Phenotypic evaluation of MI genes in mouse models


Funding ID

81Z1700102

Project number

442

Institution
Universität zu Lübeck
Project leader
Cor de Wit
Site
Hamburg/Kiel/Lübeck
Short description

This project is aimed to analyse mouse models that carry identified CAD/MI genes with respect to flow regulation in the microcirculation, neointima formation in carotid artery, and … 

This project is aimed to analyse mouse models that carry identified CAD/MI genes with respect to flow regulation in the microcirculation, neointima formation in carotid artery, and platelet aggregation in arterioles. Flow regulation is studied by measuring arteriolar diameter changes in the in vivo setting before and after stimulation using vasoactive agents. Neointima formation is an in vivo model of atherosclerosis that induces a switch in smooth muscle phenotype. Thrombus formation is initiated in vivo in arterioles by mechanical or excitation of light-sensitive dyes to induce platelet activation. By these means we aim to obtain insight into pathophysiological mechanisms that are initiated by such genes of risk which ultimately may cause or promote CAD/MI.

Project type
Partner Site Projects
Keywords
endothelium, microcirculation, knockout-models
Topic
genetics of cardiovascular diseases
Funding
€ 352.396,59
Begin
01.01.2015
End
31.12.2018