Publikationen 2022

Hier finden Sie die Publikationen des DZHK. Grau markierte Erstautoren sind DZHK-Nachwuchswissenschaftler. Bitte informieren Sie sich über weitere Publikationen auch auf den Internetseiten der am DZHK beteiligten Forschungseinrichtungen.

Zu den DZHK Papers of the Month

Januar

Association of renin and aldosterone with glucose metabolism in a Western European population: the KORA F4/FF4 study. Then, C., Ritzel, K., Herder, C., Then, H., Sujana, C., Heier, M., Meisinger, C., Peters, A., Koenig, W., Rathmann, W., Roden, M., Maalmi, H., Stumvoll, M., Meitinger, T., Bidlingmaier, M., Seissler, J., Thorand, B. & Reincke, M. BMJ Open Diabetes Res Care 10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35086943  

Intraocular Pressure and Its Relation to Ocular Geometry: Results From the Gutenberg Health Study. Hoffmann, E. M., Aghayeva, F., Wagner, F. M., Fiess, A., Nagler, M., Munzel, T., Wild, P. S., Beutel, M. E., Schmidtmann, I., Lackner, K. J., Pfeiffer, N. & Schuster, A. K. Invest Ophthalmol Vis Sci 63, 40 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35089330  

Stroke and Thromboembolism in Patients with Heart Failure and Sinus Rhythm: A Matter of Risk Stratification? Rivas, A., Lauw, M. N., Schnabel, R. B., Crowther, M. & Van Spall, H. G. C. Thromb Haemost 122, 871-878 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35045579  

Thrombosis and Haemostasis 2021 Editors' Choice Papers. Weber, C., Rigby, A. & Lip, G. Y. H. Thromb Haemost 122, 163-170 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35038760  

A Rollercoaster Plunge into 2022. Lip, G. Y. H., Rigby, A. & Weber, C. Thromb Haemost 122, 1-4 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35038759  

Epigenetic scores for the circulating proteome as tools for disease prediction. Gadd, D. A., Hillary, R. F., McCartney, D. L., Zaghlool, S. B., Stevenson, A. J., Cheng, Y., Fawns-Ritchie, C., Nangle, C., Campbell, A., Flaig, R., Harris, S. E., Walker, R. M., Shi, L., Tucker-Drob, E. M., Gieger, C., Peters, A., Waldenberger, M., Graumann, J., McRae, A. F., Deary, I. J. et al. Elife 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35023833  

Carbon-mixed dental cement for fixing fiber optic ferrules prevents visually triggered locomotive enhancement in mice upon optogenetic stimulation. Araragi, N., Alenina, N. & Bader, M. Heliyon 8, e08692 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35024491  

Physical Performance and Non-Esterified Fatty Acids in Men and Women after Transcatheter Aortic Valve Implantation (TAVI). Hardrich, M., Haase-Fielitz, A., Fielitz, J., Boschmann, M., Pivovarova-Ramich, O., Pfeiffer, A. F. H., Rudovich, N., Weylandt, K. H. & Butter, C. Nutrients 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35011078  

Risk prediction in patients with low-flow, low-gradient aortic stenosis and reduced ejection fraction undergoing TAVI. Ludwig, S., Gossling, A., Seiffert, M., Westermann, D., Sinning, J. M., Sugiura, A., Adam, M., Mauri, V., Frank, D., Seoudy, H., Rudolph, T., Potratz, M., Conradi, L. & Schofer, N. Open Heart 9 (2022). https://www.ncbi.nlm.nih.gov/pubmed/34987075  

[Care of adults with congenital heart diseases in Germany-Leading role by internal medicine specialists and general practitioners]. Kaemmerer, H., Freilinger, S., Neidenbach, R., Achenbach, S., Andonian, C., Ewert, P., de Haan, F., Nagdyman, N., Schelling, J., Hofbeck, M., Bauer, U., Huntgeburth, M. & Meinertz, T. Internist (Berl) 63, 95-102 (2022). https://www.ncbi.nlm.nih.gov/pubmed/34985563  

Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function. Hawe, J. S., Wilson, R., Schmid, K. T., Zhou, L., Lakshmanan, L. N., Lehne, B. C., Kuhnel, B., Scott, W. R., Wielscher, M., Yew, Y. W., Baumbach, C., Lee, D. P., Marouli, E., Bernard, M., Pfeiffer, L., Matias-Garcia, P. R., Autio, M. I., Bourgeois, S., Herder, C., Karhunen, V. et al. Nat Genet 54, 18-29 (2022). https://www.ncbi.nlm.nih.gov/pubmed/34980917  

Cigarette smoke augments CSF3 expression in neutrophils to compromise alveolar-capillary barrier function during influenza infection. McGrath, J. J. C., Vanderstocken, G., Dvorkin-Gheva, A., Cass, S. P., Afkhami, S., Fantauzzi, M. F., Thayaparan, D., Reihani, A., Wang, P., Beaulieu, A., Shen, P., Morissette, M., Jimenez-Saiz, R., Revill, S. D., Tabuchi, A., Zabini, D., Lee, W. L., Richards, C. D., Miller, M. S., Ask, K. et al. Eur Respir J 60 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35058252  

Access Route and Clinical Outcomes After Ticagrelor Versus Prasugrel in Patients With Acute Coronary Syndrome Undergoing Invasive Treatment Strategy. Hemetsberger, R., Richardt, G., Lahu, S., Valina, C., Menichelli, M., Abdelghani, M., Wohrle, J., Toelg, R., Witzenbichler, B., Mankerious, N., Liebetrau, C., Bernlochner, I., Hamm, C. W., Allali, A., Joner, M., Fusaro, M., Xhepa, E., Hapfelmeier, A., Kufner, S., Sager, H. B. et al. Cardiovasc Revasc Med 41, 122-128 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35045943  

Redox Regulatory Changes of Circadian Rhythm by the Environmental Risk Factors Traffic Noise and Air Pollution. Daiber, A., Frenis, K., Kuntic, M., Li, H., Wolf, E., Kilgallen, A. B., Lecour, S., Van Laake, L. W., Schulz, R., Hahad, O. & Munzel, T. Antioxid Redox Signal (2022). https://www.ncbi.nlm.nih.gov/pubmed/35088601

Association of thyroid function with insulin resistance: data from two population-based studies. Spira, D., Buchmann, N., Dorr, M., Markus, M. R. P., Nauck, M., Schipf, S., Spranger, J., Demuth, I., Steinhagen-Thiessen, E., Volzke, H. & Ittermann, T. Eur Thyroid J 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35085102  

Detection and analysis of cerebral aneurysms based on X-ray rotational angiography - the CADA 2020 challenge. Ivantsits, M., Goubergrits, L., Kuhnigk, J. M., Huellebrand, M., Bruening, J., Kossen, T., Pfahringer, B., Schaller, J., Spuler, A., Kuehne, T., Jia, Y., Li, X., Shit, S., Menze, B., Su, Z., Ma, J., Nie, Z., Jain, K., Liu, Y., Lin, Y. et al. Med Image Anal 77, 102333 (2022). https://www.ncbi.nlm.nih.gov/pubmed/34998111  

Pulsed-field ablation combined with ultrahigh-density mapping in patients undergoing catheter ablation for atrial fibrillation: Practical and electrophysiological considerations. Gunawardene, M. A., Schaeffer, B. N., Jularic, M., Eickholt, C., Maurer, T., Akbulak, R. O., Flindt, M., Anwar, O., Pape, U. F., Maasberg, S., Gessler, N., Hartmann, J. & Willems, S. J Cardiovasc Electrophysiol 33, 345-356 (2022). https://www.ncbi.nlm.nih.gov/pubmed/34978360

Circulating Interleukin-6 Levels and Incident Ischemic Stroke: A Systematic Review and Meta-analysis of Prospective Studies. Papadopoulos, A., Palaiopanos, K., Bjorkbacka, H., Peters, A., de Lemos, J. A., Seshadri, S., Dichgans, M. & Georgakis, M. K. Neurology 98, e1002-e1012 (2022). https://www.ncbi.nlm.nih.gov/pubmed/34969940

Right atriotomy closure with modified ventricular assist device ring. Lanmuller, P., Eulert-Grehn, J. J., Starck, C., Falk, V. & Potapov, E. J Card Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35094449

Evaluation of systemic inflammation in response to remote ischemic preconditioning in patients undergoing transcatheter aortic valve replacement (TAVR). Zhang, K., Troeger, W., Kuhn, M., Wiedemann, S., Ibrahim, K., Pfluecke, C., Sveric, K. M., Winzer, R., Fedders, D., Ruf, T. F., Strasser, R. H., Linke, A., Quick, S. & Heidrich, F. M. Rev Cardiovasc Med 23, 20 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35092212  

Human-Device Interaction in the Life Science Laboratory. Soldner, R., Rheinlander, S., Meyer, T., Olszowy, M. & Austerjost, J. Adv Biochem Eng Biotechnol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35091814  

HFA-PEFF score: prognosis in patients with preserved ejection fraction after transcatheter aortic valve implantation. Seoudy, H., von Eberstein, M., Frank, J., Thomann, M., Puehler, T., Lutter, G., Lutz, M., Bramlage, P., Frey, N., Saad, M. & Frank, D. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35092186  

Generation of homozygous Nav1.8 knock-out iPSC lines by CRISPR Cas9 genome editing to investigate a potential new antiarrhythmic strategy. Maurer, W., Hartmann, N., Argyriou, L., Sossalla, S. & Streckfuss-Bomeke, K. Stem Cell Res 60, 102677 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35092938  

Progressive Hereditary Transthyretin-Related Amyloidosis (ATTRv) Aggravated by ATTR Wild-Type and Complement Activation. Mattig, I., Heidecker, B., Tschope, C., Messroghli, D., Eurich, D., Kleefeld, F., Gaedeke, J., Stenzel, W., Schmidt, H. H., Rocken, C., Knebel, F. & Hahn, K. J Neuropathol Exp Neurol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35092287  

Controlled-Level EVERolimus in Acute Coronary Syndrome (CLEVER-ACS) - A phase II, randomized, double-blind, multi-center, placebo-controlled trial. Klingenberg, R., Stahli, B. E., Heg, D., Denegri, A., Manka, R., Kapos, I., von Eckardstein, A., Carballo, D., Hamm, C. W., Vietheer, J., Rolf, A., Landmesser, U., Mach, F., Moccetti, T., Jung, C., Kelm, M., Munzel, T., Pedrazzini, G., Raber, L., Windecker, S. et al. Am Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35092722 

Motion-compensated fat-water imaging for 3D cardiac MRI at ultra-high fields. Dietrich, S., Aigner, C. S., Mayer, J., Kolbitsch, C., Schulz-Menger, J., Schaeffter, T. & Schmitter, S. Magn Reson Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/35092090  

Telemedical cardiac risk assessment by implantable cardiac monitors in patients after myocardial infarction with autonomic dysfunction (SMART-MI-DZHK9): a prospective investigator-initiated, randomised, multicentre, open-label, diagnostic trial. Bauer, A., Sappler, N., von Stulpnagel, L., Klemm, M., Schreinlechner, M., Wenner, F., Schier, J., Al Tawil, A., Dolejsi, T., Krasniqi, A., Eiffener, E., Bongarth, C., Stuhlinger, M., Huemer, M., Gori, T., Wakili, R., Sahin, R., Schwinger, R., Lutz, M., Luik, A. et al. Lancet Digit Health 4, e105-e116 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35090674  

A practical guide to setting up pig models for cardiovascular catheterization, electrophysiological assessment and heart disease research. Schuttler, D., Tomsits, P., Bleyer, C., Vlcek, J., Pauly, V., Hesse, N., Sinner, M., Merkus, D., Hamers, J., Kaab, S. & Clauss, S. Lab Anim (NY) 51, 46-67 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35087256  

Accuracy and Acute Efficacy of the Novel Injection-Based Occlusion Algorithm in Cryoballoon Pulmonary Vein Isolation Guided by Dielectric Imaging. Rottner, L., Moser, F., Weimann, J., Moser, J., Schleberger, R., Lemoine, M., Munkler, P., Dinshaw, L., Risius, T., Kirchhof, P., Ouyang, F., Reissmann, B., Metzner, A. & Rillig, A. Circ Arrhythm Electrophysiol 15, e010174 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35089058  

Where the Action Is-Leukocyte Recruitment in Atherosclerosis. Mauersberger, C., Hinterdobler, J., Schunkert, H., Kessler, T. & Sager, H. B. Front Cardiovasc Med 8, 813984 (2021). https://www.ncbi.nlm.nih.gov/pubmed/35087886  

[Ocular manifestations in patients with COVID-19]. Hosel, K., von der Burchard, C., Schunk, D., Franzenburg, J., Bahmer, T., Frank, D., Dargvainiene, J. & Roider, J. B. Ophthalmologe, 1-6 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35089415  

Immune Mechanisms of Plaque Instability. Gerhardt, T., Haghikia, A., Stapmanns, P. & Leistner, D. M. Front Cardiovasc Med 8, 797046 (2021). https://www.ncbi.nlm.nih.gov/pubmed/35087883  

Social Equity in the Efficacy of Computer-Based and In-Person Brief Alcohol Interventions Among General Hospital Patients With At-Risk Alcohol Use: A Randomized Controlled Trial. Freyer-Adam, J., Baumann, S., Bischof, G., Staudt, A., Goeze, C., Gaertner, B. & John, U. JMIR Ment Health 9, e31712 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35089156  

Patterned Illumination Techniques in Optogenetics: An Insight Into Decelerating Murine Hearts. Diaz-Maue, L., Steinebach, J. & Richter, C. Front Physiol 12, 750535 (2021). https://www.ncbi.nlm.nih.gov/pubmed/35087413  

Serum creatinine baseline fluctuation and acute kidney injury after intravenous or intra-arterial contrast agent administration - an intraindividual comparison as part of a randomized controlled trial. Bosserdt, M., Martus, P., Tauber, R., Dreger, H., Dewey, M. & Schonenberger, E. Nephrol Dial Transplant (2022). https://www.ncbi.nlm.nih.gov/pubmed/35090035  

Interpretation and actionability of genetic variants in cardiomyopathies: a position statement from the European Society of Cardiology Council on cardiovascular genomics. Arbustini, E., Behr, E. R., Carrier, L., van Duijn, C., Evans, P., Favalli, V., van der Harst, P., Haugaa, K. H., Jondeau, G., Kaab, S., Kaski, J. P., Kavousi, M., Loeys, B., Pantazis, A., Pinto, Y., Schunkert, H., Di Toro, A., Thum, T., Urtis, M., Waltenberger, J. et al. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35089333  

Impact of inferior vena cava entry characteristics on tricuspid annular access during transcatheter interventions. Ranard, L. S., Vahl, T. P., Chung, C. J., Sadri, S., Khalique, O. K., Hamid, N., Nazif, T., George, I., Ng, V., Patel, A., Rezende, C. P., Reisman, M., Latib, A., Hausleiter, J., Sorajja, P., Bapat, V. N., Tang, G. H. L., Davidson, C. J., Zahr, F., Makkar, R. et al. Catheter Cardiovasc Interv (2022). https://www.ncbi.nlm.nih.gov/pubmed/35084803  

Preventing heart failure: a position paper of the Heart Failure Association in collaboration with the European Association of Preventive Cardiology. Piepoli, M. F., Adamo, M., Barison, A., Bestetti, R. B., Biegus, J., Bohm, M., Butler, J., Carapetis, J., Ceconi, C., Chioncel, O., Coats, A., Crespo-Leiro, M. G., de Simone, G., Drexel, H., Emdin, M., Farmakis, D., Halle, M., Heymans, S., Jaarsma, T., Jankowska, E. et al. Eur J Prev Cardiol 29, 275-300 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35083485  

Recent Advances in Modeling Mitochondrial Cardiomyopathy Using Human Induced Pluripotent Stem Cells. Pavez-Giani, M. G. & Cyganek, L. Front Cell Dev Biol 9, 800529 (2021). https://www.ncbi.nlm.nih.gov/pubmed/35083221   

Optimization of contrast material administration for coronary CT angiography using a software-based test-bolus evaluation algorithm. Fischer, A. M., Decker, J. A., Schoepf, J., Varga-Szemes, A., Flohr, T., Schmidt, B., Gutjahr, R., Sahbaee, P., Giovagnoli, D. A., Emrich, T., Martinez, J. D., Lari, K. B., Bayer, R. R., 2nd & Martin, S. S. Br J Radiol, 20201456 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35084228  

Comparative analysis of common alignment tools for single-cell RNA sequencing. Bruning, R. S., Tombor, L., Schulz, M. H., Dimmeler, S. & John, D. Gigascience 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35084033  

Human engineered heart tissue transplantation in a guinea pig chronic injury model. von Bibra, C., Shibamiya, A., Geertz, B., Querdel, E., Kohne, M., Studemann, T., Starbatty, J., Schmidt, F. N., Hansen, A., Hiebl, B., Eschenhagen, T. & Weinberger, F. J Mol Cell Cardiol 166, 1-10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35081367  

Cardiac fibroblast activation detected by (68)Gallium-FAPI-46 positron emission tomography-magnetic resonance imaging as a sign of chronic activity in cardiac sarcoidosis. Siebermair, J., Kessler, L., Kupusovic, J., Rassaf, T. & Rischpler, C. Eur Heart J Case Rep 6, ytac005 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35079689  

Real-time radial tagging for quantification of left ventricular torsion. Mohammadi, E., Nasiraei-Moghaddam, A. & Uecker, M. Magn Reson Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/35081262  

Population-based cohort imaging: skeletal muscle mass by magnetic resonance imaging in correlation to bioelectrical-impedance analysis. Kiefer, L. S., Fabian, J., Rospleszcz, S., Lorbeer, R., Machann, J., Kraus, M. S., Fischer, M., Roemer, F., Rathmann, W., Meisinger, C., Heier, M., Nikolaou, K., Peters, A., Storz, C., Schlett, C. L. & Bamberg, F. J Cachexia Sarcopenia Muscle (2022). https://www.ncbi.nlm.nih.gov/pubmed/35080141  

Medication for patient-athletes-the therapeutic use exemption procedure. Fiorentini, C., Esefeld, K. & Halle, M. Eur J Prev Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35080612  

Trends and predictors of radiation exposure in percutaneous coronary intervention: the PROTECTION VIII study. Stocker, T. J., Abdel-Wahab, M., Mollmann, H., Deseive, S., Massberg, S. & Hausleiter, J. EuroIntervention (2022). https://www.ncbi.nlm.nih.gov/pubmed/35076020  

Evaluation of a rapid deployment prosthesis strategy for the treatment of aortic valve endocarditis. Belyaev, S., Herrmann, F. E. M., Dashkevich, A., Wenke, K., Vlachea, P., von der Linden, J., Banafsche, R., Hagl, C. & Juchem, G. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35076056  

Myocardial Deformation in the Pediatric Age Group: Normal Values for Strain and Strain Rate Using 2D Magnetic Resonance Feature Tracking. Voges, I., Negwer, I., Caliebe, A., Boroni Grazioli, S., Daubeney, P. E. F., Uebing, A., Pennell, D. J. & Krupickova, S. J Magn Reson Imaging (2022). https://www.ncbi.nlm.nih.gov/pubmed/35072310  

Prognostic value of beta-blocker doses in patients with ventricular tachyarrhythmias. Schupp, T., Ziyadova, S., Reinhardt, J., Sag, Y. U., von Zworowsky, M., Reiser, L., Abumayyaleh, M., Weidner, K., Saleh, A., Mashayekhi, K., Bertsch, T., Abba, M. L., Akin, I. & Behnes, M. Heart Vessels (2022). https://www.ncbi.nlm.nih.gov/pubmed/35072762  

Exercise and Carotid Properties in the Young-The KiGGS-2 Study. Konigstein, K., Buschges, J. C., Sarganas, G., Krug, S., Neuhauser, H. & Schmidt-Trucksass, A. Front Cardiovasc Med 8, 767025 (2021). https://www.ncbi.nlm.nih.gov/pubmed/35071349  

A cytosolic disulfide bridge-supported dimerization is crucial for stability and cellular distribution of Coxsackievirus B3 protein 3A. Voss, M., Kleinau, G., Gimber, N., Janek, K., Bredow, C., Thery, F., Impens, F., Schmoranzer, J., Scheerer, P., Kloetzel, P. M. & Beling, A. FEBS J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35066984  

Diagnostic Accuracy of High-Sensitive Troponin for the Identification of Myocardial Infarction in Patients Presenting with Acute Heart Failure. Ledwoch, J., Schneider, A., Leidgschwendner, K., Kraxenberger, J., Krauth, A., Schneider, V., Martens, E., Muller, A., Laugwitz, K. L. & Kupatt, C. J Emerg Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/35065860  

Cascaded neural network-based CT image processing for aortic root analysis. Kruger, N., Meyer, A., Tautz, L., Hullebrand, M., Wamala, I., Pullig, M., Kofler, M., Kempfert, J., Sundermann, S., Falk, V. & Hennemuth, A. Int J Comput Assist Radiol Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35066774  

Disturbed lipid and amino acid metabolisms in COVID-19 patients. Masoodi, M., Peschka, M., Schmiedel, S., Haddad, M., Frye, M., Maas, C., Lohse, A., Huber, S., Kirchhof, P., Nofer, J. R. & Renne, T. J Mol Med (Berl), 1-14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35064792  

Prognostic value of epicardial adipose tissue volume in combination with coronary plaque and flow assessment for the prediction of major adverse cardiac events. Brandt, V., Bekeredjian, R., Schoepf, U. J., Varga-Szemes, A., Emrich, T., Aquino, G. J., Decker, J., Bayer, R. R., 2nd, Ellis, L., Ebersberger, U. & Tesche, C. Eur J Radiol 148, 110157 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35063819  

Tissue-specific multi-omics analysis of atrial fibrillation. Assum, I., Krause, J., Scheinhardt, M. O., Muller, C., Hammer, E., Borschel, C. S., Volker, U., Conradi, L., Geelhoed, B., Zeller, T., Schnabel, R. B. & Heinig, M. Nat Commun 13, 441 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35064145  

Tissue Engineered Transcatheter Pulmonary Valved Stent Implantation: Current State and Future Prospect. Zhang, X., Puehler, T., Seiler, J., Gorb, S. N., Sathananthan, J., Sellers, S., Haneya, A., Hansen, J. H., Uebing, A., Muller, O. J., Frank, D. & Lutter, G. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35054905  

Cardiohepatic Syndrome Is Associated With Poor Prognosis in Patients Undergoing Tricuspid Transcatheter Edge-to-Edge Valve Repair. Stolz, L., Orban, M., Besler, C., Kresoja, K. P., Braun, D., Doldi, P., Orban, M., Hagl, C., Rommel, K. P., Mayerle, J., Hausleiter, S., Low, K., Higuchi, S., Wild, M., Unterhuber, M., Massberg, S., Nabauer, M., Thiele, H., Lurz, P. & Hausleiter, J. JACC Cardiovasc Interv 15, 179-189 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35057989  

Effects of Alirocumab on Triglyceride Metabolism: A Fat-Tolerance Test and Nuclear Magnetic Resonance Spectroscopy Study. Metzner, T., Leitner, D. R., Mellitzer, K., Beck, A., Sourij, H., Stojakovic, T., Reishofer, G., Marz, W., Landmesser, U., Scharnagl, H., Toplak, H. & Silbernagel, G. Biomedicines 10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35052871  

Short-Term Treatment with Alirocumab, Flow-Dependent Dilatation of the Brachial Artery and Use of Magnetic Resonance Diffusion Tensor Imaging to Evaluate Vascular Structure: An Exploratory Pilot Study. Metzner, T., Leitner, D. R., Dimsity, G., Gunzer, F., Opriessnig, P., Mellitzer, K., Beck, A., Sourij, H., Stojakovic, T., Deutschmann, H., Marz, W., Landmesser, U., Brodmann, M., Reishofer, G., Scharnagl, H., Toplak, H. & Silbernagel, G. Biomedicines 10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35052831  

Increased Salt Intake Decreases Diet-Induced Thermogenesis in Healthy Volunteers: A Randomized Placebo-Controlled Study. Mahler, A., Klamer, S., Maifeld, A., Bartolomaeus, H., Marko, L., Chen, C. Y., Forslund, S. K., Boschmann, M., Muller, D. N. & Wilck, N. Nutrients 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35057434  

Association between thyroid function and assessment of hepatic fat and iron contents by magnetic resonance imaging. Ittermann, T., Khattak, R. M., Markus, M. R. P., Kuhn, J. P., Kromrey, M. L., Targher, G., Steveling, A., Nauck, M. & Volzke, H. Endocr Connect 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35060922   

Biomarkers-in-Cardiology 8 RE-VISITED-Consistent Safety of Early Discharge with a Dual Marker Strategy Combining a Normal hs-cTnT with a Normal Copeptin in Low-to-Intermediate Risk Patients with Suspected Acute Coronary Syndrome-A Secondary Analysis of the Randomized Biomarkers-in-Cardiology 8 Trial. Giannitsis, E., Garfias-Veitl, T., Slagman, A., Searle, J., Muller, C., Blankenberg, S., von Haehling, S., Katus, H. A., Hamm, C. W., Huber, K., Vollert, J. O. & Mockel, M. Cells 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35053326  

Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells. Baltzer, S., Bulatov, T., Schmied, C., Kramer, A., Berger, B. T., Oder, A., Walker-Gray, R., Kuschke, C., Zuhlke, K., Eichhorst, J., Lehmann, M., Knapp, S., Weston, J., von Kries, J. P., Sussmuth, R. D. & Klussmann, E. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35054947  

Hybrid Surgery for Severe Mitral Valve Calcification: Limitations and Caveats for an Open Transcatheter Approach. Bagaev, E., Ali, A., Saha, S., Sadoni, S., Orban, M., Naebauer, M., Mehilli, J., Massberg, S., Oberbach, A. & Hagl, C. Medicina (Kaunas) 58 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35056401  

Emerging Role of cAMP/AMPK Signaling. Aslam, M. & Ladilov, Y. Cells 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35053423  

Exercise-dependent changes in ventricular-arterial coupling and aortopulmonary collateral flow in Fontan patients: a real-time CMR study. Latus, H., Hofmann, L., Gummel, K., Khalil, M., Yerebakan, C., Waschulzik, B., Schranz, D., Voges, I., Jux, C. & Reich, B. Eur Heart J Cardiovasc Imaging (2022). https://www.ncbi.nlm.nih.gov/pubmed/35045176  

Association of Telomere Length With Risk of Disease and Mortality. Schneider, C. V., Schneider, K. M., Teumer, A., Rudolph, K. L., Hartmann, D., Rader, D. J. & Strnad, P. JAMA Intern Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/35040871  

Stepwise approach for diagnosis and management of Takotsubo syndrome with cardiac imaging tools. Santoro, F., Mallardi, A., Leopizzi, A., Vitale, E., Stiermaier, T., Trambaiolo, P., Di Biase, M., Eitel, I. & Brunetti, N. D. Heart Fail Rev (2022). https://www.ncbi.nlm.nih.gov/pubmed/35040000  

MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endothelium. Kremer, V., Bink, D. I., Stanicek, L., van Ingen, E., Gimbel, T., Hilderink, S., Gunther, S., Nossent, A. Y. & Boon, R. A. Sci Rep 12, 843 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35039572   

Does Age Matter? Pulmonary Endarterectomy in the Elderly Patient with CTEPH. Wiedenroth, C. B., Bandorski, D., Ariobi, K., Ghofrani, H. A., Lankeit, M., Liebetrau, C., Pruefer, D., Mayer, E., Kriechbaum, S. D. & Guth, S. Thorac Cardiovasc Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35038757  

Refining imaging tools to detect advanced fibrosis: could liver surface nodularity address an unmet need in the NAFLD epidemic? Schattenberg, J. M. & Emrich, T. Eur Radiol 32, 1757-1759 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35084517  

Apolipoprotein E derived from CD11c(+) cells ameliorates atherosclerosis. Sauter, M., Sauter, R. J., Nording, H., Lin, C., Olbrich, M., Autenrieth, S., Gleissner, C., Thunemann, M., Otero, N., Lutgens, E., Aherrahrou, Z., Wolf, D., Zender, L., Meuth, S., Feil, R. & Langer, H. F. iScience 25, 103677 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35036868  

Additive value of epicardial adipose tissue quantification to coronary CT angiography-derived plaque characterization and CT fractional flow reserve for the prediction of lesion-specific ischemia. Brandt, V., Decker, J., Schoepf, U. J., Varga-Szemes, A., Emrich, T., Aquino, G., Bayer, R. R., 2nd, Carson, L., Sullivan, A., Ellis, L., von Knebel Doeberitz, P. L., Ebersberger, U., Bekeredjian, R. & Tesche, C. Eur Radiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35037968  

Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors. Becker, J., Stanifer, M. L., Leist, S. R., Stolp, B., Maiakovska, O., West, A., Wiedtke, E., Borner, K., Ghanem, A., Ambiel, I., Tse, L. V., Fackler, O. T., Baric, R. S., Boulant, S. & Grimm, D. Mol Ther (2022). https://www.ncbi.nlm.nih.gov/pubmed/35038579  

Prognostic impact of high-sensitive troponin on 30-day mortality in patients with acute heart failure and different classes of left ventricular ejection fraction. Ledwoch, J., Kraxenberger, J., Krauth, A., Schneider, A., Leidgschwendner, K., Schneider, V., Muller, A., Laugwitz, K. L., Kupatt, C. & Martens, E. Heart Vessels (2022). https://www.ncbi.nlm.nih.gov/pubmed/35034171  

Establishment of an induced pluripotent stem cell line DHMi005-A from a healthy male proband. Dressen, M., Luzius, T., Lahm, H., Neb, I., Doppler, S. A., Schneider, S., Dzilic, E., Lange, R. & Krane, M. Stem Cell Res 59, 102662 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35033855  

A junctional cAMP compartment regulates rapid Ca(2+) signaling in atrial myocytes. Brandenburg, S., Pawlowitz, J., Steckmeister, V., Subramanian, H., Uhlenkamp, D., Scardigli, M., Mushtaq, M., Amlaz, S. I., Kohl, T., Wegener, J. W., Arvanitis, D. A., Sanoudou, D., Sacconi, L., Hasenfuss, G., Voigt, N., Nikolaev, V. O. & Lehnart, S. E. J Mol Cell Cardiol 165, 141-157 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35033544  

Robustness of outcomes in trials evaluating sodium-glucose co-transporter 2 inhibitors for heart failure. Usman, M. S., Khan, M. S., Fonarow, G. C., Greene, S. J., Friede, T., Vaduganathan, M., Filippatos, G., Coats, A. J. S., Anker, S. D. & Butler, J. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35029056  

Comprehensive analyses of the inotropic compound omecamtiv mecarbil in rat and human cardiac preparations. Rhoden, A., Schulze, T., Pietsch, N., Christ, T., Hansen, A. & Eschenhagen, T. Am J Physiol Heart Circ Physiol 322, H373-H385 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35030072   

[The new ESC guidelines 2021 on prevention of cardiovascular diseases : Appeal for prevention]. Fegers-Wustrow, I., Wimbauer, F. & Halle, M. Herz 47, 55-62 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35029736  

Assessment of frailty prior to TAVI: Can it now be measured objectively? Renker, M. & Kim, W. K. Int J Cardiol 350, 104-105 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35026339  

Endothelial Retargeting of AAV9 In Vivo. Bozoglu, T., Lee, S., Ziegler, T., Jurisch, V., Maas, S., Baehr, A., Hinkel, R., Hoenig, A., Hariharan, A., Kim, C. I., Decker, S., Sami, H., Koppara, T., Oellinger, R., Muller, O. J., Frank, D., Megens, R., Nelson, P., Weber, C., Schnieke, A. et al. Adv Sci (Weinh), e2103867 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35023328  

Low cardiopulmonary fitness is associated with higher liver fat content and higher gamma-glutamyltransferase concentrations in the general population - "The Sedentary's Liver". Zinterl, I., Ittermann, T., Schipf, S., Gross, S., Anspieler, H., Kim, S., Ewert, R., Bulow, R., Kuhn, J. P., Lerch, M. M., Volzke, H., Felix, S. B., Bahls, M., Targher, G., Dorr, M. & Markus, M. R. P. Liver Int (2022). https://www.ncbi.nlm.nih.gov/pubmed/35020966  

Acceptance and safety of femoral versus radial access for percutaneous coronary intervention (PCI): results from a large monitor-controlled German registry (QuIK). Reifart, J., Gohring, S., Albrecht, A., Haerer, W., Levenson, B., Ringwald, G., Gartner, P. & Reifart, N. BMC Cardiovasc Disord 22, 7 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35016644   

Meconium Microbiome of Very Preterm Infants across Germany. Klopp, J., Ferretti, P., Meyer, C. U., Hilbert, K., Haiss, A., Marissen, J., Henneke, P., Hudalla, H., Pirr, S., Viemann, D., Zemlin, M., Forslund, S. K., Hartel, C., Bork, P., Gehring, S., Van Rossum, T. & and the, P. C. mSphere 7, e0080821 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35019670   

Single-center experience of ultra-high-density mapping guided catheter ablation of focal atrial tachycardia. Kellnar, A., Fichtner, S., Mehr, M., Czermak, T., Sinner, M. F., Lackermair, K. & Estner, H. L. Clin Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35019172  

MicroRNA-365 regulates human cardiac action potential duration. Esfandyari, D., Idrissou, B. M. G., Hennis, K., Avramopoulos, P., Dueck, A., El-Battrawy, I., Gruter, L., Meier, M. A., Nager, A. C., Ramanujam, D., Dorn, T., Meitinger, T., Hagl, C., Milting, H., Borggrefe, M., Fenske, S., Biel, M., Dendorfer, A., Sassi, Y., Moretti, A. et al. Nat Commun 13, 220 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35017523  

Simultaneous [18F]fluoride and gadobutrol enhanced coronary positron emission tomography/magnetic resonance imaging for in vivo plaque characterization. Wurster, T. H., Landmesser, U., Abdelwahed, Y. S., Skurk, C., Morguet, A., Leistner, D. M., Frohlich, G., Haghikia, A., Engel, L. C., Schuster, A., Noutsias, M., Schulze, D., Hamm, B., Furth, C., Brenner, W., Botnar, R. M., Bigalke, B. & Makowski, M. R. Eur Heart J Cardiovasc Imaging (2022). https://www.ncbi.nlm.nih.gov/pubmed/35015852  

Synthesis of C-Oligosaccharides through Versatile C(sp(3) )-H Glycosylation of Glycosides. Wu, J., Kopp, A. & Ackermann, L. Angew Chem Int Ed Engl, e202114993 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35015329  

Skeletal muscle derived Musclin protects the heart during pathological overload. Szaroszyk, M., Kattih, B., Martin-Garrido, A., Trogisch, F. A., Dittrich, G. M., Grund, A., Abouissa, A., Derlin, K., Meier, M., Holler, T., Korf-Klingebiel, M., Volker, K., Garfias Macedo, T., Pablo Tortola, C., Boschmann, M., Huang, N., Froese, N., Zwadlo, C., Malek Mohammadi, M., Luo, X. et al. Nat Commun 13, 149 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35013221  

Education and certification on heart failure of the Heart Failure Association of the European Society of Cardiology. Mullens, W., Coats, A., Seferovic, P., Metra, M., Mebazaa, A., Ruschitzka, F., Filippatos, G., Volterrani, M., Ponikowski, P., Jankowska, E. A., Chioncel, O., McDonagh, T. A., Piepoli, M. F., Milicic, D., Thum, T., Hill, L., Abdelhamid, M., Adamopoulos, S., Belenkov, Y., Gal, T. B. et al. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35014132  

Biodegradable Poly-epsilon-Caprolactone Scaffolds with ECFCs and iMSCs for Tissue-Engineered Heart Valves. Lutter, G., Puehler, T., Cyganek, L., Seiler, J., Rogler, A., Herberth, T., Knueppel, P., Gorb, S. N., Sathananthan, J., Sellers, S., Muller, O. J., Frank, D. & Haben, I. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35008953  

Spironolactone is associated with reduced mitotane levels in adrenocortical carcinoma patients. Haberbosch, L., Maurer, L., Sandforth, A., Wernicke, C., Spranger, J., Mai, K. & Jumpertz von Schwartzenberg, R. Endocr Relat Cancer 29, 121-128 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35014973  

[ESC guidelines 2021 on cardiac pacing and cardiac resynchronization therapy : What's new?]. Vogler, J., Keelani, A., Traub, A. & Tilz, R. R. Herz 47, 31-40 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35006289  

The Role of Junctophilin Proteins in Cellular Function. Lehnart, S. E. & Wehrens, X. H. T. Physiol Rev (2022). https://www.ncbi.nlm.nih.gov/pubmed/35001666  

First Transfemoral TAV-in-TAV Implantation of an ACURATE Neo2 Into a Degenerated Lotus Prosthesis. Kim, W. K., Charitos, E. I., Choi, Y. H. & Hamm, C. W. Can J Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35007707  

Sparse 3D contrast-enhanced whole-heart imaging for coronary artery evaluation. Ansari, U., Janssen, S., Baumann, S., Borggrefe, M., Waldeck, S., Schonberg, S., Papavassiliu, T. & Overhoff, D. Herz (2022). https://www.ncbi.nlm.nih.gov/pubmed/35006290  

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC working group on myocardial function and the ESC Working Group on Cellular Biology of the Heart. van der Velden, J., Asselbergs, F. W., Bakkers, J., Batkai, S., Bertrand, L., Bezzina, C. R., Bot, I., Brundel, B., Carrier, L., Chamuleau, S., Ciccarelli, M., Dawson, D., Davidson, S. M., Dendorfer, A., Duncker, D. J., Eschenhagen, T., Fabritz, L., Falcao-Pires, I., Ferdinandy, P., Giacca, M. et al. Cardiovasc Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/34999816  

Multi-organ assessment in mainly non-hospitalized individuals after SARS-CoV-2 infection: The Hamburg City Health Study COVID programme. Petersen, E. L., Gossling, A., Adam, G., Aepfelbacher, M., Behrendt, C. A., Cavus, E., Cheng, B., Fischer, N., Gallinat, J., Kuhn, S., Gerloff, C., Koch-Gromus, U., Harter, M., Hanning, U., Huber, T. B., Kluge, S., Knobloch, J. K., Kuta, P., Schmidt-Lauber, C., Lutgehetmann, M. et al. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/34999762  

Polygenic Risk Scores for Predicting Adverse Outcomes After Coronary Revascularization. Aittokallio, J., Kauko, A., Vaura, F., Salomaa, V., Kiviniemi, T., FinnGen, Schnabel, R. B. & Niiranen, T. Am J Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/34998506  

Effects of whole-body MRI on outpatient health service costs: a general-population prospective cohort study in Mecklenburg-Vorpommern, Germany. Schmidt, C. O., Sierocinski, E., Baumeister, S., Hegenscheid, K., Volzke, H. & Chenot, J. F. BMJ Open 12, e056572 (2022). https://www.ncbi.nlm.nih.gov/pubmed/34996801  

Cap analysis of gene expression reveals alternative promoter usage in a rat model of hypertension. Dahale, S., Ruiz-Orera, J., Silhavy, J., Hubner, N., van Heesch, S., Pravenec, M. & Atanur, S. S. Life Sci Alliance 5 (2022). https://www.ncbi.nlm.nih.gov/pubmed/34996843  

Travelling with heart failure: risk assessment and practical recommendations. von Haehling, S., Birner, C., Dworatzek, E., Frantz, S., Hellenkamp, K., Israel, C. W., Kempf, T., Klein, H. H., Knosalla, C., Laufs, U., Raake, P., Wachter, R. & Hasenfuss, G. Nat Rev Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/34992256  

Comparison of feasibility and results of frailty assessment methods prior to left ventricular assist device implantation. Roehrich, L., Sundermann, S. H., Just, I. A., Kopp Fernandes, L., Stein, J., Solowjowa, N., Mulzer, J., Mueller, M., Hummel, M., Knierim, J., Potapov, E., Falk, V. & Schoenrath, F. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/34994094  

The Gutenberg health study: a five-year prospective analysis of psychosocial working conditions using COPSOQ (Copenhagen psychosocial Questoinnaire) and ERI (effort-reward imbalance). Nuebling, M., Hegewald, J., Starke, K. R., Lincke, H. J., Jankowiak, S., Liebers, F., Latza, U., Letzel, S., Riechmann-Wolf, M., Gianicolo, E., Beutel, M., Pfeiffer, N., Lackner, K., Munzel, T., Wild, P. S. & Seidler, A. BMC Public Health 22, 24 (2022). https://www.ncbi.nlm.nih.gov/pubmed/34991529  

Management of patients with mitral regurgitation ineligible for standard therapy undergoing TMVI screening. Ludwig, S., Sedighian, R., Weimann, J., Koell, B., Waldschmidt, L., Schafer, A., Seiffert, M., Westermann, D., Reichenspurner, H., Blankenberg, S., Schofer, N., Lubos, E., Conradi, L. & Kalbacher, D. EuroIntervention (2022). https://www.ncbi.nlm.nih.gov/pubmed/34992049  

A Novel Transcatheter Heart Valve for an Overcrowded TAVR Market: What Should We Focus On? Lange, R. & Vitanova, K. JACC Cardiovasc Interv 15, 105-106 (2022). https://www.ncbi.nlm.nih.gov/pubmed/34991815  

Evidence-based cardiovascular magnetic resonance cost-effectiveness calculator for the detection of significant coronary artery disease. Pandya, A., Yu, Y. J., Ge, Y., Nagel, E., Kwong, R. Y., Bakar, R. A., Grizzard, J. D., Merkler, A. E., Ntusi, N., Petersen, S. E., Rashedi, N., Schwitter, J., Selvanayagam, J. B., White, J. A., Carr, J., Raman, S. V., Simonetti, O. P., Bucciarelli-Ducci, C., Sierra-Galan, L. M., Ferrari, V. A. et al. J Cardiovasc Magn Reson 24, 1 (2022). https://www.ncbi.nlm.nih.gov/pubmed/34986851  

Cell cycle defects underlie childhood-onset cardiomyopathy associated with Noonan syndrome. Meier, A. B., Raj Murthi, S., Rawat, H., Toepfer, C. N., Santamaria, G., Schmid, M., Mastantuono, E., Schwarzmayr, T., Berutti, R., Cleuziou, J., Ewert, P., Gorlach, A., Klingel, K., Laugwitz, K. L., Seidman, C. E., Seidman, J. G., Moretti, A. & Wolf, C. M. iScience 25, 103596 (2022). https://www.ncbi.nlm.nih.gov/pubmed/34988410  

Left atrial strain predicts exercise capacity in heart failure independently of left ventricular ejection fraction. Maffeis, C., Rossi, A., Cannata, L., Zocco, C., Belyavskiy, E., Radhakrishnan, A. K., Feuerstein, A., Morris, D. A., Pieske-Kraigher, E., Pieske, B., Edelmann, F. & Temporelli, P. L. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/34989138  

Association of circulating MR-proADM with all-cause and cardiovascular mortality in the general population: Results from the KORA F4 cohort study. Gar, C., Thorand, B., Herder, C., Sujana, C., Heier, M., Meisinger, C., Peters, A., Koenig, W., Rathmann, W., Roden, M., Stumvoll, M., Maalmi, H., Meitinger, T., Then, H., Seissler, J. & Then, C. PLoS One 17, e0262330 (2022). https://www.ncbi.nlm.nih.gov/pubmed/34990470  

Pathophysiological pathways related to high plasma growth differentiation factor 15 concentrations in patients with heart failure. Ceelen, D., Voors, A. A., Tromp, J., van Veldhuisen, D. J., Dickstein, K., de Boer, R. A., Lang, C. C., Anker, S. D., Ng, L. L., Metra, M., Ponikowski, P. & Figarska, S. M. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/34989084  

Early benefit with empagliflozin in heart failure with preserved ejection fraction: insights from the EMPEROR-Preserved trial. Butler, J., Siddiqi, T. J., Filippatos, G., Ferreira, J. P., Pocock, S. J., Zannad, F. & Anker, S. D. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/34989083  

"Precision-CT(O)": CTO-lesions unraveled by multimodality cardiac imaging. Abdelwahed, Y. S., Blum, E., Landmesser, U., Werner, G. S. & Leistner, D. M. Int J Cardiovasc Imaging (2022). https://www.ncbi.nlm.nih.gov/pubmed/34982310  

Implication of proliferation gene biomarkers in pulmonary hypertension. Yan, Y., Jiang, R., Yuan, P., Wen, L., Pang, X. B., Jing, Z. C., He, Y. Y. & Han, Z. Y. Animal Model Exp Med 4, 369-380 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34977488 

Anatomical suitability and off-label use of contemporary transcatheter heart valves. Werner, N., Renker, M., Dorr, O., Bauer, T., Nef, H., Choi, Y. H., Hamm, C. W., Zahn, R. & Kim, W. K. Int J Cardiol 350, 96-103 (2022). https://www.ncbi.nlm.nih.gov/pubmed/34979147  

State-of-the-art: Insights from the Ross Registry. Fujita, B., Aboud, A., Sievers, H. H. & Ensminger, S. JTCVS Tech 10, 396-400 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34977764  

The year in cardiovascular medicine 2021: interventional cardiology. Escaned, J., Jaffer, F. A., Mehilli, J. & Mehran, R. Eur Heart J 43, 377-386 (2022). https://www.ncbi.nlm.nih.gov/pubmed/34974613  

Circulating Interleukin-6 Levels and Incident Ischemic Stroke: A Systematic Review and Meta-analysis of Prospective Studies. Papadopoulos, A., Palaiopanos, K., Bjorkbacka, H., Peters, A., de Lemos, J. A., Seshadri, S., Dichgans, M. & Georgakis, M. K. Neurology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34969940  

Histopathology-Based Deep-Learning Predicts Atherosclerotic Lesions in Intravascular Imaging. Holmberg, O., Lenz, T., Koch, V., Alyagoob, A., Utsch, L., Rank, A., Sabic, E., Seguchi, M., Xhepa, E., Kufner, S., Cassese, S., Kastrati, A., Marr, C., Joner, M. & Nicol, P. Front Cardiovasc Med 8, 779807 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34970608  

PET/MR Technology: Advancement and Challenges. Bogdanovic, B., Solari, E. L., Villagran Asiares, A., McIntosh, L., van Marwick, S., Schachoff, S. & Nekolla, S. G. Semin Nucl Med (2021). https://www.ncbi.nlm.nih.gov/pubmed/34969520  

Remote Speech Analysis in the Evaluation of Hospitalized Patients With Acute Decompensated Heart Failure. Amir, O., Abraham, W. T., Azzam, Z. S., Berger, G., Anker, S. D., Pinney, S. P., Burkhoff, D., Shallom, I. D., Lotan, C. & Edelman, E. R. JACC Heart Fail 10, 41-49 (2022). https://www.ncbi.nlm.nih.gov/pubmed/34969496 


Februar

Transcriptional Alterations in X-Linked Dystonia-Parkinsonism Caused by the SVA Retrotransposon. Pozojevic, J., Algodon, S. M., Cruz, J. N., Trinh, J., Bruggemann, N., Lass, J., Grutz, K., Schaake, S., Tse, R., Yumiceba, V., Kruse, N., Schulz, K., Sreenivasan, V. K. A., Rosales, R. L., Jamora, R. D. G., Diesta, C. C. E., Matschke, J., Glatzel, M., Seibler, P., Handler, K. et al. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35216353   

Induction of Hepatitis E Virus Anti-ORF3 Antibodies from Systemic Administration of a Muscle-Specific Adeno-Associated Virus (AAV) Vector. Maurer, L., El Andari, J., Rapti, K., Spreyer, L., Steinmann, E., Grimm, D. & Dao Thi, V. L. Viruses 14 (2022). www.ncbi.nlm.nih.gov/pubmed/35215859

Synergistic Adverse Effects of Azithromycin and Hydroxychloroquine on Human Cardiomyocytes at a Clinically Relevant Treatment Duration. Li, W., Luo, X., Poetsch, M. S., Oertel, R., Nichani, K., Schneider, M., Strano, A., Hasse, M., Steiner, R. P., Cyganek, L., Hettwer, K., Uhlig, S., Simon, K., Guan, K. & Schubert, M. Pharmaceuticals (Basel) 15 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35215332  

Trends and Risk Factors of In-Hospital Mortality of Patients with COVID-19 in Germany: Results of a Large Nationwide Inpatient Sample. Hobohm, L., Sagoschen, I., Barco, S., Schmidtmann, I., Espinola-Klein, C., Konstantinides, S., Munzel, T. & Keller, K. Viruses 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35215869  

Takotsubo Syndrome: Translational Implications and Pathomechanisms. Fan, X., Yang, G., Kowitz, J., Akin, I., Zhou, X. & El-Battrawy, I. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35216067  

The Spontaneous Course of Human Herpesvirus 6 DNA-Associated Myocarditis and the Effect of Immunosuppressive Intervention. Elsanhoury, A., Kuhl, U., Stautner, B., Klein, O., Krannich, A., Morris, D., Willner, M., Jankowska, E., Klingel, K., Van Linthout, S. & Tschope, C. Viruses 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35215893  

A Non-Canonical Link between Non-Coding RNAs and Cardiovascular Diseases. Natarelli, L. & Weber, C. Biomedicines 10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35203652  

LMNA Mutation in a Family with a Strong History of Sudden Cardiac Death. Keil, L., Berisha, F., Knappe, D., Kubisch, C., Shoukier, M., Kirchhof, P., Fabritz, L., Hellenbroich, Y., Woitschach, R. & Magnussen, C. Genes (Basel) 13 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35205214  

Depletion of Homeostatic Antibodies against Malondialdehyde-Modified Low-Density Lipoprotein Correlates with Adverse Events in Major Vascular Surgery. Hartley, A., Pradeep, M., Van den Berg, V., Khan, A. H. A., Shah, H. A., Allaf, M., Chow, A., Caga-Anan, M., Shalhoub, J., Koenig, W., Fisher, M., Haskard, D. O. & Khamis, R. Y. Antioxidants (Basel) 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35204154  

New Tricks with Old Dogs: Computational Identification and Experimental Validation of New miRNA-mRNA Regulation in hiPSC-CMs. Bencun, M., Britto-Borges, T., Eschenbach, J. & Dieterich, C. Biomedicines 10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35203600  

Enhanced Cardiac CaMKII Oxidation and CaMKII-Dependent SR Ca Leak in Patients with Sleep-Disordered Breathing. Arzt, M., Drzymalski, M. A., Ripfel, S., Meindl, S., Biedermann, A., Durczok, M., Keller, K., Mustroph, J., Katz, S., Tafelmeier, M., Lebek, S., Florchinger, B., Camboni, D., Wittmann, S., Backs, J., Schmid, C., Maier, L. S. & Wagner, S. Antioxidants (Basel) 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35204213  

It Is Not Carved in Stone-The Need for a Genetic Reevaluation of Variants in Pediatric Cardiomyopathies. Westphal, D. S., Pollmann, K., Marschall, C., Wacker-Gussmann, A., Oberhoffer-Fritz, R., Laugwitz, K. L., Ewert, P. & Wolf, C. M. J Cardiovasc Dev Dis 9 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35200695  

Home-Based Long-Term Physical Endurance and Inspiratory Muscle Training for Children and Adults With Fontan Circulation-Initial Results From a Prospective Study. Dirks, S., Kramer, P., Schleiger, A., Speck, H. M., Wolfarth, B., Thouet, T., Berger, F., Sallmon, H. & Ovroutski, S. Front Cardiovasc Med 8, 784648 (2021). https://www.ncbi.nlm.nih.gov/pubmed/35198605

Impact of the 2009 ESC Guideline Change on Surgically Treated Infective Endocarditis. Weber, C., Luehr, M., Petrov, G., Misfeld, M., Akhyari, P., Tugtekin, S. M., Diab, M., Saha, S., Elderia, A., Lichtenberg, A., Hagl, C., Doenst, T., Matschke, K., Borger, M. A. & Wahlers, T. Ann Thorac Surg 114, 1349-1356 (2022).

