Vascular end organ damage


Funding ID

81Z1700105

Project number

445

Institution
Universität zu Lübeck
Project leader
Markus Schwaninger
Site
Hamburg/Kiel/Lübeck
Short description

Our project investigates vascular pruning and remodeling in mouse models of disease. We focus on (i) diabetes and (ii) incontinentia pigmenti, a genetic disease that leads to vascular … 

Our project investigates vascular pruning and remodeling in mouse models of disease. We focus on (i) diabetes and (ii) incontinentia pigmenti, a genetic disease that leads to vascular pathology in the brain. Although diverse in etiology, the two conditions share an involvement of the proinflammatory transcription factor NF-?B. To explore whether interfering with NF-?B signaling offers therapeutic opportunities, we employ classical small-molecule pharmacology as well as gene therapy approaches. Optical coherence tomography and various physiological or morphological techniques are used to evaluate the vasculature.

Project type
Partner Site Projects
Keywords
optical coherence tomography, diabetic complications, diabetic microvascular pathology, incontinentia pigmenti, small vessel diseases, NF-kB, gene therapy
Topic
endothelial cells/vascular function
Funding
€ 250.009,05
Begin
01.01.2015
End
31.12.2018