart, Lung and Blood Institute
Despite the astonishing progress that cardiovascular research has made in recent decades, cardiovascular diseases remain the biggest cause of death and disability globally, meaning urgent progress is needed.

International funders aim to improve global heart health (22.06.2021) press release