Immunotherapy of Vascular Disease


Funding ID

81Z1600212

Project number

433

Institution
Klinikum der Universität München
Project leader
Christian Weber
Site
München
Short description

The newly established research group headed by the DZHK-Professor Oliver Soehnlein shall develop and pursue novel concepts for target identification and therapeutic exploitation in the … 

The newly established research group headed by the DZHK-Professor Oliver Soehnlein shall develop and pursue novel concepts for target identification and therapeutic exploitation in the context of the chemokine-interactome, leukocytic granule proteins, and costimulatory molecules for the treatment of inflammatory aspects of cardiovascular diseases. These are based on detailed structure-function analyses, modelling of molecular interactions, and synthetic peptide chemistry for generation of interceptors, which shall be validated and optimized for safety and efficacy during atherogenic immune cell recruitment. It is the aim to generate peptides for use in clinical studies which shall be realized in subsequent funding periods.

Project type
Partner Site Projects
Keywords
chemokine, heteromer, neutrophil, platelet, inflammation, recruitment
Topic
inflammation/vascular inflammation
Funding
€ 1.849.181,03
Begin
15.10.2011
End
31.12.2018