Pre-admission antiplatelet therapy and treatment effect of ticagrelor vs. prasugrel in patients with acute coronary syndromes-a subgroup analysis of the ISAR-REACT 5 trial. Lahu, S., Ndrepepa, G., Neumann, F. J., Menichelli, M., Bernlochner, I., Richardt, G., Wöhrle, J., Witzenbichler, B., Hemetsberger, R., Mayer, K., Akin, I., Cassese, S., Gewalt, S., Xhepa, E., Kufner, S., Valina, C., Sager, H. B., Joner, M., Ibrahim, T., Laugwitz, K. L. et al. Eur Heart J Cardiovasc Pharmacother 8, 687-694 (2022).

Interventional Procedures for Left Ventricular Assist Device-Associated Complications. Lanmueller, P., Eulert-Grehn, J. J., Unbehaun, A., Klein, C., Hommel, M., Kofler, M., Kempfert, J., Hoermandinger, C., Kaufmann, F., Stawowy, P., Dreysse, S., Mulzer, J., Mueller, M., Falk, V., Schoenrath, F., Potapov, E. & Just, I. A. ASAIO J 68, 1332-1338 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35184090 

Changes in Endocan and Dermatan Sulfate Are Associated with Biomechanical Properties of Abdominal Aortic Wall during Aneurysm Expansion and Rupture. Metschl, S., Bruder, L., Paloschi, V., Jakob, K., Reutersberg, B., Reeps, C., Maegdefessel, L., Gee, M., Eckstein, H. H. & Pelisek, J. Thromb Haemost 122, 1513-1523 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35170008 

The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis. Fiorito, G., Pedron, S., Ochoa-Rosales, C., McCrory, C., Polidoro, S., Zhang, Y., Dugue, P. A., Ratliff, S., Zhao, W. N., McKay, G. J., Costa, G., Solinas, M. G., Harris, K. M., Tumino, R., Grioni, S., Ricceri, F., Panico, S., Brenner, H., Schwettmann, L., Waldenberger, M. et al. J Gerontol A Biol Sci Med Sci 77, 1750-1759 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35172329 

Synthesis and in vitro Study of Artemisinin/Synthetic Peroxide-Based Hybrid Compounds against SARS-CoV-2 and Cancer. Herrmann, L., Yaremenko, I. A., Çapcı, A., Struwe, J., Tailor, D., Dheeraj, A., Hodek, J., Belyakova, Y. Y., Radulov, P. S., Weber, J., Malhotra, S. V., Terent'ev, A. O., Ackermann, L. & Tsogoeva, S. B. ChemMedChem 17, e202200005 (2022).

Hypothalamic Galanin-producing neurons regulate stress in zebrafish through a peptidergic, self-inhibitory loop. Corradi, L., Bruzzone, M., Maschio, M. D., Sawamiphak, S. & Filosa, A. Curr Biol 32, 1497-1510 e1495 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35219430  

Cytokine Hemoadsorption During Cardiac Surgery Versus Standard Surgical Care for Infective Endocarditis (REMOVE): Results From a Multicenter Randomized Controlled Trial. Diab, M., Lehmann, T., Bothe, W., Akhyari, P., Platzer, S., Wendt, D., Deppe, A. C., Strauch, J., Hagel, S., Gunther, A., Faerber, G., Sponholz, C., Franz, M., Scherag, A., Velichkov, I., Silaschi, M., Fassl, J., Hofmann, B., Lehmann, S., Schramm, R. et al. Circulation 145, 959-968 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35213213  

Redox-dependent loss of flavin by mitochondria complex I is different in brain and heart. Yoval-Sanchez, B., Ansari, F., James, J., Niatsetskaya, Z., Sosunov, S., Filipenko, P., Tikhonova, I. G., Ten, V., Wittig, I., Rafikov, R. & Galkin, A. Redox Biol 51, 102258 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35189550

A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome. Widjaja, A. A., Shekeran, S. G., Adami, E., Ting, J. G. W., Tan, J., Viswanathan, S., Lim, S. Y., Tan, P. H., Hubner, N., Coffman, T. & Cook, S. A. J Am Soc Nephrol 33, 718-730 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35140116

Computed tomographic assessment of right ventricular long axis strain for prognosis after transcatheter aortic valve replacement. Aquino, G. J., Decker, J. A., Schoepf, U. J., Carson, L., Fiegel, M., Paladugu, N., Brandt, V., Yacoub, B., Emrich, A. L., Kroencke, T., Burt, J. R., Bayer, R., 2nd, Emrich, T. & Varga-Szemes, A. Eur J Radiol 149, 110212 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35220197  

Impact of the 2009 ESC Guideline Change on Surgically Treated Infective Endocarditis. Weber, C., Luehr, M., Petrov, G., Misfeld, M., Akhyari, P., Tugtekin, S. M., Diab, M., Saha, S., Elderia, A., Lichtenberg, A., Hagl, C., Doenst, T., Matschke, K., Borger, M. A., Wahlers, T. & Clinical, M. P. o. A. o. I. E. i. G. S. G. Ann Thorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35216990   

Interferon-beta Suppresses Transcriptionally Active Parvovirus B19 Infection in Viral Cardiomyopathy: A Subgroup Analysis of the BICC-Trial. Schultheiss, H. P., Bock, C. T., Aleshcheva, G., Baumeier, C., Poller, W. & Escher, F. Viruses 14 (2022). www.ncbi.nlm.nih.gov/pubmed/35216037

A potential future Fontan modification: preliminary in vitro data of a pressure-generating tube from engineered heart tissue. Kohne, M., Behrens, C. S., Studemann, T., Bibra, C. V., Querdel, E., Shibamiya, A., Geertz, B., Olfe, J., Huners, I., Jockenhovel, S., Hubler, M., Eschenhagen, T., Sachweh, J. S., Weinberger, F. & Biermann, D. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35218664   

Phenotypic spectrum of BLM- and RMI1-related Bloom syndrome. Gonenc, II, Elcioglu, N. H., Martinez Grijalva, C., Aras, S., Grossmann, N., Praulich, I., Altmuller, J., Kaulfuss, S., Li, Y., Nurnberg, P., Burfeind, P., Yigit, G. & Wollnik, B. Clin Genet (2022). https://www.ncbi.nlm.nih.gov/pubmed/35218564   

Symptom Severity and Health-Related Quality of Life in Patients with Atrial Fibrillation: Findings from the Observational ARENA Study. Sadlonova, M., Senges, J., Nagel, J., Celano, C., Klasen-Max, C., Borggrefe, M., Akin, I., Thomas, D., Schwarzbach, C. J., Kleeman, T., Schneider, S., Hochadel, M., Suselbeck, T., Schwacke, H., Alonso, A., Haass, M., Ladwig, K. H. & Herrmann-Lingen, C. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35207412  

Improving adaptive seamless designs through Bayesian optimization. Richter, J., Friede, T. & Rahnenfuhrer, J. Biom J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35212423  

Being Overweight or Obese Is Associated with an Increased Platelet Reactivity Despite Dual Antiplatelet Therapy with Aspirin and Clopidogrel. Puccini, M., Rauch, C., Jakobs, K., Friebel, J., Hassanein, A., Landmesser, U. & Rauch, U. Cardiovasc Drugs Ther (2022). https://www.ncbi.nlm.nih.gov/pubmed/35211819  

Of hypes and paradigms in the search of the ideal valved conduit in the young. Peterss, S., Hagl, C. & Pichlmaier, M. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35213693  

Reactive Oxygen Species Differentially Modulate the Metabolic and Transcriptomic Response of Endothelial Cells. Muller, N., Warwick, T., Noack, K., Malacarne, P. F., Cooper, A. J. L., Weissmann, N., Schroder, K., Brandes, R. P. & Rezende, F. Antioxidants (Basel) 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35204316  

Intracranial haemorrhage in adult patients on venoarterial extracorporeal membrane oxygenation. Lusebrink, E., Zimmer, S., Schrage, B., Dabboura, S., Majunke, N., Scherer, C., Aksoy, A., Krogmann, A., Hoffmann, S., Szczanowicz, L., Binzenhofer, L., Peterss, S., Kuhn, C., Hagl, C., Massberg, S., Schafer, A., Thiele, H., Westermann, D., Orban, M. & Group, I.-V.-E. I. Eur Heart J Acute Cardiovasc Care (2022). https://www.ncbi.nlm.nih.gov/pubmed/35213724  

Polygenic risk score: a tool ready for clinical use? Kavousi, M. & Schunkert, H. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35211747  

Polycystic ovarian syndrome increases prevalence of concentric hypertrophy in normotensive obese women. De Jong, K. A., Berisha, F., Naderpoor, N., Appelbe, A., Kotowicz, M. A., Cukier, K., McGee, S. L. & Nikolaev, V. O. PLoS One 17, e0263312 (2022).

Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility. Barc, J., Tadros, R., Glinge, C., Chiang, D. Y., Jouni, M., Simonet, F., Jurgens, S. J., Baudic, M., Nicastro, M., Potet, F., Offerhaus, J. A., Walsh, R., Choi, S. H., Verkerk, A. O., Mizusawa, Y., Anys, S., Minois, D., Arnaud, M., Duchateau, J., Wijeyeratne, Y. D. et al. Nat Genet 54, 232-239 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35210625

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection. Pekayvaz, K., Leunig, A., Kaiser, R., Joppich, M., Brambs, S., Janjic, A., Popp, O., Nixdorf, D., Fumagalli, V., Schmidt, N., Polewka, V., Anjum, A., Knottenberg, V., Eivers, L., Wange, L. E., Gold, C., Kirchner, M., Muenchhoff, M., Hellmuth, J. C., Scherer, C. et al. Nat Commun 13, 1018 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35197461  

Influence of ejection fraction on biomarker expression and response to spironolactone in people at risk of heart failure: findings from the HOMAGE trial. Ferreira, J. P., Verdonschot, J. A. J., Girerd, N., Bozec, E., Pellicori, P., Collier, T., Mariottoni, B., Cosmi, F., Hazebroek, M., Cuthbert, J., Petutschnigg, J., Heymans, S., Staessen, J. A., Pieske, B., Edelman, F., Clark, A. L., Diez, J., Gonzalez, A., Rossignol, P., Cleland, J. G. et al. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35199421  

Percutaneous coronary intervention for chronic total occlusion in octogenarians: a propensity score study. Blessing, R. R. L., Ahoopai, M., Geyer, M., Brandt, M., Zeiher, A. M., Vasa-Nicotera, M., Munzel, T., Wenzel, P., Gori, T. & Dimitriadis, Z. Sci Rep 12, 3073 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35197506  

Renin, aldosterone, the aldosterone-to-renin ratio, and incident hypertension among normotensive subjects from the general population. Arnold, N., Hermanns, I. M., Schulz, A., Hahad, O., Schmitt, V. H., Panova-Noeva, M., Prochaska, J. H., Binder, H., Pfeiffer, N., Beutel, M., Lackner, K. J., Munzel, T. & Wild, P. S. Cardiovasc Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/35199135  

Role of TRPC6 in kidney damage after acute ischemic kidney injury. Zheng, Z., Tsvetkov, D., Bartolomaeus, T. U. P., Erdogan, C., Krugel, U., Schleifenbaum, J., Schaefer, M., Nurnberg, B., Chai, X., Ludwig, F. A., N'Diaye, G., Kohler, M. B., Wu, K., Gollasch, M. & Marko, L. Sci Rep 12, 3038 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35194063  

Effects of Atrial Fibrillation on the Human Ventricle. Pabel, S., Knierim, M., Stehle, T., Alebrand, F., Paulus, M., Sieme, M., Herwig, M., Barsch, F., Kortl, T., Poppl, A., Wenner, B., Ljubojevic-Holzer, S., Molina, C. E., Dybkova, N., Camboni, D., Fischer, T. H., Sedej, S., Scherr, D., Schmid, C., Brochhausen, C. et al. Circ Res, CIRCRESAHA121319718 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35193397  

Late Gadolinium Enhancement Cardiac Magnetic Resonance Imaging: From Basic Concepts to Emerging Methods. Holtackers, R. J., Emrich, T., Botnar, R. M., Kooi, M. E., Wildberger, J. E. & Kreitner, K. F. Rofo (2022). https://www.ncbi.nlm.nih.gov/pubmed/35196714  

Surgery for infective endocarditis following low-intermediate risk transcatheter aortic valve replacement-a multicentre experience. Saha, S., Joskowiak, D., Marin-Cuartas, M., Diab, M., Schwaiger, B. M., Sandoval-Boburg, R., Popov, A. F., Weber, C., Varghese, S., Martens, A., Cebotari, S., Scherner, M., Eichinger, W., Holzhey, D., Dohle, D. S., Wahlers, T., Doenst, T., Misfeld, M., Mehilli, J., Massberg, S. et al. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35190828   

Effect of Sunitinib Treatment on Skin Sodium Accumulation in Patients With Renal Cancer: a Pilot Study. Marko, L., Dorr, A., Linz, P., van den Meiracker, A. H., Garrelds, I. M., Kuehne, T., Dechend, R., Danser, A. H. J., Florcken, A. & Muller, D. N. Hypertension, HYPERTENSIONAHA12219079 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35189705  

Preadmission antiplatelet therapy and treatment effect of ticagrelor versus prasugrel in patients with acute coronary syndromes - a subgroup analysis of the ISAR-REACT 5 trial. Lahu, S., Ndrepepa, G., Neumann, F. J., Menichelli, M., Bernlochner, I., Richardt, G., Wohrle, J., Witzenbichler, B., Hemetsberger, R., Mayer, K., Akin, I., Cassese, S., Gewalt, S., Xhepa, E., Kufner, S., Valina, C., Sager, H. B., Joner, M., Ibrahim, T., Laugwitz, K. L. et al. Eur Heart J Cardiovasc Pharmacother (2022). https://www.ncbi.nlm.nih.gov/pubmed/35191982  

Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study. Kaura, A., Hartley, A., Panoulas, V., Glampson, B., Shah, A. S. V., Davies, J., Mulla, A., Woods, K., Omigie, J., Shah, A. D., Thursz, M. R., Elliott, P., Hemmingway, H., Williams, B., Asselbergs, F. W., O'Sullivan, M., Lord, G. M., Trickey, A., Sterne, J. A., Haskard, D. O. et al. PLoS Med 19, e1003911 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35192610  

Predictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1). Berling-Ernst, A., Yahiaoui-Doktor, M., Kiechle, M., Engel, C., Lammert, J., Grill, S., Dukatz, R., Rhiem, K., Baumann, F. T., Bischoff, S. C., Erickson, N., Schmidt, T., Niederberger, U., Siniatchkin, M. & Halle, M. Sci Rep 12, 2907 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35190584  

QRS micro-fragmentation as a mortality predictor. Hnatkova, K., Andrsova, I., Novotny, T., Britton, A., Shipley, M., Vandenberk, B., Sprenkeler, D. J., Junttila, J., Reichlin, T., Schlogl, S., Vos, M. A., Friede, T., Bauer, A., Huikuri, H. V., Willems, R., Schmidt, G., Franz, M. R., Sticherling, C., Zabel, M. & Malik, M. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35187560  

 

MRI-Detected Brain Lesions and Cognitive Function in Patients With Atrial Fibrillation Undergoing Left Atrial Catheter Ablation in the Randomized AXAFA-AFNET 5 Trial. Haeusler, K. G., Eichner, F. A., Heuschmann, P. U., Fiebach, J. B., Engelhorn, T., Blank, B., Callans, D., Elvan, A., Grimaldi, M., Hansen, J., Hindricks, G., Al-Khalidi, H. R., Mont, L., Nielsen, J. C., Piccini, J. P., Schotten, U., Themistoclakis, S., Vijgen, J., Di Biase, L. & Kirchhof, P. Circulation 145, 906-915 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35135308  

Neurofilament proteins as a potential biomarker in chemotherapy-induced polyneuropathy. Huehnchen, P., Schinke, C., Bangemann, N., Dordevic, A. D., Kern, J., Maierhof, S. K., Hew, L., Nolte, L., Kortvelyessy, P., Gopfert, J. C., Ruprecht, K., Somps, C. J., Blohmer, J. U., Sehouli, J., Endres, M. & Boehmerle, W. JCI Insight 7 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35133982  

Severe heart failure in the setting of inflammatory cardiomyopathy with likely pathogenic titin variant. Mueller, M., Zwinger, L., Klaassen, S., Poller, W., Monserrat Iglesias, L., Pablo Ochoa, J., Klingel, K., Landmesser, U. & Heidecker, B. Int J Cardiol Heart Vasc 39, 100969 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35198726  

Dopamine D1/D5 Receptor Signaling Is Involved in Arrhythmogenesis in the Setting of Takotsubo Cardiomyopathy. Huang, M., Yang, Z., Li, Y., Lan, H., Cyganek, L., Yuecel, G., Lang, S., Bieback, K., El-Battrawy, I., Zhou, X., Borggrefe, M. & Akin, I. Frontiers in Cardiovascular Medicine 8, 777463 (2022).

Bacteriophage therapy as a treatment option for complex cardiovascular implant infection: The German Heart Center Berlin experience. Tkhilaishvili, T., Potapov, E., Starck, C., Mulzer, J., Falk, V., Trampuz, A. & Schoenrath, F. The Journal of Heart and Lung Transplantation (2022).

Interventional Procedures for Left Ventricular Assist Device-Associated Complications. Lanmueller, P., Eulert-Grehn, J.-J., Unbehaun, A., Klein, C., Hommel, M., Kofler, M., Kempfert, J., Hoermandinger, C., Kaufmann, F., Stawowy, P., Dreysse, S., Mulzer, J., Mueller, M., Falk, V., Schoenrath, F., Potapov, E. & Just, I. A. ASAIO Journal Publish Ahead of Print (2022).

Coronary angiography in acute ischemic stroke patients: frequency and determinants of pathological findings in a multicenter cohort study. Litmeier, S., Meinel, T. R., von Rennenberg, R., Kniepert, J. U., Audebert, H. J., Endres, M., Jung, S., Scheitz, J. F. & Nolte, C. H. J Neurol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35182178   

Conduction disturbances following transcatheter aortic valve implantation: Any room for improvement? Charitos, E. & Kim, W. K. Int J Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35182652  

Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease. Talmor-Barkan, Y., Bar, N., Shaul, A. A., Shahaf, N., Godneva, A., Bussi, Y., Lotan-Pompan, M., Weinberger, A., Shechter, A., Chezar-Azerrad, C., Arow, Z., Hammer, Y., Chechi, K., Forslund, S. K., Fromentin, S., Dumas, M. E., Ehrlich, S. D., Pedersen, O., Kornowski, R. & Segal, E. Nat Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/35177859  

Nationwide Registry-Based Analysis of Infective Endocarditis Risk After Pulmonary Valve Replacement. Stammnitz, C., Huscher, D., Bauer, U. M. M., Urban, A., Nordmeyer, J., Schubert, S., Photiadis, J., Berger, F., Klaassen, S. & German Competence Network for Congenital Heart Defects, I. J Am Heart Assoc, e022231 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35179045  

Colchicine prevents disease progression in viral myocarditis via modulating the NLRP3 inflammasome in the cardiosplenic axis. Pappritz, K., Lin, J., El-Shafeey, M., Fechner, H., Kuhl, U., Alogna, A., Spillmann, F., Elsanhoury, A., Schulz, R., Tschope, C. & Van Linthout, S. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35178861  

Microbiome and metabolome features of the cardiometabolic disease spectrum. Fromentin, S., Forslund, S. K., Chechi, K., Aron-Wisnewsky, J., Chakaroun, R., Nielsen, T., Tremaroli, V., Ji, B., Prifti, E., Myridakis, A., Chilloux, J., Andrikopoulos, P., Fan, Y., Olanipekun, M. T., Alves, R., Adiouch, S., Bar, N., Talmor-Barkan, Y., Belda, E., Caesar, R. et al. Nat Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/35177860  

Not only lungs: COVID-19 hits platelets as well. Bongiovanni, D., Klug, M., Valgimigli, M. & Bernlochner, I. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35178570  

The Association of Depression and All-Cause Mortality: Explanatory Factors and the Influence of Gender. Wicke, F. S., Ernst, M., Otten, D., Werner, A., Dreier, M., Brahler, E., Tibubos, A. N., Reiner, I., Michal, M., Wiltink, J., Munzel, T., Lackner, K. J., Pfeiffer, N., Konig, J., Wild, P. S. & Beutel, M. E. J Affect Disord (2022). https://www.ncbi.nlm.nih.gov/pubmed/35176339  

Rodent models for gait network disorders in Parkinson's disease - a translational perspective. Wenger, N., Vogt, A., Skrobot, M., Garulli, E. L., Kabaoglu, B., Salchow-Hommen, C., Schauer, T., Kroneberg, D., Schuhmann, M., Ip, C. W., Harms, C., Endres, M., Isaias, I., Tovote, P. & Blum, R. Exp Neurol, 114011 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35176273   

Evaluation of the spline reconstruction technique for preclinical PET imaging. Vrachliotis, A., Kastis, G. A., Protonotarios, N. E., Fokas, A. S., Nekolla, S. G., Anagnostopoulos, C. D., Costaridou, L. & Gaitanis, A. Comput Methods Programs Biomed 217, 106668 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35176596  

CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes. Stathopoulou, K., Schnittger, J., Raabe, J., Fleischer, F., Mangels, N., Piasecki, A., Findlay, J., Hartmann, K., Krasemann, S., Schlossarek, S., Uebeler, J., Wixler, V., Blake, D. J., Baillie, G. S., Carrier, L., Ehler, E. & Cuello, F. FEBS J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35176204  

Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes. Li, L., Chen, Z., von Scheidt, M., Li, S., Steiner, A., Guldener, U., Koplev, S., Ma, A., Hao, K., Pan, C., Lusis, A. J., Pang, S., Kessler, T., Ermel, R., Sukhavasi, K., Ruusalepp, A., Gagneur, J., Erdmann, J., Kovacic, J. C., Bjorkegren, J. L. M. et al. Basic Res Cardiol 117, 6 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35175464  

Deep breathing couples CSF and venous flow dynamics. Kollmeier, J. M., Gurbuz-Reiss, L., Sahoo, P., Badura, S., Ellebracht, B., Keck, M., Gartner, J., Ludwig, H. C., Frahm, J. & Dreha-Kulaczewski, S. Sci Rep 12, 2568 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35173200  

Neutrophil-Platelet Interactions as Novel Treatment Targets in Cardiovascular Disease. Kaiser, R., Escaig, R., Erber, J. & Nicolai, L. Front Cardiovasc Med 8, 824112 (2021). https://www.ncbi.nlm.nih.gov/pubmed/35174225  

Prognostic Implications of a Second Peak of High-Sensitivity Troponin T After Myocardial Infarction. Hartikainen, T. S., Gossling, A., Sorensen, N. A., Lehmacher, J., Neumann, J. T., Blankenberg, S. & Westermann, D. Front Cardiovasc Med 8, 780198 (2021). https://www.ncbi.nlm.nih.gov/pubmed/35174220  

A novel Troponin I mutation associated with severe restrictive cardiomyopathy-a case report of a 27-year-old woman with fatigue. Gerhardt, T., Monserrat, L., Landmesser, U. & Poller, W. Eur Heart J Case Rep 6, ytac053 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35174310  

Long-Term Effects of Aircraft Noise Exposure on Vascular Oxidative Stress, Endothelial Function and Blood Pressure: No Evidence for Adaptation or Tolerance Development. Frenis, K., Kalinovic, S., Ernst, B. P., Kvandova, M., Al Zuabi, A., Kuntic, M., Oelze, M., Stamm, P., Bayo Jimenez, M. T., Kij, A., Keppeler, K., Klein, V., Strohm, L., Ubbens, H., Daub, S., Hahad, O., Kroller-Schon, S., Schmeisser, M. J., Chlopicki, S., Eckrich, J. et al. Front Mol Biosci 8, 814921 (2021). https://www.ncbi.nlm.nih.gov/pubmed/35174211  

Treatment standards for direct oral anticoagulants in patients with acute ischemic stroke and non-valvular atrial fibrillation: A survey among German stroke units. Fastner, C., Szabo, K., Samartzi, M., Kruska, M., Akin, I., Platten, M., Baumann, S. & Alonso, A. PLoS One 17, e0264122 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35176109  

Muscarinic receptor activation reduces force and arrhythmias in human atria independent of IK,ACh. Petersen, J., Castro, L., Pedersen Bengaard, A. K., Pecha, S., Ismaili, D., Schulz, C., Sahni, J., Steenpass, A., Meier, C., Reichenspurner, H., Jespersen, T., Eschenhagen, T. & Christ, T. J Cardiovasc Pharmacol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35170489  

Distribution and prognostic impact of coronary artery disease and nonischemic cardiomyopathies in patients with electrical storm. Muller, J., Behnes, M., Ellguth, D., Schupp, T., Taton, G., Reiser, L., Engelke, N., Borggrefe, M., Reichelt, T., Bollow, A., Kim, S. H., Barth, C., Weidner, K., Battrawy, I. E., Ansari, U., Akin, M., Grosse Meininghaus, D., Mashayekhi, K. & Akin, I. Coron Artery Dis (2022). https://www.ncbi.nlm.nih.gov/pubmed/35170551  

Patient profile and outcomes associated with follow-up in specialty vs. primary care in heart failure. Lindberg, F., Lund, L. H., Benson, L., Schrage, B., Edner, M., Dahlstrom, U., Linde, C., Rosano, G. & Savarese, G. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35170237  

Nitroxyl Donor CXL-1020 Lowers Blood Pressure by Targeting C195 in Cyclic Guanosine-3',5'-Monophosphate-Dependent Protein Kinase I. Kamynina, A., Guttzeit, S., Eaton, P. & Cuello, F. Hypertension, HYPERTENSIONAHA12218756 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35168371  

One-year results following PASCAL-based or MitraClip-based mitral valve transcatheter edge-to-edge repair. Geis, N. A., Schlegel, P., Heckmann, M. B., Katus, H. A., Frey, N., Crespo Lopez, P. & Raake, P. W. J. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35170230  

The role of epigenetic clocks in explaining educational inequalities in mortality: a multi-cohort study and meta-analysis. Fiorito, G., Pedron, S., Ochoa-Rosales, C., McCrory, C., Polidoro, S., Zhang, Y., Dugue, P. A., Ratliff, S., Zhao, W. N., McKay, G. J., Costa, G., Solinas, M. G., Mullan Harris, K., Tumino, R., Grioni, S., Ricceri, F., Panico, S., Brenner, H., Schwettmann, L., Waldenberger, M. et al. J Gerontol A Biol Sci Med Sci (2022). https://www.ncbi.nlm.nih.gov/pubmed/35172329  

Reply to Van den Eyde et al. Voges, I. & Gabbert, D. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35167668  

Tackling postoperative sudden cardiac death in high-risk cardiac surgical patients-role of wearable cardioverter defibrillators. Starck, C., Kaemmel, J. & Falk, V. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35165712  

Iron Deficiency and Reduced Muscle Strength in Patients with Acute and Chronic Ischemic Stroke. Scherbakov, N., Sandek, A., Valentova, M., Mayer, A., von Haehling, S., Jankowska, E., Anker, S. D. & Doehner, W. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35160047  

Population-based screening in children for early diagnosis and treatment of familial hypercholesterolemia: design of the VRONI study. Sanin, V., Schmieder, R., Ates, S., Schlieben, L. D., Wiehler, J., Sun, R., Decker, M., Sander, M., Holdenrieder, S., Kohlmayer, F., Friedmann, A., Mall, V., Feiler, T., Dressler, A., Strom, T. M., Prokisch, H., Meitinger, T., von Scheidt, M., Koenig, W., Leipold, G. et al. Eur J Public Health (2022). https://www.ncbi.nlm.nih.gov/pubmed/35165720   

Association between Duration of Deep Hypothermic Circulatory Arrest and Surgical Outcome in Patients with Acute Type A Aortic Dissection: A Large Retrospective Cohort Study. Salehi Ravesh, M., Friedrich, C., Schoettler, J., Hummitzsch, L., Elke, G., Salem, M., Lutter, G., Puehler, T., Cremer, J. & Haneya, A. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35160094  

Longitudinal association of Apolipoprotein E polymorphism with lipid profile, type 2 diabetes and metabolic syndrome: Results from a 15 year follow-up study. Pitchika, A., Ricardo Paulista Markus, M., Schipf, S., Teumer, A., Van der Auwera, S., Nauck, M., Dorr, M., Felix, S., Jorgen Grabe, H., Volzke, H. & Ittermann, T. Diabetes Res Clin Pract 185, 109778 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35167921  

Switching in the expression pattern of actin isoforms marks the onset of contractility and distinct mechanodynamic behavior during cardiomyocyte differentiation. Pires, R. H., Dau, T. H., Manu, E., Shree, N. & Otto, O. Physiol Rep 10, e15171 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35166060  

Soluble ST2 Receptor: Biomarker of Left Ventricular Impairment and Functional Status in Patients with Inflammatory Cardiomyopathy. Obradovic, D. M., Buttner, P., Rommel, K. P., Blazek, S., Loncar, G., von Haehling, S., von Roeder, M., Lucke, C., Gutberlet, M., Thiele, H., Lurz, P. & Besler, C. Cells 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35159224  

The Role of Oncostatin M and Its Receptor Complexes in Cardiomyocyte Protection, Regeneration, and Failure. Kubin, T., Gajawada, P., Bramlage, P., Hein, S., Berge, B., Cetinkaya, A., Burger, H., Schonburg, M., Schaper, W., Choi, Y. H. & Richter, M. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35163735  

Improving robustness of automatic cardiac function quantification from cine magnetic resonance imaging using synthetic image data. Gheorghita, B. A., Itu, L. M., Sharma, P., Suciu, C., Wetzl, J., Geppert, C., Ali, M. A. A., Lee, A. M., Piechnik, S. K., Neubauer, S., Petersen, S. E., Schulz-Menger, J. & Chitiboi, T. Sci Rep 12, 2391 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35165324  

Iron deficiency is related to low functional outcome in patients at early rehabilitation after acute stroke. Doehner, W., Scherbakov, N., Schellenberg, T., Jankowska, E. A., Scheitz, J. F., von Haehling, S. & Joebges, M. J Cachexia Sarcopenia Muscle (2022). https://www.ncbi.nlm.nih.gov/pubmed/35166066  

Expression and Characterization of Relaxin Family Peptide Receptor 1 Variants. Speck, D., Kleinau, G., Meininghaus, M., Erbe, A., Einfeldt, A., Szczepek, M., Scheerer, P. & Putter, V. Front Pharmacol 12, 826112 (2021). https://www.ncbi.nlm.nih.gov/pubmed/35153771  

Use of hiPSC-Derived Cardiomyocytes to Rule Out Proarrhythmic Effects of Drugs: The Case of Hydroxychloroquine in COVID-19. Sala, L., Leonov, V., Mura, M., Giannetti, F., Khudiakov, A., Moretti, A., Crotti, L., Gnecchi, M. & Schwartz, P. J. Front Physiol 12, 730127 (2021). https://www.ncbi.nlm.nih.gov/pubmed/35153806  

Paracrine Interleukin 6 Induces Cerebral Remodeling at Early Stages After Unilateral Common Carotid Artery Occlusion in Mice. Kuffner, M. T. C., Koch, S. P., Kirchner, M., Mueller, S., Lips, J., An, J., Mertins, P., Dirnagl, U., Endres, M., Boehm-Sturm, P., Harms, C. & Hoffmann, C. J. Front Cardiovasc Med 8, 805095 (2021). https://www.ncbi.nlm.nih.gov/pubmed/35155612  

Stroke events after transcatheter aortic valve implantation: Temporal relationships and affected brain regions. Linder, M., Higgen, F. L., Voigtlander, L., Weimann, J., Ludwig, S., Waldschmidt, L., Focke, C., Bhadra, O., Grundmann, D., Demal, T., von Zastrow, A., Schafer, A., Schirmer, J., Reichenspurner, H., Blankenberg, S., Westermann, D., Schofer, N., Conradi, L., Thomalla, G. & Seiffert, M. Am Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35149038  

The European Registry for Patients with Mechanical Circulatory Support of the European Association for Cardio-Thoracic Surgery: third report. de By, T., Schoenrath, F., Veen, K. M., Mohacsi, P., Stein, J., Alkhamees, K. M. M., Anastasiadis, K., Berhnardt, A., Beyersdorf, F., Caliskan, K., Reineke, D., Damman, K., Fiane, A., Gkouziouta, A., Gollmann-Tepekoylu, C., Finn, G., Hulman, M., Iacovoni, A., Loforte, A., Merkely, B. et al. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35150247  

Impact of prenatal and childhood adversity effects around World War II on multimorbidity: results from the KORA-Age study. Arshadipour, A., Thorand, B., Linkohr, B., Rospleszcz, S., Ladwig, K. H., Heier, M. & Peters, A. BMC Geriatr 22, 115 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35148691  

Target and non-target vessel related events at 10 years post percutaneous coronary intervention. Coughlan, J. J., Aytekin, A., Xhepa, E., Cassese, S., Joner, M., Koch, T., Wiebe, J., Lenz, T., Rheude, T., Pellegrini, C., Gewalt, S., Ibrahim, T., Laugwitz, K. L., Schunkert, H., Kastrati, A. & Kufner, S. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35147767  

Ticagrelor after Acute Coronary Syndrome: One For All or Part of Personalized Medicine? Akin, I. & Nienaber, C. A. Lancet Reg Health Eur 14, 100309 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35146475  

Non-human primate pluripotent stem cells for the preclinical testing of regenerative therapies. Rodriguez-Polo, I. & Behr, R. Neural Regen Res 17, 1867-1874 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35142660  

Serum Calcification Propensity and Calcification of the Abdominal Aorta in Patients With Primary Aldosteronism. Kantauskaite, M., Bolten, K., Boschheidgen, M., Schmidt, C., Kolb, T., Eckardt, K. U., Pasch, A., Schimmoller, L., Rump, L. C., Voelkl, J. & Stegbauer, J. Front Cardiovasc Med 9, 771096 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35141300  

Functional improvement following direct interventional leaflet repair of severe tricuspid regurgitation. Volz, M. J., Hoerbrand, I., Konstandin, M. H., Mereles, D., Weiss, C., Warnecke, G., Frey, N., Aurich, M. & Raake, P. W. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35137567  

The additional use of strain measurements for timing of treatment in severe aortic regurgitation. Sinning, C. Int J Cardiovasc Imaging (2022). https://www.ncbi.nlm.nih.gov/pubmed/35138473  

Feasibility and preliminary efficacy of perioperative interventions in patients undergoing coronary artery bypass grafting: the randomized controlled I-COPE trial. Sadlonova, M., Nagel, J., Becker, S., Neumann, S., Staab, J., Meyer, T., Celano, C. M., Amonoo, H. L., Fangauf, S. V., Herrmann-Lingen, C., Kutschka, I. & Friedrich, M. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35137022  

Thyroid Function and the Risk of Prediabetes and Type 2 Diabetes. Roa Duenas, O. H., Van der Burgh, A. C., Ittermann, T., Ligthart, S., Ikram, M. A., Peeters, R. & Chaker, L. J Clin Endocrinol Metab (2022). https://www.ncbi.nlm.nih.gov/pubmed/35137143  

Atrial fibrillation in patients on left ventricular assist device support-to treat or not to treat. Potapov, E. V. & Schoenrath, F. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35137027  

Targeted proteomics improves cardiovascular risk prediction in secondary prevention. Nurmohamed, N. S., Belo Pereira, J. P., Hoogeveen, R. M., Kroon, J., Kraaijenhof, J. M., Waissi, F., Timmerman, N., Bom, M. J., Hoefer, I. E., Knaapen, P., Catapano, A. L., Koenig, W., de Kleijn, D., Visseren, F. L. J., Levin, E., Stroes, E. S. G. & Group, U.-S. S. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35139537  

Prognostic impact of secondary prevention after coronary artery bypass grafting-insights from the TiCAB trial. Heer, T., von Scheidt, M., Boening, A., Heyken, C., Gusmini, F., de Waha, A., Kuna, C., Fach, A., Grothusen, C., Oberhoffer, M., Knosalla, C., Walther, T., Danner, B. C., Misfeld, M., Wimmer-Greinecker, G., Siepe, M., Grubitzsch, H., Joost, A., Schaefer, A., Conradi, L. et al. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35138350  

MRI-Detected Brain Lesions and Cognitive Function in Atrial Fibrillation Patients Undergoing Left Atrial Catheter Ablation in the Randomized AXAFA-AFNET 5 Trial. Hausler, K. G., Eichner, F. A., Heuschmann, P. U., Fiebach, J. B., Engelhorn, T., Blank, B., Callans, D., Elvan, A., Grimaldi, M., Hansen, J., Hindricks, G., Al-Khalidi, H. R., Mont, L., Nielsen, J. C., Piccini, J. P., Schotten, U., Themistoclakis, S., Vijgen, J., Di Biase, L. & Kirchhof, P. Circulation (2022). https://www.ncbi.nlm.nih.gov/pubmed/35135308  

Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture-prone atherosclerotic plaques. Edsfeldt, A., Swart, M., Singh, P., Dib, L., Sun, J., Cole, J. E., Park, I., Al-Sharify, D., Persson, A., Nitulescu, M., Das Neves Borges, P., Kassiteridi, C., Goddard, M. E., Lee, R., Volkov, P., Orho-Melander, M., Maegdefessel, L., Nilsson, J., Udalova, I., Goncalves, I. et al. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35139193  

J wave syndromes in patients with spinal and bulbar muscular atrophy. Steinmetz, K., Rudic, B., Borggrefe, M., Muller, K., Siebert, R., Rottbauer, W., Ludolph, A., Buckert, D. & Rosenbohm, A. J Neurol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35132468  

Birth weight and heart failure: hindsight as an exact science? Fonseca, G., Garfias-Veitl, T. & von Haehling, S. Eur J Prev Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35134156  

Myogenic Vasoconstriction Requires Canonical Gq/11 Signaling of the Angiotensin II Type 1 Receptor. Cui, Y., Kassmann, M., Nickel, S., Zhang, C., Alenina, N., Anistan, Y. M., Schleifenbaum, J., Bader, M., Welsh, D. G., Huang, Y. & Gollasch, M. J Am Heart Assoc 11, e022070 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35132870  

Teleproctoring for Training in Structural Heart Interventions: Initial Real-World Experience During the COVID-19 Pandemic. Beyhoff, N., Zhu, M., Zanders, L., Leistner, D. M., Nobles, A., Schroeder, M., Barbieri, F., Landmesser, U. & Reinthaler, M. J Am Heart Assoc 11, e023757 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35132869  

[Drop in oxygen saturation and blood pressure as well as increase in central venous pressure during mitral valve clipping in an 81-year-old female patient]. Volz, M. J., Aurich, M., Konstandin, M., Katus, H. A., Frey, N., Kreusser, M. M. & Raake, P. W. Internist (Berl) (2022). https://www.ncbi.nlm.nih.gov/pubmed/35129621  

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement. Sun, X., Hao, Y., Sebastian Kiekenap, J. F., Emeis, J., Steitz, M., Breitenstein-Attach, A., Berger, F. & Schmitt, B. J Vis Exp (2022). https://www.ncbi.nlm.nih.gov/pubmed/35129181  

