Myocardial RNA Therapy


Funding ID

81Z3600431

Project number

493

Institution
Technische Universität München
Project leader
Stefan Engelhardt
Site
München
Short description

This project aims to develop RNA-based therapeutics that interfere with myocardial damage. For this purpose several cardiovascular microRNAs have been identified and functionally … 

This project aims to develop RNA-based therapeutics that interfere with myocardial damage. For this purpose several cardiovascular microRNAs have been identified and functionally characterized with regard to their capacity to regulate key cellular signaling pathways. A subset of these miRNAs are being validated in mouse models of disease and approaches for their therapeutic manipulation are being developed. This involves studies that aim to optimize the pharmacokinetics and pharmacodynamics of miRNA inhibitor molecules.

Project type
Partner Site Projects
Keywords
miRNA-based therapy, microRNA, AntagomiR, anti-miR, AAV
Topic
DNA/RNA based, protein based therapy
Funding
€ 1.966.524,12
Begin
15.10.2011
End
31.12.2018