From channelopathies to clinical arrhythmias


Funding ID

81Z2500201

Project number

464

Institution
Ruprecht-Karls-Universität Heidelberg
Project leader
Martin Borggrefe
Site
Heidelberg/Mannheim
Short description

Investigation of underlying mechanisms and identification of new therapeutic targets: hiPSC-CMs possess characteristics similar to that of native human cardiomyocytes and can model the … 

Investigation of underlying mechanisms and identification of new therapeutic targets: hiPSC-CMs possess characteristics similar to that of native human cardiomyocytes and can model the main features of some heart diseases. They provide a new platform to study the disease pathology and screen drugs. The aim of our study is to use the hiPSC-CMs modeling the arrhythmogenic heart diseases (SQTs, LQTs, Brugada syndrome, ARVC, HCM and DCM) for studying the underlying mechanisms and identifying new therapeutic targets for the treatment of the diseases. In addition, we will test effects of drugs on the “diseased” hiPSC-CMs and design better drug treatments for the diseases

Project type
Partner Site Projects
Keywords
iPS, arrhythmias, Patch-clamp
Topic
iPSC
Funding
€ 587.627,67
Begin
01.01.2015
End
31.12.2018