Nutritional Pharmacology
- Funding ID
81Z5100254
- Project number
498
- Institution
- Charité - Universitätsmedizin Berlin
- Project leader
- Ulrich Kintscher
- Site
- Berlin
- Short description
-
This study aims to investigate the preventive actions of new lipid mediators on myocardial hypertrophy and heart failure. We could recently show that palmitoleic acid (C16:1n7) promotes …
This study aims to investigate the preventive actions of new lipid mediators on myocardial hypertrophy and heart failure. We could recently show that palmitoleic acid (C16:1n7) promotes the development of physiological cardiac remodeling (Foryst-Ludwig A, J Biol Chem 2015). In continuation of this, we are now focusing on new ?-3 fatty acids. We will test the anti-hypertrophic/ anti-fibrotic potential of anti-inflammatory lipid mediators such as resolvins, protectins und maresins in different disease models such as TAC or isoprenalin injection.
- Project type
- Partner Site Projects
- Keywords
- lipids, metabolism, heart failure
- Topic
- cardiac hypertrophy/remodeling
- Funding
- € 554.977,80
- Begin
- 01.01.2015
- End
- 31.12.2018