Platform Reprogramming


Funding ID

81Z7600671

Project number

534

Institution
Klinikum rechts der Isar der Technischen Universität München
Project leader
Laugwitz/Moretti
Site
München
Short description

The focus of this project is the generation of patient-specific models of monogenic and complex cardiovascular diseases using induced pluripotent stem cells (iPSCs) in order to study the … 

The focus of this project is the generation of patient-specific models of monogenic and complex cardiovascular diseases using induced pluripotent stem cells (iPSCs) in order to study the molecular pathways that drive the disease and screen for both genes and drugs that can block the disease onset or progression at a cellular level. We work on optimization of reprogramming methods and differentiation protocols into the cardiovascular lineages as well as the development of high-throughput functional assays and CRISPR/Cas9-based genome editing in iPSCs.

Project type
Partner Site Projects
Keywords
induced pluripotent stem cells, disease modelling, drug/intervention testing
Topic
iPSC
Funding
€ 725.269,93
Begin
15.10.2011
End
31.12.2018