Experimental and integrative analysis of CAD


Funding ID

81Z1600512

Project number

438

Institution
Deutsches Herzzentrum München
Project leader
Heribert Schunkert
Site
München
Short description

Our group has significantly contributed to the discovery and functional analysis of a large number of genomic variants which were identified to be genome-wide significantly associated … 

Our group has significantly contributed to the discovery and functional analysis of a large number of genomic variants which were identified to be genome-wide significantly associated with coronary artery disease. Hence, several transgenic animal models as well as novel bioinformatics strategies have been established to enable the analysis of networks and signaling pathways. In the project “Experimental and integrative analysis of CAD” we aim to experimentally explore these tools of functional gene analysis. Furthermore, using OMICS datasets and animal models, which are based on the genome-wide significant coronary artery disease loci, we aim to improve the understanding of the molecular consequences of the identified variants for the development of coronary artery disease and myocardial infarction.

Project type
Partner Site Projects
Keywords
animal models, genome-wide association studies, coronary artery disease, myocardial infarction
Topic
genetics of cardiovascular diseases
Funding
€ 832.156,69
Begin
01.01.2013
End
31.12.2018