From GWAS hits to novel treatment targets


Funding ID

81Z1700101

Project number

440

Institution
Universität zu Lübeck
Project leader
Jeanette Erdmann
Site
Hamburg/Kiel/Lübeck
Short description

The project aims to systematically explore the human genome in cardiovascular disease, as well as to study the functional consequences of genomic variations in human cell and animal … 

The project aims to systematically explore the human genome in cardiovascular disease, as well as to study the functional consequences of genomic variations in human cell and animal models. We wish to enhance diagnostic and therapeutic options particularly in the context of atherosclerosis and myocardial infarction. We systematically explored genome-wide association as well as genome-wide sequencing data and contributed to the identification of most currently known alleles affecting risk of the disease. Transgenic animal models (mice), also based on these newly identified genes, are about to further refine the mechanistic understanding of these processes. We aim to utilize these resources for the benefit of patients in terms of improved risk prediction and individualized medical treatment.

Project type
Partner Site Projects
Keywords
myocardial infarction, coronary artery disease, genetics, GWAS, animal models, SNPs, NGS
Topic
genetics of cardiovascular diseases
Funding
€ 1.841.521,35
Begin
05.11.2014
End
31.12.2018