Research areas: aging, non-coding RNA
Jeanette Erdmann is DZHK Professor for Cardiogenetics at the University of Lübeck. Her main interest is unravelling the genetics of cardiovascular disease and myocardial infarction to develop novel therapeutic targets.
The Institute for Cardiogenetics aims to better understand the genetic factors that lead to cardiovascular diseases, eg. atherosclerosis and myocardial infarction – more commonly known as heart attack. There is an urgent need to progress beyond current state-of-the-art genetics by adding further levels of omics data and approaches that include markers of regulatory function.
By integrating bioinformatical, epidemiological, clinical and experimental data, we propose to elucidate the functional basis of already-known genetic loci, as well as identify novel pathways to further understand the pathomechanisms leading to these life-threatening diseases. To fulfill these overarching goals the Institute for Cardiogenetics hosts an interdisciplinary as well as international research team of 25 scientists, PhD and MD students and technicians.
Major achievements and awards
- Member of the “Stiftungsrat” University of Lübeck (2019-ongoing)
- Deputy Editor, Circulation: Genomics and Precision Medicine (2019-2022)
- Coordinator of the BHF/DZHK funded VIAgenomics consortium (Genetic discovery-based targeting of the vascular interface in atherosclerosis) (2019-2022)
- Highly cited researcheraccording to Web of Science in category cross-field (2006-2016)
- Gründerpreis der Sparkasse Lübeck (iPS-HL) (2014)
- Präventionspreis der Deutschen Gesellschaft für Innere Medizin (2010)
Erdmann J, [...], Meitinger T, Hengstenberg C, Schunkert H. (2013) Dysfunctional nitric oxide signalling increases risk of myocardial infarction. Nature. 504:432-6.]
Samani NJ, Erdmann J, [...], Schunkert H. (2007) Genomewide association analysis of coronary artery disease. N Engl J Med. 357:443-53.
Stitziel NO, Stirrups KE, Masca N, Erdmann J, […], Schunkert H. (2016) Coding Variation in ANGPTL4, LPL, and SVEP1 and risk of coronary disease. N Engl J Med. 374:1134-1144.
Nikpay M, Goel A, Won HH, […], Erdmann J, […], CARDIoGRAMplusC4D Consortium. (2015) A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet. 47:1121-1130.
Brænne I, Kleinecke M, Reiz B, Graf E, Strom T, Wieland T, Fischer M, Kessler T, Hengstenberg C, Meitinger T, Erdmann J, Schunkert H. (2015) Systematic analysis of variants related to familial hypercholesterolemia in families with premature myocardial infarction. Eur J Hum Genet. 24:191-197.
Kessler T, Zhang L, Liu Z, Yin X, Huang Y, Wang Y, Fu Y, Mayr M, Ge Q, Xu Q, Zhu Y, Wang X, Schmidt K, de Wit C, Erdmann J, Schunkert H, Aherrahrou Z, Kong W. (2015) ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1. Circulation. 131(13):1191-201.
Myocardial Infarction Genetics Consortium Investigators, Stitziel NO, Won HH, [...], Erdmann J, Schunkert H, [...], Kathiresan S. (2014) Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med. 371:2072-82.
Schunkert H, [...], Erdmann J, Samani NJ. (2011) Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 43:333-8.
CARDIoGRAMplusC4D Consortium, [...], Erdmann J, [...], Schunkert H, Samani NJ. (2013) Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 45:25-33
Erdmann J, […], Schunkert H. (2009) New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet. 41:280-2