Endothelial cell dynamics in vascular remodelling


Funding ID

81Z1100104

Project number

424

Institution
Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader
Holger Gerhardt
Site
Berlin
Short description

Our recent work on endothelial cell specification, competition, dynamic rearrangements, Notch signalling synchronization, and vessel regression established key principles in vascular … 

Our recent work on endothelial cell specification, competition, dynamic rearrangements, Notch signalling synchronization, and vessel regression established key principles in vascular patterning and malformations. Challenges ahead lie in the multiscale and multiphysics nature of vascular remodelling. Our project bridges across scales and disciplines to establish mechanisms of dynamic cell polarity establishment and regulation of endothelial cell shape in vascular remodelling, as well as transmission and integration of physical forces with signalling to influence shape and polarity of individual cells. We then ask how collective cell behaviour under the influence of the above-mentioned principles is coordinated with blood flow and tissue responses to achieve functional remodelling.

Project type
Partner Site Projects
Keywords
angiogenesis, imaging, blood flow, mouse, zebrafish
Topic
vascular remodelling/altering
Funding
€ 2.358.269,00
Begin
01.01.2015
End
31.12.2018