Low-energy defibrillation of ventricular fibrillati-on in pigs as an animal model for heart failure


Funded period

2016 – 2019

Granted budget

€ 1,022,999

Indication

ventricular fibrillation

Therapeutic Principle

Medicinal Product

Principal Investigator

Stefan Luther, Gerd Hasenfuß (Max Planck Institute for Dynamics and Self-Organisation, University Medical Centre Göttingen)

In previous studies run by the working group led by Stefan Luther it was shown that the energy applied in cardiac arrhythmias could be reduced by 80 to 90 percent compared to conventional defibrillations.

In order to translate these results successfully into clinical application, the necessary proof of efficacy in an animal model is to be produced in the scope of this project: the termination of ventricular fibrillation by means of a novel defibrillator compared to conventional defibrillation will be examined in pigs used as an animal model for heart failure. The results will constitute the foundation for preparing a study for a first-in-human application