Minimally invasive valve resection and replacement: polycarbonateurethane valved stent implantation


Funding ID

81Z2700203

Project number

477

Institution
Universitätsklinikum Schleswig-Holstein
Project leader
Georg Lutter
Site
Hamburg/Kiel/Lübeck
Short description

Tissue engineering is an upcoming technique for heart valve replacement, providing a living valve, capable of growth and biological integration. Heart valves made of synthetic polymers … 

Tissue engineering is an upcoming technique for heart valve replacement, providing a living valve, capable of growth and biological integration. Heart valves made of synthetic polymers such as polyurethanes exhibit biocompatibility, bioresorbability and excellent mechanical properties with high durability. Endothelial progenitor cells (EPCs) are ideal candidates for vascular regenerative therapy, as they participate in blood vessel formation and incorporate into damaged vascular structure. In this project, the optimal conditions for administration of EPCs on polymeric scaffolds will be improved. Functionality, biocompatibility, inflammatory capacity and biological integrity of these engineered valved stents will be analysed in vivo (sheep model) for human cardiovascular application.

Project type
Partner Site Projects
Keywords
tissue engineering, endothelial progenitor cells, cell seeding, polymeric scaffolds
Topic
stem cells/cardiac regeneration
Funding
€ 280.000,00
Begin
01.11.2014
End
31.12.2018