Recommendations in pre-procedural imaging assessment for TAVI intervention: SIC-SIRM position paper part 2 (CT and MR angiography, standard medical reporting, future perspectives). Marano, R., Pontone, G., Agricola, E., Alushi, B., Bartorelli, A., Cameli, M., Carrabba, N., Esposito, A., Faletti, R., Francone, M., Galea, N., Golino, P., Guglielmo, M., Palmisano, A., Petronio, S., Petulla, M., Pradella, S., Ribichini, F., Romeo, F., Russo, V. et al. Radiol Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/35129758  

Different Rates of Bioprosthetic Aortic Valve Failure With Perimount and Trifecta Bioprostheses. Lange, R., Alalawi, Z., Voss, S., Boehm, J., Krane, M. & Vitanova, K. Front Cardiovasc Med 8, 822893 (2021). https://www.ncbi.nlm.nih.gov/pubmed/35127875  

Phosphodiesterases S-sulfhydration contributes to human skeletal muscle function. Vellecco, V., Panza, E., Bibli, S. I., Casillo, G. M., Raucci, F., Manzo, O. L., Smimmo, M., Villani, R., Cavezza, M. R., Fleming, I., d'Emmanuele di Villa Bianca, R., Maione, F., Cirino, G. & Bucci, M. Pharmacol Res 177, 106108 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35121122  

Stable patients with suspected myocardial ischemia: comparison of machine-learning computed tomography-based fractional flow reserve and stress perfusion cardiovascular magnetic resonance imaging to detect myocardial ischemia. Lossnitzer, D., Klenantz, S., Andre, F., Goerich, J., Schoepf, U. J., Pazzo, K. L., Sommer, A., Brado, M., Guckel, F., Sokiranski, R., Becher, T., Akin, I., Buss, S. J. & Baumann, S. BMC Cardiovasc Disord 22, 34 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35120459  

Generation of a CRISPR/Cas edited human induced pluripotent stem cell line DHMi005-A-1 carrying a patient-specific disease-causing point mutation in the TBX5 gene. Lahm, H., Heinrich, P., Zierler, E., Dzilic, E., Neb, I., Luzius, T., Doppler, S. A., Schneider, S., Lange, R., Krane, M. & Dressen, M. Stem Cell Res 60, 102691 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35121196  

Case Report: Cytomegalovirus Reactivation and Pericarditis Following ChAdOx1 nCoV-19 Vaccination Against SARS-CoV-2. Pluss, M., Mese, K., Kowallick, J. T., Schuster, A., Tampe, D. & Tampe, B. Front Immunol 12, 784145 (2021). https://www.ncbi.nlm.nih.gov/pubmed/35116025  

Effects of sacubitril/valsartan versus valsartan on renal function in patients with and without diabetes and heart failure with preserved ejection fraction: insights from PARAGON-HF. Peikert, A., Vaduganathan, M., Mc Causland, F., Claggett, B. L., Chatur, S., Packer, M., Pfeffer, M. A., Zannad, F., Lefkowitz, M. P., Pieske, B., Dungen, H. D., McMurray, J. J. V. & Solomon, S. D. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35119183  

Early risk stratification in patients with cardiogenic shock irrespective of the underlying cause - the Cardiogenic Shock Score. Beer, B. N., Jentzer, J. C., Weimann, J., Dabboura, S., Yan, I., Sundermeyer, J., Kirchhof, P., Blankenberg, S., Schrage, B. & Westermann, D. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35119176  

Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels. S, O. B., Holmes, A. P., Johnson, D. M., Kabir, S. N., C, O. S., M, O. R., Avezzu, A., Reyat, J. S., Hall, A. W., Apicella, C., Ellinor, P. T., Niederer, S., Tucker, N. R., Fabritz, L., Kirchhof, P. & Pavlovic, D. J Mol Cell Cardiol 166, 23-35 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35114252  

Impact of thyroid dysfunction on short-term outcomes and long-term mortality in patients with pulmonary embolism. Pohl, K. R., Hobohm, L., Krieg, V. J., Sentler, C., Rogge, N. I. J., Steimke, L., Ebner, M., Lerchbaumer, M., Hasenfuss, G., Konstantinides, S., Lankeit, M. & Keller, K. Thromb Res 211, 70-78 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35114459  

Web of Science's Citation Median Metrics Overcome the Major Constraints of the Journal Impact Factor. Daugherty, A., Hegele, R. A., Lu, H. S., Mackman, N., Rader, D. J. & Weber, C. Arterioscler Thromb Vasc Biol, ATVBAHA122317426 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35109675  

Interactions Between Atrial Fibrillation and Natriuretic Peptide in Predicting Heart Failure Hospitalization or Cardiovascular Death. Brady, P. F., Chua, W., Nehaj, F., Connolly, D. L., Khashaba, A., Purmah, Y. J. V., Ul-Qamar, M. J., Thomas, M. R., Varma, C., Schnabel, R. B., Zeller, T., Fabritz, L. & Kirchhof, P. F. J Am Heart Assoc 11, e022833 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35112889  

Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators. Wesseler, F., Riege, D., Puthanveedu, M., Halver, J., Muller, E., Bertrand, J., Antonchick, A. P., Sievers, S., Waldmann, H. & Schade, D. J Med Chem (2022). https://www.ncbi.nlm.nih.gov/pubmed/35108017  

Diffusion-Weighted Imaging and Fluid-Attenuated Inversion Recovery Quantification to Predict Diffusion-Weighted Imaging-Fluid-Attenuated Inversion Recovery Mismatch Status in Ischemic Stroke With Unknown Onset. Scheldeman, L., Wouters, A., Dupont, P., Christensen, S., Boutitie, F., Cheng, B., Ebinger, M., Endres, M., Fiebach, J. B., Gerloff, C., Muir, K. W., Nighoghossian, N., Pedraza, S., Simonsen, C. Z., Thijs, V., Thomalla, G. & Lemmens, R. Stroke, STROKEAHA121036871 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35105179  

A quantitative RT-PCR protocol to adapt and quantify RBM20-dependent exon splicing of targets at the human locus. Rebs, S., Buchwald, T. A. & Streckfuss-Bomeke, K. STAR Protoc 3, 101117 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35106501  

Successfully implemented artificial intelligence and machine learning applications in cardiology: State-of-the-art review. Van den Eynde, J., Lachmann, M., Laugwitz, K. L., Manlhiot, C. & Kutty, S. Trends Cardiovasc Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/35101642  

Prediction of risk for bleeding, myocardial infarction and mortality after percutaneous coronary intervention in patients with acute coronary syndromes. Ndrepepa, G., Neumann, F. J., Menichelli, M., Richardt, G., Cassese, S., Xhepa, E., Kufner, S., Lahu, S., Aytekin, A., Sager, H. B., Joner, M., Ibrahim, T., Muller, A., Fusaro, M., Hapfelmeier, A., Laugwitz, K. L., Schunkert, H., Kastrati, A. & Kasel, M. Coron Artery Dis (2022). https://www.ncbi.nlm.nih.gov/pubmed/35102066  

Mental Health-Related Risk Factors and Interventions in Patients with Heart Failure. A Position Paper endorsed by the European Association of Preventive Cardiology (EAPC). Ladwig, K. H., Baghai, T. C., Doyle, F., Hamer, M., Herrmann-Lingen, C., Kunschitz, E., Lemogne, C., Beresnevaite, M., Compare, A., von Kanel, R., Sager, H. B. & Kop, W. J. Eur J Prev Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35104845  

Improved Quantification of Cell Density in the Arterial Wall-A Novel Nucleus Splitting Approach Applied to 3D Two-Photon Laser-Scanning Microscopy. van der Laan, K. W. F., Reesink, K. D., van der Bruggen, M. M., Jaminon, A. M. G., Schurgers, L. J., Megens, R. T. A., Huberts, W., Delhaas, T. & Spronck, B. Front Physiol 12, 814434 (2021). https://www.ncbi.nlm.nih.gov/pubmed/35095571  

Tailoring Cardiac Synthetic Transcriptional Modulation Towards Precision Medicine. Schoger, E., Lelek, S., Panakova, D. & Zelarayan, L. C. Front Cardiovasc Med 8, 783072 (2021). https://www.ncbi.nlm.nih.gov/pubmed/35097003  

Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration. Rivard, L., Friberg, L., Conen, D., Healey, J. S., Berge, T., Boriani, G., Brandes, A., Calkins, H., Camm, A. J., Yee Chen, L., Lluis Clua Espuny, J., Collins, R., Connolly, S., Dagres, N., Elkind, M. S. V., Engdahl, J., Field, T. S., Gersh, B. J., Glotzer, T. V., Hankey, G. J. et al. Circulation 145, 392-409 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35100023  

Coronary Artery Disease in Patients Presenting With Acute Ischemic Stroke or Transient Ischemic Attack and Elevated Troponin Levels. Kruska, M., Kolb, A., Fastner, C., Mildenberger, I., Hetjens, S., Kittel, M., Bail, K., Behnes, M., Akin, I., Borggrefe, M., Szabo, K. & Baumann, S. Front Neurol 12, 781553 (2021). https://www.ncbi.nlm.nih.gov/pubmed/35095727  

Single-cell transcription profiles in Bloom syndrome patients link BLM deficiency with altered condensin complex expression signatures. Gonenc, II, Wolff, A., Schmidt, J., Zibat, A., Muller, C., Cyganek, L., Argyriou, L., Raschle, M., Yigit, G. & Wollnik, B. Hum Mol Genet (2022). https://www.ncbi.nlm.nih.gov/pubmed/35099000  

Muscle Mass and Inflammation in Older Adults: Impact of the Metabolic Syndrome. Buchmann, N., Fielitz, J., Spira, D., Konig, M., Norman, K., Pawelec, G., Goldeck, D., Demuth, I. & Steinhagen-Thiessen, E. Gerontology, 1-10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35100595


März

Pulmonary Embolism and Pregnancy-Challenges in Diagnostic and Therapeutic Decisions in High-Risk Patients. Hobohm, L., Farmakis, I. T., Munzel, T., Konstantinides, S. & Keller, K. Front Cardiovasc Med 9, 856594 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35350540  

Novel Nongenetic Murine Model of Hyperglycemia and Hyperlipidemia-Associated Aggravated Atherosclerosis. Gaul, S., Shahzad, K., Medert, R., Gadi, I., Mader, C., Schumacher, D., Wirth, A., Ambreen, S., Fatima, S., Boeckel, J. N., Khawaja, H., Haas, J., Brune, M., Nawroth, P. P., Isermann, B., Laufs, U. & Freichel, M. Front Cardiovasc Med 9, 813215 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35350534  

Pak2 Regulation of Nrf2 Serves as a Novel Signaling Nexus Linking ER Stress Response and Oxidative Stress in the Heart. Binder, P., Nguyen, B., Collins, L., Zi, M., Liu, W., Christou, F., Luo, X., Hille, S. S., Frey, N., Cartwright, E. J., Chernoff, J., Muller, O. J., Guan, K. & Wang, X. Front Cardiovasc Med 9, 851419 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35350536  

Molecular consequences of SARS-CoV-2 liver tropism. Wanner, N., Andrieux, G., Badia, I. M. P., Edler, C., Pfefferle, S., Lindenmeyer, M. T., Schmidt-Lauber, C., Czogalla, J., Wong, M. N., Okabayashi, Y., Braun, F., Lutgehetmann, M., Meister, E., Lu, S., Noriega, M. L. M., Gunther, T., Grundhoff, A., Fischer, N., Brauninger, H., Lindner, D. et al. Nat Metab 4, 310-319 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35347318  

Severe Acute Respiratory Distress Syndrome (ARDS) or Severely Increased Chest Wall Elastance? Lindner, S., Durschmied, D., Akin, I. & Britsch, S. Cureus 14, e22541 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35345704  

Requirement of Na+/H+ Exchanger NHE1 for Vasopressin-Induced Osteogenic Signaling and Calcification in Human Aortic Smooth Muscle Cells. Zhu, X., Ma, K., Zhou, K., Pan, X., Liu, J., Nurnberg, B., Alesutan, I., Volkl, J. & Lang, F. Kidney Blood Press Res 47, 399-409 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35339998  

Immuno-PET Imaging of Atherosclerotic Plaques with [(89)Zr]Zr-Anti-CD40 mAb-Proof of Concept. Poels, K., Schreurs, M., Jansen, M., Vugts, D. J., Seijkens, T. T. P., van Dongen, G., Lutgens, E. & Beaino, W. Biology (Basel) 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35336782   

Boosting targeted genome editing using the hei-tag. Thumberger, T., Tavhelidse-Suck, T., Gutierrez-Triana, J. A., Cornean, A., Medert, R., Welz, B., Freichel, M. & Wittbrodt, J. Elife 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35333175  

Decreased Intrathecal Concentrations of Free Light Chains Kappa in Multiple Sclerosis Patients Taking Very High Effective Disease-Modifying Treatment. Susse, M., Konen, F. F., Schwenkenbecher, P., Budde, K., Nauck, M., Grothe, M., Hannich, M. J. & Skripuletz, T. Diagnostics (Basel) 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35328273  

Mechanistic Insights into Inorganic Nitrite-Mediated Vasodilation of Isolated Aortic Rings under Oxidative/Hypertensive Conditions and S-Nitros(yl)ation of Proteins in Germ-Free Mice. Stamm, P., Kalinovic, S., Oelze, M., Steven, S., Czarnowski, A., Kvandova, M., Bayer, F., Reinhardt, C., Munzel, T. & Daiber, A. Biomedicines 10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35327532  

Repair of Mitral Valves with Severe Annular Dilatation and Abundant Leaflet Tissue Using a Prosthetic Ring with a Large Anterior-Posterior Diameter. Sideris, K., Burri, M., Bordne, J., Vitanova, K., Voss, B., Krane, M. & Lange, R. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35330034  

Association of Plasma Methylglyoxal Increase after Myocardial Infarction and the Left Ventricular Ejection Fraction. Heber, S., Haller, P. M., Kiss, A., Jager, B., Huber, K. & Fischer, M. J. M. Biomedicines 10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35327407  

Transcatheter Aortic Valve Replacement with the Self-Expandable Core Valve Evolut Prosthesis Using the Cusp-Overlap vs. Tricusp-View. Doldi, P. M., Stolz, L., Escher, F., Steffen, J., Gmeiner, J., Roden, D., Linnemann, M., Low, K., Deseive, S., Stocker, T. J., Orban, M., Theiss, H., Rizas, K., Curta, A., Sadoni, S., Buech, J., Joskowiak, D., Peterss, S., Hagl, C., Massberg, S. et al. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35329887  

Lipoprotein(a) and Metabolic Syndrome. Buchmann, N., Ittermann, T., Demuth, I., Markus, M. R. P., Volzke, H., Dorr, M., Friedrich, N., Lerch, M. M., Santos, R. D., Schipf, S. & Steinhagen-Thiessen, E. Dtsch Arztebl Int 119, 270-276 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35331368  

Soluble ST2 as a Potential Biomarker for Risk Assessment of Pulmonary Hypertension in Patients Undergoing TAVR? Boxhammer, E., Mirna, M., Baz, L., Bacher, N., Topf, A., Sipos, B., Franz, M., Kretzschmar, D., Hoppe, U. C., Lauten, A. & Lichtenauer, M. Life (Basel) 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35330140  

Effects of Artificial Intelligence-Derived Body Composition on Kidney Graft and Patient Survival in the Eurotransplant Senior Program. Beetz, N. L., Geisel, D., Shnayien, S., Auer, T. A., Globke, B., Ollinger, R., Trippel, T. D., Schachtner, T. & Fehrenbach, U. Biomedicines 10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35327356  

Cardiovascular Inflammaging: Mechanisms and Translational Aspects. Barcena, M. L., Aslam, M., Pozdniakova, S., Norman, K. & Ladilov, Y. Cells 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35326461  

Somatostatin Primes Endothelial Cells for Agonist-Induced Hyperpermeability and Angiogenesis In Vitro. Aslam, M., Idrees, H., Ferdinandy, P., Helyes, Z., Hamm, C. & Schulz, R. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35328517  

Glucose Counteracts Isoprenaline Effects on Ion Channel Functions in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Qiao, L., Fan, X., Yang, Z., El-Battrawy, I., Zhou, X. & Akin, I. J Cardiovasc Dev Dis 9 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35323624  

Pleiotropic Effects of PCSK9: Focus on Thrombosis and Haemostasis. Puccini, M., Landmesser, U. & Rauch, U. Metabolites 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35323669   

A Case Series of Concomitant Cardiac Electrical Disease among Takotsubo Syndrome Patients and Literature Review. El-Battrawy, I., Erath, J. W., Vamos, M., Aweimer, A., Mugge, A., Lang, S., Ansari, U., Gietzen, T. & Akin, I. J Cardiovasc Dev Dis 9 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35323627 

Disruptors of AKAP-Dependent Protein-Protein Interactions. Walker-Gray, R., Pallien, T., Miller, D. C., Oder, A., Neuenschwander, M., von Kries, J. P., Diecke, S. & Klussmann, E. Methods Mol Biol 2483, 117-139 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35286673  

Generation of Transgenic Mice Expressing Cytosolic and Targeted FRET Biosensors for cAMP and cGMP. Kurelic, R. & Nikolaev, V. O. Methods Mol Biol 2483, 241-254 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35286680  

Live Cell Imaging of Cyclic Nucleotides in Human Cardiomyocytes. Beneke, K. & Molina, C. E. Methods Mol Biol 2483, 195-204 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35286677  

The Ketogenic Diet: Is It an Answer for Sarcopenic Obesity? Ilyas, Z., Perna, S., T, A. A., Zahid, M. N., Spadaccini, D., Gasparri, C., Peroni, G., Faragli, A., Alogna, A., La Porta, E., Ali Redha, A., Negro, M., Cerullo, G., D'Antona, G. & Rondanelli, M. Nutrients 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35276979  

Uncovering the molecular identity of cardiosphere-derived cells (CDCs) by single-cell RNA sequencing. Kogan, P. S., Wirth, F., Tomar, A., Darr, J., Teperino, R., Lahm, H., Dressen, M., Puluca, N., Zhang, Z., Neb, I., Beck, N., Luzius, T., de la Osa de la Rosa, L., Gartner, K., Huls, C., Zeidler, R., Ramanujam, D., Engelhardt, S., Wenk, C., Holdt, L. M. et al. Basic Res Cardiol 117, 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35258704  

Relevance of Cor Pulmonale in COPD With and Without Pulmonary Hypertension: A Retrospective Cohort Study. Yogeswaran, A., Kuhnert, S., Gall, H., Faber, M., Krauss, E., Rako, Z. A., Keranov, S., Grimminger, F., Ghofrani, H. A., Naeije, R., Seeger, W., Richter, M. J. & Tello, K. Front Cardiovasc Med 9, 826369 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35252399  

Dysregulated Immunity in Pulmonary Hypertension: From Companion to Composer. Funk-Hilsdorf, T. C., Behrens, F., Grune, J. & Simmons, S. Front Physiol 13, 819145 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35250621  

Midwall Fibrosis and Cardiac Mechanics: Rigid Body Rotation Is a Novel Marker of Disease Severity in Pediatric Primary Dilated Cardiomyopathy. Al-Wakeel-Marquard, N., Seidel, F., Kuhnisch, J., Kuehne, T., Berger, F., Messroghli, D. R. & Klaassen, S. Front Cardiovasc Med 8, 810005 (2021). https://www.ncbi.nlm.nih.gov/pubmed/35252369  

Minimally invasive approach to the treatment of atrial fibrillation: Concomitant Convergent and LARIAT procedure. Van Praet, K. M., Nersesian, G., Kofler, M., Heil, E., Unbehaun, A., Klein, C., Kempfert, J., Falk, V., Gerds-Li, J. H. & Starck, C. Multimed Man Cardiothorac Surg 2022 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35245005  

COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences. Martinez-Salazar, B., Holwerda, M., Studle, C., Piragyte, I., Mercader, N., Engelhardt, B., Rieben, R. & Doring, Y. Front Cell Dev Biol 10, 824851 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35242762  

Editorial: Metabolic Regulation of Cardiac and Vascular Cell Function: Physiological and Pathophysiological Implications. Khan, M., Volkers, M. & Wende, A. R. Front Physiol 13, 849869 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35242056  

Laser Capture Microdissection-Based mRNA Expression Microarrays and Single-Cell RNA Sequencing in Atherosclerosis Research. Zhang, X., Wang, Z., Zhang, C., Li, Y., Lu, S., Steffens, S., Mohanta, S., Weber, C., Habenicht, A. & Yin, C. Methods Mol Biol 2419, 715-726 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35237997  

Combined Single-Cell RNA and Single-Cell alpha/beta T Cell Receptor Sequencing of the Arterial Wall in Atherosclerosis. Wang, Z., Zhang, X., Zhang, C., Li, Y., Lu, S., Mohanta, S., Weber, C., Habenicht, A. & Yin, C. Methods Mol Biol 2419, 727-746 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35237998  

Tissue Clearing Approaches in Atherosclerosis. Sun, T., Li, Y., Forstera, B., Stanic, K., Lu, S., Steffens, S., Yin, C., Erturk, A., Megens, R. T. A., Weber, C., Habenicht, A. & Mohanta, S. K. Methods Mol Biol 2419, 747-763 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35237999  

Three-Dimensional Visualization of Atherosclerotic Vessels by Tissue Clearing and Light-Sheet Fluorescence Microscopy. Becher, T., Riascos-Bernal, D. F., Chi, J., Cohen, P. & Sibinga, N. E. S. Methods Mol Biol 2419, 841-851 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35238005   

Circulating microRNAs in the prediction of BAV aortopathy: do the expression patterns correlate between blood and aortic tissue? Naito, S., Sequeira-Gross, T., Petersen, J., Detlef, I., Sachse, M., Zeller, T., Reichenspurner, H. & Girdauskas, E. Rev Cardiovasc Med 23, 47 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35229538  

Relationship between plasma Neuregulin-1 and cardiac function in patients with ST-elevation myocardial infarction. Haller, P. M., Goncalves, I. F., Acar, E., Jager, B., Pilz, P. M., Wojta, J., Huber, K., Kiss, A. & Podesser, B. K. Rev Cardiovasc Med 23, 63 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35229554  

Iron Deficiency Impacts Diastolic Function, Aerobic Exercise Capacity, and Patient Phenotyping in Heart Failure With Preserved Ejection Fraction: A Subanalysis of the OptimEx-Clin Study. Gevaert, A. B., Mueller, S., Winzer, E. B., Duvinage, A., Van de Heyning, C. M., Pieske-Kraigher, E., Beckers, P. J., Edelmann, F., Wisloff, U., Pieske, B., Adams, V., Halle, M., Van Craenenbroeck, E. M. & OptimEx-Clin Study, G. Front Physiol 12, 757268 (2021). https://www.ncbi.nlm.nih.gov/pubmed/35222057  

Assessment and mitigation of bleeding risk in atrial fibrillation and venous thromboembolism: A Position Paper from the ESC Working Group on Thrombosis, in collaboration with the European Heart Rhythm Association, the Association for Acute CardioVascular Care and the Asia-Pacific Heart Rhythm Society. Gorog, D. A., Gue, Y. X., Chao, T. F., Fauchier, L., Ferreiro, J. L., Huber, K., Konstantinidis, S. V., Lane, D. A., Marin, F., Oldgren, J., Potpara, T., Roldan, V., Rubboli, A., Sibbing, D., Tse, H. F., Vilahur, G. & Lip, G. Y. H. Europace 24, 1844-1871 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35323922  

The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell-monocyte crosstalk and protects against atherosclerosis via the NF-kappaB pathway. Farina, F. M., Serio, S., Hall, I. F., Zani, S., Cassanmagnago, G. A., Climent, M., Civilini, E., Condorelli, G., Quintavalle, M. & Elia, L. Eur Heart J 43, 4562-4576 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35292818  

Heart-Type Fatty Acid Binding Protein, Cardiovascular Outcomes, and Death: Findings From the German CKD Cohort Study. Schneider, M. P., Schmid, M., Nadal, J., Wanner, C., Krane, V., Floege, J., Saritas, T., Busch, M., Sitter, T., Friedrich, N., Stockmann, H., Meiselbach, H., Nauck, M., Kronenberg, F. & Eckardt, K. U. Am J Kidney Dis 80, 483-494.e481 (2022).

Animal models of pulmonary hypertension due to left heart disease. Liu, S. F. & Yan, Y. Animal Model Exp Med 5, 197-206 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35234367  

Multicenter comparison of latest-generation balloon-expandable versus self-expanding transcatheter heart valves: Ultra versus Evolut. Rheude, T., Pellegrini, C., Allali, A., Bleiziffer, S., Kim, W. K., Neuser, J., Landt, M., Rudolph, T., Renker, M., Widder, J. D., Qu, L., Alvarez-Covarrubias, H. A., Mayr, N. P., Richardt, G., Xhepa, E. & Joner, M. Int J Cardiol 357, 115-120 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35337936   

Cardiac mechanisms of the beneficial effects of SGLT2 inhibitors in heart failure: Evidence for potential off-target effects. Dyck, J. R. B., Sossalla, S., Hamdani, N., Coronel, R., Weber, N. C., Light, P. E. & Zuurbier, C. J. J Mol Cell Cardiol 167, 17-31 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35331696

P2Y12-dependent activation of hematopoietic stem and progenitor cells promotes emergency hematopoiesis after myocardial infarction. Seung, H., Wrobel, J., Wadle, C., Buhler, T., Chiang, D., Rettkowski, J., Cabezas-Wallscheid, N., Hechler, B., Stachon, P., Maier, A., Weber, C., Wolf, D., Duerschmied, D., Idzko, M., Bode, C., von Zur Muhlen, C., Hilgendorf, I. & Heidt, T. Basic Res Cardiol 117, 16 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35353230  

Comparison of cardiac volumetry using real-time MRI during free-breathing with standard cine MRI during breath-hold in children. Rower, L. M., Radke, K. L., Hussmann, J., Malik, H., Uelwer, T., Voit, D., Frahm, J., Wittsack, H. J., Harmeling, S., Pillekamp, F. & Klee, D. Pediatr Radiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35353211  

Increased cardiovascular risk in boys born with hypospadias: intriguing observations and remaining questions. Krankel, N. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35352117  

Detection of cardiac apoptosis by [(18)F]ML-10 in a mouse model of permanent LAD ligation. Fischer, M., Olivier, J., Lindner, S., Zacherl, M. J., Massberg, S., Bartenstein, P., Ziegler, S., Brendel, M., Lehner, S., Boening, G. & Todica, A. Mol Imaging Biol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35352214  

Hemodynamic Effects of Sacubitril/Valsartan in Patients with Reduced Left Ventricular Ejection Fraction Over 24 Months: A Retrospective Study. Abumayyaleh, M., Demmer, J., Krack, C., Pilsinger, C., El-Battrawy, I., Behnes, M., Aweimer, A., Mugge, A., Lang, S. & Akin, I. Am J Cardiovasc Drugs (2022). https://www.ncbi.nlm.nih.gov/pubmed/35353351  

Cohort Profile Update: The Study of Health in Pomerania (SHIP). Volzke, H., Schossow, J., Schmidt, C. O., Jurgens, C., Richter, A., Werner, A., Werner, N., Radke, D., Teumer, A., Ittermann, T., Schauer, B., Henck, V., Friedrich, N., Hannemann, A., Winter, T., Nauck, M., Dorr, M., Bahls, M., Felix, S. B., Stubbe, B. et al. Int J Epidemiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35348705  

Long-term impact of the metabolic status on weight loss-induced health benefits. Soll, D., Gawron, J., Pletsch-Borba, L., Spranger, J. & Mai, K. Nutr Metab (Lond) 19, 25 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35346256  

[Long-term course of heart disease: How can psychosocial care be improved?]. Ladwig, K. H., Lurz, J. & Lukaschek, K. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 65, 481-487 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35347347  

Feasibility, Acceptability, and Preliminary Efficacy of a Positive Psychology Intervention in Patients With Coronary Heart Disease: A Randomized Controlled Trial. Sadlonova, M., Kermani, M. B., Huffman, J. C., Nikrahan, G. R., Sadeghi, M. & Celano, C. M. J Acad Consult Liaison Psychiatry (2022). https://www.ncbi.nlm.nih.gov/pubmed/35342036  

[Analytical Quality of Glucose Measurements in Germany]. Freckmann, G., Heinemann, L., Pleus, S., Petersmann, A., Kaiser, P. & Nauck, M. Dtsch Med Wochenschr 147, 407-413 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35345048  

Transcatheter mitral valve implantation in the ongoing structural heart revolution. Sa, M. P., Ramlawi, B., Gray, W. A., Malin, J. H., Van den Eynde, J., Sicouri, S., Torregrossa, G., Klein, C., Heil, E., Sundermann, S. H., Emmerich, A., Kempfert, J., Kofler, M., Falk, V., Unbehaun, A. & Van Praet, K. M. J Card Surg 37, 1691-1704 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35340080   

COVID-19-associated cardiac pathology at post-mortem evaluation: A Collaborative systematic Review. Almamlouk, R., Kashour, T., Obeidat, S., Bois, M. C., Maleszewski, J. J., Omrani, O. A., Tleyjeh, R., Berbari, E., Chakhachiro, Z., Zein-Sabatto, B., Gerberi, D., Tleyjeh, I. M. & Cardiac Autopsy in, C.-S. G. Clin Microbiol Infect (2022). https://www.ncbi.nlm.nih.gov/pubmed/35339672  

Characteristics and outcomes of patients screened for transcatheter mitral valve implantation: 1-year results from the CHOICE-MI registry. Ben Ali, W., Ludwig, S., Duncan, A., Weimann, J., Nickenig, G., Tanaka, T., Coisne, A., Vincentelli, A., Makkar, R., Webb, J. G., Akodad, M., Muller, D. W. M., Praz, F., Wild, M. G., Hausleiter, J., Goel, S. S., von Ballmoos, M. W., Denti, P., Chehab, O., Redwood, S. et al. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35338542  

Effects of Apolipoprotein E polymorphism on carotid intima-media thickness, incident myocardial infarction and incident stroke. Pitchika, A., Markus, M. R. P., Schipf, S., Teumer, A., Van der Auwera, S., Nauck, M., Dorr, M., Felix, S., Grabe, H. J., Volzke, H. & Ittermann, T. Sci Rep 12, 5142 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35332187  

Fractal analysis of 4D dynamic myocardial stress-CT perfusion imaging differentiates micro- and macrovascular ischemia in a multi-center proof-of-concept study. Michallek, F., Nakamura, S., Ota, H., Ogawa, R., Shizuka, T., Nakashima, H., Wang, Y. N., Ito, T., Sakuma, H., Dewey, M. & Kitagawa, K. Sci Rep 12, 5085 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35332236  

Expression of cardiovascular-related microRNAs is altered in L-arginine:glycine amidinotransferase deficient mice. Jensen, M., Muller, C., Hubner, N., Patone, G., Saar, K., Choe, C. U., Schwedhelm, E. & Zeller, T. Sci Rep 12, 5108 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35332188  

Cardiac remodelling - Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology. Gonzalez, A., Richards, A. M., de Boer, R. A., Thum, T., Arfsten, H., Hulsmann, M., Falcao-Pires, I., Diez, J., Foo, R. S. Y., Chan, M. Y., Aimo, A., Anene-Nzelu, C. G., Abdelhamid, M., Adamopoulos, S., Anker, S. D., Belenkov, Y., Gal, T. B., Cohen-Solal, A., Bohm, M., Chioncel, O. et al. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35334137  

Responder analysis for improvement in 6-min walk test with ferric carboxymaltose in patients with heart failure with reduced ejection fraction and iron deficiency. Anker, S. D., Ponikowski, P., Khan, M. S., Friede, T., Jankowska, E. A., Fabien, V., Goehring, U. M., Metra, M., Pina, I. L., Coats, A. J. S., Rosano, G., Dorigotti, F., Comin-Colet, J., Van Veldhuisen, D. J., Filippatos, G. S. & Butler, J. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35334136  

Nuclear receptor activation shapes spatial genome organization essential for gene expression control: lessons learned from the vitamin D receptor. Warwick, T., Schulz, M. H., Gilsbach, R., Brandes, R. P. & Seuter, S. Nucleic Acids Res 50, 3745-3763 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35325193  

Risk-related short-term clinical outcomes after transcatheter aortic valve implantation and their impact on early mortality: an analysis of claims-based data from Germany. Schofer, N., Jeschke, E., Kroger, J., Baberg, H., Falk, V., Gummert, J. F., Hamm, C. W., Mockel, M., Gossling, A., Malzahn, J., Gunster, C. & Blankenberg, S. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35325270  

Brugada Syndrome: Different Experimental Models and the Role of Human Cardiomyocytes From Induced Pluripotent Stem Cells. Li, Y., Lang, S., Akin, I., Zhou, X. & El-Battrawy, I. J Am Heart Assoc 11, e024410 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35322667  

Soluble lectin-like oxidized low-density lipoprotein receptor-1 predicts premature death in acute coronary syndromes. Kraler, S., Wenzl, F. A., Georgiopoulos, G., Obeid, S., Liberale, L., von Eckardstein, A., Muller, O., Mach, F., Raber, L., Losdat, S., Schmiady, M. O., Stellos, K., Stamatelopoulos, K., Camici, G. G., Srdic, A., Paneni, F., Akhmedov, A. & Luscher, T. F. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35325132  

Risk Factors, Subsequent Disease Onset, and Prognostic Impact of Myocardial Infarction and Atrial Fibrillation. Camen, S., Csengeri, D., Geelhoed, B., Niiranen, T., Gianfagna, F., Vishram-Nielsen, J. K., Costanzo, S., Soderberg, S., Vartiainen, E., Borschel, C. S., Donati, M. B., Lochen, M. L., Ojeda, F. M., Kontto, J., Mathiesen, E. B., Jensen, S., Koenig, W., Kee, F., de Gaetano, G., Zeller, T. et al. J Am Heart Assoc 11, e024299 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35322680  

Weight loss did not modify macronutrient specific response of hormones and satiety in overweight and obese people without metabolic disease - results from a clinical trial. Li, L., Decker, A. M., Stobaus, N., Beer, F., Grittner, U., Spranger, J. & Mai, K. Clin Nutr 41, 948-957 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35303516  

Predicting visceral adipose tissue in older adults: A pilot clinical study. Perna, S., Faragli, A., Spadaccini, D., Peroni, G., Gasparri, C., Al-Mannai, M. A., Casali, P. M., La Porta, E., Kelle, S., Alogna, A. & Rondanelli, M. Clin Nutr 41, 810-816 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35263690  

Role of Reticulated Platelets in Cardiovascular Disease. Bongiovanni, D., Han, J., Klug, M., Kirmes, K., Viggiani, G., von Scheidt, M., Schreiner, N., Condorelli, G., Laugwitz, K. L. & Bernlochner, I. Arterioscler Thromb Vasc Biol, ATVBAHA121316244 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35321562  

TAVI in patients with low-flow low-gradient aortic stenosis-short-term and long-term outcomes. Steffen, J., Reissig, N., Andreae, D., Beckmann, M., Haum, M., Fischer, J., Theiss, H., Braun, D., Orban, M., Rizas, K., Sadoni, S., Nabauer, M., Peterss, S., Hausleiter, J., Massberg, S. & Deseive, S. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35320407  

Progressive machine-based resistance training for prevention and treatment of sarcopenia in the oldest old: A systematic review and meta-analysis. Mende, E., Moeinnia, N., Schaller, N., Weiss, M., Haller, B., Halle, M. & Siegrist, M. Exp Gerontol, 111767 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35318104   

Movement therapy in advanced heart failure assisted by a lightweight wearable robot: a feasibility pilot study. Just, I. A., Fries, D., Loewe, S., Falk, V., Cesarovic, N., Edelmann, F., Feuerstein, A., Haufe, F. L., Xiloyannis, M., Riener, R. & Schoenrath, F. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35320878  

Sample size calculation for the augmented logrank test in randomized clinical trials. Hattori, S., Komukai, S. & Friede, T. Stat Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/35319100  

Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS). Haffke, M., Freitag, H., Rudolf, G., Seifert, M., Doehner, W., Scherbakov, N., Hanitsch, L., Wittke, K., Bauer, S., Konietschke, F., Paul, F., Bellmann-Strobl, J., Kedor, C., Scheibenbogen, C. & Sotzny, F. J Transl Med 20, 138 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35317812  

Challenges in the conduct of randomised controlled trials in cardiogenic shock complicating acute myocardial infarction. Freund, A., Desch, S. & Thiele, H. J Geriatr Cardiol 19, 125-129 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35317398  

In vivo and ex vivo electrophysiological study of the mouse heart to characterize the cardiac conduction system, including atrial and ventricular vulnerability. Hennis, K., Rotzer, R. D., Rilling, J., Wu, Y., Thalhammer, S. B., Biel, M., Wahl-Schott, C. & Fenske, S. Nat Protoc (2022). https://www.ncbi.nlm.nih.gov/pubmed/35314849  

Different activation of MAPKs and Akt/GSK3beta after preload vs. afterload elevation. Hartmann, N., Preuss, L., Mohamed, B. A., Schnelle, M., Renner, A., Hasenfuss, G. & Toischer, K. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35315235  

Empagliflozin in patients with type 2 diabetes mellitus and chronic obstructive pulmonary disease. Anker, S. D., Sander, L. E., Fitchett, D. H., Zinman, B., Pernille Ofstad, A., Wanner, C., Vedin, O., Lauer, S., Verma, S., Yaggi, H. K. & Inzucchi, S. E. Diabetes Res Clin Pract, 109837 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35314257  

The Role of Glutamine and Glutaminase in Pulmonary Hypertension. Wang, S., Yan, Y., Xu, W. J., Gong, S. G., Zhong, X. J., An, Q. Y., Zhao, Y. L., Liu, J. M., Wang, L., Yuan, P. & Jiang, R. Front Cardiovasc Med 9, 838657 (2022).

Platelets, Thromboinflammation and Neurovascular Disease. Sun, Y. & Langer, H. F. Front Immunol 13, 843404 (2022).

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats. Sang, P., Kucherenko, M. M., Yao, J., Li, Q., Simmons, S., Kuebler, W. M. & Knosalla, C. J Vis Exp (2022). https://www.ncbi.nlm.nih.gov/pubmed/35311828  

Targeting platelet-derived CXCL12 impedes arterial thrombosis. Leberzammer, J., Agten, S. M., Blanchet, X., Duan, R., Ippel, H., Megens, R. T. A., Schulz, C., Aslani, M., Duchene, J., Doring, Y., Jooss, N. J., Zhang, P., Brandl, R., Stark, K., Siess, W., Jurk, K., Heemskerk, J. W. M., Hackeng, T. M., Mayo, K. H., Weber, C. et al. Blood (2022). https://www.ncbi.nlm.nih.gov/pubmed/35313337   

Coronary artery disease, left ventricular function and cardiac biomarkers determine all-cause mortality in cancer patients-a large monocenter cohort study. Finke, D., Heckmann, M. B., Wilhelm, S., Entenmann, L., Hund, H., Bougatf, N., Katus, H. A., Frey, N. & Lehmann, L. H. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35312818  

Stroke after transcatheter aortic valve replacement: A severe complication with low predictability. Eschenbach, L. K., Erlebach, M., Deutsch, M. A., Ruge, H., Bleiziffer, S., Holzer, L., Krane, M., Voss, S., Lange, R. & Burri, M. Catheter Cardiovasc Interv (2022). https://www.ncbi.nlm.nih.gov/pubmed/35312220  

Svep1 stabilises developmental vascular anastomosis in reduced flow conditions. Coxam, B., Collins, R. T., Hussmann, M., Huisman, Y., Meier, K., Jung, S., Bartels-Klein, E., Szymborska, A., Finotto, L., Helker, C. S. M., Stainier, D. Y. R., Schulte-Merker, S. & Gerhardt, H. Development 149 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35312765  

Genetically determined reproductive aging and coronary heart disease: a bidirectional two-sample Mendelian Randomization. Dam, V., Onland-Moret, N. C., Burgess, S., Chirlaque, M. D., Peters, S. A. E., Schuit, E., Tikk, K., Weiderpass, E., Oliver-Williams, C., Wood, A. M., Tjonneland, A., Dahm, C. C., Overvad, K., Boutron-Ruault, M. C., Schulze, M. B., Trichopoulou, A., Ferrari, P., Masala, G., Krogh, V., Tumino, R. et al. J Clin Endocrinol Metab (2022). https://www.ncbi.nlm.nih.gov/pubmed/35306566  

Clinical characteristics and outcome of biopsy-proven myocarditis in children - Results of the German prospective multicentre registry "MYKKE". Seidel, F., Opgen-Rhein, B., Rentzsch, A., Boehne, M., Wannenmacher, B., Boecker, D., Reineker, K., Grafmann, M., Wiegand, G., Hecht, T., Kiski, D., Fischer, M., Papakostas, K., Ruf, B., Kramp, J., Khalil, M., Kaestner, M., Steinmetz, M., Fischer, G., Ozcan, S. et al. Int J Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35304189  

Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease. Santovito, D. & Weber, C. Nat Rev Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35304600  

Does social support prevent suicidal ideation in women and men? Gender-sensitive analyses of an important protective factor within prospective community cohorts. Otten, D., Ernst, M., Tibubos, A. N., Brahler, E., Fleischer, T., Schomerus, G., Wild, P. S., Zoller, D., Binder, H., Kruse, J., Johar, H., Atasoy, S., Grabe, H. J., Ladwig, K. H., Munzel, T., Volzke, H., Konig, J. & Beutel, M. E. J Affect Disord 306, 157-166 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35304236  

Single-centre outcome of extracorporeal membrane oxygenation after the neonatal Norwood procedure. Mayr, B., Kido, T., Holder, S., Wallner, M., Vodiskar, J., Strbad, M., Ruf, B., Hager, A., Ewert, P., Horer, J., Lange, R. & Ono, M. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35304610  

Sudden cardiac death while waiting: do we need the wearable cardioverter-defibrillator? Israel, C., Staudacher, I., Leclercq, C., Botto, G. L., Scherr, D., Fach, A., Duru, F., Zylla, M. M., Katus, H. A. & Thomas, D. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35305126  

MicroRNAs Regulate TASK-1 and Are Linked to Myocardial Dilatation in Atrial Fibrillation. Wiedmann, F., Kraft, M., Kallenberger, S., Buscher, A., Paasche, A., Blochberger, P. L., Seeger, T., Javorszky, N., Warnecke, G., Arif, R., Kremer, J., Karck, M., Frey, N. & Schmidt, C. J Am Heart Assoc, e023472 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35301863  

Regression from pathological hypertrophy in mice is sexually dimorphic and stimulus-specific. Muehleman, D. L., Crocini, C., Swearingen, A. R., Ozeroff, C. D. & Leinwand, L. A. Am J Physiol Heart Circ Physiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35302880  

Impact of Right Ventricular Pressure Load After Repair of Tetralogy of Fallot. Latus, H., Stammermann, J., Voges, I., Waschulzik, B., Gutberlet, M., Diller, G. P., Schranz, D., Ewert, P., Beerbaum, P., Kuhne, T., Sarikouch, S. & German Competence Network for Congenital Heart Defects Investigators. J Am Heart Assoc, e022694 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35301850  

The normalized slope conductance as a tool for quantitative analysis of current-voltage relations. Hermann, C., Treder, A., Naher, M., Geiseler, R., Gudermann, T., Mederos, Y. S. M. & Storch, U. Biophys J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35300969  

Association of MRI-based adrenal gland volume and impaired glucose metabolism in a population-based cohort study. Askani, E., Rospleszcz, S., Lorbeer, R., Kulka, C., von Kruchten, R., Muller-Peltzer, K., Hasic, D., Kellner, E., Reisert, M., Rathmann, W., Peters, A., Schlett, C. L., Bamberg, F. & Storz, C. Diabetes Metab Res Rev, e3528 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35303389  

Targeting MuRF1 by small molecules in a HFpEF rat model improves myocardial diastolic function and skeletal muscle contractility. Adams, V., Schauer, A., Augstein, A., Kirchhoff, V., Draskowski, R., Jannasch, A., Goto, K., Lyall, G., Mannel, A., Barthel, P., Mangner, N., Winzer, E. B., Linke, A. & Labeit, S. J Cachexia Sarcopenia Muscle (2022). https://www.ncbi.nlm.nih.gov/pubmed/35301823  

Specific inhibition of the transporter MRP4/ABCC4 affects multiple signaling pathways and thrombus formation in human platelets. Wolf, R., Grammbauer, S., Palankar, R., Tolksdorf, C., Moritz, E., Bohm, A., Hasan, M., Hafkemeyer, A., Greinacher, A., Tzvetkov, M. V., Rauch, B. H. & Jedlitschky, G. Haematologica (2022). https://www.ncbi.nlm.nih.gov/pubmed/35295075  

A systematic review and meta-analysis of the cerebrovascular event incidence after transcatheter aortic valve implantation. Meertens, M. M., Macherey, S., Asselberghs, S., Lee, S., Schipper, J. H., Mees, B., Eitel, I., Baldus, S., Frerker, C. & Schmidt, T. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35298700  

TAVR or SAVR? What can we learn from a pooled meta-analysis of reconstructed time to event data? Lange, R., Vitanova, K. & Ruge, H. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35298634  

Dronedarone for the Treatment of Atrial Fibrillation with Concomitant Heart Failure with Preserved and Mildly Reduced Ejection Fraction: Post-Hoc Analysis of the ATHENA Trial. Vaduganathan, M., Piccini, J. P., Camm, A. J., Crijns, H., Anker, S. D., Butler, J., Stewart, J., Braceras, R., Albuquerque, A. P., Wieloch, M. & Hohnloser, S. H. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35293087  

