Prof. Dr. rer. nat. Tanja Zeller

Contact:

University Heart Center Hamburg
Molecular Cardiology, Genomics and Systems Biology
Campus Forschung, Building N27

Martinistrasse 52
20246 Hamburg

Email: t.zeller(at)uke.de

Website: www.uke.de

Research areas: molecular cardiology, systems biology, genomics


Tanja Zeller is DZHK Professor for Genomics and Systems Biology at the University Medical Center Hamburg-Eppendorf since 1 October 2014. Her research focuses on identifying molecular biomarkers in the field of cardiovascular diseases. The research group led by Tanja Zeller combines molecular and cell biological as well as bioinformatics and statistical methods with genetic and clinical epidemiology to develop systems medicine approaches.

Research focus

The research group of Prof. Tanja Zeller conducts so-called OMICS analyses to investigate the relationship between genetic variants, transcripts, proteins, and metabolites with cardiovascular phenotypes. In molecular and cell biological experiments, the function, and role of the genetic variants or the corresponding candidate genes for the cardiovascular system are investigated. Large amounts of data and biomaterial from population-based and disease-based cohort studies are used to enable this research.

Ursachen von Herzkrankheiten bekämpfen: DNA-Analyse bei 9.000 Menschen am UKE

Mit einem Forschungsprogramm am Universitätsklinikum Hamburg-Eppendorf (UKE) sollen die Ursachen für Herz-Kreislauf-Erkrankungen näher erforscht werden: Hierzu wird das Erbgut von 9.000 Menschen analysiert. Das Forschungsprojekt der Hamburger und Schweizer Wissenschaftler sei das größte dieser Art im deutschsprachigen Raum. SAT1 berichtet in einem Newsbeitrag.

Major achievements and awards

  • Award Outstanding Reviewer 2019 for Circulation
  • Speaker Systems Medicine Project Committee since 2016
  • Best Doctoral Thesis, University Gießen

Key publications

Neumann JT, Twerenbold R, Ojeda F, Sörensen NA, Chapman AR, Shah ASV, Anand A, Boeddinghaus J, Nestelberger T, Badertscher P, Mokhtari A, Pickering JW, Troughton RW, Greenslade J, Parsonage W, Mueller-Hennessen M, Gori T, Jernberg T, Morris N, Liebetrau C, Hamm C, Katus HA, Münzel T, Landmesser U, Salomaa V, Iacoviello L, Ferrario MM, Giampaoli S, Kee F, Thorand B, Peters A, Borchini R, Jørgensen T, Söderberg S, Sans S, Tunstall-Pedoe H, Kuulasmaa K, Renné T, Lackner KJ, Worster A, Body R, Ekelund U, Kavsak PA, Keller T, Lindahl B, Wild P, Giannitsis E, Than M, Cullen LA, Mills NL, Mueller C, Zeller T, Westermann D, Blankenberg S. Application of High-Sensitivity Troponin in Suspected Myocardial Infarction. N Engl J Med. 2019; 380(26):2529-2540.

Diagnostic Evaluation of a High-Sensitivity Troponin I Point-of-Care Assay. Sörensen NA, Neumann JT, Ojeda F, Giannitsis E, Spanuth E, Blankenberg S, Westermann D, Zeller T. Clin Chem. 2019 Dec;65(12):1592-1601

Rat atrial engineered heart tissue: a new in vitro model to study atrial biology. Krause J, Löser A, Lemoine MD, Christ T, Scherschel K, Meyer C, Blankenberg S, Zeller T, Eschenhagen T, Stenzig J. Basic Res Cardiol. 2018 Sep 3;113(5):41. 

Schofer N, Ludwig S, Rübsamen N, Schnabel R, Lackner K, Ruprecht H, Bickel C, Landmesser U, Blankenberg S, Zeller T. Corrigendum to "Prognostic Impact of Interleukin-1 Receptor Antagonist in Patients with documented Coronary Artery Disease" [Int. J. Cardiol. 257 (2018) 24-29]. Int J Cardi. 2018;261:239. 

Karakas M, Schulte C, Appelbaum S, Ojeda F, Lackner KJ, Münzel T, Schnabel RB, Blankenberg S, Zeller T. Circulating microRNAs strongly predict cardiovascular death in patients with coronary artery disease-results from the large AtheroGene study. Eur Heart J. 2017 Feb 14; 38(7):516-523. doi: 10.1093/eurheartj/ehw250

Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure. Zeller T, Schurmann C, Schramm K, Müller C, Kwon S, Wild PS, Teumer A, Herrington D, Schillert A, Iacoviello L, Kratzer A, Jagodzinski A, Karakas M, Ding J, Neumann JT, Kuulasmaa K, Gieger C, Kacprowski T, Schnabel RB, Roden M, Wahl S, Rotter JI, Ojeda F, Carstensen-Kirberg M, Tregouet DA, Dörr M, Meitinger T, Lackner KJ, Wolf P, Felix SB, Landmesser U, Costanzo S, Ziegler A, Liu Y, Völker U, Palmas W, Prokisch H, Guo X, Herder C, Blankenberg S, Homuth G. Hypertension. 2017 Oct;70(4):743-750. 

Molecular Characterization of the NLRC4 Expression in Relation to Interleukin-18 Levels. Zeller T, Haase T, Müller C, Riess H, Lau D, Zeller S, Krause J, Baumert J, Pless O, Dupuis J, Wild PS, Eleftheriadis M, Waldenberger M, Zeilinger S, Ziegler A, Peters A, Tiret L, Proust C, Marzi C, Munzel T, Strauch K, Prokisch H, Lackner KJ, Herder C, Thorand B, Benjamin EJ, Blankenberg S, Koenig W, Schnabel RB. Circ Cardiovasc Genet. 2015 Oct;8(5):717-26

Dichloroacetate prevents restenosis in preclinical animal models of vessel injury. Deuse T, Hua X, Wang D, Maegdefessel L, Heeren J, Scheja L, Bolaños JP, Rakovic A, Spin JM, Stubbendorff M, Ikeno F, Länger F, Zeller T, Schulte-Uentrop L, Stoehr A, Itagaki R, Haddad F, Eschenhagen T, Blankenberg S, Kiefmann R, Reichenspurner H, Velden J, Klein C, Yeung A, Robbins RC, Tsao PS, Schrepfer S. Nature. 2014 May 29;509(7502):641-4 

Assessment of microRNAs in patients with unstable angina pectoris. Zeller T, Keller T, Ojeda F, Reichlin T, Twerenbold R, Tzikas S, Wild PS, Reiter M, Czyz E, Lackner KJ, Munzel T, Mueller C, Blankenberg S. Eur Heart J. 2014 Aug 14;35(31):2106-14 

Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies. Choe CU, Atzler D, Wild PS, Carter AM, Böger RH, Ojeda F, Simova O, Stockebrand M, Lackner K, Nabuurs C, Marescau B, Streichert T, Müller C, Lüneburg N, De Deyn PP, Benndorf RA, Baldus S, Gerloff C, Blankenberg S, Heerschap A, Grant PJ, Magnus T, Zeller T*, Isbrandt D*, Schwedhelm E*. Circulation. 2013 Sep 24;128(13):1451-61