Alternatives Spleißen als therapeutisches Target für Erkrankungen des Herzens


Funding ID

81Z2100102

Project number

450

Institution
Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader
Michael Gotthardt
Site
Berlin
Short description

The project „alternative splicing as a therapeutic target for cardiac diseases“ builds on our identification of RBM20 as a splice factor with substrates related to sarcomere function and … 

The project „alternative splicing as a therapeutic target for cardiac diseases“ builds on our identification of RBM20 as a splice factor with substrates related to sarcomere function and calcium homeostasis. We will study the regulation of RBM20 expression and function, as well as its interaction with other proteins to identify potential therapeutic targets. Through the coordinated interference with cardiac isoform expression, we will adapt the elastic and electrical properties of the heart.

Project type
Partner Site Projects
Keywords
RNA, splicing, therapy
Topic
cardiomyocyte function
Funding
€ 361.000,00
Begin
01.01.2015
End
31.12.2018