Simultaneous assessment of spontaneous cage activity and voluntary wheel running in group-housed mice. Reuser, A., Wenzel, K., Felix, S. B., Dorr, M., Bahls, M. & Konemann, S. Sci Rep 12, 4444 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35292692  

Clinical impact of changes in mitral regurgitation severity after medical therapy optimization in heart failure. Pagnesi, M., Adamo, M., Sama, I. E., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G. S., Inciardi, R. M., Lang, C. C., Lombardi, C. M., Ng, L. L., Ponikowski, P., Samani, N. J., Zannad, F., van Veldhuisen, D. J., Voors, A. A. & Metra, M. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35294624  

Mind and body interventions in cardiology : The importance of the brain-heart connection. Lurz, J. & Ladwig, K. H. Herz 47, 103-109 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35292838  

A system for real-time multivariate feature combination of endoscopic mitral valve simulator training data. Fuchs, R., Van Praet, K. M., Bieck, R., Kempfert, J., Holzhey, D., Kofler, M., Borger, M. A., Jacobs, S., Falk, V. & Neumuth, T. Int J Comput Assist Radiol Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35294716  

The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell-monocyte crosstalk and protects against atherosclerosis via the NF-kappaB pathway. Farina, F. M., Serio, S., Hall, I. F., Zani, S., Cassanmagnago, G. A., Climent, M., Civilini, E., Condorelli, G., Quintavalle, M. & Elia, L. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35292818  

Heart-Type Fatty Acid Binding Protein, Cardiovascular Outcomes, and Death: Findings From the German CKD Cohort Study. Schneider, M. P., Schmid, M., Nadal, J., Wanner, C., Krane, V., Floege, J., Saritas, T., Busch, M., Sitter, T., Friedrich, N., Stockmann, H., Meiselbach, H., Nauck, M., Kronenberg, F., Eckardt, K. U. & Investigators, G. S. Am J Kidney Dis (2022). https://www.ncbi.nlm.nih.gov/pubmed/35288215  

Determination of scar area using native and post-contrast T1 mapping: Agreement with late gadolinium enhancement. Kolentinis, M., Carerj, L. M., Vidalakis, E., Giokoglu, E., Martin, S., Arendt, C., Vogl, T. J., Nagel, E. & Puntmann, V. O. Eur J Radiol 150, 110242 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35290909  

CRISPR somatic genome engineering and cancer modeling in the mouse pancreas and liver. Kaltenbacher, T., Loprich, J., Maresch, R., Weber, J., Muller, S., Oellinger, R., Gross, N., Griger, J., de Andrade Kratzig, N., Avramopoulos, P., Ramanujam, D., Brummer, S., Widholz, S. A., Barthel, S., Falcomata, C., Pfaus, A., Alnatsha, A., Mayerle, J., Schmidt-Supprian, M., Reichert, M. et al. Nat Protoc (2022). https://www.ncbi.nlm.nih.gov/pubmed/35288718  

Plasma circulating micro-RNAs associated with alexithymia reflect a high overlap on neuropsychiatric outcomes. Van der Auwera, S., Ameling, S., Nauck, M., Volzke, H., Volker, U. & Grabe, H. J. J Affect Disord 305, 206-212 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35283179  

Recommendations in pre-procedural imaging assessment for transcatheter aortic valve implantation intervention: Italian Society of Cardiology (SIC)-Italian Society of Medical and Interventional Radiology (SIRM) position paper part 1 (Clinical Indication and Basic Technical Aspects, Heart Team, Role of Echocardiography). Pontone, G., Marano, R., Agricola, E., Alushi, B., Bartorelli, A., Cameli, M., Carrabba, N., Esposito, A., Faletti, R., Francone, M., Galea, N., Golino, P., Guglielmo, M., Palmisano, A., Petronio, S., Petulla, M., Pradella, S., Ribichini, F., Romeo, F., Russo, V. et al. J Cardiovasc Med (Hagerstown) 23, 216-227 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35287156  

Association between hepatic iron overload assessed by magnetic resonance imaging and glucose intolerance states in the general population. Naeem, M., Schipf, S., Bulow, R., Werner, N., Dorr, M., Lerch, M. M., Kuhn, J. P., Rathmann, W., Nauck, M., Paulista Markus, M. R., Targher, G., Ittermann, T. & Volzke, H. Nutr Metab Cardiovasc Dis (2022). https://www.ncbi.nlm.nih.gov/pubmed/35282980  

Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy. Kaur, N., Ruiz-Velasco, A., Raja, R., Howell, G., Miller, J. M., Abouleisa, R. R. E., Ou, Q., Mace, K., Hille, S. S., Frey, N., Binder, P., Smith, C. P., Fachim, H., Soran, H., Swanton, E., Mohamed, T. M. A., Muller, O. J., Wang, X., Chernoff, J., Cartwright, E. J. et al. iScience 25, 103973 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35281739  

Analysis of myocardial cellular gene expression during pressure overload reveals matrix based functional intercellular communication. Froese, N., Cordero, J., Abouissa, A., Trogisch, F. A., Grein, S., Szaroszyk, M., Wang, Y., Gigina, A., Korf-Klingebiel, M., Bosnjak, B., Davenport, C. F., Wiehlmann, L., Geffers, R., Riechert, E., Jurgensen, L., Boileau, E., Lin, Y., Dieterich, C., Forster, R., Bauersachs, J. et al. iScience 25, 103965 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35281736  

Chronic isoprenaline/phenylephrine vs. exclusive isoprenaline stimulation in mice: critical contribution of alpha1-adrenoceptors to early cardiac stress responses. Dewenter, M., Pan, J., Knodler, L., Tzschockel, N., Henrich, J., Cordero, J., Dobreva, G., Lutz, S., Backs, J., Wieland, T. & Vettel, C. Basic Res Cardiol 117, 15 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35286475  

Transcatheter Tricuspid Valve Replacement With the EVOQUE System: 1-Year Outcomes of a Multicenter, First-in-Human Experience. Webb, J. G., Chuang, A. M., Meier, D., von Bardeleben, R. S., Kodali, S. K., Smith, R. L., Hausleiter, J., Ong, G., Boone, R., Ruf, T., George, I., Szerlip, M., Nabauer, M., Ali, F. M., Moss, R., Kreidel, F., Bapat, V., Schnitzler, K., Ye, J., Wild, M. et al. JACC Cardiovasc Interv 15, 481-491 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35272772  

Effect of Leisure Sports on Exercise Capacity and Quality of Life in Patients with a Fontan Circulation. Niemann, A., Rinne, K., Hansen, J. H., Scheewe, J., Uebing, A. & Voges, I. Am J Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35279276  

Health Status Improvement with Ferric Carboxymaltose in Heart Failure with Reduced Ejection Fraction and Iron Deficiency. Butler, J., Khan, M. S., Friede, T., Jankowska, E. A., Fabien, V., Goehring, U. M., Dorigotti, F., Metra, M., Pina, I. L., Coats, A. J., Rosano, G., Comin-Colet, J., Van Veldhuisen, D. J., Filippatos, G. S., Anker, S. D. & Ponikowski, P. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35279929  

Use of evidence-based therapy in heart failure with reduced ejection fraction across age strata. Stolfo, D., Lund, L. H., Becher, P. M., Orsini, N., Thorvaldsen, T., Benson, L., Hage, C., Dahlstrom, U., Sinagra, G. & Savarese, G. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35278267  

Surrogate markers of gut dysfunction are related to heart failure severity and outcome - from the BIOSTAT-CHF consortium. Israr, M. Z., Zhan, H., Salzano, A., Voors, A. A., Cleland, J. G., Anker, S. D., Metra, M., van Veldhuisen, D. J., Lang, C. C., Zannad, F., Samani, N. J., Ng, L. L., Suzuki, T. & investigators, B.-C. Am Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35278373  

Endoaortic Balloon Occlusion During Minimally Invasive Mitral Valve Surgery. Van Praet, K. M., Kofler, M., Sundermann, S. H. & Kempfert, J. Innovations (Phila), 15569845221083047 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35275021  

To quantify or not to quantify, that is the question: Semi-quantitative vs. visual analysis of Rb-82 myocardial perfusion imaging PET. Rischpler, C., Kersting, D. & Nekolla, S. G. J Nucl Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35274212  

H-ABC- and dystonia-causing TUBB4A mutations show distinct pathogenic effects. Krajka, V., Vulinovic, F., Genova, M., Tanzer, K., Jijumon, A. S., Bodakuntla, S., Tennstedt, S., Mueller-Fielitz, H., Meier, B., Janke, C., Klein, C. & Rakovic, A. Sci Adv 8, eabj9229 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35275727  

Retraction notice to "Astragalus polysaccharide ameliorates lipopolysaccharide-induced cell injury in ATDC5 cells via miR-92a/KLF4 mediation" [Biomed. Pharmacother. 118 (2019) 109180]. Fan, L., Li, M., Cao, F. Y., Zeng, Z. W., Li, X. B., Ma, C., Ru, J. T. & Wu, X. J. Biomed Pharmacother 148, 112780 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35272895  

Regulation of Ion Channel Function in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Cancer Cell Secretion Through DNA Methylation. Zhong, R., Zhang, F., Yang, Z., Li, Y., Xu, Q., Lan, H., Lang, S., Cyganek, L., Burgermeister, E., El-Battrawy, I., Zhou, X., Akin, I. & Borggrefe, M. Front Cardiovasc Med 9, 839104 (2022).

Tph2 Gene Expression Defines Ethanol Drinking Behavior in Mice. Zaniewska, M., Mosienko, V., Bader, M. & Alenina, N. Cells 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35269497  

Chrono-pharmacology-based antiplatelet therapy for acute myocardial infarction. Tual-Chalot, S. & Stellos, K. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35266001  

Mitral valve prolapse: will genetics finally solve the puzzle? Trenkwalder, T. & Krane, M. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35265976  

Impact of energy drink versus coffee consumption on periodic repolarization dynamics: an interventional study. Schuttler, D., Rudi, W. S., Bauer, A., Hamm, W. & Brunner, S. Eur J Nutr (2022). https://www.ncbi.nlm.nih.gov/pubmed/35266046  

Angiotensin Converting Enzyme Inhibitors versus Receptor Blockers in Patients with Ventricular Tachyarrhythmias. Schupp, T., Behnes, M., Abumayyaleh, M., Weidner, K., Mashayekhi, K., Bertsch, T. & Akin, I. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35268553  

Cardiac Myxomas Resembling Malignant Neoplasia: Incidentally Diagnosed vs. Cerebral Embolized Myxomas. Salem, M., Hillmer, J., Friedrich, C., Panholzer, B., Saad, M., Salem, M., Frank, D., Ernst, M., Maetzler, W., Puehler, T., Lutter, G., Schoeneich, F., Haneya, A., Cremer, J. & Schoettler, J. Cancers (Basel) 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35267419  

Imaging of arrhythmia: Real-time cardiac magnetic resonance imaging in atrial fibrillation. Laubrock, K., von Loesch, T., Steinmetz, M., Lotz, J., Frahm, J., Uecker, M. & Unterberg-Buchwald, C. Eur J Radiol Open 9, 100404 (2022).

Local dose rate effects in implantable cardioverter-defibrillators with flattening filter free and flattened photon radiation. Gauter-Fleckenstein, B., Tulumen, E., Rudic, B., Borggrefe, M., Polednik, M. & Fleckenstein, J. Strahlenther Onkol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35267050  

Extracorporeal Membrane Oxygenation in Infarct-Related Cardiogenic Shock. Freund, A., Desch, S., Poss, J., Sulimov, D., Sandri, M., Majunke, N. & Thiele, H. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35268347  

A Vegfc-Emilin2a-Cxcl8a Signaling Axis Required for Zebrafish Cardiac Regeneration. El-Sammak, H., Yang, B., Guenther, S., Chen, W., Marin-Juez, R. & Stainier, D. Y. R. Circ Res, CIRCRESAHA121319929 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35264012  

Single-cell technologies to decipher cardiovascular diseases. Abplanalp, W. T., Tucker, N. & Dimmeler, S. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35265972  

Impact of baseline left ventricular ejection fraction on long-term outcomes in cardiac contractility modulation therapy. Yucel, G., Fastner, C., Hetjens, S., Toepel, M., Schmiel, G., Yazdani, B., Husain-Syed, F., Liebe, V., Rudic, B., Akin, I., Borggrefe, M. & Kuschyk, J. Pacing Clin Electrophysiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35262210  

The effects of common genetic variation in 96 genes involved in thyroid hormone regulation on TSH and FT4 concentrations. Sterenborg, R., Galesloot, T. E., Teumer, A., Netea-Maier, R. T., Speed, D., Meima, M. E., Visser, W. E., Smit, J. W. A., Peeters, R. P. & Medici, M. J Clin Endocrinol Metab (2022). https://www.ncbi.nlm.nih.gov/pubmed/35262175  

A novel single-cell RNA-sequencing approach and its applicability connecting genotype to phenotype in ageing disease. Shomroni, O., Sitte, M., Schmidt, J., Parbin, S., Ludewig, F., Yigit, G., Zelarayan, L. C., Streckfuss-Bomeke, K., Wollnik, B. & Salinas, G. Sci Rep 12, 4091 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35260714  

Pharmacological treatment options for heart failure with reduced ejection fraction: A 2022 update. Hellenkamp, K., Nolte, K. & von Haehling, S. Expert Opin Pharmacother, 1-8 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35260016  

Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients. Haupt, L. P., Rebs, S., Maurer, W., Hubscher, D., Tiburcy, M., Pabel, S., Maus, A., Kohne, S., Tappu, R., Haas, J., Li, Y., Sasse, A., Santos, C. C. X., Dressel, R., Wojnowski, L., Bunt, G., Mobius, W., Shah, A. M., Meder, B., Wollnik, B. et al. Basic Res Cardiol 117, 13 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35260914  

Evolution of Artificial Intelligence-Powered Technologies in Biomedical Research and Healthcare. Diaz-Flores, E., Meyer, T. & Giorkallos, A. Adv Biochem Eng Biotechnol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35262750  

Clinical frailty, and not features of acute infection, is associated with late mortality in COVID-19: a retrospective cohort study. Vlachogiannis, N. I., Baker, K. F., Georgiopoulos, G., Lazaridis, C., van der Loeff, I. S., Hanrath, A. T., Sopova, K., Tual-Chalot, S., Gatsiou, A., Spyridopoulos, I., Stamatelopoulos, K., Duncan, C. J. A. & Stellos, K. J Cachexia Sarcopenia Muscle (2022). https://www.ncbi.nlm.nih.gov/pubmed/35257497   

Missense Variant E1295K of Sodium Channel SCN5A Associated With Recurrent Ventricular Fibrillation and Myocardial Inflammation. Poller, W., Escher, F., Haas, J., Heidecker, B., Schultheiss, H. P., Attanasio, P., Skurk, C., Haghikia, A., Meder, B. & Klaassen, S. JACC Case Rep 4, 280-286 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35257103  

Carotid Intima-Media Thickness Percentiles in Adolescence and Young Adulthood and Their Association With Obesity and Hypertensive Blood Pressure in a Population Cohort. Neuhauser, H. K., Buschges, J., Schaffrath Rosario, A., Schienkiewitz, A., Sarganas, G., Konigstein, K., Schweizer, D. & Schmidt-Trucksass, A. Hypertension, HYPERTENSIONAHA12118521 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35255707  

Uncovering the molecular identity of cardiosphere-derived cells (CDCs) by single-cell RNA sequencing. Kogan, P. S., Wirth, F., Tomar, A., Darr, J., Teperino, R., Lahm, H., Dressen, M., Puluca, N., Zhang, Z., Neb, I., Beck, N., Luzius, T., de la Osa de la Rosa, L., Gartner, K., Huls, C., Zeidler, R., Ramanujam, D., Engelhardt, S., Wenk, C., Holdt, L. M. et al. Basic Res Cardiol 117, 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35258704  

How many molecules of mitochondrial complex I are in a cell? Ansari, F., Yoval, B., Niatsetskaya, Z., Ten, V., Wittig, I. & Galkin, A. Anal Biochem, 114646 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35259403  

Targeting the CCL2-CCR2 axis for atheroprotection. Georgakis, M. K., Bernhagen, J., Heitman, L. H., Weber, C. & Dichgans, M. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35253053  

Generation of heterozygous (MRli003-A-3) and homozygous (MRli003-A-4) TRPM4 knockout human iPSC lines. Zhang, F., Meier, A. B., Lipp, P., Laugwitz, K. L., Dorn, T. & Moretti, A. Stem Cell Res 60, 102731 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35245852  

Isotropic 3D compressed sensing (CS) based sequence is comparable to 2D-LGE in left ventricular scar quantification in different disease entities. Fenski, M., Grandy, T. H., Viezzer, D., Kertusha, S., Schmidt, M., Forman, C. & Schulz-Menger, J. Int J Cardiovasc Imaging (2022). https://www.ncbi.nlm.nih.gov/pubmed/35243574  

[Morphological and functional diagnostics of coronary artery disease by computed tomography]. Baumann, S., Overhoff, D., Tesche, C., Korosoglou, G., Kelle, S., Nassar, M., Buss, S. J., Andre, F., Renker, M., Schoepf, U. J., Akin, I., Waldeck, S., Schoenberg, S. O. & Lossnitzer, D. Herz (2022). https://www.ncbi.nlm.nih.gov/pubmed/35244729  

Durability of benefit after transcatheter tricuspid valve intervention: insights from actigraphy. Stocker, T. J., Cohen, D. J., Arnold, S. V., Sommer, S., Braun, D., Stolz, L., Hertell, H., Weckbach, L. T., Wild, M. G., Doldi, P., Orban, M., Orban, M., Deseive, S., Higuchi, S., Massberg, S., Nabauer, M. & Hausleiter, J. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35239253  

CT or Invasive Coronary Angiography in Stable Chest Pain. Group, D. T., Maurovich-Horvat, P., Bosserdt, M., Kofoed, K. F., Rieckmann, N., Benedek, T., Donnelly, P., Rodriguez-Palomares, J., Erglis, A., Stechovsky, C., Sakalyte, G., Cemerlic Adic, N., Gutberlet, M., Dodd, J. D., Diez, I., Davis, G., Zimmermann, E., Kepka, C., Vidakovic, R., Francone, M. et al. N Engl J Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/35240010  

Properties and fate of human mesenchymal stem cells upon miRNA let-7f-promoted recruitment to atherosclerotic plaques. Egea, V., Megens, R. T. A., Santovito, D., Wantha, S., Brandl, R., Siess, W., Khani, S., Soehnlein, O., Bartelt, A., Weber, C. & Ries, C. Cardiovasc Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/35238350  

Visceral and renal malperfusion syndromes in acute aortic dissection type A: the fate of the branch vessel. Buech, J., Radner, C., Fabry, T. G., Horke, K. M., Ali, A., Saha, S., Hagl, C., Pichlmaier, M. A. & Peterss, S. J Cardiovasc Surg (Torino) (2022). https://www.ncbi.nlm.nih.gov/pubmed/35238524  

Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study. Portilla-Fernandez, E., Klarin, D., Hwang, S. J., Biggs, M. L., Bis, J. C., Weiss, S., Rospleszcz, S., Natarajan, P., Hoffmann, U., Rogers, I. S., Truong, Q. A., Volker, U., Dorr, M., Bulow, R., Criqui, M. H., Allison, M., Ganesh, S. K., Yao, J., Waldenberger, M., Bamberg, F. et al. Hum Mol Genet (2022). https://www.ncbi.nlm.nih.gov/pubmed/35234888  

Links between ectopic and abdominal fat and systemic inflammation: New insights from the SHIP-Trend study. Ponce-de-Leon, M., Hannemann, A., Linseisen, J., Nauck, M., Lerch, M. M., Bulow, R., Volzke, H., Friedrich, N., Kassubek, J., Muller, H. P., Baumeister, S. E. & Meisinger, C. Dig Liver Dis (2022). https://www.ncbi.nlm.nih.gov/pubmed/35232676  

From atherosclerosis to myocardial infarction - a process-oriented model investigating the role of risk factors. Simonetto, C., Heier, M., Peters, A., Kaiser, J. C. & Rospleszcz, S. Am J Epidemiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35231928  

DNA topoisomerase inhibition with the HIF inhibitor acriflavine promotes transcription of lncRNAs in endothelial cells. Seredinski, S., Boos, F., Gunther, S., Oo, J. A., Warwick, T., Izquierdo Ponce, J., Lillich, F. F., Proschak, E., Knapp, S., Gilsbach, R., Pfluger-Muller, B., Brandes, R. P. & Leisegang, M. S. Mol Ther Nucleic Acids 27, 1023-1035 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35228897  

Short-term effects of cold spells on plasma viscosity: Results from the KORA cohort study in Augsburg, Germany. Ni, W., Schneider, A., Wolf, K., Zhang, S., Chen, K., Koenig, W., Peters, A. & Breitner, S. Environ Pollut 302, 119071 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35231540  

RGS3L allows for an M2 muscarinic receptor-mediated RhoA-dependent inotropy in cardiomyocytes. Levay, M. K., Krobert, K. A., Vogt, A., Ahmad, A., Jungmann, A., Neuber, C., Pasch, S., Hansen, A., Muller, O. J., Lutz, S. & Wieland, T. Basic Res Cardiol 117, 8 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35230541  

Thrombus formation at the inflow cannula of continuous-flow left ventricular assist devices-A systematic analysis. Kaufmann, F., Hormandinger, C., Knosalla, C., Falk, V. & Potapov, E. Artif Organs (2022). https://www.ncbi.nlm.nih.gov/pubmed/35230721  

Ticagrelor Monotherapy or Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation: Per-Protocol Analysis of the GLOBAL LEADERS Trial. Gragnano, F., Zwahlen, M., Vranckx, P., Heg, D., Schmidlin, K., Hamm, C., Steg, P. G., Gargiulo, G., McFadden, E. P., Onuma, Y., Chichareon, P., Benit, E., Mollmann, H., Janssens, L., Leonardi, S., Zurakowski, A., Arrivi, A., Van Geuns, R. J., Huber, K., Slagboom, T. et al. J Am Heart Assoc, e024291 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35229616  

Thyroid function, pernicious anemia, and erythropoiesis: a two-sample Mendelian randomization study. Kjaergaard, A. D., Teumer, A., Marouli, E., Deloukas, P., Kus, A., Sterenborg, R., Asvold, B. O., Medici, M. & Ellervik, C. Hum Mol Genet (2022). https://www.ncbi.nlm.nih.gov/pubmed/35225327  


April

Do it "RIGHT": HeartMate 3 as Destination Therapy Right Ventricular Assist Device in a Patient With Arrhythmogenic Right Ventricular Cardiomyopathy. Hanuna, M., Kaab, S., Hagl, C. & Mueller, C. S. ASAIO J 69, e46-e48 (2023). www.ncbi.nlm.nih.gov/pubmed/35471649  

Endoaortic balloon occlusion in minimally invasive mitral valve surgery. Van Praet, K. M., Nersesian, G., Montagner, M., Akansel, S., Eggert-Doktor, D., Kofler, M., Sundermann, S., Falk, V. & Kempfert, J. Multimed Man Cardiothorac Surg 2022 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35467092  

Percutaneous transseptal transcatheter mitral valve-in-valve implantation under endovascular cerebral protection. Van Praet, K. M., Nersesian, G., Kukucka, M., Heil, E., Kofler, M., Falk, V., Kempfert, J., Klein, C. & Unbehaun, A. Multimed Man Cardiothorac Surg 2022 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35467091  

Case Series of Potential Cardiac Inflammation Associated With Various SARS-CoV-2 Vaccinations Assessed by Cardiac MRI. Jahnke, C., Doeblin, P., Tanacli, R., Witt, U., Schneider, M., Stehning, C., Pieske, B. & Kelle, S. Front Cardiovasc Med 9, 829392 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35463791  

Platelet Subtypes in Inflammatory Settings. Hamad, M. A., Krauel, K., Schanze, N., Gauchel, N., Stachon, P., Nuehrenberg, T., Zurek, M. & Duerschmied, D. Front Cardiovasc Med 9, 823549 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35463762  

Stroke Complications in Patients Requiring Durable Mechanical Circulatory Support Systems After Extracorporeal Life Support. Saeed, D., Loforte, A., Morshuis, M., Schibilsky, D., Zimpfer, D., Riebandt, J., Pappalardo, F., Attisani, M., Rinaldi, M., Haneya, A., Ramjankhan, F., Donker, D. W., Jorde, U. P., Pacini, D., Otto, W., Stein, J., Lewin, D., Jawad, K., Wieloch, R., Ayala, R. et al. ASAIO J 69, 145-150 (2023). https://www.ncbi.nlm.nih.gov/pubmed/35438667  

Formation and Maintenance of the Natural Bypass Vessels of the Brain. Perovic, T., Harms, C. & Gerhardt, H. Front Cardiovasc Med 9, 778773 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35391845  

CT-Based Simulation of Left Ventricular Hemodynamics: A Pilot Study in Mitral Regurgitation and Left Ventricle Aneurysm Patients. Obermeier, L., Vellguth, K., Schlief, A., Tautz, L., Bruening, J., Knosalla, C., Kuehne, T., Solowjowa, N. & Goubergrits, L. Front Cardiovasc Med 9, 828556 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35391837  

Predictive Value of Two-Dimensional Speckle-Tracking Echocardiography in Patients Undergoing Surgical Ventricular Restoration. Nemchyna, O., Solowjowa, N., Dandel, M., Hrytsyna, Y., Stein, J., Knierim, J., Schoenrath, F., Hennig, F., Falk, V. & Knosalla, C. Front Cardiovasc Med 9, 824467 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35387444  

Case Report: Residual Atrial Shunt Lesions in Aging Adults With Congenital Heart Disease: An Underestimated Risk of Stroke? Schneider, M., Dannenberg, V., Opgen-Rhein, B., Berger, F., Pieske, B., Gabriel, H. & Boldt, L. H. Front Cardiovasc Med 9, 847244 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35369334  

Acculturation and Anger Expression Among Iranian Migrants in Germany. Gilan, D., Werner, A. M., Hahad, O., Lieb, K., Frankenberg, E. & Bongard, S. Front Psychol 13, 715152 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35369188  

A Mixed-Methods Investigation of Medical Follow-Up in Long-Term Childhood Cancer Survivors: What Are the Reasons for Non-Attendance? Ernst, M., Brahler, E., Faber, J., Wild, P. S., Merzenich, H. & Beutel, M. E. Front Psychol 13, 846671 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35369241   

Cascaded learning in intravascular ultrasound: coronary stent delineation in manual pullbacks. Wissel, T., Riedl, K. A., Schaefers, K., Nickisch, H., Brunner, F. J., Schnellbaecher, N. D., Blankenberg, S., Seiffert, M. & Grass, M. J Med Imaging (Bellingham) 9, 025001 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35360417  

Manual Compression versus Suture-Mediated Closure Device Technique for VA-ECMO Decannulation. Scherer, C., Stremmel, C., Lusebrink, E., Stocker, T. J., Stark, K., Schonegger, C., Kellnar, A., Kleeberger, J., Hanuna, M., Petzold, T., Peterss, S., Braun, D., Hausleiter, J., Hagl, C., Massberg, S. & Orban, M. J Interv Cardiol 2022, 9915247 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35360094  

A Mathematical Model for Electrical Activity in Pig Atrial Tissue. Peris-Yague, V., Rubio, T., Fakuade, F. E., Voigt, N., Luther, S. & Majumder, R. Front Physiol 13, 812535 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35360247  

A Multimodal Score Accurately Classifies Fontan Failure and Late Mortality in Adult Fontan Patients. Kramer, P., Schleiger, A., Schafstedde, M., Danne, F., Nordmeyer, J., Berger, F. & Ovroutski, S. Front Cardiovasc Med 9, 767503 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35360016  

Disease Severity in Moderate-to-Severe COVID-19 Is Associated With Platelet Hyperreactivity and Innate Immune Activation. Jakobs, K., Reinshagen, L., Puccini, M., Friebel, J., Wilde, A. B., Alsheik, A., Rroku, A., Landmesser, U., Haghikia, A., Krankel, N. & Rauch-Krohnert, U. Front Immunol 13, 844701 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35359931  

A Collaborative Approach for the Development and Application of Machine Learning Solutions for CMR-Based Cardiac Disease Classification. Huellebrand, M., Ivantsits, M., Tautz, L., Kelle, S. & Hennemuth, A. Front Cardiovasc Med 9, 829512 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35360025

Editorial: Advances in the Prevention and Rehabilitation of Cardiovascular Diseases via Aerobic Exercise. Cao, R. Y., Kelle, S. & Yang, J. Front Cardiovasc Med 9, 858785 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35360019  

Identification of Specific Coronary Artery Disease Phenotypes Implicating Differential Pathophysiologies. Krohn, J. B., Nguyen, Y. N., Akhavanpoor, M., Erbel, C., Domschke, G., Linden, F., Kleber, M. E., Delgado, G., Marz, W., Katus, H. A. & Gleissner, C. A. Front Cardiovasc Med 9, 778206 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35355960   

Thrombocytopenia and splenic platelet-directed immune responses after IV ChAdOx1 nCov-19 administration. Nicolai, L., Leunig, A., Pekayvaz, K., Esefeld, M., Anjum, A., Rath, J., Riedlinger, E., Ehreiser, V., Mader, M., Eivers, L., Hoffknecht, M. L., Zhang, Z., Kugelmann, D., Rossaro, D., Escaig, R., Kaiser, R., Polewka, V., Titova, A., Petzold, T., Spiekermann, K. et al. Blood 140, 478-490 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35486845  

Adult congenital heart disease patients undergoing mechanical circulatory support: Not all patients are the same. Csengeri, D., Bernhardt, A. M. & Sinning, C. J Heart Lung Transplant 41, 896-897 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35474250  

Variability of biomarkers used for the classification of metabolic syndrome: A repeated measurements study. Ittermann, T., Dorr, M., Markus, M. R. P., Nauck, M., Jurgens, C., Schipf, S., Schmidt, C. O., Volzke, H. & Richter, A. Nutr Metab Cardiovasc Dis 32, 1693-1702 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35469729  

Chronic thromboembolic pulmonary hypertension and impairment after pulmonary embolism: the FOCUS study. Valerio, L., Mavromanoli, A. C., Barco, S., Abele, C., Becker, D., Bruch, L., Ewert, R., Faehling, M., Fistera, D., Gerhardt, F., Ghofrani, H. A., Grgic, A., Grunig, E., Halank, M., Held, M., Hobohm, L., Hoeper, M. M., Klok, F. A., Lankeit, M., Leuchte, H. H., Martin, N., Mayer, E., Meyer, F. J., Neurohr, C., Opitz, C., Schmidt, K. H., Seyfarth, H. J., Wachter, R., Wilkens, H., Wild, P. S., Konstantinides, S. V., Rosenkranz, S. & Investigators, F. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35484821  

Establishing a robotic-assisted PCI program: experiences at a large tertiary referral center. Brunner, F. J., Waldeyer, C., Zengin-Sahm, E., Kondziella, C., Schrage, B., Clemmensen, P., Westermann, D., Blankenberg, S. & Seiffert, M. Heart Vessels (2022). https://www.ncbi.nlm.nih.gov/pubmed/35487996

Computational and experimental methods for classifying variants of unknown clinical significance. Spielmann, M. & Kircher, M. Cold Spring Harb Mol Case Stud 8 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35483875  

Neuroimmune cardiovascular interfaces control atherosclerosis. Mohanta, S. K., Peng, L., Li, Y., Lu, S., Sun, T., Carnevale, L., Perrotta, M., Ma, Z., Forstera, B., Stanic, K., Zhang, C., Zhang, X., Szczepaniak, P., Bianchini, M., Saeed, B. R., Carnevale, R., Hu, D., Nosalski, R., Pallante, F., Beer, M., Santovito, D., Erturk, A., Mettenleiter, T. C., Klupp, B. G., Megens, R. T. A., Steffens, S., Pelisek, J., Eckstein, H. H., Kleemann, R., Habenicht, L., Mallat, Z., Michel, J. B., Bernhagen, J., Dichgans, M., D'Agostino, G., Guzik, T. J., Olofsson, P. S., Yin, C., Weber, C., Lembo, G., Carnevale, D. & Habenicht, A. J. R. Nature 605, 152-159 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35477759  

A machine learning algorithm for electrocardiographic fQRS quantification validated on multi-center data. Villa, A., Vandenberk, B., Kentta, T., Ingelaere, S., Huikuri, H. V., Zabel, M., Friede, T., Sticherling, C., Tuinenburg, A., Malik, M., Van Huffel, S., Willems, R. & Varon, C. Sci Rep 12, 6783 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35474073  

Periprocedural myocardial injury according to optical characteristics of neointima and treatment modality of in-stent restenosis. Nano, N., Aytekin, A., Ndrepepa, G., Seguchi, M., Bresha, J., Alvarez Covarrubias, H. A., Nicol, P., Lenz, T., Lahu, S., Gewalt, S., Voll, F., Rheude, T., Wiebe, J., Schunkert, H., Kufner, S., Cassese, S., Joner, M., Kastrati, A. & Xhepa, E. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35476138  

Effect of obesity on the associations of 25-hydroxyvitamin D with prevalent and incident distal sensorimotor polyneuropathy: population-based KORA F4/FF4 study. Maalmi, H., Herder, C., Huth, C., Rathmann, W., Bonhof, G. J., Heier, M., Koenig, W., Roden, M., Peters, A., Ziegler, D. & Thorand, B. Int J Obes (Lond) 46, 1366-1374 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35474356  

Serial Assessment of Right Ventricular Deformation in Patients With Hypoplastic Left Heart Syndrome: A Cardiovascular Magnetic Resonance Feature Tracking Study. Kanngiesser, L. M., Freitag-Wolf, S., Boroni Grazioli, S., Gabbert, D. D., Hansen, J. H., Uebing, A. S. & Voges, I. J Am Heart Assoc 11, e025332 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35475354  

Exome sequencing in individuals with cardiovascular laterality defects identifies potential candidate genes. Breuer, K., Riedhammer, K. M., Muller, N., Schaidinger, B., Dombrowsky, G., Dittrich, S., Zeidler, S., Bauer, U. M. M., Westphal, D. S., Meitinger, T., Dakal, T. C., Hitz, M. P., Breuer, J., Reutter, H., Hilger, A. C. & Hoefele, J. Eur J Hum Genet (2022). https://www.ncbi.nlm.nih.gov/pubmed/35474353  

Stent Optimization Using Optical Coherence Tomography and Its Prognostic Implications After Percutaneous Coronary Intervention. Rai, H., Harzer, F., Otsuka, T., Abdelwahed, Y. S., Antuna, P., Blachutzik, F., Koppara, T., Raber, L., Leistner, D. M., Alfonso, F., Nef, H., Seguchi, M., Aytekin, A., Xhepa, E., Kufner, S., Cassese, S., Laugwitz, K. L., Byrne, R. A., Kastrati, A. & Joner, M. J Am Heart Assoc 11, e02393 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35470682  

Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI. Kaiser, R., Escaig, R., Kranich, J., Hoffknecht, M. L., Anjum, A., Polewka, V., Mader, M., Hu, W., Belz, L., Gold, C., Titova, A., Lorenz, M., Pekayvaz, K., Kaab, S., Gaertner, F., Stark, K., Brocker, T., Massberg, S. & Nicolai, L. Blood (2022). https://www.ncbi.nlm.nih.gov/pubmed/35472164  

Towards lower radiation and contrast media dose CT angiography of the aorta by artificial intelligence-supported iterative reconstructions. Halfmann, M. C. & Emrich, T. Eur J Radiol 151, 110327 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35472648  

Which patients with aortic stenosis should be referred to surgery rather than transcatheter aortic valve implantation? Windecker, S., Okuno, T., Unbehaun, A., Mack, M., Kapadia, S. & Falk, V. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35466382  

Cardiac Cachexia Revisited: The Role of Wasting in Heart Failure. Valentova, M., Anker, S. D. & von Haehling, S. Cardiol Clin 40, 199-207 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35465894  

[Cost-benefit analysis of new lipid-lowering agents]. Blaum, C., Arnold, N. & Waldeyer, C. Herz 47, 236-243 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35467096  

Temporary mechanical circulatory support: Devices, outcomes, and future directions. Baran, D. A., Jaiswal, A., Hennig, F. & Potapov, E. J Heart Lung Transplant 41, 678-691 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35461760  

Clinical Profile, Arrhythmias, and Adverse Cardiac Outcomes in Emery-Dreifuss Muscular Dystrophies: A Systematic Review of the Literature. Valenti, A. C., Albini, A., Imberti, J. F., Vitolo, M., Bonini, N., Lattanzi, G., Schnabel, R. B. & Boriani, G. Biology (Basel) 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35453731  

Treatment of Transthyretin Amyloid Cardiomyopathy: The Current Options, the Future, and the Challenges. Tschope, C. & Elsanhoury, A. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35456241  

Heart Failure Severity Closely Correlates with Intestinal Dysbiosis and Subsequent Metabolomic Alterations. Spehlmann, M. E., Rangrez, A. Y., Dhotre, D. P., Schmiedel, N., Chavan, N., Bang, C., Muller, O. J., Shouche, Y. S., Franke, A., Frank, D. & Frey, N. Biomedicines 10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35453559  

Therapeutic Alternatives in Diabetic Foot Patients without an Option for Revascularization: A Narrative Review. Ruemenapf, G., Morbach, S. & Sigl, M. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35456247  

Validation of the 30-Year Framingham Risk Score in a German Population-Based Cohort. Rospleszcz, S., Starnecker, F., Linkohr, B., von Scheidt, M., Gieger, C., Schunkert, H., Peters, A. & DigiMed Bayern, C. Diagnostics (Basel) 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35454012  

Prediction of Successful Pharmacological Cardioversion in Acute Symptomatic Atrial Fibrillation: The Successful Intravenous Cardioversion for Atrial Fibrillation (SIC-AF) Score. Niederdockl, J. D., Simon, A., Buchtele, N., Schutz, N., Cacioppo, F., Oppenauer, J., Gupta, S., Lutnik, M., Schnaubelt, S., Spiel, A., Roth, D., Wimbauer, F., Fegers-Wustrow, I., Esefeld, K., Halle, M., Scharhag, J., Laschitz, T., Herkner, H., Domanovits, H. & Schwameis, M. J Pers Med 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35455660  

Straightforward Analysis of Sulfated Glycosaminoglycans by MALDI-TOF Mass Spectrometry from Biological Samples. Kruger, L., Biskup, K., Karampelas, V., Ludwig, A., Kasper, A. S., Poller, W. C. & Blanchard, V. Biology (Basel) 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35453706  

Simultaneous Quantification and Pharmacokinetic Characterization of Doxapram and 2-Ketodoxapram in Porcine Plasma and Brain Tissue. Kraft, M., Foerster, K. I., Wiedmann, F., Sauter, M., Paasche, A., Blochberger, P. L., Yesilgoz, B., L'Hoste, Y., Frey, N., Haefeli, W. E., Burhenne, J. & Schmidt, C. Pharmaceutics 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35456597  

The Structural and the Functional Aspects of Intercellular Communication in iPSC-Cardiomyocytes. Kiss, E., Fischer, C., Sauter, J. M., Sun, J. & Ullrich, N. D. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35457277  

Introduction of Lazy Luna an automatic software-driven multilevel comparison of ventricular function quantification in cardiovascular magnetic resonance imaging. Hadler, T., Wetzl, J., Lange, S., Geppert, C., Fenski, M., Abazi, E., Groschel, J., Ammann, C., Wenson, F., Topper, A., Dauber, S. & Schulz-Menger, J. Sci Rep 12, 6629 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35459270  

Pooled Analysis of Complications with Transvenous ICD Compared to Subcutaneous ICD in Patients with Catecholaminergic Polymorphic Ventricular Arrhythmia. Eckert, H., El-Battrawy, I., Veith, M., Roterberg, G., Kowitz, J., Lang, S., Zhou, X., Akin, I., Mugge, A. & Aweimer, A. J Pers Med 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35455651   

Human UPF3A and UPF3B enable fault-tolerant activation of nonsense-mediated mRNA decay. Wallmeroth, D., Lackmann, J. W., Kueckelmann, S., Altmuller, J., Dieterich, C., Boehm, V. & Gehring, N. H. EMBO J, e109191 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35451084  

Definition, Classification and Diagnosis of Diabetes Mellitus. Schleicher, E., Gerdes, C., Petersmann, A., Muller-Wieland, D., Muller, U. A., Freckmann, G., Heinemann, L., Nauck, M. & Landgraf, R. Exp Clin Endocrinol Diabetes (2022). https://www.ncbi.nlm.nih.gov/pubmed/35451038  

Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease. Paeslack, N., Mimmler, M., Becker, S., Gao, Z., Khuu, M. P., Mann, A., Malinarich, F., Regen, T. & Reinhardt, C. Amino Acids (2022). https://www.ncbi.nlm.nih.gov/pubmed/35451695  

Assessment of Myocardial Microstructure in a Murine Model of Obesity-Related Cardiac Dysfunction by Diffusion Tensor Magnetic Resonance Imaging at 7T. Lohr, D., Thiele, A., Stahnke, M., Braun, V., Smeir, E., Spranger, J., Brachs, S., Klopfleisch, R., Foryst-Ludwig, A., Schreiber, L. M., Kintscher, U. & Beyhoff, N. Front Cardiovasc Med 9, 839714 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35449873  

Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK-STAT signaling in macrophages by perturbing lipid raft structures. Hammoud, M. K., Dietze, R., Pesek, J., Finkernagel, F., Unger, A., Bieringer, T., Nist, A., Stiewe, T., Bhagwat, A. M., Nockher, W. A., Reinartz, S., Muller-Brusselbach, S., Graumann, J. & Muller, R. Mol Oncol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35451191  

Background calcium influx in arrhythmia: lead actor or extra? Fakuade, F. E., Fauconnier, J. & Voigt, N. J Physiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35451079  

Optical coherence tomography in coronary atherosclerosis assessment and intervention. Araki, M., Park, S. J., Dauerman, H. L., Uemura, S., Kim, J. S., Di Mario, C., Johnson, T. W., Guagliumi, G., Kastrati, A., Joner, M., Holm, N. R., Alfonso, F., Wijns, W., Adriaenssens, T., Nef, H., Rioufol, G., Amabile, N., Souteyrand, G., Meneveau, N., Gerbaud, E., Opolski, M. P., Gonzalo, N., Tearney, G. J., Bouma, B., Aguirre, A. D., Mintz, G. S., Stone, G. W., Bourantas, C. V., Raber, L., Gili, S., Mizuno, K., Kimura, S., Shinke, T., Hong, M. K., Jang, Y., Cho, J. M., Yan, B. P., Porto, I., Niccoli, G., Montone, R. A., Thondapu, V., Papafaklis, M. I., Michalis, L. K., Reynolds, H., Saw, J., Libby, P., Weisz, G., Iannaccone, M., Gori, T., Toutouzas, K., Yonetsu, T., Minami, Y., Takano, M., Raffel, O. C., Kurihara, O., Soeda, T., Sugiyama, T., Kim, H. O., Lee, T., Higuma, T., Nakajima, A., Yamamoto, E., Bryniarski, K. L., Di Vito, L., Vergallo, R., Fracassi, F., Russo, M., Seegers, L. M., McNulty, I., Park, S., Feldman, M., Escaned, J., Prati, F., Arbustini, E., Pinto, F. J., Waksman, R., Garcia-Garcia, H. M., Maehara, A., Ali, Z., Finn, A. V., Virmani, R., Kini, A. S., Daemen, J., Kume, T., Hibi, K., Tanaka, A., Akasaka, T., Kubo, T., Yasuda, S., Croce, K., Granada, J. F., Lerman, A., Prasad, A., Regar, E., Saito, Y., Sankardas, M. A., Subban, V., Weissman, N. J., Chen, Y., Yu, B., Nicholls, S. J., Barlis, P., West, N. E. J., Arbab-Zadeh, A., Ye, J. C., Dijkstra, J., Lee, H., Narula, J., Crea, F., Nakamura, S., Kakuta, T., Fujimoto, J., Fuster, V. & Jang, I. K. Nat Rev Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35449407  

Antiarrhythmic Effects of Vernakalant in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes from a Patient with Short QT Syndrome Type 1. Xu, Q., Huang, X., Meng, Z., Li, Y., Zhong, R., Li, X., Cyganek, L., El-Battrawy, I., Akin, I., Zhou, X. & Lan, H. J Cardiovasc Dev Dis 9 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35448088  

Heart failure in the general population and impact of the 2021 European Society of Cardiology Heart Failure Guidelines. Wenzel, J. P., Nikorowitsch, J., Bei der Kellen, R., Magnussen, C., Bonin-Schnabel, R., Westermann, D., Twerenbold, R., Kirchhof, P., Blankenberg, S. & Schrage, B. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35445582  

Quantitative Flow Ratio or Angiography for the Assessment of Non-culprit Lesions in Acute Coronary Syndromes: Protocol of the Randomized Trial QUOMODO. Ullrich, H., Olschewski, M., Belhadj, K. A., Munzel, T. & Gori, T. Front Cardiovasc Med 9, 815434 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35445090  

Depressive symptoms predict the incidence of common chronic diseases in women and men in a representative community sample. Otten, D., Ernst, M., Werner, A. M., Tibubos, A. N., Reiner, I., Brahler, E., Wiltink, J., Michal, M., Nagler, M., Wild, P. S., Munzel, T., Konig, J., Lackner, K. J., Peiffer, N. & Beutel, M. E. Psychol Med, 1-9 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35443907  

Assessment of sex- and age-dependency of risk factors for intimal hyperplasia in heart transplant patients using the high resolution of optical coherence tomography. Orban, M., Dietl, M., Dischl, D., von Samson-Himmelstjerna, P., Neubarth-Mayer, J., Struven, A., Tengler, A., Jakob, A., Fischer, M., Rizas, K., Petzold, T., Orban, M., Braun, D., Hausleiter, J., Hagl, C., Haas, N. A., Mehilli, J., Pozza, R. D., Massberg, S. & Ulrich, S. Int J Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35447273  

Ablation Lesion Assessment with MRI. Mont, L., Roca-Luque, I. & Althoff, T. F. Arrhythm Electrophysiol Rev 11, e02 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35444808  

Lipopolysaccharide Modifies Sodium Current Kinetics through ROS and PKC Signalling in Induced Pluripotent Stem-Derived Cardiomyocytes from Brugada Syndrome Patient. Liao, Z., Li, Y., Fan, X., Yang, Z., El-Battrawy, I., Zhou, X. & Akin, I. J Cardiovasc Dev Dis 9 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35448095  

Tenascin-X Mediates Flow-Induced Suppression of EndMT and Atherosclerosis. Liang, G., Wang, S., Shao, J., Jin, Y., Xu, L., Yan, Y., Gunther, S., Wang, L. & Offermanns, S. Circ Res, 101161CIRCRESAHA121320694 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35443807  

NMR Metabolomics Reveal Urine Markers of Microbiome Diversity and Identify Benzoate Metabolism as a Mediator between High Microbial Alpha Diversity and Metabolic Health. Hertel, J., Fassler, D., Heinken, A., Weiss, F. U., Ruhlemann, M., Bang, C., Franke, A., Budde, K., Henning, A. K., Petersmann, A., Volker, U., Volzke, H., Thiele, I., Grabe, H. J., Lerch, M. M., Nauck, M., Friedrich, N. & Frost, F. Metabolites 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35448495  

Treatment of the Aortic Root in Acute Aortic Dissection Type A: Insights from the German Registry for Acute Aortic Dissection Type A (GERAADA) Registry. Kallenbach, K., Busch, C., Rylski, B., Dohle, D. S., Kruger, T., Holubec, T., Brickwedel, J., Poling, J., Noack, T., Hagl, C., Jawny, P., Boning, A., Chalabi, K., Karck, M. & Arif, R. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35441677  

Effects of renin-angiotensin system inhibitor type and dosage on survival after transcatheter aortic valve implantation. Fischer-Rasokat, U., Bansch, C., Renker, M., Rolf, A., Charitos, E. I., Weferling, M., Liebetrau, C., Herrmann, E., Choi, Y. H., Hamm, C. W. & Kim, W. K. Eur Heart J Cardiovasc Pharmacother (2022). https://www.ncbi.nlm.nih.gov/pubmed/35441662  

Movement therapy in lung transplantation candidates assisted by a lightweight wearable robot. Just, I. A., Fries, D., Loewe, S., Falk, V., Cesarovic, N., Kemper, D., Edelmann, F., Feuerstein, A., Haufe, F. L., Xiloyannis, M., Riener, R. & Schoenrath, F. Assist Technol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35438604  

Frontiers in CardioVascular Biomedicine (FCVB) 2022 Budapest is on in person! The excellent programme proves that scientists won against COVID-19. Ferdinandy, P., Koller, Á., Weber, C., Wojta, J. & Waltenberger, J. Cardiovasc Res 118, e59-e61 (2022).

Frontiers of CardioVascular Biomedicine 2022 Budapest is on in person! The excellent program proves that scientists won against Covid-19. Ferdinandy, P., Koller, A., Weber, C., Wojta, J. & Waltenberger, J. Cardiovasc Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/35438746  

Ten-year patterns of stent thrombosis after percutaneous coronary intervention with new- versus early-generation drug-eluting stents: insights from the DECADE cooperation. Coughlan, J. J., Maeng, M., Raber, L., Brugaletta, S., Aytekin, A., Okkels Jensen, L., Bar, S., Ortega-Paz, L., Laugwitz, K. L., Madsen, M., Heg, D., Sabate, M., Kufner, S., Warnakula Olesen, K. K., Kastrati, A., Windecker, S. & Cassese, S. Rev Esp Cardiol (Engl Ed) (2022). https://www.ncbi.nlm.nih.gov/pubmed/35437213  

Machine learning-based identification of risk-factor signatures for undiagnosed atrial fibrillation in primary prevention and post-stroke in clinical practice. Schnabel, R. B., Witt, H., Walker, J., Ludwig, M., Geelhoed, B., Kossack, N., Schild, M., Miller, R. & Kirchhof, P. Eur Heart J Qual Care Clin Outcomes (2022). https://www.ncbi.nlm.nih.gov/pubmed/35436783  

Targeting Cell-Specific Molecular Mechanisms of Innate Immunity in Atherosclerosis. Sauter, M. & Langer, H. F. Front Physiol 13, 802990 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35432000  

Prognostic Power of Pulmonary Arterial Compliance Is Boosted by a Hemodynamic Unloading Test With Glyceryl Trinitrate in Heart Failure Patients With Post-capillary Pulmonary Hypertension. Rieth, A. J., Grun, D., Zarogiannis, G., Kriechbaum, S. D., Wolter, S., Richter, M. J., Tello, K., Kruger, U., Mitrovic, V., Rosenkranz, S., Hamm, C. W. & Keller, T. Front Cardiovasc Med 9, 838898 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35433862  

The AT1 Receptor Blocker Telmisartan Reduces Intestinal Mucus Thickness in Obese Mice. Nickel, L., Sunderhauf, A., Rawish, E., Stolting, I., Derer, S., Thorns, C., Matschl, U., Othman, A., Sina, C. & Raasch, W. Front Pharmacol 13, 815353 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35431918  

Micro-dislodgement of a self-expanding transcatheter heart valve: Incidence, predictors, and outcomes. Kim, W. K., Renker, M., Dorr, O., Nef, H., Fischer-Rasokat, U., Choi, Y. H., Hamm, C. W. & Charitos, E. Int J Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35436560  

Ruthenaelectro-catalyzed C-H acyloxylation for late-stage tyrosine and oligopeptide diversification. Hou, X., Kaplaneris, N., Yuan, B., Frey, J., Ohyama, T., Messinis, A. M. & Ackermann, L. Chem Sci 13, 3461-3467 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35432858   

Cellular Chitchatting: Exploring the Role of Exosomes as Cardiovascular Risk Factors. Germena, G., Zelarayan, L. C. & Hinkel, R. Front Cell Dev Biol 10, 860005 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35433670  

Transmitral Gradients Following Transcatheter Edge-to-Edge Repair: Are Mean Gradients Meaningful? Hahn, R. T. & Hausleiter, J. JACC Cardiovasc Interv (2022). https://www.ncbi.nlm.nih.gov/pubmed/35430172  

Severe low-gradient aortic stenosis: impact of inadequate left ventricular responses to high afterload on diagnosis and therapeutic decision-making. Dandel, M. & Hetzer, R. Heart Fail Rev (2022). https://www.ncbi.nlm.nih.gov/pubmed/35430696  

Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20. Vieira-Vieira, C. H., Dauksaite, V., Sporbert, A., Gotthardt, M. & Selbach, M. Mol Cell (2022). https://www.ncbi.nlm.nih.gov/pubmed/35427468  

Clinical implications of low estimated protein intake in patients with heart failure. Streng, K. W., Hillege, H. L., Ter Maaten, J. M., van Veldhuisen, D. J., Dickstein, K., Ng, L. L., Samani, N. J., Metra, M., Ponikowski, P., Cleland, J. G., Anker, S. D., Romaine, S. P. R., Damman, K., van der Meer, P., Lang, C. C. & Voors, A. A. J Cachexia Sarcopenia Muscle (2022). https://www.ncbi.nlm.nih.gov/pubmed/35426256  

Not the classical serendipity: does doxapram treat atrial fibrillation? Liutkute, A., Brundel, B. J. & Voigt, N. Cardiovasc Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/35425974  

Generation of heterozygous (MRli003-A-5) and homozygous (MRli003-A-6) voltage-sensing knock-in human iPSC lines by CRISPR/Cas9 editing of the AAVS1 locus. Zhang, F., Meier, A. B., Sinnecker, D., Engelhardt, S., Lipp, P., Laugwitz, K. L., Dorn, T. & Moretti, A. Stem Cell Res 61, 102785 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35421847  

Symptom burden, psychosocial distress and palliative care needs in heart failure - A cross-sectional explorative pilot study. Strangl, F., Ischanow, E., Ullrich, A., Oechsle, K., Fluschnik, N., Magnussen, C., Knappe, D., Grahn, H., Blankenberg, S., Bokemeyer, C., Kirchhof, P. & Rybczynski, M. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35420358  

Surgical Restoration of Antero-Apical Left Ventricular Aneurysms: Cardiac Computed Tomography for Therapy Planning. Solowjowa, N., Nemchyna, O., Hrytsyna, Y., Meyer, A., Hennig, F., Falk, V. & Knosalla, C. Front Cardiovasc Med 9, 763073 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35419444  

Four decades of experience of prosthetic valve endocarditis reflect a high variety of diverse pathogens. Oberbach, A., Schlichting, N., Hagl, C., Lehmann, S., Kullnick, Y., Friedrich, M., Kohl, U., Horn, F., Kumbhari, V., Loffler, B., Schmidt, F., Joskowiak, D., Born, F., Saha, S. & Bagaev, E. Cardiovasc Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/35420122  

Prediction of disability-free survival in healthy older people. Neumann, J. T., Thao, L. T. P., Murray, A. M., Callander, E., Carr, P. R., Nelson, M. R., Wolfe, R., Woods, R. L., Reid, C. M., Shah, R. C., Newman, A. B., Williamson, J. D., Tonkin, A. M., McNeil, J. J. & investigators, A. Geroscience 44, 1641-1655 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35420334  

Natural killer cells act as an extrinsic barrier for in vivo reprogramming. Melendez, E., Chondronasiou, D., Mosteiro, L., Martinez de Villarreal, J., Fernandez-Alfara, M., Lynch, C. J., Grimm, D., Real, F. X., Alcami, J., Climent, N., Pietrocola, F. & Serrano, M. Development 149 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35420133  

Targeting the adipose tissue: heart crosstalk in pressure overload-induced heart failure. Tual-Chalot, S. & Stellos, K. Cardiovasc Res 118, 1854-1856 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35416985  

The Polyscore of autonomic parameters predicts mortality and identifies low-risk individuals among diabetic survivors of acute myocardial infarction. Steger, A., Dommasch, M., Muller, A., Barthel, P., Sinnecker, D., Wieg, L., Hapfelmeier, A., Heidegger, H. H., Huster, K. M., Martens, E., Laugwitz, K. L., Schmidt, G. & Dirschinger, R. Sci Rep 12, 6069 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35414085   

CARMA: what goes around, comes around for the heart. Juni, R. P. & Boon, R. A. Cardiovasc Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/35416964  

Patient related outcomes of mechanical lead extraction techniques (PROMET) study: A comparison of two professions. Akhtar, Z., Gallagher, M. M., Elbatran, A. I., Starck, C. T., Gonzalez, E., Al-Razzo, O., Mazzone, P., Delnoy, P. P., Breitenstein, A., Steffel, J., Eulert-Grehn, J., Lanmuller, P., Melillo, F., Marzi, A., Leung, L. W., Domenichini, G. & Sohal, M. Pacing Clin Electrophysiol 45, 658-665 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35417049  

The Evolution of Complex Muscle Cell In Vitro Models to Study Pathomechanisms and Drug Development of Neuromuscular Disease. Zschuntzsch, J., Meyer, S., Shahriyari, M., Kummer, K., Schmidt, M., Kummer, S. & Tiburcy, M. Cells 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35406795

C-Reactive Protein to Albumin Ratio in Patients Undergoing Transcatheter Aortic Valve Replacement. Seoudy, H., Shamekhi, J., Voigtlander, L., Ludwig, S., Frank, J., Kujat, T., Bramlage, P., Al-Kassou, B., Sugiura, A., Rangrez, A. Y., Schofer, N., Puehler, T., Lutter, G., Seiffert, M., Nickenig, G., Conradi, L., Frey, N., Westermann, D., Sinning, J. M. & Frank, D. Mayo Clin Proc 97, 931-940 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35410750  

A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals. Rohling, M., Kempf, K., Banzer, W., Braumann, K. M., Fuhrer-Sakel, D., Halle, M., McCarthy, D., Martin, S., Scholze, J., Toplak, H., Berg, A., Predel, H. G. & Acoorh Study, G. Nutrients 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35406053  

Molecular Effects of Auto-Antibodies on Angiotensin II Type 1 Receptor Signaling and Cell Proliferation. Philippe, A., Kleinau, G., Gruner, J. J., Wu, S., Postpieszala, D., Speck, D., Heidecke, H., Dowell, S. J., Riemekasten, G., Hildebrand, P. W., Kamhieh-Milz, J., Catar, R., Szczepek, M., Dragun, D. & Scheerer, P. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35409344  

Interdependence of Angiogenesis and Arteriogenesis in Development and Disease. le Noble, F. & Kupatt, C. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35409246  

Elevation of cardiac biomarkers in stroke is associated with pathological findings on cardiac MRI-results of the HEart and BRain interfaces in Acute Stroke study. von Rennenberg, R., Herm, J., Krause, T., Hellwig, S., Stengl, H., Scheitz, J. F., Elgeti, T., Nagel, S. N., Endres, M., Haeusler, K. G. & Nolte, C. H. Int J Stroke, 17474930221095698 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35403503  

Combining 3D-Printing and Electrospinning to Manufacture Biomimetic Heart Valve Leaflets. Freystetter, B., Grab, M., Grefen, L., Bischof, L., Isert, L., Mela, P., Bezuidenhout, D., Hagl, C. & Thierfelder, N. J Vis Exp (2022). https://www.ncbi.nlm.nih.gov/pubmed/35404357  

Validity of a multidimensional comprehensive psychosocial screening instrument based on the ESC cardiovascular prevention guidelines - Evidence from the general and cardiovascular patient population. van den Houdt, S., Albus, C., Herrmann-Lingen, C., Widdershoven, J. & Kupper, N. J Psychosom Res 157, 110791 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35398675  

TAVR - From inoperable to younger, lower-risk patients: A slippery slope? Unbehaun, A., Abdullah, M., Hooda, A., Gedela, M., Kempfert, J., Klein, C. & Tang, G. H. L. Prog Cardiovasc Dis (2022). https://www.ncbi.nlm.nih.gov/pubmed/35398162  

Rapid shear stress-dependent ENaC membrane insertion is mediated by the endothelial glycocalyx and the mineralocorticoid receptor. Cosgun, Z. C., Sternak, M., Fels, B., Bar, A., Kwiatkowski, G., Pacia, M. Z., Herrnbock, L., Lindemann, M., Stegbauer, J., Hoges, S., Chlopicki, S. & Kusche-Vihrog, K. Cell Mol Life Sci 79, 235 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35397686  

Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno-Associated Viral Vector rAAV9P1. Bauer, A., Puglisi, M., Nagl, D., Schick, J. A., Werner, T., Klingl, A., El Andari, J., Hornung, V., Kessler, H., Gotz, M., Grimm, D. & Brack-Werner, R. Adv Sci (Weinh) 9, e2104979 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35398994  

UBTF::ATXN7L3 gene fusion defines novel B cell precursor ALL subtype with CDX2 expression and need for intensified treatment. Bastian, L., Hartmann, A. M., Beder, T., Hanzelmann, S., Kassens, J., Bultmann, M., Hoeppner, M. P., Franzenburg, S., Wittig, M., Franke, A., Nagel, I., Spielmann, M., Reimer, N., Busch, H., Schwartz, S., Steffen, B., Viardot, A., Dohner, K., Kondakci, M., Wulf, G., Wendelin, K., Renzelmann, A., Kiani, A., Trautmann, H., Neumann, M., Gokbuget, N., Bruggemann, M. & Baldus, C. D. Leukemia 36, 1676-1680 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35397658  

Matched comparison of 3 cerebral perfusion strategies in open zone-0 anastomosis for acute type A aortic dissection. Montagner, M., Kofler, M., Pitts, L., Heck, R., Buz, S., Kurz, S., Falk, V. & Kempfert, J. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35396839  

Generation of two human iPSC lines, HMGUi003-A and MRIi028-A, carrying pathogenic biallelic variants in the PPCS gene. Iuso, A., Zhang, F., Rusha, E., Campbell, B., Dorn, T., Zanuttigh, E., Haas, D., Anikster, Y., Lederer, G., Pertek, A., Nteli, P., Laugwitz, K. L. & Moretti, A. Stem Cell Res 61, 102773 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35397396  

Non-robotic minimally invasive mitral valve repair: a 20-year single-centre experience. Feirer, N., Kornyeva, A., Lang, M., Sideris, K., Voss, B., Krane, M., Lange, R. & Vitanova, K. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35396837  

Pediatric heart transplantation in infants and small children under 3 years of age: Single center experience - "Early and long-term results". Rosenthal, L. L., Ulrich, S. M., Zimmerling, L., Brenner, P., Muller, C., Michel, S., Horer, J., Netz, H., Haas, N. A. & Hagl, C. Int J Cardiol 356, 45-50 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35395286  

Mechano-signaling via Piezo1 prevents activation and p53-mediated senescence of muscle stem cells. Peng, Y., Du, J., Gunther, S., Guo, X., Wang, S., Schneider, A., Zhu, L. & Braun, T. Redox Biol 52, 102309 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35395625  

Cardiac remodeling in patients with centrifugal left ventricular assist devices assessed by serial echocardiography. Mulzer, J., Krastev, H., Hoermandinger, C., Merke, N., Alhaloush, M., Schoenrath, F., Falk, V., Potapov, E. & Knierim, J. Echocardiography 39, 667-677 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35393693  

Dysregulated diurnal cortisol patterns are associated with cardiovascular mortality: Findings from the KORA-F3 study. Karl, S., Johar, H., Ladwig, K. H., Peters, A. & Lederbogen, F. Psychoneuroendocrinology 141, 105753 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35395560   

Galectin-3 inhibitors as novel antithrombotic drugs with almost no bleeding risk: wishful thinking or a realistic vision? Jakobs, K. & Rauch, U. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35393607  

Transcatheter implantation of covered stents serving as extravascular conduits-Proof of a CT-based approach in three cases. Ewert, P., Eicken, A., Tanase, D., Georgiev, S., Will, A., Pankalla, C., Nagdyman, N., Meierhofer, C. & Horer, J. Catheter Cardiovasc Interv 99, 2054-2063 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35395135  

Pharmacological Targeting of the CCL2/CCR2 Axis for Atheroprotection: A Meta-Analysis of Preclinical Studies. Zivkovic, L., Asare, Y., Bernhagen, J., Dichgans, M. & Georgakis, M. K. Arterioscler Thromb Vasc Biol 42, e131-e144 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35387476  

Biomarker changes as surrogate endpoints in early-phase trials in heart failure with reduced ejection fraction. Savarese, G., Uijl, A., Ouwerkerk, W., Tromp, J., Anker, S. D., Dickstein, K., Hage, C., Lam, C. S. P., Lang, C. C., Metra, M., Ng, L. L., Orsini, N., Samani, N. J., van Veldhuisen, D. J., Cleland, J. G. F., Voors, A. A. & Lund, L. H. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35388650  

Endocrine and molecular factors of increased female reproductive performance in the Dummerstorf high-fertility mouse line FL1. Ludwig, C. L. M., Bohleber, S., Rebl, A., Wirth, E. K., Venuto, M. T., Langhammer, M., Schweizer, U., Weitzel, J. M. & Michaelis, M. J Mol Endocrinol 69, 285-298 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35388794  

Transmural myocardial repair with engineered heart muscle in a rat model of heterotopic heart transplantation - A proof-of-concept study. Jebran, A. F., Tiburcy, M., Biermann, D., Balfanz, P., Didie, M., Karikkineth, B. C., Schondube, F., Kutschka, I. & Zimmermann, W. H. J Mol Cell Cardiol 168, 3-12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35390437   

A Family and a Genome-Wide Polygenic Risk Score Are Independently Associated With Stroke in a Population-Based Study. Hammerle, M., Forer, L., Schonherr, S., Peters, A., Grallert, H., Kronenberg, F., Gieger, C. & Lamina, C. Stroke 53, 2331-2339 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35387493  

Cardio-oncology imaging tools at the translational interface. Yaros, K., Eksi, B., Chandra, A., Agusala, K., Lehmann, L. H. & Zaha, V. G. J Mol Cell Cardiol 168, 24-32 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35385715  

Attentive follow-up to counter alarmism. Twerenbold, R., Cavus, E. & Blankenberg, S. Eur Heart J 43, 1994 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35383357  

ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury. Rohlfing, A. K., Kolb, K., Sigle, M., Ziegler, M., Bild, A., Munzer, P., Sudmann, J., Dicenta, V., Harm, T., Manke, M. C., Geue, S., Kremser, M., Chatterjee, M., Liang, C., von Eysmondt, H., Dandekar, T., Heinzmann, D., Gunter, M., von Ungern-Sternberg, S., Buttcher, M., Castor, T., Mencl, S., Langhauser, F., Sies, K., Ashour, D., Beker, M. C., Lammerhofer, M., Autenrieth, S. E., Schaffer, T. E., Laufer, S., Szklanna, P., Maguire, P., Heikenwalder, M., Muller, K. A. L., Hermann, D. M., Kilic, E., Stumm, R., Ramos, G., Kleinschnitz, C., Borst, O., Langer, H. F., Rath, D. & Gawaz, M. Nat Commun 13, 1823 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35383158  

New ESC/EACTS guideline recommendations for the treatment of secondary mitral regurgitation: reflections on the evidence. Frerker, C., Karam, N., Hahn, R. T., Thiele, H., Stone, G. W., Treede, H. & Hausleiter, J. Eur J Heart Fail 24, 746-749 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35385192  

Adverse events and stroke prevention by interventional left atrial appendage occlusion in patients with low CHA2 DS2 -VASc score-results from the multicenter German LAARGE registry. Fastner, C., Brachmann, J., Lewalter, T., Zeymer, U., Sievert, H., Ledwoch, J., Geist, V., Hochadel, M., Schneider, S., Senges, J., Akin, I. & Ansari, U. Catheter Cardiovasc Interv 99, 2064-2070 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35384249  

The everlasting challenge to identify deep vein thrombosis in both clinical practice and research. Behrendt, C. A., Twerenbold, R. & Blankenberg, S. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35383353  

Clinical implementation of RNA sequencing for Mendelian disease diagnostics. Yepez, V. A., Gusic, M., Kopajtich, R., Mertes, C., Smith, N. H., Alston, C. L., Ban, R., Beblo, S., Berutti, R., Blessing, H., Ciara, E., Distelmaier, F., Freisinger, P., Haberle, J., Hayflick, S. J., Hempel, M., Itkis, Y. S., Kishita, Y., Klopstock, T., Krylova, T. D., Lamperti, C., Lenz, D., Makowski, C., Mosegaard, S., Muller, M. F., Munoz-Pujol, G., Nadel, A., Ohtake, A., Okazaki, Y., Procopio, E., Schwarzmayr, T., Smet, J., Staufner, C., Stenton, S. L., Strom, T. M., Terrile, C., Tort, F., Van Coster, R., Vanlander, A., Wagner, M., Xu, M., Fang, F., Ghezzi, D., Mayr, J. A., Piekutowska-Abramczuk, D., Ribes, A., Rotig, A., Taylor, R. W., Wortmann, S. B., Murayama, K., Meitinger, T., Gagneur, J. & Prokisch, H. Genome Med 14, 38 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35379322   

Effects of caloric restriction on the gut microbiome are linked with immune senescence. Sbierski-Kind, J., Grenkowitz, S., Schlickeiser, S., Sandforth, A., Friedrich, M., Kunkel, D., Glauben, R., Brachs, S., Mai, K., Thurmer, A., Radonic, A., Drechsel, O., Turnbaugh, P. J., Bisanz, J. E., Volk, H. D., Spranger, J. & von Schwartzenberg, R. J. Microbiome 10, 57 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35379337  

Analytical interference of 33 different hemoglobin variants on HbA1c measurements comparing high-performance liquid chromatography with whole blood enzymatic assay: A multi-center study. Zechmeister, B., Erden, T., Kreutzig, B., Weber, M., Joly, P., Erdmann, J., Brockmann-Honig, C., Fischer, A. & Eidizadeh, A. Clin Chim Acta 531, 145-151 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35378091  

Transcatheter aortic valve-in-valve implantation under cerebral protection in a patient with a deteriorated 19-mm rapid-deployment bioprosthetic valve. Van Praet, K. M., Nersesian, G., Kukucka, M., Heil, E., Kofler, M., Falk, V., Klein, C., Kempfert, J. & Unbehaun, A. Multimed Man Cardiothorac Surg 2022 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35377972  

Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction. Cornean, A., Gierten, J., Welz, B., Mateo, J. L., Thumberger, T. & Wittbrodt, J. Elife 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35373735  

Selective optogenetic control of Gq signaling using human Neuropsin. Wagdi, A., Malan, D., Sathyanarayanan, U., Beauchamp, J. S., Vogt, M., Zipf, D., Beiert, T., Mansuroglu, B., Dusend, V., Meininghaus, M., Schneider, L., Kalthof, B., Wiegert, J. S., Konig, G. M., Kostenis, E., Patejdl, R., Sasse, P. & Bruegmann, T. Nat Commun 13, 1765 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35365606  

Computed tomography predictors of structural valve degeneration in patients undergoing transcatheter aortic valve implantation with balloon-expandable prostheses. Guglielmo, M., Fusini, L., Muratori, M., Tamborini, G., Mantegazza, V., Andreini, D., Annoni, A., Babbaro, M., Baggiano, A., Conte, E., Carriero, S., Formenti, A., Guaricci, A. I., Mancini, E., Mollace, R., Muscogiuri, G., Mushtaq, S., Ricci, F., Rossi, A., Scafuri, S., Alushi, B., Cau, C., Cau, R., Cesarano, M., Saba, L., Rabbat, M., Pepi, M. & Pontone, G. Eur Radiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35364711  

Partial ring annuloplasty in the management of mitral annular calcification. Akansel, S., Kofler, M., Sundermann, S. H., Van Praet, K. M., Falk, V. & Kempfert, J. J Card Surg 37, 1749-1752 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35366352  

Cardiac disease and prognosis associated with ventricular tachyarrhythmias in young adults and adults. Weidner, K., Behnes, M., Schupp, T., Hoppner, J., El-Battrawy, I., Ansari, U., Saleh, A., Taton, G., Reiser, L., Bollow, A., Reichelt, T., Ellguth, D., Engelke, N., Bertsch, T., Grosse Meininghaus, D., Hoffmann, U. & Akin, I. BMC Cardiovasc Disord 22, 136 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35361107  

High resolution optical mapping of cardiac electrophysiology in pre-clinical models. O'Shea, C., Winter, J., Kabir, S. N., O'Reilly, M., Wells, S. P., Baines, O., Sommerfeld, L. C., Correia, J., Lei, M., Kirchhof, P., Holmes, A. P., Fabritz, L., Rajpoot, K. & Pavlovic, D. Sci Data 9, 135 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35361792  

An inhibitory effect on the nuclear accumulation of phospho-STAT1 by its unphosphorylated form. Menon, P. R., Staab, J., Gregus, A., Wirths, O. & Meyer, T. Cell Commun Signal 20, 42 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35361236  

Frailty, Guideline-Directed Medical Therapy, and Outcomes in HFrEF: From the GUIDE-IT Trial. Khan, M. S., Segar, M. W., Usman, M. S., Singh, S., Greene, S. J., Fonarow, G. C., Anker, S. D., Felker, G. M., Januzzi, J. L., Jr., Butler, J. & Pandey, A. JACC Heart Fail 10, 266-275 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35361446  

Comparison of American and European Guidelines for Primary Prevention of Cardiovascular Disease: JACC Guideline Comparison. Fegers-Wustrow, I., Gianos, E., Halle, M. & Yang, E. J Am Coll Cardiol 79, 1304-1313 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35361353  

Surgical treatment of tricuspid valve dysplasia in children. Cleuziou, J., Pringsheim, M., Stroh, A., Burri, M., Lange, R. & Horer, J. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35362523  

Synthetic Extracellular Volume in Cardiac Magnetic Resonance Without Blood Sampling: a Reliable Tool to Replace Conventional Extracellular Volume. Chen, W., Doeblin, P., Al-Tabatabaee, S., Klingel, K., Tanacli, R., Jakob Weiss, K., Stehning, C., Patel, A. R., Pieske, B., Zou, J. & Kelle, S. Circ Cardiovasc Imaging 15, e013745 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35360924  

Impact of machine-learning-based coronary computed tomography angiography-derived fractional flow reserve on decision-making in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement. Brandt, V., Schoepf, U. J., Aquino, G. J., Bekeredjian, R., Varga-Szemes, A., Emrich, T., Bayer, R. R., 2nd, Schwarz, F., Kroencke, T. J., Tesche, C. & Decker, J. A. Eur Radiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35359166  

Loss of Endothelial Cytochrome P450 Reductase Induces Vascular Dysfunction in Mice. Malacarne, P. F., Ratiu, C., Gajos-Draus, A., Muller, N., Lopez, M., Pfluger-Muller, B., Ding, X., Warwick, T., Oo, J., Siragusa, M., Angioni, C., Gunther, S., Weigert, A., Geisslinger, G., Lutjohann, D., Schunck, W. H., Fleming, I., Brandes, R. P. & Rezende, F. Hypertension 79, 1216-1226 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35354305  

Serum starvation induces sexual dimorphisms in secreted proteins of human umbilical vein endothelial cells (HUVECs) from twin pairs. Lorenz, M., Witt, E., Volker, U., Stangl, K., Stangl, V. & Hammer, E. Proteomics, e2100168 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35357760  

Comparison of transient and permanent LAD ligation in mice using 18F-FDG PET imaging. Fischer, M., Weinberger, T., Messerer, D., Zacherl, M. J., Schulz, C., Massberg, S., Bartenstein, P., Lehner, S., Boening, G. & Todica, A. Ann Nucl Med 36, 533-543 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35355159


Mai

MicroRNA-26b Attenuates Platelet Adhesion and Aggregation in Mice. Peters, L. J. F., Baaten, C., Maas, S. L., Lu, C., Nagy, M., Jooss, N. J., Bidzhekov, K., Santovito, D., Moreno-Andres, D., Jankowski, J., Biessen, E. A. L., Doring, Y., Heemskerk, J. W. M., Weber, C., Kuijpers, M. J. E. & van der Vorst, E. P. C. Biomedicines 10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35625720  

Dual-Positive MPO- and PR3-ANCA-Associated Vasculitis Following SARS-CoV-2 mRNA Booster Vaccination: A Case Report and Systematic Review. Baier, E., Olgemoller, U., Biggemann, L., Buck, C. & Tampe, B. Vaccines (Basel) 10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35632410  

Defined Engineered Human Myocardium for Disease Modeling, Drug Screening, and Heart Repair. Tiburcy, M., Meyer, T., Satin, P. L. & Zimmermann, W. H. Methods Mol Biol 2485, 213-225 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35618908  

Human-Engineered Atrial Tissue for Studying Atrial Fibrillation. Krause, J., Lemme, M., Mannhardt, I., Eder, A., Ulmer, B., Eschenhagen, T. & Stenzig, J. Methods Mol Biol 2485, 159-173 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35618905  

Lung cell toxicity of co-exposure to airborne particulate matter and extremely low-frequency magnetic field. Panjali, Z., Abdolmaleki, P., Hajipour-Verdom, B., Hahad, O. & Zendehdel, R. Xenobiotica 52, 370-379 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35608272  

Incidence and Outcome of Patients with Cardiogenic Shock and Detection of Herpes Simplex Virus in the Lower Respiratory Tract. Scherer, C., Lusebrink, E., Binzenhofer, L., Stocker, T. J., Kupka, D., Chung, H. P., Stambollxhiu, E., Alemic, A., Kellnar, A., Deseive, S., Stark, K., Petzold, T., Hagl, C., Hausleiter, J., Massberg, S. & Orban, M. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35566477  

Structural Analysis of Mitochondrial Dynamics-From Cardiomyocytes to Osteoblasts: A Critical Review. Mendelsohn, D. H., Schnabel, K., Mamilos, A., Sossalla, S., Pabel, S., Duerr, G. D., Keller, K., Schmitt, V. H., Barsch, F., Walter, N., Wong, R. M. Y., El Khassawna, T., Niedermair, T., Alt, V., Rupp, M. & Brochhausen, C. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35562962  

Artificial Intelligence Enabled Fully Automated CMR Function Quantification for Optimized Risk Stratification in Patients Undergoing Transcatheter Aortic Valve Replacement. Evertz, R., Lange, T., Backhaus, S. J., Schulz, A., Beuthner, B. E., Topci, R., Toischer, K., Puls, M., Kowallick, J. T., Hasenfuss, G. & Schuster, A. J Interv Cardiol 2022, 1368878 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35539443  

Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed. Taub, M. A., Conomos, M. P., Keener, R., Iyer, K. R., Weinstock, J. S., Yanek, L. R., Lane, J., Miller-Fleming, T. W., Brody, J. A., Raffield, L. M., McHugh, C. P., Jain, D., Gogarten, S. M., Laurie, C. A., Keramati, A., Arvanitis, M., Smith, A. V., Heavner, B., Barwick, L., Becker, L. C. et al. Cell Genom 2 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35530816  

Angiotensin and Endothelin Receptor Structures With Implications for Signaling Regulation and Pharmacological Targeting. Speck, D., Kleinau, G., Szczepek, M., Kwiatkowski, D., Catar, R., Philippe, A. & Scheerer, P. Front Endocrinol (Lausanne) 13, 880002 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35518926  

Hemodynamic Changes During Physiological and Pharmacological Stress Testing in Patients With Heart Failure: A Systematic Review and Meta-Analysis. Bingel, A., Messroghli, D., Weimar, A., Runte, K., Salcher-Konrad, M., Kelle, S., Pieske, B., Berger, F., Kuehne, T., Goubergrits, L., Fuerstenau, D. & Kelm, M. Front Cardiovasc Med 9, 718114 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35514442  

Magnetic resonance imaging-based diagnosis of aortitis preceding development of a thoracic aneurysm in a patient with giant cell arteritis: a case report. Lutter, G., Puehler, T., Rocken, C. & Both, M. Eur Heart J Case Rep 6, ytac152 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35505863  

CILP1 as a biomarker for right ventricular dysfunction in patients with ischemic cardiomyopathy. Keranov, S., Jafari, L., Haen, S., Vietheer, J., Kriechbaum, S., Dorr, O., Liebetrau, C., Troidl, C., Rutsatz, W., Rieth, A., Hamm, C. W., Nef, H., Rolf, A. & Keller, T. Pulm Circ 12, e12062 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35506075  

Transcatheter Caval Valve Implantation for Tricuspid Regurgitation After Single Leaflet Device Attachment. Rroku, A., Barbieri, F., Landmesser, U., Skurk, C., Kasner, M. & Reinthaler, M. JACC Case Rep 4, 481-485 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35493801  

Sex disparities in patients with suspected COVID-19 presenting at an emergency department in Switzerland. Arslani, K., Eken, C., Tschudin-Sutter, S., Gebhard, C. E., Zellweger, N., Bassetti, S., Bingisser, R., Lampart, M., Osswald, S., Kuster, G. M., Twerenbold, R. & investigators, C. Swiss Med Wkly 152 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35633632  

Effect of Thrombin on the Metabolism and Function of Murine Macrophages. Ukan, U., Delgado Lagos, F., Kempf, S., Gunther, S., Siragusa, M., Fisslthaler, B. & Fleming, I. Cells 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35626753  

Structured, Harmonized, and Interoperable Integration of Clinical Routine Data to Compute Heart Failure Risk Scores. Sommer, K. K., Amr, A., Bavendiek, U., Beierle, F., Brunecker, P., Dathe, H., Eils, J., Ertl, M., Fette, G., Gietzelt, M., Heidecker, B., Hellenkamp, K., Heuschmann, P., Hoos, J. D. E., Kesztyus, T., Kerwagen, F., Kindermann, A., Krefting, D., Landmesser, U., Marschollek, M. et al. Life (Basel) 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35629415  

Atherosclerosis and Its Impact on the Outcomes of Patients with Deep Venous Thrombosis. Keller, K., Prochaska, J. H., Coldewey, M., Gobel, S., Schmitt, V. H., Hahad, O., Ullmann, A., Nagler, M., Lamparter, H., Espinola-Klein, C., Munzel, T. & Wild, P. S. Life (Basel) 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35629401  

Pulmonary Artery Pressure-Guided Telemonitoring Reduced Pulmonary Artery Pressure but Did Not Result in Higher Doses of Guideline-Directed Medical Therapy-Observations from an Advanced Elderly German Heart Failure Cohort. Herrmann, E. J., Raghavan, B., Eissing, N., Fichtlscherer, S., Hamm, C. W. & Assmus, B. Life (Basel) 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35629432  

Metabolomic Profiling in Patients with Heart Failure and Exercise Intolerance: Kynurenine as a Potential Biomarker. Bekfani, T., Bekhite, M., Neugebauer, S., Derlien, S., Hamadanchi, A., Nisser, J., Hilse, M. S., Haase, D., Kretzschmar, T., Wu, M. F., Lichtenauer, M., Kiehntopf, M., von Haehling, S., Schlattmann, P., Lehmann, G., Franz, M., Mobius-Winkler, S. & Schulze, C. Cells 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35626711  

Right Antero-Lateral Mini-Thoracotomy Surgical Aortic Valve Replacement. Van Praet, K. M., Nersesian, G., Kofler, M., Sundermann, S. H., Unbehaun, A., Falk, V. & Kempfert, J. Surg Technol Int 41 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35623038  

David Procedure as Valve-Sparing Root Replacement. Pitts, L., Van Praet, K. M., Montagner, M., Kofler, M., Falk, V. & Kempfert, J. Surg Technol Int 41 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35623037  

Rac1 regulates lipid droplets formation, nanomechanical, and nanostructural changes induced by TNF in vascular endothelium in the isolated murine aorta. Pacia, M. Z., Chorazy, N., Sternak, M., Fels, B., Pacia, M., Kepczynski, M., Kusche-Vihrog, K. & Chlopicki, S. Cell Mol Life Sci 79, 317 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35622139  

The Relationship Between Vitamin D and Postoperative Atrial Fibrillation: A Prospective Cohort Study. Ohlrogge, A. H., Brederecke, J., Ojeda, F. M., Pecha, S., Borschel, C. S., Conradi, L., Rimkus, V., Blankenberg, S., Zeller, T. & Schnabel, R. B. Front Nutr 9, 851005 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35619954  

Clinical utility of inflammatory biomarkers in COVID-19 in direct comparison to other respiratory infections-A prospective cohort study. Lampart, M., Zellweger, N., Bassetti, S., Tschudin-Sutter, S., Rentsch, K. M., Siegemund, M., Bingisser, R., Osswald, S., Kuster, G. M. & Twerenbold, R. PLoS One 17, e0269005 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35622838  

Understanding the Role of SERCA2a Microdomain Remodeling in Heart Failure Induced by Obesity and Type 2 Diabetes. Lai, P., Nikolaev, V. O. & De Jong, K. A. J Cardiovasc Dev Dis 9 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35621874  

Generalizability of the EAST-AFNET 4 Trial: Assessing Outcomes of Early Rhythm-Control Therapy in Patients With Atrial Fibrillation. Dickow, J., Kirchhof, P., Van Houten, H. K., Sangaralingham, L. R., Dinshaw, L. H. W., Friedman, P. A., Packer, D. L., Noseworthy, P. A. & Yao, X. J Am Heart Assoc 11, e024214 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35621202  

Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity. Batlle, D., Monteil, V., Garreta, E., Hassler, L., Wysocki, J., Chandar, V., Schwartz, R. E., Mirazimi, A., Montserrat, N., Bader, M. & Penninger, J. M. Cell 185, 1837-1839 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35623327  

Remote control of the heart and beyond. Zimmermann, W. H. Science 376, 917-918 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35617399  

Stand-alone Focal Impulse and Rotor Modulation (FIRM) ablation versus second-generation cryoballoon pulmonary vein isolation for paroxysmal atrial fibrillation. Tilz, R. R., Yalin, K., Lyan, E., Heeger, C. H., Schluter, M., Fink, T., Sciacca, V., Liosis, S., Kuck, K. H., Popescu, S. S., Mortensen, K., Meyer-Saraei, R., Eitel, C. & Vogler, J. J Cardiovasc Electrophysiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35615939  

Hidden Agenda - The Involvement of Endoplasmic Reticulum Stress and Unfolded Protein Response in Inflammation-Induced Muscle Wasting. Kny, M. & Fielitz, J. Front Immunol 13, 878755 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35615361  

Population kinetics of homoarginine and optimized supplementation for cardiovascular risk reduction. Kleist, C. J., Choe, C. U., Atzler, D., Schonhoff, M., Boger, R., Schwedhelm, E. & Wicha, S. G. Amino Acids 54, 889-896 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35618975  

Gender Differences in Takotsubo Syndrome. Arcari, L., Nunez Gil, I. J., Stiermaier, T., El-Battrawy, I., Guerra, F., Novo, G., Musumeci, B., Cacciotti, L., Mariano, E., Caldarola, P., Parisi, G., Montisci, R., Vitale, E., Sclafani, M., Volpe, M., Corbi-Pasqual, M., Martinez-Selles, M., Almendro-Delia, M., Sionis, A., Uribarri, A. et al. J Am Coll Cardiol 79, 2085-2093 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35618345  

Implementation of a Clinical Trial Recruitment Support System Based on Fast Healthcare Interoperability Resources (FHIR) in a Cardiology Department. Scherer, C., Endres, S., Orban, M., Kaab, S., Massberg, S., Winter, A. & Lobe, M. Stud Health Technol Inform 294, 440-444 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35612118  

Patient Characteristics, Procedural Characteristics, and Outcomes in Patients Having Lead Extraction in a High-Volume Center. O'Connor, M., Schmidt, P., Knoll, K., Schaarschmidt, C., Bock, M., Bahlke, F., Georgi, M., Frohlich, R., Sonne, C., Kottmaier, M., Reents, T., Bourier, F., Hessling, G., Deisenhofer, I., Kolb, C. & Lennerz, C. Am J Cardiol 176, 51-57 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35613955  

The long non-coding RNA MEG8 induces an endothelial barrier through regulation of microRNA-370 and -494 processing. Kremer, V., Stanicek, L., van Ingen, E., Bink, D. I., Hilderink, S., Tijsen, A. J., Wittig, I., Magdefessel, L., Nossent, A. Y. & Boon, R. A. J Cell Sci 135 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35611612  

Serotonin limits generation of chromaffin cells during adrenal organ development. Kameneva, P., Melnikova, V. I., Kastriti, M. E., Kurtova, A., Kryukov, E., Murtazina, A., Faure, L., Poverennaya, I., Artemov, A. V., Kalinina, T. S., Kudryashov, N. V., Bader, M., Skoda, J., Chlapek, P., Curylova, L., Sourada, L., Neradil, J., Tesarova, M., Pasqualetti, M., Gaspar, P. et al. Nat Commun 13, 2901 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35614045  

Protective actions of nuclear factor erythroid 2-related factor 2 (NRF2) and downstream pathways against environmental stressors. Bayo Jimenez, M. T., Frenis, K., Hahad, O., Steven, S., Cohen, G., Cuadrado, A., Munzel, T. & Daiber, A. Free Radic Biol Med 187, 72-91 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35613665  

Virtual reality in cardiac interventions-New tools or new toys? Sundermann, S. H., Hennemuth, A. & Kempfert, J. J Card Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35610730  

Safety and performance of a novel cerebral embolic protection device for transcatheter aortic valve implantation: the PROTEMBO C Trial. Jagielak, D., Targonski, R., Frerker, C., Abdel-Wahab, M., Wilde, J., Werner, N., Lauterbach, M., Leick, J., Grygier, M., Misterski, M., Erglis, A., Narbute, I., Witkowski, A. R., Adam, M., Frank, D., Gatto, F., Schmidt, T. & Lansky, A. J. EuroIntervention (2022). https://www.ncbi.nlm.nih.gov/pubmed/35608032  

Insulin-Like Growth Factor, Inflammation, and MRI Markers of Alzheimer's Disease in Predominantly Middle-Aged Adults. Wittfeld, K., Raman, M. R., Conner, S. C., Aslam, A., Teumer, A., Nauck, M., Hosten, N., Habes, M., DeCarli, C., Vasan, R. S., Beiser, A. S., Himali, J. J., Seshadri, S., Grabe, H. J. & Satizabal, C. L. J Alzheimers Dis (2022). https://www.ncbi.nlm.nih.gov/pubmed/35599493  

Real-Time Electrocardiogram Monitoring during Treadmill Training in Mice. Tomsits, P., Sharma Chivukula, A., Raj Chataut, K., Simahendra, A., Weckbach, L. T., Brunner, S. & Clauss, S. J Vis Exp (2022). https://www.ncbi.nlm.nih.gov/pubmed/35604201  

Drug-coated balloons in below-the-knee arteries. Stoll, F., Uslu, R., Blessing, E., Frey, N., Katus, H. A., Erbel, C., Heilmeier, B. & Muller, O. J. Vasa (2022). https://www.ncbi.nlm.nih.gov/pubmed/35604329  

Lived experiences of patients implanted with left ventricular assist devices. Inyom, C., Haese, T., Schoenrath, F., Potapov, E. & Knierim, J. Heart Lung 55, 155-161 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35605356  

Inflammatory Mediators in Atherosclerotic Vascular Remodeling. Evans, B. R., Yerly, A., van der Vorst, E. P. C., Baumgartner, I., Bernhard, S. M., Schindewolf, M. & Doring, Y. Front Cardiovasc Med 9, 868934 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35600479  

Awareness of sex and gender dimensions among physicians: the European federation of internal medicine assessment of gender differences in Europe (EFIM-IMAGINE) survey. Biskup, E., Marra, A. M., Ambrosino, I., Barbagelata, E., Basili, S., de Graaf, J., Gonzalvez-Gasch, A., Kaaja, R., Karlafti, E., Lotan, D., Kautzky-Willer, A., Perticone, M., Politi, C., Schenck-Gustafsson, K., Vilas-Boas, A., Roeters van Lennep, J., Gans, E. A., Regitz-Zagrosek, V., Pilote, L., Proietti, M. et al. Intern Emerg Med 17, 1395-1404 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35604515  

Outcomes with empagliflozin in heart failure with preserved ejection fraction using DELIVER-like endpoint definitions. Anker, S. D., Siddiqi, T. J., Filippatos, G., Zannad, F., Ferreira, J. P., Pocock, S. J., Brueckmann, M., Zeller, C., Packer, M. & Butler, J. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35604680  

Maternal socioeconomic and lifestyle factors and life dissatisfaction associated with a small for gestational age infant. The Survey of Neonates in Pomerania (SNiP). Pierdant, G., Ittermann, T., Freyer-Adam, J., Siewert-Markus, U., Grabe, H. J., Dorr, M., Heckmann, M., Zygmunt, M., Lange, A. E. & Markus, M. R. P. Arch Gynecol Obstet (2022). https://www.ncbi.nlm.nih.gov/pubmed/35599250  

Infective endocarditis due to Staphylococcus aureus in adults with congenital heart disease: The next challenge. Tutarel, O. Int J Cardiol 362, 74-75 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35597497  

Distinct pathophysiological pathways in women and men with heart failure. Ravera, A., Santema, B. T., de Boer, R. A., Anker, S. D., Samani, N. J., Lang, C. C., Ng, L., Cleland, J. G. F., Dickstein, K., Lam, C. S. P., Van Spall, H. G. C., Filippatos, G., van Veldhuisen, D. J., Metra, M., Voors, A. A. & Sama, I. E. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35596674  

Intranasal application of adeno-associated viruses: a systematic review. Gadenstaetter, A. J., Schmutzler, L., Grimm, D. & Landegger, L. D. Transl Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/35597541  

Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium. Siland, J. E., Geelhoed, B., Roselli, C., Wang, B., Lin, H. J., Weiss, S., Trompet, S., van den Berg, M. E., Soliman, E. Z., Chen, L. Y., Ford, I., Jukema, J. W., Macfarlane, P. W., Kornej, J., Lin, H., Lunetta, K. L., Kavousi, M., Kors, J. A., Ikram, M. A., Guo, X. et al. PLoS One 17, e0268768 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35594314  

Midterm Follow-up of the Transatrial-to-Left Ventricle Cannulation for Acute Type A Dissection. Puehler, T., Friedrich, C., Lutter, G., Frank, D., Saad, M., Seoudy, H., Salem, M., Schoettler, J., Cremer, J. & Haneya, A. Ann Thorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35595088  

Association of early electrical changes with cardiovascular outcomes in immune checkpoint inhibitor myocarditis. Power, J. R., Alexandre, J., Choudhary, A., Ozbay, B., Hayek, S. S., Asnani, A., Tamura, Y., Aras, M., Cautela, J., Thuny, F., Gilstrap, L., Arangalage, D., Ewer, S., Huang, S., Deswal, A., Palaskas, N. L., Finke, D., Lehmann, L. H., Ederhy, S., Moslehi, J. et al. Arch Cardiovasc Dis 115, 315-330 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35595646  

Empagliflozin in patients post myocardial infarction rationale and design of the EMPACT-MI trial. Harrington, J., Udell, J. A., Jones, W. S., Anker, S. D., Bhatt, D. L., Petrie, M. C., Vedin, O., Sumin, M., Zwiener, I., Hernandez, A. F. & Butler, J. Am Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35595091  

Inflammation and remodeling pathways and risk of cardiovascular events in patients with ischemic heart failure and reduced ejection fraction. Girerd, N., Cleland, J., Anker, S. D., Byra, W., Lam, C. S. P., Lapolice, D., Mehra, M. R., van Veldhuisen, D. J., Bresso, E., Lamiral, Z., Greenberg, B. & Zannad, F. Sci Rep 12, 8574 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35595781  

Sodium Glucose Cotransporter-2 Inhibition for Acute Myocardial Infarction: JACC Review Topic of the Week. Udell, J. A., Jones, W. S., Petrie, M. C., Harrington, J., Anker, S. D., Bhatt, D. L., Hernandez, A. F. & Butler, J. J Am Coll Cardiol 79, 2058-2068 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35589167  

The erythropoietin-derived peptide ARA 284 reduces tissue wasting and improves survival in a rat model of cancer cachexia. Palus, S., Elkina, Y., Braun, T., von Haehling, S., Dohner, W., Anker, S. D., Cerami, A., Brines, M. & Springer, J. J Cachexia Sarcopenia Muscle (2022). https://www.ncbi.nlm.nih.gov/pubmed/35586884  

Clinical Features and Natural History of Preadolescent Nonsyndromic Hypertrophic Cardiomyopathy. Norrish, G., Cleary, A., Field, E., Cervi, E., Boleti, O., Ziolkowska, L., Olivotto, I., Khraiche, D., Limongelli, G., Anastasakis, A., Weintraub, R., Biagini, E., Ragni, L., Prendiville, T., Duignan, S., McLeod, K., Ilina, M., Fernandez, A., Marrone, C., Bokenkamp, R. et al. J Am Coll Cardiol 79, 1986-1997 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35589160  

Characterization of critically ill patients with septic shock and sepsis-associated cardiomyopathy using cardiovascular MRI. Muehlberg, F., Blaszczyk, E., Will, K., Wilczek, S., Brederlau, J. & Schulz-Menger, J. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35587684

Obesity and Its Impact on Adverse In-Hospital Outcomes in Hospitalized Patients With COVID-19. Keller, K., Sagoschen, I., Schmitt, V. H., Sivanathan, V., Espinola-Klein, C., Lavie, C. J., Munzel, T. & Hobohm, L. Front Endocrinol (Lausanne) 13, 876028 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35586628  

Adjunctive Left Atrial Posterior Wall Isolation in Treating Atrial Fibrillation: Insight From a Large Secondary Analysis. Jiang, X., Liao, J., Ling, Z., Meyer, C., Sommer, P., Futyma, P., Martinek, M., Schratter, A., Acou, W. J., Wang, J., Zhu, L., Kiuchi, M. G., Purerfellner, H., Schmidt, B., Chun, J. K. R., Yin, Y. & Chen, S. JACC Clin Electrophysiol 8, 605-618 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35589173  

Identification of adeno-associated virus variants for gene transfer into human neural cell types by parallel capsid screening. Flitsch, L. J., Borner, K., Stullein, C., Ziegler, S., Sonntag-Buck, V., Wiedtke, E., Semkova, V., Au Yeung, S. W. C., Schlee, J., Hajo, M., Mathews, M., Ludwig, B. S., Kossatz, S., Kessler, H., Grimm, D. & Brustle, O. Sci Rep 12, 8356 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35589936  

Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages' transition into a pro-inflammatory state. Bosmans, L. A., van Tiel, C. M., Aarts, S., Willemsen, L., Baardman, J., van Os, B. W., den Toom, M., Beckers, L., Ahern, D. J., Levels, J. H. M., Jongejan, A., Moerland, P. D., Verberk, S. G. S., van den Bossche, J., de Winther, M., Weber, C., Atzler, D., Monaco, C., Gerdes, N., Shami, A. et al. Cardiovasc Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/35587037  

Impact of cardiac amyloidosis on outcomes of patients hospitalized with heart failure. Sebastian, G., Lukas, H., Alexander, D., Tommaso, G., Thomas, M., Rapezzi, C., Philip, W. & Karsten, K. Eur J Intern Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/35584975  

Impact of cardiac amyloidosis on outcomes of patients hospitalized with heart failure. Gobel, S., Hobohm, L., Desuki, A., Gori, T., Munzel, T., Claudio, R., Wenzel, P. & Keller, K. Eur J Intern Med 102, 88-96 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35584975  

New remote cerebral microbleeds in acute ischemic stroke: an analysis of the randomized, placebo-controlled WAKE-UP trial. Braemswig, T. B., Vynckier, J., Jensen, M., Boutitie, F., Galinovic, I., Simonsen, C. Z., Cheng, B., Cho, T. H., Scheitz, J. F., Fiehler, J., Puig, J., Thijs, V., Fiebach, J. B., Muir, K. W., Nighoghossian, N., Ebinger, M., Pedraza, S., Thomalla, G., Gerloff, C., Endres, M. et al. J Neurol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35585334  

Epicutaneous application of Imiquimod to model psoriasis-like skin disease induces water-saving aestivation motifs and vascular inflammation. Wild, J., Ringen, J., Bieler, T., Knopp, T., Lagrange, J., Molitor, M., Sies, K., Kropp, A., Keller, K., Daiber, A., Munzel, T., Rauh, M., Waisman, A., Wenzel, P., Titze, J. & Karbach, S. J Invest Dermatol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35580696  

The interplay between genetic variation and gene expression of the glucocorticoid receptor gene NR3C1 and blood cortisol levels on verbal memory and hippocampal volumes. Van der Auwera, S., Klinger-Konig, J., Wittfeld, K., Terock, J., Hannemann, A., Bulow, R., Nauck, M., Volker, U., Volzke, H. & Grabe, H. J. Eur Arch Psychiatry Clin Neurosci (2022). https://www.ncbi.nlm.nih.gov/pubmed/35579746  

The need for increased pragmatism in cardiovascular clinical trials. Usman, M. S., Van Spall, H. G. C., Greene, S. J., Pandey, A., McGuire, D. K., Ali, Z. A., Mentz, R. J., Fonarow, G. C., Spertus, J. A., Anker, S. D., Butler, J., James, S. K. & Khan, M. S. Nat Rev Cardiol, 1-14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35581337  

Piezo2 is not an indispensable mechanosensor in murine cardiomyocytes. Kloth, B., Mearini, G., Weinberger, F., Stenzig, J., Geertz, B., Starbatty, J., Lindner, D., Schumacher, U., Reichenspurner, H., Eschenhagen, T. & Hirt, M. N. Sci Rep 12, 8193 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35581325

Carotid ultrasonography improves residual risk stratification in guidelines-defined high cardiovascular risk patients. Georgiopoulos, G., Mavraganis, G., Delialis, D., Georgiou, S., Aivalioti, E., Patras, R., Petropoulos, I., Dimopoulou, M. A., Angelidakis, L., Sianis, A., Bampatsias, D., Dimoula, A., Maneta, E., Kosmopoulos, M., Vardavas, C., Stellos, K. & Stamatelopoulos, K. Eur J Prev Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35580589  

Head-to-head comparison between recommendations by the ESC and ACC/AHA/HFSA heart failure guidelines. Bayes-Genis, A., Aimo, A., Metra, M., Anker, S., Seferovic, P., Rapezzi, C., Castiglione, V., Nunez, J., Emdin, M., Rosano, G. & Coats, A. J. S. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35579428  

Increased Concentrations of Circulating Interleukins following Non-Invasive Vagus Nerve Stimulation: Results from a Randomized, Sham-Controlled, Crossover Study in Healthy Subjects. Veiz, E., Kieslich, S. K., Czesnik, D., Herrmann-Lingen, C., Meyer, T. & Staab, J. Neuroimmunomodulation, 1-10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35576915  

The Bidirectional Link Between RNA Cleavage and Polyadenylation and Genome Stability: Recent Insights From a Systematic Screen. Spada, S., Luke, B. & Danckwardt, S. Front Genet 13, 854907 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35571036  

Compensatory Upregulation of Anti-Beta-Adrenergic Receptor Antibody Levels Might Prevent Heart Failure Presentation in Pediatric Myocarditis. Seidel, F., Scheibenbogen, C., Heidecke, H., Opgen-Rhein, B., Pickardt, T., Klingel, K., Berger, F., Messroghli, D. & Schubert, S. Front Pediatr 10, 881208 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35573966  

RNA modification mapping with JACUSA2. Piechotta, M., Naarmann-de Vries, I. S., Wang, Q., Altmuller, J. & Dieterich, C. Genome Biol 23, 115 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35578346  

Very-high-power short-duration ablation for treatment of premature ventricular contractions - The FAST-AND-FURIOUS PVC study. Heeger, C. H., Popescu, S. S., Kirstein, B., Hatahet, S., Traub, A., Phan, H. L., Feher, M., G, D. A., Keelani, A., Schluter, M., Vogler, J., Eitel, C., Kuck, K. H. & Tilz, R. R. Int J Cardiol Heart Vasc 40, 101042 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35573650  

Case Report: Transient Increase of CMR T1 Mapping Indices in a Patient With COVID-19 mRNA Vaccine Induced Acute Myocarditis. Ansari, U., Britsch, S., Rogowski, S., Duerschmied, D. & Papavassiliu, T. Front Cardiovasc Med 9, 880717 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35571183

Gender-Specific Performance of One- Compared to Two-Catheter Concepts in Transradial Coronary Angiography - Insights From the Randomized UDDC-Radial-Trial. Schneider, V. S., Lubking, L., Stahli, B. E., Skurk, C., Lauten, A., Mochmann, H. C., Schauerte, P., Riedel, M., Steinbeck, L., Rauch-Krohnert, U., Klotsche, J., Landmesser, U., Frohlich, G. & Leistner, D. M. Cardiovasc Revasc Med 43, 49-54 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35570153  

Association between bone turnover markers and periodontitis: A population-based cross-sectional study. Reckelkamm, S. L., Hannemann, A., Kocher, T., Nauck, M., Volzke, H., Ehmke, B., Rauner, M., Alayash, Z., Baumeister, S. E., Nolde, M. & Holtfreter, B. J Clin Periodontol 49, 633-641 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35569034  

Whole blood transcriptomic profiling identifies molecular pathways related to cardiovascular mortality in heart failure. Nath, M., Romaine, S. P. R., Koekemoer, A., Hamby, S., Webb, T. R., Nelson, C. P., Castellanos-Uribe, M., Papakonstantinou, M., Anker, S. D., Lang, C. C., Metra, M., Zannad, F., Filippatos, G., van Veldhuisen, D. J., Cleland, J. G., Ng, L. L., May, S. T., Marelli-Berg, F., Voors, A. A., Timmons, J. A. et al. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35570197  

Heat shock protein A4 ablation leads to skeletal muscle myopathy associated with dysregulated autophagy and induced apoptosis. Elkenani, M., Barakat, A. Z., Held, T., Rodrigues, D. M., Mobarak, S., Swarnka, S., Adham, I. M. & Mohamed, B. A. J Transl Med 20, 229 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35568953  

Surgical aortic valve replacement in patients aged 50-69 years-insights from the German Aortic Valve Registry (GARY). Vogt, F., Santarpino, G., Fujita, B., Frerker, C., Bauer, T., Beckmann, A., Bekeredjian, R., Bleiziffer, S., Mollmann, H., Walther, T., Beyersdorf, F., Hamm, C., Boning, A., Baldus, S., Ensminger, S., Fischlein, T., Eckner, D. & Board, G. E. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35567484  

Behavioral Health Risk Factors and Motivation to Change among Cardiovascular General Hospital Patients Aged 50 to 79 Years. Siewert-Markus, U., Ulbricht, S., Gaertner, B., Zyriax, B. C., Dorr, M., Tobschall, S., Baumann, S., John, U. & Freyer-Adam, J. Nutrients 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35565928  

Comparable Analysis of Acute Changes in Vascular Tone after Coffee versus Energy Drink Consumption. Schuttler, D., Hamm, W., Kellnar, A., Brunner, S. & Stremmel, C. Nutrients 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35565863  

Peripheral Serotonin Deficiency Affects Anxiety-like Behavior and the Molecular Response to an Acute Challenge in Rats. Sbrini, G., Hanswijk, S. I., Brivio, P., Middelman, A., Bader, M., Fumagalli, F., Alenina, N., Homberg, J. R. & Calabrese, F. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35563331  

Overexpression of Renin-B Induces Warburg-like Effects That Are Associated with Increased AKT/mTOR Signaling. Golchert, J., Staar, D., Bennewitz, J., Hartmann, M., Hoffmann, N., Ameling, S., Volker, U., Peters, J. & Wanka, H. Cells 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35563765  

Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture-prone atherosclerotic plaques. Edsfeldt, A., Swart, M., Singh, P., Dib, L., Sun, J., Cole, J. E., Park, I., Al-Sharify, D., Persson, A., Nitulescu, M., Borges, P. D. N., Kassiteridi, C., Goddard, M. E., Lee, R., Volkov, P., Orho-Melander, M., Maegdefessel, L., Nilsson, J., Udalova, I., Goncalves, I. et al. Eur Heart J 43, 1864-1877 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35567557  

In vivo Visualization of M2 Macrophages in the Myocardium After Myocardial Infarction (MI) Using (68) Ga-NOTA-Anti-MMR Nb: Targeting Mannose Receptor (MR, CD206) on M2 Macrophages. Varasteh, Z., Braeuer, M., Mohanta, S., Steinsiek, A. L., Habenicht, A., Omidvari, N., Topping, G. J., Rischpler, C., Weber, W. A., Sager, H. B., Raes, G., Hernot, S. & Schwaiger, M. Front Cardiovasc Med 9, 889963 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35548425  

Anticoagulation for Percutaneous Ventricular Assist Device-Supported Cardiogenic Shock: JACC Review Topic of the Week. Vandenbriele, C., Arachchillage, D. J., Frederiks, P., Giustino, G., Gorog, D. A., Gramegna, M., Janssens, S., Meyns, B., Polzin, A., Scandroglio, M., Schrage, B., Stone, G. W., Tavazzi, G., Vanassche, T., Vranckx, P., Westermann, D., Price, S. & Chieffo, A. J Am Coll Cardiol 79, 1949-1962 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35550692  

Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors. Poch, C. M., Foo, K. S., De Angelis, M. T., Jennbacken, K., Santamaria, G., Bahr, A., Wang, Q. D., Reiter, F., Hornaschewitz, N., Zawada, D., Bozoglu, T., My, I., Meier, A., Dorn, T., Hege, S., Lehtinen, M. L., Tsoi, Y. L., Hovdal, D., Hyllner, J., Schwarz, S. et al. Nat Cell Biol 24, 659-671 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35550611  

Letter to the Editor. Response to "Diagnosis of CAV in OCT Scans From Heart Transplanted Patients". Orban, M. & Massberg, S. Transplant Direct 8, e1326 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35557990  

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Mahajan, A., Spracklen, C. N., Zhang, W., Ng, M. C. Y., Petty, L. E., Kitajima, H., Yu, G. Z., Rueger, S., Speidel, L., Kim, Y. J., Horikoshi, M., Mercader, J. M., Taliun, D., Moon, S., Kwak, S. H., Robertson, N. R., Rayner, N. W., Loh, M., Kim, B. J., Chiou, J. et al. Nat Genet 54, 560-572 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35551307  

Integrated care for optimizing the management of stroke and associated heart disease: a position paper of the European Society of Cardiology Council on Stroke. Lip, G. Y. H., Lane, D. A., Lenarczyk, R., Boriani, G., Doehner, W., Benjamin, L. A., Fisher, M., Lowe, D., Sacco, R. L., Schnabel, R., Watkins, C., Ntaios, G. & Potpara, T. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35552401

Periprocedural Strategies for Stroke Prevention in Patients Undergoing Transcatheter Aortic Valve Implantation. Linder, M. & Seiffert, M. Front Cardiovasc Med 9, 892956 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35557539  

Paediatric inflammatory multisystem syndrome - temporally associated with SARS-CoV-2 (PIMS-TS) - a German single centre real-life evaluation of the Swiss and UK consensus statements. Jenke, A. & Steinmetz, M. Cardiol Young, 1-5 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35546290  

Integrative analysis of clinical and epigenetic biomarkers of mortality. Huan, T., Nguyen, S., Colicino, E., Ochoa-Rosales, C., Hill, W. D., Brody, J. A., Soerensen, M., Zhang, Y., Baldassari, A., Elhadad, M. A., Toshiko, T., Zheng, Y., Domingo-Relloso, A., Lee, D. H., Ma, J., Yao, C., Liu, C., Hwang, S. J., Joehanes, R., Fornage, M. et al. Aging Cell 21, e13608 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35546478  

Zfp580 Regulates Paracrine and Endocrine Igf1 and Igfbp3 Differently in the Brain and Blood After a Murine Stroke. Hoffmann, C. J., Kuffner, M. T. C., Lips, J., Lorenz, S., Endres, M. & Harms, C. Front Physiol 13, 887180 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35557964  

Paradigm shift: new concepts for HCN4 function in cardiac pacemaking. Hennis, K., Biel, M., Fenske, S. & Wahl-Schott, C. Pflugers Arch 474, 649-663 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35556164  

Rapid Inflammasome Activation Is Attenuated in Post-Myocardial Infarction Monocytes. Giral, H., Franke, V., Moobed, M., Muller, M. F., Lubking, L., James, D. M., Hartung, J., Kuschnerus, K., Meteva, D., Seppelt, C., Jakob, P., Klingenberg, R., Krankel, N., Leistner, D., Zeller, T., Blankenberg, S., Zimmermann, F., Haghikia, A., Luscher, T. F., Akalin, A. et al. Front Immunol 13, 857455 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35558073  

The Increasing Role of Rhythm Control in Patients With Atrial Fibrillation: JACC State-of-the-Art Review. Camm, A. J., Naccarelli, G. V., Mittal, S., Crijns, H., Hohnloser, S. H., Ma, C. S., Natale, A., Turakhia, M. P. & Kirchhof, P. J Am Coll Cardiol 79, 1932-1948 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35550691  

Graded lower body negative pressure induces intraventricular negative pressures and incremental diastolic suction: a pressure-volume study in a porcine model. Berboth, L., Zirngast, B., Manninger, M., Steendijk, P., Tschope, C., Scherr, D., Hinghofer-Szalkay, H. G., Goswami, N., Petersen, L. G., Machler, H. & Alogna, A. J Appl Physiol (1985) 133, 20-26 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35546125  

Molybdenum Cofactor Catabolism Unravels the Physiological Role of the Drug Metabolizing Enzyme Thiopurine S-Methyltransferase. Pristup, J., Schaeffeler, E., Arjune, S., Hofmann, U., Angel Santamaria-Araujo, J., Leuthold, P., Friedrich, N., Nauck, M., Mayr, S., Haag, M., Muerdter, T., Marner, F. J., Relling, M. V., Evans, W. E., Schwarz, G. & Schwab, M. Clin Pharmacol Ther (2022). https://www.ncbi.nlm.nih.gov/pubmed/35538648  

Multicomponent intervention to prevent mobility disability in frail older adults: randomised controlled trial (SPRINTT project). Bernabei, R., Landi, F., Calvani, R., Cesari, M., Del Signore, S., Anker, S. D., Bejuit, R., Bordes, P., Cherubini, A., Cruz-Jentoft, A. J., Di Bari, M., Friede, T., Gorostiaga Ayestaran, C., Goyeau, H., Jonsson, P. V., Kashiwa, M., Lattanzio, F., Maggio, M., Mariotti, L., Miller, R. R. et al. BMJ 377, e068788 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35545258  

Reference Values for Pediatric Atrial Volumes Assessed by Steady-State Free-Precession Magnetic Resonance Imaging Using Monoplane and Biplane Area-Length Methods. Voges, I., Caliebe, A., Hinz, S., Boroni Grazioli, S., Gabbert, D. D., Wegner, P., Uebing, A. S., Daubeney, P. E. F., Pennell, D. J. & Krupickova, S. J Magn Reson Imaging (2022). https://www.ncbi.nlm.nih.gov/pubmed/35535720  

Association of C-Terminal Pro-Endothelin-1 with Mortality in the Population-Based KORA F4 Study. Then, C., Sujana, C., Herder, C., Then, H., Heier, M., Meisinger, C., Peters, A., Koenig, W., Rathmann, W., Maalmi, H., Ritzel, K., Roden, M., Stumvoll, M., Thorand, B. & Seissler, J. Vasc Health Risk Manag 18, 335-346 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35535305  

Intravenous immunoglobulins for treatment of severe COVID-19-related acute encephalopathy. Huo, S., Ferse, C., Bosl, F., Reincke, S. M., Enghard, P., Hinrichs, C., Treskatsch, S., Angermair, S., Eckardt, K. U., Audebert, H. J., Ploner, C. J., Endres, M., Pruss, H., Franke, C. & Scheibe, F. J Neurol, 1-8 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35538168  

Sphingosine-1-phosphate and vascular disease in the general population. Rotheudt, L., Moritz, E., Markus, M. R. P., Albrecht, D., Volzke, H., Friedrich, N., Schwedhelm, E., Daum, G., Schminke, U., Felix, S. B., Rauch, B. H., Dorr, M. & Bahls, M. Atherosclerosis 350, 73-81 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35533519  

Combined Oral Triglyceride and Glucose Tolerance Test After Acute Ischemic Stroke to Predict Recurrent Vascular Events: The Berlin "Cream&Sugar" Study. Nave, A. H., Kaynak, N., Mai, K., Siegerink, B., Laufs, U., Heuschmann, P. U., Liman, T. G., Ebinger, M. & Endres, M. Stroke, 101161STROKEAHA122038732 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35531780   

Long noncoding RNAs in cardiometabolic disorders. Juni, R. P., t Hart, K. C., Houtkooper, R. H. & Boon, R. A. FEBS Lett 596, 1367-1387 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35531641  

The splicing-regulatory lncRNA NTRAS sustains vascular integrity. Fouani, Y., Kirchhof, L., Stanicek, L., Luxan, G., Heumuller, A. W., Knau, A., Fischer, A., Devraj, K., John, D., Neumann, P., Bindereif, A., Boon, R. A., Liebner, S., Wittig, I., Mogler, C., Karimova, M., Dimmeler, S. & Jae, N. EMBO Rep 23, e54157 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35527520  

Propofol versus midazolam sedation in patients with cardiogenic shock - an observational propensity-matched study. Scherer, C., Kleeberger, J., Kellnar, A., Binzenhofer, L., Lusebrink, E., Stocker, T. J., Berghoff, S. A., Keutner, A., Thienel, M., Deseive, S., Stark, K., Braun, D., Orban, M., Petzold, T., Brunner, S., Hagl, C., Hausleiter, J., Massberg, S. & Orban, M. J Crit Care 71, 154051 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35526506  

Association of osteopontin with kidney function and kidney failure in chronic kidney disease patients: the GCKD study. Steinbrenner, I., Sekula, P., Kotsis, F., von Cube, M., Cheng, Y., Nadal, J., Schmid, M., Schneider, M. P., Krane, V., Nauck, M., Eckardt, K. U., Schultheiss, U. T. & investigators, G. Nephrol Dial Transplant (2022). https://www.ncbi.nlm.nih.gov/pubmed/35524694  

Association of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis. Kuramatsu, J. B., Gerner, S. T., Ziai, W., Bardutzky, J., Sembill, J. A., Sprugel, M. I., Mrochen, A., Kolbl, K., Ram, M., Avadhani, R., Falcone, G. J., Selim, M. H., Lioutas, V. A., Endres, M., Zweynert, S., Vajkoczy, P., Ringleb, P. A., Purrucker, J. C., Volkmann, J., Neugebauer, H. et al. Stroke 53, 2876-2886 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35521958  

A prospective case-control validation of procalcitonin as a biomarker diagnosing pacemaker and implantable cardioverter defibrillator pocket infection. Knoll, K., O'Connor, M., Chouchane, A., Haller, B., Schaarschmidt, C., Bock, M., Forschner, L., Frohlich, R., Kottmaier, M., Bourier, F., Reents, T., Hessling, G., Deisenhofer, I., Kolb, C. & Lennerz, C. Kardiol Pol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35521718  

The Atrial Fibrillation Heart Team-guiding therapy in left atrial appendage occlusion with increasingly complex patients and little evidence. Kany, S., Metzner, A., Lubos, E. & Kirchhof, P. Eur Heart J 43, 1691-1692 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35523426  

Phenotypic screen identifies FOXO inhibitor to counteract maturation and promote expansion of human iPS cell-derived cardiomyocytes. Schade, D., Drowley, L., Wang, Q. D., Plowright, A. T. & Greber, B. Bioorg Med Chem 65, 116782 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35512484  

Heart Sweet Heart - Cardiac long-term effects of sugar kisses. Markus, M. R. P. & Dorr, M. Eur J Prev Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35512424  

Long-Term Outcomes of Patients With Elevated Mitral Valve Pressure Gradient After Mitral Valve Edge-to-Edge Repair. Koell, B., Ludwig, S., Weimann, J., Waldschmidt, L., Hildebrandt, A., Schofer, N., Schirmer, J., Westermann, D., Reichenspurner, H., Blankenberg, S., Conradi, L., Lubos, E. & Kalbacher, D. JACC Cardiovasc Interv 15, 922-934 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35512916  

Treatment of the aortic root in acute aortic dissection type A: insights from the German Registry for Acute Aortic Dissection Type A. Kallenbach, K., Busch, C., Rylski, B., Dohle, D. S., Kruger, T., Holubec, T., Brickwedel, J., Poling, J., Noack, T., Hagl, C., Jawny, P., Boning, A., Chalabi, K., Karck, M. & Arif, R. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35511255  

Treating depression in patients with heart failure: what is (not) recommended? Herrmann-Lingen, C. Eur J Prev Cardiol 29, 2137-2139 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35512436  

Perceived vs. objective frailty in patients with atrial fibrillation and impact on anticoagulant dosing: an ETNA-AF-Europe sub-analysis. Diemberger, I., Fumagalli, S., Mazzone, A. M., Bakhai, A., Reimitz, P. E., Pecen, L., Manu, M. C., Gordillo de Souza, J. A., Kirchhof, P. & De Caterina, R. Europace (2022). https://www.ncbi.nlm.nih.gov/pubmed/35512229  

Course of disease and risk factors for hospitalization in outpatients with a SARS-CoV-2 infection. Schafer, E., Scheer, C., Salje, K., Fritz, A., Kohlmann, T., Hubner, N. O., Napp, M., Fiedler-Lacombe, L., Stahl, D., Rauch, B., Nauck, M., Volker, U., Felix, S., Lucchese, G., Floel, A., Engeli, S., Hoffmann, W., Hahnenkamp, K. & Tzvetkov, M. V. Sci Rep 12, 7249 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35508524  

Right on target: The next class of efficient, safe, and specific RNAi triggers. Becker, J., Fischer, N. & Grimm, D. Mol Ther Nucleic Acids 28, 363-365 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35505965  

DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases. Wielscher, M., Mandaviya, P. R., Kuehnel, B., Joehanes, R., Mustafa, R., Robinson, O., Zhang, Y., Bodinier, B., Walton, E., Mishra, P. P., Schlosser, P., Wilson, R., Tsai, P. C., Palaniswamy, S., Marioni, R. E., Fiorito, G., Cugliari, G., Karhunen, V., Ghanbari, M., Psaty, B. M. et al. Nat Commun 13, 2408 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35504910  

Cerebral oxygen saturation as outcome predictor after transfemoral transcatheter aortic valve implantation. Seppelt, P. C., Mas-Peiro, S., Van Linden, A., Iken, S., Zacharowski, K., Walther, T., Fichtlscherer, S. & Vasa-Nicotera, M. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35505123  

Predictors of primary prevention implantable cardioverter-defibrillator use in heart failure with reduced ejection fraction: impact of the predicted risk of sudden cardiac death and all-cause mortality. Schrage, B., Lund, L. H., Benson, L., Dahlstrom, U., Shadman, R., Linde, C., Braunschweig, F., Levy, W. C. & Savarese, G. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35502681  

Myeloid differentiation factor-2 activates monocytes in patients with dilated cardiomyopathy. Feldtmann, R., Kummel, A., Chamling, B., Strohbach, A., Lehnert, K., Gross, S., Loerzer, L., Riad, A., Lindner, D., Westermann, D., Fielitz, J., Dorr, M. & Felix, S. B. Immunology 167, 40-53 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35502635  

Increased cytosolic calcium buffering contributes to a cellular arrhythmogenic substrate in iPSC-cardiomyocytes from patients with dilated cardiomyopathy. Jung, P., Seibertz, F., Fakuade, F. E., Ignatyeva, N., Sampathkumar, S., Ritter, M., Li, H., Mason, F. E., Ebert, A. & Voigt, N. Basic Res Cardiol 117, 5 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35499658  

Association Between the Acidemia, Lactic Acidosis, and Shock Severity With Outcomes in Patients With Cardiogenic Shock. Jentzer, J. C., Schrage, B., Patel, P. C., Kashani, K. B., Barsness, G. W., Holmes, D. R., Jr., Blankenberg, S., Kirchhof, P. & Westermann, D. J Am Heart Assoc 11, e024932 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35491996  

Diagnostic role of echocardiography for patients with heart failure symptoms and preserved left ventricular ejection fraction. Hagendorff, A., Stobe, S., Kandels, J., de Boer, R. & Tschope, C. Herz (2022). https://www.ncbi.nlm.nih.gov/pubmed/35499562  

ExomeChip-based rare variant association study in restless legs syndrome. Tilch, E., Schormair, B., Zhao, C., Hogl, B., Stefani, A., Berger, K., Trenkwalder, C., Bachmann, C. G., Hornyak, M., Fietze, I., Muller-Nurasyid, M., Peters, A., Herms, S., Nothen, M. M., Muller-Myhsok, B., Oexle, K. & Winkelmann, J. Sleep Med 94, 26-30 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35489115  

Up next: The dawn of systems biology in HFpEF research. Bode, D., Sotomayor-Flores, C. & Schiattarella, G. G. J Mol Cell Cardiol 168, 96-97 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35489386  

Cardiac remodelling - Part 2: Clinical, imaging and laboratory findings. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology. Aimo, A., Vergaro, G., Gonzalez, A., Barison, A., Lupon, J., Delgado, V., Richards, A. M., de Boer, R. A., Thum, T., Arfsten, H., Hulsmann, M., Falcao-Pires, I., Diez, J., Foo, R. S. Y., Chan, M. Y. Y., Anene-Nzelu, C. G., Abdelhamid, M., Adamopoulos, S., Anker, S. D., Belenkov, Y. et al. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35488811  


Juni

Diagnostic Value of sST2, VCAM-1, and Adiponectin in Patients with Breast Cancer to Predict Anti-Tumour Treatment-Related Cardiac Events: A Pilot Study. Rosenkaimer, S. L., Winter, L., Sieburg, T., Maier, S., Mavratzas, A., Hofmann, W. K., Akin, I., Duerschmied, D., Hofheinz, R. D. & Hohneck, A. Oncol Res Treat 45, 598-607 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35764064   

Immunometabolic Mechanisms of Heart Failure with Preserved Ejection Fraction. Schiattarella, G. G., Alcaide, P., Condorelli, G., Gillette, T. G., Heymans, S., Jones, E. A. V., Kallikourdis, M., Lichtman, A., Marelli-Berg, F., Shah, S., Thorp, E. B. & Hill, J. A. Nat Cardiovasc Res 1, 211-222 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35755006  

Validation of Cardiovascular Risk Prediction by the Arriba Instrument. Angelow, A., Klotzer, C., Donner-Banzhoff, N., Haasenritter, J., Schmidt, C. O., Dorr, M. & Chenot, J. F. Dtsch Arztebl Int 119, 476-482 (2022). www.ncbi.nlm.nih.gov/pubmed/35635438  

Effects of Early Empagliflozin Initiation on Diuresis and Kidney Function in Patients With Acute Decompensated Heart Failure (EMPAG-HF). Schulze, P. C., Bogoviku, J., Westphal, J., Aftanski, P., Haertel, F., Grund, S., von Haehling, S., Schumacher, U., Mobius-Winkler, S. & Busch, M. Circulation 146, 289-298 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35766022  

First clinical experience of high-power ablation of atrial fibrillation with a novel contact force-sensing gold-tip catheter. Parwani, A. S., Jayanata, A., Kraft, R., Lacour, P., Blaschke, F., Pieske, B. & Boldt, L. H. Cardiol J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35762071  

Empagliflozin for Heart Failure With Preserved Left Ventricular Ejection Fraction With and Without Diabetes. Filippatos, G., Butler, J., Farmakis, D., Zannad, F., Ofstad, A. P., Ferreira, J. P., Green, J. B., Rosenstock, J., Schnaidt, S., Brueckmann, M., Pocock, S. J., Packer, M., Anker, S. D., Committees, E. M.-P. T. & Investigators. Circulation 146, 676-686 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35762322  

Association of birth weight with corneal aberrations in adulthood – Results from a population-based study. Fieß, A., Urschitz, M. S., Nagler, M., Nickels, S., Marx-Groß, S., Münzel, T., Wild, P. S., Beutel, M. E., Lackner, K. J., Pfeiffer, N. & Schuster, A. K. Journal of Optometry (2022).

Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension. Tabeling, C., Gonzalez Calera, C. R., Lienau, J., Hoppner, J., Tschernig, T., Kershaw, O., Gutbier, B., Naujoks, J., Herbert, J., Opitz, B., Gruber, A. D., Hocher, B., Suttorp, N., Heidecke, H., Burmester, G. R., Riemekasten, G., Siegert, E., Kuebler, W. M. & Witzenrath, M. Front Immunol 13, 895501 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35757687  

LINC01013 Is a Determinant of Fibroblast Activation and Encodes a Novel Fibroblast-Activating Micropeptide. Quaife, N. M., Chothani, S., Schulz, J. F., Lindberg, E. L., Vanezis, K., Adami, E., O'Fee, K., Greiner, J., Litvinukova, M., van Heesch, S., Whiffin, N., Hubner, N., Schafer, S., Rackham, O., Cook, S. A. & Barton, P. J. R. J Cardiovasc Transl Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/35759180  

Targeted Analysis of circRNA Expression in Patient Samples by Lexo-circSeq. Naarmann-de Vries, I. S., Eschenbach, J., Schudy, S., Meder, B. & Dieterich, C. Front Mol Biosci 9, 875805 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35755822  

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model. Hao, Y., Sun, X., Kiekenap, J. F. S., Emeis, J., Steitz, M., Breitenstein-Attach, A., Berger, F. & Schmitt, B. J Vis Exp (2022). https://www.ncbi.nlm.nih.gov/pubmed/35758699  

Respiratory and heart rate dynamics during peripheral chemoreceptor deactivation compared to targeted sympathetic and sympathetic/parasympathetic (co-)activation. Apelt-Glitz, K., Alken, F. A., Jungen, C., Scherschel, K., Klocker, N. & Meyer, C. Auton Neurosci 241, 103009 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35753247  

Prevention of sudden death in heart failure with reduced ejection fraction: Do we still need ICD for primary prevention? Abdelhamid, M., Rosano, G., Metra, M., Adamopoulos, S., Bohm, M., Chioncel, O., Filippatos, G., Jankowska, E. A., Lopatin, Y., Lund, L., Milicic, D., Moura, B., Ben Gal, T., Ristic, A., Rakisheva, A., Savarese, G., Mullens, W., Piepoli, M., Bayes-Genis, A., Thum, T. et al. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35753058  

Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood-brain barrier in acute ischemic stroke. Spitzer, D., Guerit, S., Puetz, T., Khel, M. I., Armbrust, M., Dunst, M., Macas, J., Zinke, J., Devraj, G., Jia, X., Croll, F., Sommer, K., Filipski, K., Freiman, T. M., Looso, M., Gunther, S., Di Tacchio, M., Plate, K. H., Reiss, Y., Liebner, S. et al. Acta Neuropathol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35752654  

ClearCNV: CNV calling from NGS panel data in the presence of ambiguity and noise. May, V., Koch, L., Fischer-Zirnsak, B., Horn, D., Gehle, P., Kornak, U., Beule, D. & Holtgrewe, M. Bioinformatics (2022). https://www.ncbi.nlm.nih.gov/pubmed/35751599  

Riociguat attenuates left ventricular proteome and microRNA profile changes after experimental aortic stenosis in mice. Benkner, A., Rudebusch, J., Nath, N., Hammer, E., Grube, K., Gross, S., Dhople, V. M., Eckstein, G., Meitinger, T., Kaderali, L., Volker, U., Fielitz, J. & Felix, S. B. Br J Pharmacol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35751875  

Evaluation of the putative lymphoma-associated point mutation D427H in the STAT3 transcription factor. Behrendsen, L. S., Menon, P. R., Khan, M. J., Gregus, A., Wirths, O., Meyer, T. & Staab, J. BMC Mol Cell Biol 23, 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35752777  

In Vivo Inhibition of TRPC6 by SH045 Attenuates Renal Fibrosis in a New Zealand Obese (NZO) Mouse Model of Metabolic Syndrome. Zheng, Z., Xu, Y., Krugel, U., Schaefer, M., Grune, T., Nurnberg, B., Kohler, M. B., Gollasch, M., Tsvetkov, D. & Marko, L. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35743312  

Transcatheter Mitral Valve Repair or Replacement: Competitive or Complementary? Xiling, Z., Puehler, T., Sondergaard, L., Frank, D., Seoudy, H., Mohammad, B., Muller, O. J., Sellers, S., Meier, D., Sathananthan, J. & Lutter, G. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35743448  

Measurement of Tetrahydrobiopterin in Animal Tissue Samples by HPLC with Electrochemical Detection-Protocol Optimization and Pitfalls. Vujacic-Mirski, K., Oelze, M., Kuntic, I., Kuntic, M., Kalinovic, S., Li, H., Zielonka, J., Munzel, T. & Daiber, A. Antioxidants (Basel) 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35740082  

Impact of different training modalities on high-density lipoprotein function in HFpEF patients: a substudy of the OptimEx trial. Sowa, P. W., Winzer, E. B., Hommel, J., Mannel, A., van Craenenbroeck, E. M., Wisloff, U., Pieske, B., Halle, M., Linke, A. & Adams, V. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35747946  

Surgery for Aortic Prosthetic Valve Endocarditis in the Transcatheter Era. Saha, S., Ali, A., Schnackenburg, P., Horke, K. M., Oberbach, A., Schlichting, N., Sadoni, S., Rizas, K., Braun, D., Luehr, M., Bagaev, E., Hagl, C. & Joskowiak, D. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35743488  

Exploring the Potential of Symmetric Exon Deletion to Treat Non-Ischemic Dilated Cardiomyopathy by Removing Frameshift Mutations in TTN. Rodriguez-Polo, I. & Behr, R. Genes (Basel) 13 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35741855  

Platelets and the Role of P2X Receptors in Nociception, Pain, Neuronal Toxicity and Thromboinflammation. Rawish, E. & Langer, H. F. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35743029  

Modulation of Rxralpha Expression in Mononuclear Phagocytes Impacts on Cardiac Remodeling after Ischemia-Reperfusion Injury. Rauber, S., Fischer, M., Messerer, D., Wimmler, V., Konda, K., Todica, A., Lorenz, M., Titova, A., Schulz, C. & Weinberger, T. Biomedicines 10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35740296  

Early and Strong Leptin Reduction Is Predictive for Long-Term Weight Loss during High-Protein, Low-Glycaemic Meal Replacement-A Subanalysis of the Randomised-Controlled ACOORH Trial. Kempf, K., Rohling, M., Banzer, W., Braumann, K. M., Halle, M., Schaller, N., McCarthy, D., Predel, H. G., Schenkenberger, I., Tan, S., Toplak, H., Martin, S., Berg, A. & Acoorh Study, G. Nutrients 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35745267  

NADPH Oxidases in Pain Processing. Kallenborn-Gerhardt, W., Schroder, K. & Schmidtko, A. Antioxidants (Basel) 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35740059  

Clinical implications of left atrial changes after optimization of medical therapy in patients with heart failure. Inciardi, R. M., Pagnesi, M., Lombardi, C. M., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G. S., Lang, C. C., Ng, L. L., Pellicori, P., Ponikowski, P., Samani, N. J., Zannad, F., van Veldhuisen, D. J., Solomon, S. D., Voors, A. A. & Metra, M. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35748048  

Ethyl Hydroxyethyl Cellulose-A Biocompatible Polymer Carrier in Blood. Eckelt, A., Wichmann, F., Bayer, F., Eckelt, J., Gross, J., Opatz, T., Jurk, K., Reinhardt, C. & Kiouptsi, K. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35742876  

Molecular Detection of Venous Thrombosis in Mouse Models Using SPECT/CT. Dickhout, A., Van de Vijver, P., Bitsch, N., van Hoof, S. J., Thomassen, S., Massberg, S., Timmerman, P., Verhaegen, F., Koenen, R. R., Dijkgraaf, I. & Hackeng, T. M. Biomolecules 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35740954  

Blinded by the Lights: OCT-Guidance for Implantation of Magnesium-Based Bioresorbable Scaffolds? Seguchi, M. & Joner, M. Cardiovasc Revasc Med 40, 111-112 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35738727  

Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs. Kokot, K. E., Kneuer, J. M., John, D., Rebs, S., Mobius-Winkler, M. N., Erbe, S., Muller, M., Andritschke, M., Gaul, S., Sheikh, B. N., Haas, J., Thiele, H., Muller, O. J., Hille, S., Leuschner, F., Dimmeler, S., Streckfuss-Bomeke, K., Meder, B., Laufs, U. & Boeckel, J. N. Basic Res Cardiol 117, 32 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35737129  

Kidney Failure among Patients with Takotsubo Syndrome or Myocardial Infarction: A Retrospective Analysis. Bill, V., El-Battrawy, I., Kummer, M., Mugge, A., Aweimer, A., Behnes, M. & Akin, I. J Cardiovasc Dev Dis 9 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35735815  

Side effects and treatment initiation barriers of SGLT2 inhibitors in heart failure: A systematic review and meta-analysis. Vukadinovic, D., Abdin, A., Anker, S. D., Rosano, G. M., Mahfoud, F., Packer, M., Butler, J. & Bohm, M. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35730422  

Clonal haematopoiesis is associated with higher mortality in patients with cardiogenic shock. Scolari, F. L., Abelson, S., Brahmbhatt, D. H., Medeiros, J. J. F., Fan, C. S., Fung, N. L., Mihajlovic, V., Anker, M. S., Otsuki, M., Lawler, P. R., Ross, H. J., Luk, A. C., Anker, S., Dick, J. E. & Billia, F. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35729851  

German Cardiac Arrest Registry: rationale and design of G-CAR. Poss, J., Sinning, C., Schreiner, I., Apfelbacher, C., Drewitz, K. P., Hosler, N., Schneider, S., Pieske, B., Bottiger, B. W., Ewen, S., Wienbergen, H., Kelm, M., Bock, D., Graf, T., Adler, C., Dutzmann, J., Knie, W., Orban, M., Zeymer, U., Michels, G. et al. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35729429  

Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy. Perea-Gil, I., Seeger, T., Bruyneel, A. A. N., Termglinchan, V., Monte, E., Lim, E. W., Vadgama, N., Furihata, T., Gavidia, A. A., Arthur Ataam, J., Bharucha, N., Martinez-Amador, N., Ameen, M., Nair, P., Serrano, R., Kaur, B., Feyen, D. A. M., Diecke, S., Snyder, M. P., Metallo, C. M. et al. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35728000  

A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth. Ong, Y. T., Andrade, J., Armbruster, M., Shi, C., Castro, M., Costa, A. S. H., Sugino, T., Eelen, G., Zimmermann, B., Wilhelm, K., Lim, J., Watanabe, S., Guenther, S., Schneider, A., Zanconato, F., Kaulich, M., Pan, D., Braun, T., Gerhardt, H., Efeyan, A. et al. Nat Metab 4, 672-682 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35726026  

Elucidation of the genetic causes of bicuspid aortic valve disease. Gehlen, J., Stundl, A., Debiec, R., Fontana, F., Krane, M., Sharipova, D., Nelson, C. P., Al-Kassou, B., Giel, A. S., Sinning, J. M., Bruenger, C. M., Zelck, C. F., Koebbe, L. L., Braund, P. S., Webb, T. R., Hetherington, S., Ensminger, S., Fujita, B., Mohamed, S. A., Shrestha, M. et al. Cardiovasc Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/35727948  

Feasible approaches and implementation challenges to atrial fibrillation screening: a qualitative study of stakeholder views in 11 European countries. Engler, D., Hanson, C. L., Desteghe, L., Boriani, G., Diederichsen, S. Z., Freedman, B., Pala, E., Potpara, T. S., Witt, H., Heidbuchel, H., Neubeck, L., Schnabel, R. B. & investigators, A.-E. BMJ Open 12, e059156 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35728895  

Blood flow meets mitophagy. Akmeric, E. B. & Gerhardt, H. J Cell Biol 221 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35727256  

Calpain cleavage of Junctophilin-2 generates a spectrum of calcium-dependent cleavage products and DNA-rich NT1-fragment domains in cardiomyocytes. Weninger, G., Pochechueva, T., El Chami, D., Luo, X., Kohl, T., Brandenburg, S., Urlaub, H., Guan, K., Lenz, C. & Lehnart, S. E. Sci Rep 12, 10387 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35725601  

Variation in Mean Arterial Pressure Increases Falls Risk in Elderly Physically Frail and Prefrail Individuals Treated With Antihypertensive Medication. Hussain, S. M., Ernst, M. E., Barker, A. L., Margolis, K. L., Reid, C. M., Neumann, J. T., Tonkin, A. M., Phuong, T. L. T., Beilin, L. J., Pham, T., Chowdhury, E. K., Cicuttini, F. M., Gilmartin-Thomas, J., Carr, P. R. & McNeil, J. J. Hypertension, 101161HYPERTENSIONAHA12219356 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35722878  

Preparation of Human Myocardial Tissue for Long-term Cultivation. Hamers, J., Sen, P., Merkus, D., Seidel, T., Lu, K. & Dendorfer, A. J Vis Exp (2022). https://www.ncbi.nlm.nih.gov/pubmed/35723462  

Predictors of post-stroke delirium incidence and duration: Results of a prospective observational study using high-frequency delirium screening. Fleischmann, R., Andrasch, T., Warwas, S., Kunz, R., Gross, S., Witt, C., Ruhnau, J., Vogelgesang, A., Ulm, L., Mengel, A. & von Sarnowski, B. Int J Stroke, 17474930221109353 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35722813  

Serum anti-NMDA-receptor antibodies and cognitive function after ischemic stroke (PROSCIS-B). Sperber, P. S., Gebert, P., Broersen, L. H. A., Huo, S., Piper, S. K., Teegen, B., Heuschmann, P. U., Pruss, H., Endres, M., Liman, T. G. & Siegerink, B. J Neurol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35718820  

Closing the gap or the beauty of alleviating our patients' symptoms. Petutschnigg, J. & Edelmann, F. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35717602  

Treatment Planning for Cardiac Radioablation: Multicenter Multiplatform Benchmarking for the XXX Trial. Kluge, A., Ehrbar, S., Grehn, M., Fleckenstein, J., Baus, W. W., Siebert, F. A., Schweikard, A., Andratschke, N., Mayinger, M. C., Boda-Heggemann, J., Buergy, D., Celik, E., Krug, D., Kovacs, B., Saguner, A. M., Rudic, B., Bergengruen, P., Boldt, L. H., Stauber, A., Zaman, A. et al. Int J Radiat Oncol Biol Phys (2022). https://www.ncbi.nlm.nih.gov/pubmed/35716847  

Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies. Gorski, M., Rasheed, H., Teumer, A., Thomas, L. F., Graham, S. E., Sveinbjornsson, G., Winkler, T. W., Gunther, F., Stark, K. J., Chai, J. F., Tayo, B. O., Wuttke, M., Li, Y., Tin, A., Ahluwalia, T. S., Arnlov, J., Asvold, B. O., Bakker, S. J. L., Banas, B., Bansal, N. et al. Kidney Int (2022). https://www.ncbi.nlm.nih.gov/pubmed/35716955 

TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy. Zhang, L., Dietsche, F., Seitaj, B., Rojas-Charry, L., Latchman, N., Tomar, D., Wust, R. C., Nickel, A., Frauenknecht, K. B., Schoser, B., Schumann, S., Schmeisser, M. J., Vom Berg, J., Buch, T., Finger, S., Wenzel, P., Maack, C., Elrod, J. W., Parys, J. B., Bultynck, G. et al. Life Sci Alliance 5 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35715207  

Pediatric Cardiac Magnetic Resonance Reference Values for Biventricular Volumes Derived From Different Contouring Techniques. Voges, I., Caliebe, A., Hinz, S., Boroni Grazioli, S., Gabbert, D. D., Daubeney, P. E. F., Uebing, A. S., Pennell, D. J. & Krupickova, S. J Magn Reson Imaging (2022). https://www.ncbi.nlm.nih.gov/pubmed/35713958  

Heterogeneity in coronary heart disease risk. Simonetto, C., Rospleszcz, S., Kaiser, J. C. & Furukawa, K. Sci Rep 12, 10131 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35710917  

Management of pericardial tamponade in the electrophysiology laboratory: results from a national survey. Metzner, A., Reubold, S. D., Schonhofer, S., Reissmann, B., Ouyang, F., Rottner, L., Schleberger, R., Dinshaw, L., Moser, J., Moser, F., Lemoine, M., Munkler, P., Kany, S., Steven, D., Sommer, P., Kirchhof, P. & Rillig, A. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35713695  

Regulatory T Cell-Related Gene Indicators in Pulmonary Hypertension. Liu, Y., Shi, J. Z., Jiang, R., Liu, S. F., He, Y. Y., van der Vorst, E. P. C., Weber, C., Doring, Y. & Yan, Y. Front Pharmacol 13, 908783 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35712711  

Brief Research Report: Quantitative Analysis of Potential Coronary Microvascular Disease in Suspected Long-COVID Syndrome. Doeblin, P., Steinbeis, F., Scannell, C. M., Goetze, C., Al-Tabatabaee, S., Erley, J., Faragli, A., Propper, F., Witzenrath, M., Zoller, T., Stehning, C., Gerhardt, H., Sanchez-Gonzalez, J., Alskaf, E., Kuhne, T., Pieske, B., Tschope, C., Chiribiri, A. & Kelle, S. Front Cardiovasc Med 9, 877416 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35711381  

Minimally-invasive mitral valve surgery after failed transcatheter mitral valve repair in an intermediate-risk cohort. Akansel, S., Kofler, M., Van Praet, K. M., Unbehaun, A., Sundermann, S. H., Jacobs, S., Falk, V. & Kempfert, J. Interact Cardiovasc Thorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35713519   

Spatial profiling of early primate gastrulation in utero. Bergmann, S., Penfold, C. A., Slatery, E., Siriwardena, D., Drummer, C., Clark, S., Strawbridge, S. E., Kishimoto, K., Vickers, A., Tewary, M., Kohler, T. N., Hollfelder, F., Reik, W., Sasaki, E., Behr, R. & Boroviak, T. E. Nature (2022). https://www.ncbi.nlm.nih.gov/pubmed/35709828  

Impact of COVID-19 on young healthcare professionals. Bahls, M., Gaber, M. H., Jorstad, H. T., Mouine, N., Scherrenberg, M. & Marques-Sule, E. Eur J Prev Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35708732  

Impact of Artificial Intelligence Assistance on Chest CT Interpretation Times: A Prospective Randomized Study. Yacoub, B., Varga-Szemes, A., Schoepf, U. J., Kabakus, I. M., Baruah, D., Burt, J. R., Aquino, G. J., Sullivan, A. K., J, O. D., Hoelzer, P., Sperl, J. & Emrich, T. AJR Am J Roentgenol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35703413  

The association between markers of type I collagen synthesis and echocardiographic response to spironolactone in patients at risk of heart failure: findings from the HOMAGE trial. Kobayashi, M., Girerd, N., Ferreira, J. P., Kevin, D., Huttin, O., Gonzalez, A., Bozec, E., Clark, A. L., Cosmi, F., Cuthbert, J., Diez, J., Edelmann, F., Hazebroek, M., Heymans, S., Mariottoni, B., Pellicori, P., Petutschnigg, J., Pieske, B., Staessen, J. A., Verdonschot, J. A. J. et al. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35703355  

Patient-Centered Outcomes in a Randomized Trial Investigating a Multimodal Prevention Program After Transient Ischemic Attack or Minor Stroke: The INSPiRE-TMS Trial. Ihl, T., Ahmadi, M., Laumeier, I., Steinicke, M., Ferse, C., Klyscz, P., Endres, M., Hastrup, S., Poppert, H., Palm, F., Kandil, F. I., Weber, J. E., von Weitzel-Mudersbach, P., Wimmer, M. L. J. & Audebert, H. J. Stroke, 101161STROKEAHA120037503 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35703097  

COVID-19 Knowledge, Attitudes, and Preventive Measures of University Students in Bahrain. Perna, S., Bahar, K., Alalwan, T. A., Zahid, M. N., Gasparri, C., Peroni, G., Faragli, A., La Porta, E., Ali Redha, A., Janahi, E. M., Ibrahim, S. & Rondanelli, M. Ann Ig 34, 398-409 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35700030  

Dose Reduction and Image Quality in Photon-counting Detector High-resolution Computed Tomography of the Chest: Routine Clinical Data. Graafen, D., Emrich, T., Halfmann, M. C., Mildenberger, P., Duber, C., Yang, Y., Othman, A. E., J, O. D., Muller, L. & Kloeckner, R. J Thorac Imaging (2022). https://www.ncbi.nlm.nih.gov/pubmed/35699680  

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. Winkler, T. W., Rasheed, H., Teumer, A., Gorski, M., Rowan, B. X., Stanzick, K. J., Thomas, L. F., Tin, A., Hoppmann, A., Chu, A. Y., Tayo, B., Thio, C. H. L., Cusi, D., Chai, J. F., Sieber, K. B., Horn, K., Li, M., Scholz, M., Cocca, M., Wuttke, M. et al. Commun Biol 5, 580 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35697829  

Sotrovimab in pediatric cardiac transplant recipients with SARS-CoV2 infection. Weber, S. C., Danne, F., Kieslich, M., Krauss, A., Berger, F. & Sallmon, H. J Heart Lung Transplant (2022). https://www.ncbi.nlm.nih.gov/pubmed/35697603  

Ablation of Outflow Tract Arrhythmias in Patients With and Without Structural Heart Disease-A Comparative Analysis. Schleberger, R., Riess, J., Brauer, A., Pinnschmidt, H. O., Rottner, L., Moser, F., Moser, J., Kany, S., My, I., Lemoine, M. D., Reissmann, B., Meyer, C., Metzner, A., Ouyang, F., Kirchhof, P. & Rillig, A. Front Cardiovasc Med 9, 910042 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35694678  

Association of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis. Pallares Robles, A., Ten Cate, V., Schulz, A., Prochaska, J. H., Rapp, S., Koeck, T., Panova-Noeva, M., Heitmeier, S., Schwers, S., Leineweber, K., Seyfarth, H. J., Opitz, C. F., Spronk, H., Espinola-Klein, C., Lackner, K. J., Munzel, T., Andrade-Navarro, M. A., Konstantinides, S. V., Ten Cate, H. & Wild, P. S. Sci Rep 12, 9761 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35697739  

Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels. Cecon, E., Fernandois, D., Renault, N., Coelho, C. F. F., Wenzel, J., Bedart, C., Izabelle, C., Gallet, S., Le Poder, S., Klonjkowski, B., Schwaninger, M., Prevot, V., Dam, J. & Jockers, R. Cell Mol Life Sci 79, 361 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35697820  

Complications of balloon pulmonary angioplasty for inoperable chronic thromboembolic pulmonary hypertension: Impact on the outcome. Wiedenroth, C. B., Deissner, H., Adameit, M. S. D., Kriechbaum, S. D., Ghofrani, H. A., Breithecker, A., Haas, M., Roller, F., Rolf, A., Hamm, C. W., Mayer, E., Guth, S. & Liebetrau, C. J Heart Lung Transplant (2022). https://www.ncbi.nlm.nih.gov/pubmed/35690560  

Alkaline phosphatase and prognosis in patients with diabetes mellitus and ischemic heart disease. Ndrepepa, G., Holdenrieder, S., Xhepa, E., Cassese, S., Lahu, S., Kufner, S. & Kastrati, A. Clin Chim Acta 533, 1-7 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35690085  

Beyond the 10-year horizon: Mitral valve repair solely with chordal replacement and annuloplasty. Lang, M., Vitanova, K., Voss, B., Feirer, N., Rheude, T., Krane, M., Gunther, T. & Lange, R. Ann Thorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35690138  

Human cardiac organoids to model COVID-19 cytokine storm induced cardiac injuries. Arhontoulis, D. C., Kerr, C. M., Richards, D., Tjen, K., Hyams, N., Jones, J. A., Deleon-Pennell, K., Menick, D., Brauninger, H., Lindner, D., Westermann, D. & Mei, Y. J Tissue Eng Regen Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/35689600  

The Transcription Factor EB (TFEB) Sensitizes the Heart to Chronic Pressure Overload. Wundersitz, S., Pablo Tortola, C., Schmidt, S., Oliveira Vidal, R., Kny, M., Hahn, A., Zanders, L., Katus, H. A., Sauer, S., Butter, C., Luft, F. C., Muller, O. J. & Fielitz, J. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35682624  

Associations of the vasoactive peptides CT-proET-1 and MR-proADM with incident type 2 diabetes: results from the BiomarCaRE Consortium. Sujana, C., Salomaa, V., Kee, F., Seissler, J., Jousilahti, P., Neville, C., Then, C., Koenig, W., Kuulasmaa, K., Reinikainen, J., Blankenberg, S., Zeller, T., Herder, C., Mansmann, U., Peters, A., Thorand, B. & BiomarCa, R. E. C. Cardiovasc Diabetol 21, 99 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35681200  

Practical Guidance for Diagnosing and Treating Iron Deficiency in Patients with Heart Failure: Why, Who and How? Sindone, A., Doehner, W., Manito, N., McDonagh, T., Cohen-Solal, A., Damy, T., Nunez, J., Pfister, O., van der Meer, P. & Comin-Colet, J. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35683366  

Hypoxia Differentially Affects Healthy Men and Women During a Daytime Nap With a Dose-Response Relationship: a Randomized, Cross-Over Pilot Study. Riveros-Rivera, A., Penzel, T., Gunga, H. C., Opatz, O., Paul, F., Klug, L., Boschmann, M. & Mahler, A. Front Physiol 13, 899636 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35685284  

Epoxyeicosatrienoic Acid and Prostanoid Crosstalk at the Receptor and Intracellular Signaling Levels to Maintain Vascular Tone. Malacarne, P. F., Bezzenberger, J., Lopez, M., Warwick, T., Muller, N., Brandes, R. P. & Rezende, F. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35682616  

Real-Time Optical Mapping of Contracting Cardiac Tissues With GPU-Accelerated Numerical Motion Tracking. Lebert, J., Ravi, N., Kensah, G. & Christoph, J. Front Cardiovasc Med 9, 787627 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35686036  

Transcriptional Effects of Candidate COVID-19 Treatments on Cardiac Myocytes. Jakobi, T., Gross, J., Cyganek, L. & Doroudgar, S. Front Cardiovasc Med 9, 844441 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35686037  

Empagliflozin and serum potassium in heart failure: an analysis from EMPEROR-Pooled. Ferreira, J. P., Zannad, F., Butler, J., Filipattos, G., Ritter, I., Schuler, E., Kraus, B. J., Pocock, S. J., Anker, S. D. & Packer, M. Eur Heart J 43, 2984-2993 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35687107  

SRF: a seriously responsible factor in cardiac development and disease. Deshpande, A., Shetty, P. M. V., Frey, N. & Rangrez, A. Y. J Biomed Sci 29, 38 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35681202  

Comparison of PCWP and LVEDP Measurements in Patients with Severe Aortic Stenosis Undergoing TAVI-Same Same but Different? Boxhammer, E., Mirna, M., Baz, L., Alushi, B., Franz, M., Kretzschmar, D., Hoppe, U. C., Lauten, A. & Lichtenauer, M. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35683367  

Neo to Neo2: A Tiny Detail With Considerable Impact. Kim, W. K. & Mollmann, H. JACC Cardiovasc Interv 15, 1111-1112 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35680189  

Clinician approach to cardiopulmonary exercise testing for exercise prescription in patients at risk of and with cardiovascular disease. D'Ascenzi, F., Cavigli, L., Pagliaro, A., Focardi, M., Valente, S., Cameli, M., Mandoli, G. E., Mueller, S., Dendale, P., Piepoli, M., Wilhelm, M., Halle, M., Bonifazi, M. & Hansen, D. Br J Sports Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/35680397  

Relationships between coagulation factors and thrombin generation in a general population with arterial and venous disease background. van Paridon, P. C. S., Panova-Noeva, M., van Oerle, R., Schulz, A., Prochaska, J. H., Arnold, N., Schmidtmann, I., Beutel, M., Pfeiffer, N., Munzel, T., Lackner, K. J., Ten Cate, H., Wild, P. S. & Spronk, H. M. H. Thromb J 20, 32 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35676710  

Finerenone Reduces Renal RORgammat gammadelta T Cells and Protects against Cardiorenal Damage. Luettges, K., Bode, M., Diemer, J. N., Schwanbeck, J., Wirth, E. K., Klopfleisch, R., Kappert, K., Thiele, A., Ritter, D., Foryst-Ludwig, A., Kolkhof, P., Wenzel, U. O. & Kintscher, U. Am J Nephrol, 1-13 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35675794  

Cross-sectional analysis of the association of periodontitis with carotid intima media thickness and atherosclerotic plaque in the Hamburg City health study. Lamprecht, R., Rimmele, D. L., Schnabel, R. B., Heydecke, G., Seedorf, U., Walther, C., Mayer, C., Struppek, J., Borof, K., Behrendt, C. A., Cheng, B., Gerloff, C., Debus, S., Smeets, R., Beikler, T., Blankenberg, S., Zeller, T., Karakas, M., Thomalla, G. & Aarabi, G. J Periodontal Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/35675038  

Control of CRK-RAC1 activity by the miR-1/206/133 miRNA family is essential for neuromuscular junction function. Klockner, I., Schutt, C., Gerhardt, T., Boettger, T. & Braun, T. Nat Commun 13, 3180 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35676269  

Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium. Gencer, S., Doring, Y., Jansen, Y., Bayasgalan, S., Yan, Y., Bianchini, M., Cimen, I., Muller, M., Peters, L. J. F., Megens, R. T. A., von Hundelshausen, P., Duchene, J., Lemnitzer, P., Soehnlein, O., Weber, C. & van der Vorst, E. P. C. Basic Res Cardiol 117, 30 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35674847  

Subtotal obstruction of the left coronary ostium by chronic neo-intimal ingrowth. Friedrich, A., Pasic, M. & Falk, V. Eur Heart J 43, 2816 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35673900  

Comorbidities in heart failure with preserved ejection fraction. Deichl, A., Wachter, R. & Edelmann, F. Herz 47, 301-307 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35674774  

Long-term effects of discontinuing renin-angiotensin system inhibitors in COVID-19. Theurl, F., Sappler, N., Rizas, K. D., Massberg, S., Bauer, A. & Schreinlechner, M. Respirology (2022). https://www.ncbi.nlm.nih.gov/pubmed/35672267  

Extracellular Inflammasome Particles Are Released After Marathon Running and Induce Proinflammatory Effects in Endothelial Cells. Kogel, A., Fikenzer, S., Uhlmann, L., Opitz, L., Kneuer, J. M., Haeusler, K. G., Endres, M., Kratzsch, J., Schwarz, V., Werner, C., Kalwa, H., Gaul, S. & Laufs, U. Front Physiol 13, 866938 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35669577  

Pig models for Duchenne muscular dystrophy - from disease mechanisms to validation of new diagnostic and therapeutic concepts. Stirm, M., Fonteyne, L. M., Shashikadze, B., Stockl, J. B., Kurome, M., Kessler, B., Zakhartchenko, V., Kemter, E., Blum, H., Arnold, G. J., Matiasek, K., Wanke, R., Wurst, W., Nagashima, H., Knieling, F., Walter, M. C., Kupatt, C., Frohlich, T., Klymiuk, N., Blutke, A. et al. Neuromuscul Disord (2022). https://www.ncbi.nlm.nih.gov/pubmed/35659494  

TAVI Under Pressure: Intra-balloon Pressure Profiles During Balloon-Expandable TAVR-First Data from a Feasibility Study. Noterdaeme, T., Marx, N., Theiss, H., Orban, M., Roden, D., Massberg, S. & Braun, D. J Cardiovasc Transl Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/35668315  

Expert proposal to characterize cardiac diseases with normal or preserved left ventricular ejection fraction and symptoms of heart failure by comprehensive echocardiography. Hagendorff, A., Helfen, A., Brandt, R., Altiok, E., Breithardt, O., Haghi, D., Knierim, J., Lavall, D., Merke, N., Sinning, C., Stobe, S., Tschope, C., Knebel, F. & Ewen, S. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35660948  

Atrial fibrillation progression and the importance of early treatment for improving clinical outcomes. Gunawardene, M. A. & Willems, S. Europace 24, ii22-ii28 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35661866  

Remnant cholesterol and atherosclerotic disease in high cardiovascular risk patients. Beyond LDL cholesterol and hypolipidemic treatment. Delialis, D., Georgiopoulos, G., Aivalioti, E., Mavraganis, G., Dimopoulou, A. M., Sianis, A., Aggelidakis, L., Patras, R., Petropoulos, I., Ioannou, S., Syrigou, R., Chatzidou, S., Kanakakis, I., Stellos, K. & Stamatelopoulos, K. Hellenic J Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35667617  

Management of in-stent restenosis. Alfonso, F., Coughlan, J. J., Giacoppo, D., Kastrati, A. & Byrne, R. A. EuroIntervention 18, e103-e123 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35656726  

Atrial fibrillation and heart failure: novel insights into the chicken and egg dilemma. Pabel, S. & Sossalla, S. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35653688  

SUMOylation in peripheral tissues under low perfusion-related pathological states. Oliveira, F., Soares, E. S., Harms, C., Cimarosti, H. I. & Sordi, R. J Cell Biochem (2022). https://www.ncbi.nlm.nih.gov/pubmed/35652521  

Prognostic markers of all-cause mortality in patients with atrial fibrillation: data from the prospective long-term registry of the German Atrial Fibrillation NETwork (AFNET): Authors' reply. Nabauer, M., Gerth, A., Wegscheider, K., Buchholz, A., Haeusler, K. G., Ravens, U., Sprenger, C., Tebbe, U., Kirchhof, P., Breithardt, G. & Steinbeck, G. Europace 24, 1872-1873 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35655121  

Acute Decompensated Heart Failure in the Setting of Acute Coronary Syndrome. Harrington, J., Jones, W. S., Udell, J. A., Hannan, K., Bhatt, D. L., Anker, S. D., Petrie, M. C., Vedin, O., Butler, J. & Hernandez, A. F. JACC Heart Fail 10, 404-414 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35654525  

Vascular aging in the young: New carotid stiffness centiles and association with general and abdominal obesity - The KIGGS cohort. Buschges, J., Schaffrath Rosario, A., Schienkiewitz, A., Konigstein, K., Sarganas, G., Schmidt-Trucksass, A. & Neuhauser, H. Atherosclerosis (2022). https://www.ncbi.nlm.nih.gov/pubmed/35654616  

SARS-CoV-2 infects human cardiomyocytes promoted by inflammation and oxidative stress. Tangos, M., Budde, H., Kolijn, D., Sieme, M., Zhazykbayeva, S., Lodi, M., Herwig, M., Gomori, K., Hassoun, R., Robinson, E. L., Meister, T. L., Jaquet, K., Kovacs, A., Mustroph, J., Evert, K., Babel, N., Fagyas, M., Lindner, D., Puschel, K., Westermann, D. et al. Int J Cardiol 362, 196-205 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35643215  

Response to AJE-00301-2022 Invited Commentary "Mechanistic and biologically based models in epidemiology; a powerful underutilized tool" by Rafael Meza & Jihyoun Jeon. Simonetto, C., Heier, M., Peters, A., Kaiser, J. C. & Rospleszcz, S. Am J Epidemiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35650119  

The impact of ultra-high-density mapping on long-term outcome after catheter ablation of ventricular tachycardia. Schleberger, R., Schwarzl, J. M., Moser, J., Nies, M., Holler, A., Munkler, P., Dinshaw, L., Jungen, C., Lemoine, M. D., Maury, P., Sacher, F., Martin, C. A., Wong, T., Estner, H. L., Jais, P., Willems, S., Eickholt, C. & Meyer, C. Sci Rep 12, 9139 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35650230  

Role of the soluble epoxide hydrolase in the hair follicle stem cell homeostasis and hair growth. Naeem, Z., Zukunft, S., Gunther, S., Liebner, S., Weigert, A., Hammock, B. D., Fromel, T. & Fleming, I. Pflugers Arch (2022). https://www.ncbi.nlm.nih.gov/pubmed/35648219  

MicroRNAs as therapeutic targets in cardiovascular disease. Laggerbauer, B. & Engelhardt, S. J Clin Invest 132 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35642640  

Left Atrial Volume Index and Outcome after Transcatheter Edge-to-edge Valve Repair for Secondary Mitral Regurgitation. Iliadis, C., Kalbacher, D., Lurz, P., Petrescu, A. M., Orban, M., Puscas, T., Lupi, L., Stazzoni, L., Pires-Morais, G., Koell, B., Besler, C., Ruf, T. F., Stolz, L., Tence, N., Adamo, M., Giannini, C., Guerreiro, C., Hellmich, M., Baldus, S., Schofer, N. et al. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35642951  

Lack of correlation between different congestion markers in acute decompensated heart failure. Haag, S., Jobs, A., Stiermaier, T., Fichera, C. F., Paitazoglou, C., Eitel, I., Desch, S. & Thiele, H. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35648271  

Multi-national survey on the methods, efficacy, and safety on the post-approval clinical use of pulsed field ablation (MANIFEST-PF). Ekanem, E., Reddy, V. Y., Schmidt, B., Reichlin, T., Neven, K., Metzner, A., Hansen, J., Blaauw, Y., Maury, P., Arentz, T., Sommer, P., Anic, A., Anselme, F., Boveda, S., Deneke, T., Willems, S., van der Voort, P., Tilz, R., Funasako, M., Scherr, D. et al. Europace (2022). https://www.ncbi.nlm.nih.gov/pubmed/35647644  

Heart failure with normal LVEF in BIOSTAT-CHF. Baumhove, L., Tromp, J., Figarska, S., van Essen, B. J., Anker, S. D., Dickstein, K., Cleland, J. G., Lang, C. C., Filippatos, G., Ng, L. L., Samani, N. J., Metra, M., van Veldhuisen, D. J., Lam, C. S. P., Voors, A. A. & van der Meer, P. Int J Cardiol 364, 85-90 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35649488  

AFM-based nanoindentation indicates an impaired cortical stiffness in the AAV-PCSK9(DY) atherosclerosis mouse model. Achner, L., Klersy, T., Fels, B., Reinberger, T., Schmidt, C. X., Gross, N., Hille, S., Muller, O. J., Aherrahrou, Z., Kusche-Vihrog, K. & Raasch, W. Pflugers Arch 474, 993-1002 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35648220  

Systolic or diastolic CT image acquisition for transcatheter aortic valve replacement - An outcome analysis. Steffen, J., Beckmann, M., Haum, M., Fischer, J., Andreae, D., Orban, M., Rizas, K., Braun, D., Orban, M., Curta, A., Hagl, C., Theiss, H. D., Mehilli, J., Massberg, S., Deseive, S. & Hausleiter, J. J Cardiovasc Comput Tomogr (2022). https://www.ncbi.nlm.nih.gov/pubmed/35637128  

Association between a polygenic and family risk score on the prevalence and incidence of myocardial infarction in the KORA-F3 study. Schnitzer, F., Forer, L., Schonherr, S., Gieger, C., Grallert, H., Kronenberg, F., Peters, A. & Lamina, C. Atherosclerosis 352, 10-17 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35636145  

Exon junction complex-associated multi-adapter RNPS1 nucleates splicing regulatory complexes to maintain transcriptome surveillance. Schlautmann, L. P., Lackmann, J. W., Altmuller, J., Dieterich, C., Boehm, V. & Gehring, N. H. Nucleic Acids Res 50, 5899-5918 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35640609  

Adverse Cardiovascular Effects of Anti-tumor Therapies in Patients With Breast Cancer: A Single-center Cross-sectional Analysis. Rosenkaimer, S., Sieburg, T., Winter, L., Mavratzas, A., Hofmann, W. K., Hofheinz, R. D., Akin, I., Duerschmied, D. & Hohneck, A. Anticancer Res 42, 3075-3084 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35641278  

Evaluation of a pneumatic tube system carrier prototype with fixing mechanism allowing for automated unloading. Martens, C. M., Schopfel, J., Bollmann, S., Hannemann, A., Zylla, S., Dahl, M. B., Gauss, F., Schedl, J., Nauck, M. & Petersmann, A. Clin Chem Lab Med 60, 1202-1210 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35635785  

Tooth loss in periodontally treated patients: A registry- and observation-based analysis. Kocher, T., Holtfreter, B., Priess, H. W., Graetz, C., Jablonowski, L., Grabe, H. J., Volzke, H., Raedel, M. & Walter, M. H. J Clin Periodontol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35634709  

Cerebral consequences of environmental noise exposure. Hahad, O., Bayo Jimenez, M. T., Kuntic, M., Frenis, K., Steven, S., Daiber, A. & Munzel, T. Environ Int 165, 107306 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35635962


Juli

3,5-T2-an Endogenous Thyroid Hormone Metabolite as Promising Lead Substance in Anti-Steatotic Drug Development? Sane, R., Wirth, E. K. & Kohrle, J. Metabolites 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35888706  

Intravital calcium imaging in myeloid leukocytes identifies calcium frequency spectra as indicators of functional states. Mehari, F. T., Miller, M., Pick, R., Bader, A., Pekayvaz, K., Napoli, M., Uhl, B., Reichel, C. A., Sperandio, M., Walzog, B., Schulz, C., Massberg, S. & Stark, K. Sci Signal 15, eabe6909 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35881691  

Edoxaban for stroke prevention in atrial fibrillation and age-adjusted predictors of clinical outcomes in routine clinical care. Kirchhof, P., Pecen, L., Bakhai, A., de Asmundis, C., de Groot, J. R., Deharo, J. C., Kelly, P., Levy, P., Lopez-de-Sa, E., Monteiro, P., Steffel, J., Waltenberger, J., Weiss, T. W., Laeis, P., Manu, M. C., Souza, J. & De Caterina, R. Eur Heart J Cardiovasc Pharmacother 9, 47-57 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35881467  

Impact of ischaemic aetiology on the efficacy of intravenous ferric carboxymaltose in patients with iron deficiency and acute heart failure: insights from the AFFIRM-AHF trial. Metra, M., Jankowska, E. A., Pagnesi, M., Anker, S. D., Butler, J., Dorigotti, F., Fabien, V., Filippatos, G., Kirwan, B. A., Macdougall, I. C., Rosano, G., Ruschitzka, F., Tomasoni, D., van der Meer, P., Ponikowski, P. & Investigators, A.-A. Eur J Heart Fail 24, 1928-1939 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35869741  

A cross-sectional analysis of post-acute COVID-19 symptoms. Perna, S., Abdulsattar, S., Alalwan, T. A., Zahid, M. N., Gasparri, C., Peroni, G., Faragli, A., La Porta, E., Ali Redha, A., Janahi, E. M. & Rondanelli, M. Ann Ig 34, 478-489 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35861720  

Cardiac Macrophages and Their Effects on Arrhythmogenesis. Xia, R., Tomsits, P., Loy, S., Zhang, Z., Pauly, V., Schuttler, D. & Clauss, S. Front Physiol 13, 900094 (2022). www.ncbi.nlm.nih.gov/pubmed/35812333

Adventures and Advances in Time Travel With Induced Pluripotent Stem Cells and Automated Patch Clamp. Rosholm, K. R., Badone, B., Karatsiompani, S., Nagy, D., Seibertz, F., Voigt, N. & Bell, D. C. Front Mol Neurosci 15, 898717 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35813069  

Health-Related Quality of Life following Surgery for Native and Prosthetic Valve Infective Endocarditis. Saha, S., Mladenova, R., Radner, C., Horke, K. M., Buech, J., Schnackenburg, P., Ali, A., Peterss, S., Juchem, G., Luehr, M., Hagl, C. & Joskowiak, D. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35806881  

Intramyocardial Inflammation after COVID-19 Vaccination: An Endomyocardial Biopsy-Proven Case Series. Baumeier, C., Aleshcheva, G., Harms, D., Gross, U., Hamm, C., Assmus, B., Westenfeld, R., Kelm, M., Rammos, S., Wenzel, P., Munzel, T., Elsasser, A., Gailani, M., Perings, C., Bourakkadi, A., Flesch, M., Kempf, T., Bauersachs, J., Escher, F. & Schultheiss, H. P. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35805941  

Three-component carboacylation of alkenes via cooperative nickelaphotoredox catalysis. Wang, D. & Ackermann, L. Chem Sci 13, 7256-7263 (2022). www.ncbi.nlm.nih.gov/pubmed/35799820

The Seasonal Fluctuation of Fatigue in Multiple Sclerosis. Grothe, M., Gross, S., Susse, M., Strauss, S. & Penner, I. K. Front Neurol 13, 900792 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35785351  

A Method to Combine Neurofilament Light Measurements From Blood Serum and Plasma in Clinical and Population-Based Studies. Rubsamen, N., Willemse, E. A. J., Leppert, D., Wiendl, H., Nauck, M., Karch, A., Kuhle, J. & Berger, K. Front Neurol 13, 894119 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35775045  

Enhanced Transduction of P2X7-Expressing Cells with Recombinant rAAV Vectors. Mann, A. M., Schafer, W., Adriouch, S., Borner, K., Grimm, D., Braren, I. & Koch-Nolte, F. Methods Mol Biol 2510, 129-144 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35776323   

Association of White Blood Cell Count With Clinical Outcome Independent of Treatment With Alteplase in Acute Ischemic Stroke. Barow, E., Quandt, F., Cheng, B., Gelderblom, M., Jensen, M., Konigsberg, A., Boutitie, F., Nighoghossian, N., Ebinger, M., Endres, M., Fiebach, J. B., Thijs, V., Lemmens, R., Muir, K. W., Pedraza, S., Simonsen, C. Z., Gerloff, C. & Thomalla, G. Front Neurol 13, 877367 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35769368  

Impact of open-irrigated radiofrequency catheter with contact force measurement on the efficacy and safety of atrial fibrillation ablation: a single-center direct comparison. Schlogl, S., Schlogl, K. S., Bengel, P., Bergau, L., Haarmann, H., Rasenack, E., Hasenfuss, G. & Zabel, M. J Interv Card Electrophysiol 65, 685-693 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35907108

The German National Pandemic Cohort Network (NAPKON): rationale, study design and baseline characteristics. Schons, M., Pilgram, L., Reese, J. P., Stecher, M., Anton, G., Appel, K. S., Bahmer, T., Bartschke, A., Bellinghausen, C., Bernemann, I., Brechtel, M., Brinkmann, F., Brunn, C., Dhillon, C., Fiessler, C., Geisler, R., Hamelmann, E., Hansch, S., Hanses, F., Hanss, S. et al. Eur J Epidemiol, 1-22 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35904671  

TRPC1 channels regulate the activation of pancreatic stellate cells through ERK1/2 and SMAD2 pathways and perpetuate their pressure-mediated activation. Radoslavova, S., Fels, B., Petho, Z., Gruner, M., Ruck, T., Meuth, S. G., Folcher, A., Prevarskaya, N., Schwab, A. & Ouadid-Ahidouch, H. Cell Calcium 106, 102621 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35905654  

Outcome after surgical embolectomy for acute pulmonary embolism. Panholzer, B., Gravert, H., Borzikowsky, C., Huenges, K., Schoettler, J., Schoeneich, F., Attmann, T., Haneya, A., Frank, D., Cremer, J. & Grothusen, C. J Cardiovasc Med (Hagerstown) 23, 519-523 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35905002  

Dual ProGlide versus ProGlide and FemoSeal for vascular access haemostasis after transcatheter aortic valve implantation. Gmeiner, J. M. D., Linnemann, M., Steffen, J., Scherer, C., Orban, M., Theiss, H., Mehilli, J., Sadoni, S., Peterss, S., Joskowiak, D., Hagl, C., Tsilimparis, N., Curta, A., Maurus, S., Doldi, P. M., Low, K., Haum, M., Roden, D., Hausleiter, J., Massberg, S. et al. EuroIntervention 18, 812-819 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35903846  

Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage. Avery, E. G., Bartolomaeus, H., Rauch, A., Chen, C. Y., N'Diaye, G., Lober, U., Bartolomaeus, T. U. P., Fritsche-Guenther, R., Rodrigues, A. F., Yarritu, A., Zhong, C., Fei, L., Tsvetkov, D., Todiras, M., Park, J. K., Marko, L., Maifeld, A., Patzak, A., Bader, M., Kempa, S. et al. Cardiovasc Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/35904261  

Remote Patient Management May Reduce All-Cause Mortality in Patients With Heart-Failure and Renal Impairment. Naik, M. G., Budde, K., Koehler, K., Vettorazzi, E., Pigorsch, M., Arkossy, O., Stuard, S., Duettmann, W., Koehler, F. & Winkler, S. Front Med (Lausanne) 9, 917466 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35899216  

Early coronary angiography in patients after out-of-hospital cardiac arrest without ST-segment elevation: Meta-analysis of randomized controlled trials. Freund, A., van Royen, N., Kern, K. B., Jobs, A., Thiele, H., Lemkes, J. S., Desch, S., Tomahawk, P. & investigators, C. Catheter Cardiovasc Interv (2022). https://www.ncbi.nlm.nih.gov/pubmed/35900214  

From novel discovery tools and biomarkers to precision medicine - basic cardiovascular science highlights of 2021/2022. Evans, P. C., Davidson, S. M., Wojta, J., Back, M., Bollini, S., Brittan, M., Catapano, A. L., Chaudhry, B., Cluitmans, M., Gnecchi, M., Guzik, T. J., Hoefer, I., Madonna, R., Monteiro, J. P., Morawietz, H., Osto, E., Padro, T., Sluimer, J. C., Tocchetti, C. G., Van der Heiden, K. et al. Cardiovasc Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/35899362  

A framework of deep learning networks provides expert-level accuracy for the detection and prognostication of pulmonary arterial hypertension. Diller, G. P., Benesch Vidal, M. L., Kempny, A., Kubota, K., Li, W., Dimopoulos, K., Arvanitaki, A., Lammers, A. E., Wort, S. J., Baumgartner, H., Orwat, S. & Gatzoulis, M. A. Eur Heart J Cardiovasc Imaging (2022). https://www.ncbi.nlm.nih.gov/pubmed/35900292  

Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction: the DIAMOND trial. Butler, J., Anker, S. D., Lund, L. H., Coats, A. J. S., Filippatos, G., Siddiqi, T. J., Friede, T., Fabien, V., Kosiborod, M., Metra, M., Pina, I. L., Pinto, F., Rossignol, P., van der Meer, P., Bahit, C., Belohlavek, J., Bohm, M., Brugts, J. J., Cleland, J. G., Ezekowitz, J. et al. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35900838  

Calcium-Controlled Reactive Oxygen Species Afterburner Perpetuates Endothelial Damage After Radiation Therapy. Brandes, R. P. & Wittig, I. Arterioscler Thromb Vasc Biol 42, 1137-1138 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35899615  

Epigenetic mechanism of L-type calcium channel beta-subunit downregulation in short QT human induced pluripotent stem cell-derived cardiomyocytes with CACNB2 mutation. Zhong, R., Zhang, F., Yang, Z., Li, Y., Xu, Q., Lan, H., Cyganek, L., El-Battrawy, I., Zhou, X., Akin, I. & Borggrefe, M. Europace 24, 2028-2036 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35894107  

Case-Fatality and Temporal Trends in Patients with Psoriasis and End-Stage Renal Disease. Wild, J., Keller, K., Karbach, S., Weinmann-Menke, J., Munzel, T. & Hobohm, L. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35893416  

In Prostate Cancer Cells Cytokines Are Early Responders to Gravitational Changes Occurring in Parabolic Flights. Schulz, H., Dietrichs, D., Wehland, M., Corydon, T. J., Hemmersbach, R., Liemersdorf, C., Melnik, D., Hubner, N., Saar, K., Infanger, M. & Grimm, D. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35887223  

Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference. Schnabel, R. B., Marinelli, E. A., Arbelo, E., Boriani, G., Boveda, S., Buckley, C. M., Camm, A. J., Casadei, B., Chua, W., Dagres, N., de Melis, M., Desteghe, L., Diederichsen, S. Z., Duncker, D., Eckardt, L., Eisert, C., Engler, D., Fabritz, L., Freedman, B., Gillet, L. et al. Europace (2022). https://www.ncbi.nlm.nih.gov/pubmed/35894842  

Ex-vivo evaluation of the Ozaki procedure in comparison with the native aortic valve and prosthetic valves. Saisho, H., Scharfschwerdt, M., Schaller, T., Sadat, N., Aboud, A., Ensminger, S. & Fujita, B. Interact Cardiovasc Thorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35895002  

Baseline Splenic Volume Outweighs Immuno-Modulated Size Changes with Regard to Survival Outcome in Patients with Hepatocellular Carcinoma under Immunotherapy. Muller, L., Gairing, S. J., Kloeckner, R., Foerster, F., Weinmann, A., Mittler, J., Stoehr, F., Emrich, T., Duber, C., Galle, P. R. & Hahn, F. Cancers (Basel) 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35892833  

Weight loss-induced improvement of body weight and insulin sensitivity is not amplified by a subsequent 12-month weight maintenance intervention but is predicted by adaption of adipose atrial natriuretic peptide system: 48-month results of a randomized controlled trial. Li, L., Soll, D., Leupelt, V., Spranger, J. & Mai, K. BMC Med 20, 238 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35897098  

Functional and structural reverse myocardial remodeling following transcatheter aortic valve replacement: a prospective cardiovascular magnetic resonance study. Lange, T., Backhaus, S. J., Beuthner, B. E., Topci, R., Rigorth, K. R., Kowallick, J. T., Evertz, R., Schnelle, M., Ravassa, S., Diez, J., Toischer, K., Seidler, T., Puls, M., Hasenfuss, G. & Schuster, A. J Cardiovasc Magn Reson 24, 45 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35897100  

Whole Exome Sequencing Enhanced Imputation Identifies 85 Metabolite Associations in the Alpine CHRIS Cohort. Konig, E., Rainer, J., Hernandes, V. V., Paglia, G., Del Greco, M. F., Bottigliengo, D., Yin, X., Chan, L. S., Teumer, A., Pramstaller, P. P., Locke, A. E. & Fuchsberger, C. Metabolites 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35888728  

The G3BP1-UPF1-Associated Long Non-Coding RNA CALA Regulates RNA Turnover in the Cytoplasm. Kirchhof, L., Fouani, Y., Knau, A., Aslan, G. S., Heumuller, A. W., Wittig, I., Muller-McNicoll, M., Dimmeler, S. & Jae, N. Noncoding RNA 8 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35893232  

Simultaneous LC-ESI-MS/MS Quantification of Levosimendan and Its Metabolites for Therapeutic Drug Monitoring of Cardiac Surgery Patients. Kipka, H., Tomasi, R., Hubner, M., Liebchen, U., Hagl, C., Wanner, K. T., Mannell, H. & Hofner, G. Pharmaceutics 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35890349  

Anosmia Testing as Early Detection of SARS-CoV-2 Positivity; A Prospective Study under Screening Conditions. Jungbauer, F., Gerhards, C., Thiaucourt, M., Behnes, M., Rotter, N., Schell, A., Haselmann, V., Neumaier, M. & Kittel, M. Life (Basel) 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35888058  

Association between Usual Dietary Intake of Food Groups and DNA Methylation and Effect Modification by Metabotype in the KORA FF4 Cohort. Hellbach, F., Baumeister, S. E., Wilson, R., Wawro, N., Dahal, C., Freuer, D., Hauner, H., Peters, A., Winkelmann, J., Schwettmann, L., Rathmann, W., Kronenberg, F., Koenig, W., Meisinger, C., Waldenberger, M. & Linseisen, J. Life (Basel) 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35888152  

Thrombelastography Compared with Multiple Impedance Aggregometry to Assess High On-Clopidogrel Reactivity in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention. Gjermeni, D., Vetter, H., Szabo, S., Anfang, V., Leggewie, S., Hesselbarth, D., Duerschmied, D., Trenk, D. & Olivier, C. B. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35888001  

APOE epsilon4 in Depression-Associated Memory Impairment-Evidence from Genetic and MicroRNA Analyses. Bonk, S., Kirchner, K., Ameling, S., Garvert, L., Volzke, H., Nauck, M., Volker, U., Grabe, H. J. & Van der Auwera, S. Biomedicines 10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35884866  

Fantastic AAV Gene Therapy Vectors and How to Find Them-Random Diversification, Rational Design and Machine Learning. Becker, J., Fakhiri, J. & Grimm, D. Pathogens 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35890005  

Edoxaban for stroke prevention in atrial fibrillation and age-adjusted predictors of clinical outcomes in routine clinical care. Kirchhof, P., Pecen, L., Bakhai, A., de Asmundis, C., de Groot, J. R., Deharo, J. C., Kelly, P., Levy, P., Lopez-de-Sa, E., Monteiro, P., Steffel, J., Waltenberger, J., Weiss, T. W., Laeis, P., Manu, M. C., Souza, J. & De Caterina, R. Eur Heart J Cardiovasc Pharmacother (2022). https://www.ncbi.nlm.nih.gov/pubmed/35881467  

TAVR for All? The Surgical Perspective. Zhang, X., Puehler, T., Frank, D., Sathananthan, J., Sellers, S., Meier, D., Both, M., Blanke, P., Seoudy, H., Saad, M., Muller, O. J., Sondergaard, L. & Lutter, G. J Cardiovasc Dev Dis 9 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35877585  

Peak Oxygen Uptake on Cardiopulmonary Exercise Test Is a Predictor for Severe Arrhythmic Events during Three-Year Follow-Up in Patients with Complex Congenital Heart Disease. von Sanden, F., Ptushkina, S., Hock, J., Fritz, C., Horer, J., Hessling, G., Ewert, P., Hager, A. & Wolf, C. M. J Cardiovasc Dev Dis 9 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35877577  

Pathogenic Variants in Cardiomyopathy Disorder Genes Underlie Pediatric Myocarditis-Further Impact of Heterozygous Immune Disorder Gene Variants? Seidel, F., Laser, K. T., Klingel, K., Dartsch, J., Theisen, S., Pickardt, T., Holtgrewe, M., Gartner, A., Berger, F., Beule, D., Milting, H., Schubert, S., Klaassen, S. & Kuhnisch, J. J Cardiovasc Dev Dis 9 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35877578  

Evidence for correlations between BMI-associated SNPs and circRNAs. Rajcsanyi, L. S., Diebels, I., Pastoors, L., Kanber, D., Peters, T., Volckmar, A. L., Zheng, Y., Grosse, M., Dieterich, C., Hebebrand, J., Kaiser, F. J., Horsthemke, B. & Hinney, A. Sci Rep 12, 12643 (2022). www.ncbi.nlm.nih.gov/pubmed/35879369

Left Ventricular Noncompaction in Children: The Role of Genetics, Morphology, and Function for Outcome. Klaassen, S., Kuhnisch, J., Schultze-Berndt, A. & Seidel, F. J Cardiovasc Dev Dis 9 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35877568  

Cardiovascular Safety Reporting in Contemporary Breast Cancer Clinical Trials. Hamid, A., Anker, M. S., Ruckdeschel, J. C., Khan, M. S., Tharwani, A., Oshunbade, A. A., Kipchumba, R. K., Thigpen, S. C., Anker, S. D., Fonarow, G. C., Hall, M. E. & Butler, J. J Am Heart Assoc 11, e025206 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35876414  

Long COVID and the cardiovascular system - elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: A joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial & Pericardial Diseases. Gyongyosi, M., Alcaide, P., Asselbergs, F. W., Brundel, B., Camici, G. G., da Costa Martins, P., Ferdinandy, P., Fontana, M., Girao, H., Gnecchi, M., Gollmann-Tepekoylu, C., Kleinbongard, P., Krieg, T., Madonna, R., Paillard, M., Pantazis, A., Perrino, C., Pesce, M., Schiattarella, G. G., Sluijter, J. P. G. et al. Cardiovasc Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/35875883

Cerebral small vessel disease burden and cognitive and functional outcomes after stroke: A multicenter prospective cohort study. Georgakis, M. K., Fang, R., During, M., Wollenweber, F. A., Bode, F. J., Stosser, S., Kindlein, C., Hermann, P., Liman, T. G., Nolte, C. H., Kerti, L., Ikenberg, B., Bernkopf, K., Poppert, H., Glanz, W., Perosa, V., Janowitz, D., Wagner, M., Neumann, K., Speck, O. et al. Alzheimers Dement (2022). https://www.ncbi.nlm.nih.gov/pubmed/35876563  

Telemedicine acceptance and efficacy in the context of preventive cardiology interventions: A systematic review. Gass, F., Halle, M. & Mueller, S. Digit Health 8, 20552076221114186 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35874861  

Severity, predictors and clinical correlates of post-COVID syndrome (PCS) in Germany: A prospective, multi-centre, population-based cohort study. Bahmer, T., Borzikowsky, C., Lieb, W., Horn, A., Krist, L., Fricke, J., Scheibenbogen, C., Rabe, K. F., Maetzler, W., Maetzler, C., Laudien, M., Frank, D., Ballhausen, S., Hermes, A., Muljukov, O., Haeusler, K. G., Mokhtari, N. E. E., Witzenrath, M., Vehreschild, J. J., Krefting, D. et al. EClinicalMedicine 51, 101549 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35875815  

SGLT2 Inhibitors: From Antihyperglycemic Agents to All-Around Heart Failure Therapy. Anker, S. D., Usman, M. S. & Butler, J. Circulation 146, 299-302 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35877834  

Impact of medication adherence on the efficacy of Baroreflex activation therapy. Schafer, A. C., Muller, D., Born, E., Muhlhaus, M., Luders, S., Wallbach, M. & Koziolek, M. J. J Clin Hypertens (Greenwich) 24, 1051-1058 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35870124  

Aortic valve neocuspidization using autologous pericardium compared to surgical aortic valve replacement. Boehm, J., Vitanova, K., Prinzing, A., Krane, M. & Lange, R. J Card Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35870166  

Effects of BNP and Sacubitrilat/Valsartan on Atrial Functional Reserve and Arrhythmogenesis in Human Myocardium. Primessnig, U., Deissler, P. M., Wakula, P., Tran, K. L., Hohendanner, F., von Lewinski, D., Blaschke, F., Knosalla, C., Falk, V., Pieske, B., Grubitzsch, H. & Heinzel, F. R. Front Cardiovasc Med 9, 859014 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35865376  

CT-Based Analysis of Left Ventricular Hemodynamics Using Statistical Shape Modeling and Computational Fluid Dynamics. Goubergrits, L., Vellguth, K., Obermeier, L., Schlief, A., Tautz, L., Bruening, J., Lamecker, H., Szengel, A., Nemchyna, O., Knosalla, C., Kuehne, T. & Solowjowa, N. Front Cardiovasc Med 9, 901902 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35865389  

Mineralocorticoid receptor-antagonism prevents COVID-19-dependent glycocalyx damage. Fels, B., Acharya, S., Vahldieck, C., Graf, T., Kading, N., Rupp, J. & Kusche-Vihrog, K. Pflugers Arch, 1-8 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35867189  

Minimising multi-centre radiomics variability through image normalisation: a pilot study. Campello, V. M., Martin-Isla, C., Izquierdo, C., Guala, A., Palomares, J. F. R., Vilades, D., Descalzo, M. L., Karakas, M., Cavus, E., Raisi-Estabragh, Z., Petersen, S. E., Escalera, S., Segui, S. & Lekadir, K. Sci Rep 12, 12532 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35869125  

Virus-induced inhibition of cardiac pacemaker channel HCN4 triggers bradycardia in human-induced stem cell system. Peischard, S., Moller, M., Disse, P., Ho, H. T., Verkerk, A. O., Strutz-Seebohm, N., Budde, T., Meuth, S. G., Schweizer, P. A., Morris, S., Mucher, L., Eisner, V., Thomas, D., Klingel, K., Busch, K. & Seebohm, G. Cell Mol Life Sci 79, 440 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35864219  

Hemodynamic stress-induced cardiac remodelling is not modulated by ablation of phosphodiesterase 4D interacting protein. Mohamed, B. A., Elkenani, M., Mobarak, S., Marques Rodrigues, D., Annamalai, K., Schnelle, M., Bader, M., Hasenfuss, G. & Toischer, K. J Cell Mol Med 26, 4440-4452 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35860864  

Colchicine Impacts Leukocyte Trafficking in Atherosclerosis and Reduces Vascular Inflammation. Meyer-Lindemann, U., Mauersberger, C., Schmidt, A. C., Moggio, A., Hinterdobler, J., Li, X., Khangholi, D., Hettwer, J., Grasser, C., Dutsch, A., Schunkert, H., Kessler, T. & Sager, H. B. Front Immunol 13, 898690 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35860249  

Restoration of Cardiomyogenesis in Aged Mouse Hearts by Voluntary Exercise. Lerchenmuller, C., Vujic, A., Mittag, S., Wang, A., Rabolli, C. P., Hess, C., Betge, F., Rangrez, A. Y., Chaklader, M., Guillermier, C., Gyngard, F., Roh, J. D., Li, H., Steinhauser, M. L., Frey, N., Rothermel, B., Dieterich, C., Rosenzweig, A. & Lee, R. T. Circulation 146, 412-426 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35862076  

Origin and function of activated fibroblast states during zebrafish heart regeneration. Hu, B., Lelek, S., Spanjaard, B., El-Sammak, H., Simoes, M. G., Mintcheva, J., Aliee, H., Schafer, R., Meyer, A. M., Theis, F., Stainier, D. Y. R., Panakova, D. & Junker, J. P. Nat Genet 54, 1227-1237 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35864193  

Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles. Hosen, M. R., Goody, P. R., Zietzer, A., Xiang, X., Niepmann, S. T., Sedaghat, A., Tiyerili, V., Chennupati, R., Moore, J. B. t., Boon, R. A., Uchida, S., Sinning, J. M., Zimmer, S., Latz, E., Werner, N., Nickenig, G. & Jansen, F. Circulation 146, 1836-1854 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35862223  

Presenting Pattern of Atrial Fibrillation and Outcomes of Early Rhythm Control Therapy. Goette, A., Borof, K., Breithardt, G., Camm, A. J., Crijns, H., Kuck, K. H., Wegscheider, K., Kirchhof, P. & Investigators, E.-A. J Am Coll Cardiol 80, 283-295 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35863844  

Autoimmunity to Sphingosine-1-Phosphate-Receptors in Systemic Sclerosis and Pulmonary Arterial Hypertension. Gluschke, H., Siegert, E., Minich, W. B., Hackler, J., Riemekasten, G., Kuebler, W. M., Simmons, S. & Schomburg, L. Front Immunol 13, 935787 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35860272  

Active multi-task learning with uncertainty weighted loss for coronary calcium scoring. Follmer, B., Biavati, F., Wald, C., Stober, S., Ma, J., Dewey, M. & Samek, W. Med Phys (2022). https://www.ncbi.nlm.nih.gov/pubmed/35861655  

Telomere Shortening in Hypertensive Heart Disease Depends on Oxidative DNA Damage and Predicts Impaired Recovery of Cardiac Function in Heart Failure. Brandt, M., Dorschmann, H., Khraisat, S., Knopp, T., Ringen, J., Kalinovic, S., Garlapati, V., Siemer, S., Molitor, M., Gobel, S., Stauber, R., Helena Karbach, S., Munzel, T., Daiber, A. & Wenzel, P. Hypertension, 101161HYPERTENSIONAHA12118935 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35862118  

Analysis of epidemiological association patterns of serum thyrotropin by combining random forests and Bayesian networks. Becker, A. K., Ittermann, T., Dorr, M., Felix, S. B., Nauck, M., Teumer, A., Volker, U., Volzke, H., Kaderali, L. & Nath, N. PLoS One 17, e0271610 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35862421  

Mosaic loss of Y chromosome during aging. Zeiher, A. & Braun, T. Science 377, 266-267 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35857599  

Impaired AMP-Activated Protein Kinase Signaling in Heart Failure With Preserved Ejection Fraction-Associated Atrial Fibrillation. Tong, D., Schiattarella, G. G., Jiang, N., Daou, D., Luo, Y., Link, M. S., Lavandero, S., Gillette, T. G. & Hill, J. A. Circulation 146, 73-76 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35858165  

Pharmacogenetics-guided dalcetrapib therapy after an acute coronary syndrome: the dal-GenE trial. Tardif, J. C., Pfeffer, M. A., Kouz, S., Koenig, W., Maggioni, A. P., McMurray, J. J. V., Mooser, V., Waters, D. D., Gregoire, J. C., L'Allier, P. L., Jukema, W. J., White, H. D., Heinonen, T., Black, D. M., Laghrissi-Thode, F., Levesque, S., Guertin, M. C., Dube, M. P. & dal-Gen, E. I. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35856777  

Spacemake: processing and analysis of large-scale spatial transcriptomics data. Sztanka-Toth, T. R., Jens, M., Karaiskos, N. & Rajewsky, N. Gigascience 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35852420  

The Spectrum of Central Nervous System Involvement in Whipple's Disease. Mecklenburg, J., Moos, V., Moter, A., Siebert, E., Nave, A. H., Schneider, T., Ruprecht, K. & Euskirchen, P. Eur J Neurol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35852414  

Particular Challenges in the Use of Pulmonary Vasodilating Therapy for Patients with Pulmonary Hypertension Secondary to Left Heart Diseases. Dandel, M. & Hetzer, R. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35853842  

Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Ralpha. Cai, Z., Tian, S., Klein, T., Tu, L., Geenen, L. W., Koudstaal, T., van den Bosch, A. E., de Rijke, Y. B., Reiss, I. K. M., Boersma, E., van der Ley, C., Van Faassen, M., Kema, I., Duncker, D. J., Boomars, K. A., Tran-Lundmark, K., Guignabert, C. & Merkus, D. Sci Rep 12, 12326 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35853948  

Artificial intelligence fully automated myocardial strain quantification for risk stratification following acute myocardial infarction. Backhaus, S. J., Aldehayat, H., Kowallick, J. T., Evertz, R., Lange, T., Kutty, S., Bigalke, B., Gutberlet, M., Hasenfuss, G., Thiele, H., Stiermaier, T., Eitel, I. & Schuster, A. Sci Rep 12, 12220 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35851282  

How COVID-19 affects microvessels in the brain. Wenzel, J. & Schwaninger, M. Brain 145, 2242-2244 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35848856  

Bestform-F - Best Function of Range of Motion: A Feasibility Study of a Multimodal Exercise Training Program for Older Adults in Retirement Homes. Schaller, N., Krusemark, H., Mende, E., Weiss, M., Spanier, B., Zelger, O., Bischof, J., Haller, B., Halle, M. & Siegrist, M. Clin Interv Aging 17, 1069-1080 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35846178  

CDK4/6 blockade provides an alternative approach for treatment of mismatch-repair deficient tumors. Salewski, I., Henne, J., Engster, L., Krone, P., Schneider, B., Redwanz, C., Lemcke, H., Henze, L., Junghanss, C. & Maletzki, C. Oncoimmunology 11, 2094583 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35845723  

Systemic gene therapy with thymosin beta4 alleviates glomerular injury in mice. Mason, W. J., Jafree, D. J., Pomeranz, G., Kolatsi-Joannou, M., Rottner, A. K., Pacheco, S., Moulding, D. A., Wolf, A., Kupatt, C., Peppiatt-Wildman, C., Papakrivopoulou, E., Riley, P. R., Long, D. A. & Vasilopoulou, E. Sci Rep 12, 12172 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35842494  

Transcatheter Mitral Valve Repair in Patients With Atrial Functional Mitral Regurgitation. Doldi, P., Stolz, L., Orban, M., Karam, N., Praz, F., Kalbacher, D., Lubos, E., Braun, D., Adamo, M., Giannini, C., Melica, B., Nabauer, M., Higuchi, S., Wild, M., Neuss, M., Butter, C., Kassar, M., Petrescu, A., Pfister, R., Iliadis, C. et al. JACC Cardiovasc Imaging (2022). https://www.ncbi.nlm.nih.gov/pubmed/35842361  

Peak O2 -pulse predicts exercise training-induced changes in peak VO2 in heart failure with preserved ejection fraction. Mueller, S., Haller, B., Feuerstein, A., Winzer, E. B., Beckers, P., Haykowsky, M. J., Gevaert, A. B., Hommel, J., Azevedo, L. F., Duvinage, A., Esefeld, K., Fegers-Wustrow, I., Christle, J. W., Pieske-Kraigher, E., Belyavskiy, E., Morris, D. A., Kropf, M., Aravind-Kumar, R., Edelmann, F., Linke, A. et al. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35840541  

Fast acquisition of left and right ventricular function parameters applying cardiovascular magnetic resonance in clinical routine - validation of a 2-shot compressed sensing cine sequence. Groschel, J., Ammann, C., Zange, L., Viezzer, D., Forman, C., Schmidt, M., Blaszczyk, E. & Schulz-Menger, J. Scand Cardiovasc J 56, 266-275 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35836407  

Response to the clinical commentary 'Telemedical monitoring by an implanted loop recorder: gateway to personalized medicine? Results of the SMART-MI study'. Rizas, K. D., Kaab, S., Massberg, S. & Bauer, A. Cardiovasc Res 118, e81 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35834784  

Non-monotonous dose response function of the termination of spiral wave chaos. Lilienkamp, T., Parlitz, U. & Luther, S. Sci Rep 12, 12043 (2022). www.ncbi.nlm.nih.gov/pubmed/35835979

Eligibility for early rhythm control in patients with atrial fibrillation in the UK Biobank. Kany, S., Cardoso, V. R., Bravo, L., Williams, J. A., Schnabel, R., Fabritz, L., Gkoutos, G. V. & Kirchhof, P. Heart (2022). https://www.ncbi.nlm.nih.gov/pubmed/35835543  

Spatial correction improves accuracy of catheter positioning during ablation of premature ventricular contractions: differences between ventricular outflow tracts and other localizations. Nies, M., Schleberger, R., Dinshaw, L., Klatt, N., Muenkler, P., Jungen, C., Rottner, L., Lemoine, M. D., Reissmann, B., Rillig, A., Metzner, A., Kirchhof, P. & Meyer, C. BMC Cardiovasc Disord 22, 312 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35831801  

Standardized annotation of translated open reading frames. Mudge, J. M., Ruiz-Orera, J., Prensner, J. R., Brunet, M. A., Calvet, F., Jungreis, I., Gonzalez, J. M., Magrane, M., Martinez, T. F., Schulz, J. F., Yang, Y. T., Alba, M. M., Aspden, J. L., Baranov, P. V., Bazzini, A. A., Bruford, E., Martin, M. J., Calviello, L., Carvunis, A. R., Chen, J. et al. Nat Biotechnol 40, 994-999 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35831657  

UFO procedure: Two small surgical details. Wert, L. & Pasic, M. J Card Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35819132  

Pathophysiological insights with relevant impact on the prognostic assessment and clinical management of patients with pulmonary arterial hypertension. Dandel, M. J Physiol 600, 3633-3634 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35818117  

Protein O-GlcNAcylation in cardiovascular diseases. Wang, H. F., Wang, Y. X., Zhou, Y. P., Wei, Y. P., Yan, Y., Zhang, Z. J. & Jing, Z. C. Acta Pharmacol Sin (2022). https://www.ncbi.nlm.nih.gov/pubmed/35817809  

Reduction of contrast agent volume utilization for cardiac catheterization in current clinical practice. Stocker, T. J., Massberg, S. & Hausleiter, J. Int J Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35817203  

[Implantation of mechanical circulatory support systems and heart transplantation in patients with end-stage heart failure : Consensus paper of the DGK, DGTHG]. Schulze, P. C., Barten, M. J., Boeken, U., Farber, G., Hagl, C. M., Jung, C., Leistner, D., Potapov, E., Bauersachs, J., Raake, P., Reiss, N., Saeed, D., Schibilsky, D., Stork, S., Veltmann, C., Rieth, A. J. & Gummert, J. Med Klin Intensivmed Notfmed (2022). https://www.ncbi.nlm.nih.gov/pubmed/35816214  

Nox4 promotes endothelial differentiation through chromatin remodeling. Hahner, F., Moll, F., Warwick, T., Hebchen, D. M., Buchmann, G. K., Epah, J., Abplanalp, W., Schader, T., Gunther, S., Gilsbach, R., Brandes, R. P. & Schroder, K. Redox Biol 55, 102381 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35810713  

Role of Gpnmb in atherosclerosis of female mice. Nickl, B., Qadri, F. & Bader, M. Biochem Biophys Res Commun 621, 20-24 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35809343  

The arch remodelling stent for DeBakey I acute aortic dissection: experience with 100 implantations. Montagner, M., Kofler, M., Seeber, F., Pitts, L., Starck, C., Sundermann, S. H., Kurz, S., Grubitzsch, H., Falk, V. & Kempfert, J. Eur J Cardiothorac Surg 62 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35809065  

VARS2 Depletion Leads to Activation of the Integrated Stress Response and Disruptions in Mitochondrial Fatty Acid Oxidation. Kayvanpour, E., Wisdom, M., Lackner, M. K., Sedaghat-Hamedani, F., Boeckel, J. N., Muller, M., Eghbalian, R., Dudek, J., Doroudgar, S., Maack, C., Frey, N. & Meder, B. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35806332  

Quantification of right atrial fibrosis by cardiac magnetic resonance: verification of the method to standardize thresholds. Gunturiz-Beltran, C., Borras, R., Alarcon, F., Garre, P., Ventura, R., Benito, E. M., Caixal, G., Althoff, T. F., Maria Tolosana, J., Arbelo, E., Roca, I., Prat-Gonzalez, S., Perea, R. J., Brugada, J., Sitges, M., Guasch, E. & Mont, L. Rev Esp Cardiol (Engl Ed) (2022). https://www.ncbi.nlm.nih.gov/pubmed/35809892  

Restenosis after Coronary Stent Implantation: Cellular Mechanisms and Potential of Endothelial Progenitor Cells (A Short Guide for the Interventional Cardiologist). Gori, T. Cells 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35805178  

Improved Generation of Human Induced Pluripotent Stem Cell-Derived Cardiac Pacemaker Cells Using Novel Differentiation Protocols. Darche, F. F., Ullrich, N. D., Huang, Z., Koenen, M., Rivinius, R., Frey, N. & Schweizer, P. A. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35806319  

miR-29c Increases Protein Synthesis in Skeletal Muscle Independently of AKT/mTOR. Alves, P. K. N., Cruz, A., Silva, W. J., Labeit, S. & Moriscot, A. S. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35806204  

Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1. Rot, A., Gutjahr, J. C., Biswas, A., Aslani, M., Hub, E., Thiriot, A., von Andrian, U. H., Megens, R. T. A., Weber, C. & Duchene, J. Cell Stem Cell 29, 1013-1015 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35803222  

Surgical explantation of failed transcatheter heart valves: indications and results. Muensterer, A., Puluca, N., Ruge, H., Vitanova, K. & Lange, R. Heart Vessels 37, 2083-2092 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35802181  

The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins alpha9beta1 and alpha4beta1. Morris, G. E., Denniff, M. J., Karamanavi, E., Andrews, S. A., Kostogrys, R. B., Bountziouka, V., Ghaderi-Najafabadi, M., Shamkhi, N., McConnell, G., Kaiser, M. A., Carleton, L., Schofield, C., Kessler, T., Rainbow, R. D., Samani, N. J. & Webb, T. R. Br J Pharmacol 179, 4958-4973 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35802072  

SVEP1 regulates GPCR-mediated vasoconstriction via integrin alpha9beta1 and alpha4beta1. Morris, G. E., Denniff, M. J., Karamanavi, E., Andrews, S. A., Kostogrys, R. B., Bountziouka, V., Ghaderi-Najafabadi, M., Shamkhi, N., McConnell, G., Kaiser, M. A., Carleton, L., Schofield, C., Kessler, T., Rainbow, R. D., Samani, N. J. & Webb, T. R. Br J Pharmacol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35802072  

Performance of an electronic health record-based predictive model to identify patients with atrial fibrillation across countries. Mokgokong, R., Schnabel, R., Witt, H., Miller, R. & Lee, T. C. PLoS One 17, e0269867 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35802569  

Informed Consent before coronary angiography and percutaneous coronary intervention from the patient's perspective: A picture is worth a thousand words. Brand, A., Crayen, C., Hamann, A., Martineck, S., Gao, L., Brand, H., Squier, S. M., Stangl, K., Kendel, F. & Stangl, V. Int J Cardiol Heart Vasc 41, 101076 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35800041  

Multi-center study of inter-rater reproducibility, image quality, and diagnostic accuracy of CZT versus conventional SPECT myocardial perfusion imaging. Mansour, N., Nekolla, S. G., Reyes, E., Angelidis, G., Georgoulias, P., Anagnostopoulos, C., Bravo, P., Bruno, I., Flotats, A., Fuentes-Ocampo, F., Sciagra, R., Keng, F., Kessler, L., Papathanasiou, M., Soman, P. & Rischpler, C. J Nucl Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35799039  

Serial Changes in Coronary Plaque Formation Using CT Angiography in Patients Undergoing PCSK9-Inhibitor Therapy With 1-year Follow-up. Baumann, S., Kettel, L., Stach, K., Ozdemir, G. H., Renker, M., Tesche, C., Becher, T., Hetjens, S., Schoepf, U. J., Akin, I., Borggrefe, M., Kramer, B. K., Schoenberg, S. O., Janssen, S., Overhoff, D. & Lossnitzer, D. J Thorac Imaging 37, 285-291 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35797638  

Transcatheter edge-to-edge mitral valve repair in mitral regurgitation: current status and future prospects. Stolz, L., Braun, D., Higuchi, S., Orban, M., Doldi, P. M., Stocker, T. J., Weckbach, L. T., Wild, M. G., Hagl, C., Massberg, S., Nabauer, M., Hausleiter, J. & Orban, M. Expert Rev Med Devices, 1-10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35791872  

Guideline-directed medical therapy in patients undergoing transcatheter edge-to-edge repair for secondary mitral regurgitation. Higuchi, S., Orban, M., Adamo, M., Giannini, C., Melica, B., Karam, N., Praz, F., Kalbacher, D., Koell, B., Stolz, L., Braun, D., Nabauer, M., Wild, M., Doldi, P., Neuss, M., Butter, C., Kassar, M., Ruf, T., Petrescu, A., Ludwig, S. et al. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35791663  

Assessment and Mitigation of Bleeding Risk in Atrial Fibrillation and Venous Thromboembolism: Executive Summary of a European and Asia-Pacific Expert Consensus Paper. Gorog, D. A., Gue, Y. X., Chao, T. F., Fauchier, L., Ferreiro, J. L., Huber, K., Konstantinidis, S. V., Lane, D. A., Marin, F., Oldgren, J., Potpara, T., Roldan, V., Rubboli, A., Sibbing, D., Tse, H. F., Vilahur, G. & Lip, G. Y. H. Thromb Haemost (2022). https://www.ncbi.nlm.nih.gov/pubmed/35793691  

Elevated blood pressure in pregnant women with gestational diabetes according to the WHO criteria: importance of overweight. Birukov, A., Glintborg, D., Schulze, M. B., Jensen, T. K., Kuxhaus, O., Andersen, L. B., Kraker, K., Polemiti, E., Jensen, B. L., Jorgensen, J. S., Dechend, R. & Andersen, M. S. J Hypertens 40, 1614-1623 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35792096

Common electrocardiogram measures are not associated with telomere length. von Falkenhausen, A. S., Freudling, R., Waldenberger, M., Gieger, C., Peters, A., Muller-Nurasyid, M., Kaab, S. & Sinner, M. F. Aging (Albany NY) 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35787517  

Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome. Morsiani, C., Bacalini, M. G., Collura, S., Moreno-Villanueva, M., Breusing, N., Burkle, A., Grune, T., Franceschi, C., De Eguileor, M. & Capri, M. Mech Ageing Dev 206, 111691 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35780970  

High-Mobility Group Box Protein 1 Is an Independent Prognostic Marker for All-Cause Mortality in Patients With Dilated Cardiomyopathy. Kummel, A., Gross, S., Feldtmann, R., Chamling, B., Strohbach, A., Lehnert, K., Bahls, M., Loerzer, L., Moormann, K., Witte, J., Riad, A., Dorr, M., Fielitz, J. & Felix, S. B. Am J Cardiol 178, 119-123 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35787339  

The need for a subsequent transvenous system in patients implanted with subcutaneous implantable cardioverter-defibrillator. Gasperetti, A., Schiavone, M., Vogler, J., Laredo, M., Fastenrath, F., Palmisano, P., Ziacchi, M., Angeletti, A., Mitacchione, G., Kaiser, L., Compagnucci, P., Breitenstein, A., Arosio, R., Vitali, F., De Bonis, S., Picarelli, F., Casella, M., Santini, L., Pignalberi, C., Lavalle, C. et al. Heart Rhythm 19, 1958-1964 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35781042  

Surgical treatment of isolated tricuspid valve endocarditis: Midterm data. Dzilic, E., Nobauer, C., Burri, M., Voss, S., Krane, M., Lange, R. & Vitanova, K. J Card Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35790024  

WARS1 and SARS1: Two tRNA synthetases implicated in autosomal recessive microcephaly. Bogershausen, N., Krawczyk, H. E., Jamra, R. A., Lin, S. J., Yigit, G., Huning, I., Polo, A. M., Vona, B., Huang, K., Schmidt, J., Altmuller, J., Luppe, J., Platzer, K., Dorgeloh, B. B., Busche, A., Biskup, S., Mendes, M. I., Smith, D. E. C., Salomons, G. S., Zibat, A. et al. Hum Mutat (2022). https://www.ncbi.nlm.nih.gov/pubmed/35790048  

Ticagrelor or prasugrel in patients with acute coronary syndrome with off-hour versus on-hour presentation: a subgroup analysis of the ISAR-REACT 5 trial. Behnes, M., Lahu, S., Ndrepepa, G., Menichelli, M., Mayer, K., Wohrle, J., Bernlochner, I., Gewalt, S., Witzenbichler, B., Hochholzer, W., Sibbing, D., Cassese, S., Angiolillo, D. J., Hemetsberger, R., Valina, C., Muller, A., Kufner, S., Hamm, C. W., Xhepa, E., Hapfelmeier, A. et al. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35789430  

Minimally Clinically Important Difference in Health Status Scores in Patients With HFrEF vs HFpEF. Butler, J., Shahzeb Khan, M., Lindenfeld, J., Abraham, W. T., Savarese, G., Salsali, A., Zeller, C., Peil, B., Filippatos, G., Ponikowski, P. & Anker, S. D. JACC Heart Fail 10, 651-661 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35780032  

Enoxaparin for primary thromboprophylaxis in symptomatic outpatients with COVID-19 (OVID): a randomised, open-label, parallel-group, multicentre, phase 3 trial. Barco, S., Voci, D., Held, U., Sebastian, T., Bingisser, R., Colucci, G., Duerschmied, D., Frenk, A., Gerber, B., Gotschi, A., Konstantinides, S. V., Mach, F., Robert-Ebadi, H., Rosemann, T., Simon, N. R., Spechbach, H., Spirk, D., Stortecky, S., Vaisnora, L., Righini, M. et al. Lancet Haematol 9, e585-e593 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35779558  

Assessment of the association of exposure to polycyclic aromatic hydrocarbons, oxidative stress, and inflammation: A cross-sectional study in Augsburg, Germany. Wu, X., Cao, X., Lintelmann, J., Peters, A., Koenig, W., Zimmermann, R., Schneider, A., Wolf, K. & group, K. O.-S. Int J Hyg Environ Health 244, 113993 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35777219  

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver. Schmid, C. D., Olsavszky, V., Reinhart, M., Weyer, V., Trogisch, F. A., Sticht, C., Winkler, M., Kurschner, S. W., Hoffmann, J., Ola, R., Staniczek, T., Heineke, J., Straub, B. K., Mittler, J., Schledzewski, K., Ten Dijke, P., Richter, K., Dooley, S., Geraud, C., Goerdt, S. et al. Hepatology (2022). https://www.ncbi.nlm.nih.gov/pubmed/35776660  

Cardio-respiratory motion-corrected 3D cardiac water-fat MRI using model-based image reconstruction. Mayer, J., Blaszczyk, E., Cipriani, A., Ferrazzi, G., Schulz-Menger, J., Schaeffter, T. & Kolbitsch, C. Magn Reson Med 88, 1561-1574 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35775790  

Exercise Testing in HFpEF: an Appraisal Through Diagnosis, Pathophysiology and Therapy A Clinical Consensus Statement of the Heart Failure Association (HFA) and European Association of Preventive Cardiology (EAPC) of the European Society of Cardiology (ESC). Marco Guazzi, M., Wilhelm, M., Halle, M., Van Craenenbroeck, E., Kemps, H., de Boer, R. A., Coats, A. J., Lund, L., Mancini, D., Borlaug, B., Filippatos, G. & Pieske, B. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35775383  

The baroreceptor reflex brought to life outside the classroom - an e-learning based asynchronous laboratory class using a non-supervised modified Active Standing Test. Heinrich, T., Sehner, S., Wageringel, I., Ehmke, H. & Schwoerer, A. P. BMC Med Educ 22, 515 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35778720  

The association of smoking and smoking cessation with prevalent and incident symptoms of depression, anxiety, and sleep disturbance in the general population. Hahad, O., Beutel, M., Gilan, D. A., Michal, M., Schulz, A., Pfeiffer, N., Konig, J., Lackner, K., Wild, P., Daiber, A. & Munzel, T. J Affect Disord 313, 100-109 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35777492  

Exercise testing in heart failure with preserved ejection fraction: an appraisal through diagnosis, pathophysiology and therapy - A clinical consensus statement of the Heart Failure Association and European Association of Preventive Cardiology of the European Society of Cardiology. Guazzi, M., Wilhelm, M., Halle, M., Van Craenenbroeck, E., Kemps, H., de Boer, R. A., Coats, A. J. S., Lund, L., Mancini, D., Borlaug, B., Filippatos, G. & Pieske, B. Eur J Heart Fail 24, 1327-1345 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35775383  

Identification of risk factors for delirium, cognitive decline, and dementia after cardiac surgery (FINDERI-find delirium risk factors): a study protocol of a prospective observational study. Sadlonova, M., Vogelgsang, J., Lange, C., Gunther, I., Wiesent, A., Eberhard, C., Ehrentraut, J., Kirsch, M., Hansen, N., Esselmann, H., Timaus, C., Asendorf, T., Breitling, B., Chebbok, M., Heinemann, S., Celano, C., Kutschka, I., Wiltfang, J., Baraki, H. & von Arnim, C. A. F. BMC Cardiovasc Disord 22, 299 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35773648  

Fibrotic plaques in heart transplanted patients and their association with insulin resistance syndrome and Lp(a). Orban, M., Kuehl, A., Dischl, D., Muller, C., Ulrich, S., Petzold, T., Rizas, K. D., Orban, M., Braun, D., Hausleiter, J., Hagl, C., Mehilli, J. & Massberg, S. Int J Cardiol 363, 218-224 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35772579  

Soil and water pollution and human health: what should cardiologists worry about? Munzel, T., Hahad, O., Daiber, A. & Landrigan, P. J. Cardiovasc Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/35772469  

Genetics and Epigenetics in Personalized Nutrition: Evidence, Expectations, and Experiences. Holzapfel, C., Waldenberger, M., Lorkowski, S., Daniel, H. & Working Group "Personalized Nutrition" of the German Nutrition, S. Mol Nutr Food Res 66, e2200077 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35770348


August

AAV-Mediated Somatic Gene Editing for Cardiac and Skeletal Muscle in a Large Animal Model. Ziegler, T., Bozoglu, T. & Kupatt, C. Methods Mol Biol 2573, 63-74 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36040587  

Enhancing Cardiomyocyte Transcription Using In Vivo CRISPR/Cas9 Systems. Schoger, E. & Zelarayan, L. C. Methods Mol Biol 2573, 53-61 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36040586  

Cardiac Gene Delivery in Large Animal Models: Selective Retrograde Venous Injection. Schlegel, P. & Raake, P. W. J. Methods Mol Biol 2573, 171-177 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36040594  

Concomitant cardiovascular malformations in isolated bicuspid aortic valve disease: a retrospective cross-sectional study and meta-analysis. Szocs, K., Toprak, B., Schon, G., Rybczynski, M., Brinken, T., Mahlmann, A., Girdauskas, E., Blankenberg, S. & von Kodolitsch, Y. Cardiovasc Diagn Ther 12, 400-414 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36033227  

Rationale and design of the AXIOMATIC-SSP phase II trial: Antithrombotic treatment with factor XIa inhibition to Optimize Management of Acute Thromboembolic events for Secondary Stroke Prevention. Sharma, M., Molina, C. A., Toyoda, K., Bereczki, D., Kasner, S. E., Lutsep, H. L., Tsivgoulis, G., Ntaios, G., Czlonkowska, A., Shuaib, A., Amarenco, P., Endres, M., Diener, H. C., Gailani, D., Kahl, A., Donovan, M., Perera, V., Li, D. & Hankey, G. J. J Stroke Cerebrovasc Dis 31, 106742 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36037679  

Rationale and design of the prevention of paclitaxel-related neurological side effects with lithium trial - Protocol of a multicenter, randomized, double-blind, placebo- controlled proof-of-concept phase-2 clinical trial. Huehnchen, P., Bangemann, N., Lischewski, S., Marschenz, S., Paul, F., Schmitz-Hubsch, T., Blohmer, J. U., Eberhardt, C., Rauch, G., Floel, A., Adam, S., Schwenkenbecher, P., Meinhold-Heerlein, I., Hoffmann, O., Ziemssen, T., Endres, M. & Boehmerle, W. Front Med (Lausanne) 9, 967964 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36035422  

Neutrophils incite and macrophages avert electrical storm after myocardial infarction. Grune, J., Lewis, A. J. M., Yamazoe, M., Hulsmans, M., Rohde, D., Xiao, L., Zhang, S., Ott, C., Calcagno, D. M., Zhou, Y., Timm, K., Shanmuganathan, M., Pulous, F. E., Schloss, M. J., Foy, B. H., Capen, D., Vinegoni, C., Wojtkiewicz, G. R., Iwamoto, Y., Grune, T. et al. Nat Cardiovasc Res 1, 649-664 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36034743  

Characteristics and Prognostic Relevance of Ventricular Arrhythmia in Patients with Myocarditis. Kahle, A. K., Gude, R., Schwarzl, J. M., Munkler, P., Akbulak, R. O., Jahnke, C., Bohnen, S., Wurger, T., Schwarzl, M., Willems, S., Radunski, U. K. & Meyer, C. J Cardiovasc Dev Dis 9 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36005407   

The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis. Jarr, K. U., Ye, J., Kojima, Y., Ye, Z., Gao, H., Schmid, S., Luo, L., Baylis, R. A., Lotfi, M., Lopez, N., Eberhard, A. V., Smith, B. R., Weissman, I. L., Maegdefessel, L. & Leeper, N. J. Nat Cardiovasc Res 1, 253-262 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35990913  

Longer leukocyte telomere length is associated with myeloid inflammation and increased mortality after transcatheter aortic valve replacement. Hoffmann, J., Tabata, N., Mas-Peiro, S., Spyridopoulos, I., Sinning, J. M., Berkowitsch, A., Martin-Ruiz, C., Al-Kassou, B., Herrmann, E., Dimmeler, S., Zeiher, A. M. & Vasa-Nicotera, M. Eur Heart J Open 2, oeac045 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35983406  

Mechanical thrombectomy in ischemic stroke after cardiovascular procedures: a propensity-matched cohort analysis. Bay, B., Gloyer, N. O., Remmel, M., Schell, M., Zelenak, K., Seiffert, M., Brunner, F. J., Clemmensen, P., Reichenspurner, H., Blankenberg, S., Thomalla, G., Fiehler, J., Conradi, L., Waldeyer, C. & Flottmann, F. J Neurointerv Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35985838

Step-by-step diagnosis and management of the nocebo/drucebo effect in statin-associated muscle symptoms patients: a position paper from the International Lipid Expert Panel (ILEP). Penson, P. E., Bruckert, E., Marais, D., Reiner, Z., Pirro, M., Sahebkar, A., Bajraktari, G., Mirrakhimov, E., Rizzo, M., Mikhailidis, D. P., Sachinidis, A., Gaita, D., Latkovskis, G., Mazidi, M., Toth, P. P., Pella, D., Alnouri, F., Postadzhiyan, A., Yeh, H. I., Mancini, G. B. J. et al. J Cachexia Sarcopenia Muscle 13, 1596-1622 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35969116  

Left ventricle- and skeletal muscle-derived fibroblasts exhibit a differential inflammatory and metabolic responsiveness to interleukin-6. Matz, I., Pappritz, K., Springer, J. & Van Linthout, S. Front Immunol 13, 947267 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35967380  

A Preclinical Study on Brugada Syndrome with a CACNB2 Variant Using Human Cardiomyocytes from Induced Pluripotent Stem Cells. Zhong, R., Schimanski, T., Zhang, F., Lan, H., Hohn, A., Xu, Q., Huang, M., Liao, Z., Qiao, L., Yang, Z., Li, Y., Zhao, Z., Li, X., Rose, L., Albers, S., Maywald, L., Muller, J., Dinkel, H., Saguner, A., Janssen, J. W. G. et al. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35955449  

High-Protein, Low-Glycaemic Meal Replacement Improves Physical Health-Related Quality of Life in High-Risk Persons for Metabolic Syndrome-A Subanalysis of the Randomised-Controlled ACOORH Trial. Kempf, K., Rohling, M., Banzer, W., Braumann, K. M., Halle, M., Schaller, N., McCarthy, D., Predel, H. G., Schenkenberger, I., Tan, S., Toplak, H., Martin, S., Berg, A. & On Behalf Of The Acoorh Study, G. Nutrients 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35956337  

Cardiovascular risk factors, exercise capacity and health literacy in patients with chronic ischaemic heart disease and type 2 diabetes mellitus in Germany: Baseline characteristics of the Lifestyle Intervention in Chronic Ischaemic Heart Disease and Type 2 Diabetes study. Dinges, S. M., Krotz, J., Gass, F., Treitschke, J., Fegers-Wustrow, I., Geisberger, M., Esefeld, K., von Korn, P., Duvinage, A., Edelmann, F., Wolfram, O., Brandts, J., Winzer, E. B., Wolfarth, B., Freigang, F., Neubauer, S., Nebling, T., Hackenberg, B., Amelung, V., Mueller, S. et al. Diab Vasc Dis Res 19, 14791641221113781 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35953083  

Valve embolization during transcatheter aortic valve implantation: Incidence, risk factors and follow-up by computed tomography. Frumkin, D., Pietron, M., Kind, A., Brand, A., Knebel, F., Laule, M., Leistner, D. M., Landmesser, U., Krackhardt, F., Sherif, M., Sundermann, S. H., Grubitzsch, H., Lembcke, A., Niehues, S. M., Stangl, K. & Dreger, H. Front Cardiovasc Med 9, 928740 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35935663  

Full-Length Spatial Transcriptomics Reveals the Unexplored Isoform Diversity of the Myocardium Post-MI. Boileau, E., Li, X., Naarmann-de Vries, I. S., Becker, C., Casper, R., Altmuller, J., Leuschner, F. & Dieterich, C. Front Genet 13, 912572 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35937994  

Platelets in Myocardial Ischemia/Reperfusion Injury. Schanze, N., Hamad, M. A., Nuhrenberg, T. G., Bode, C. & Duerschmied, D. Hamostaseologie (2022). https://www.ncbi.nlm.nih.gov/pubmed/35913081  

Editorial: Impact of the gut microbiota on cardiovascular medicine. Haghikia, A., van Mens, T. E., Pontarollo, G. & Reinhardt, C. Front Med (Lausanne) 9, 939890 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35911413  

Different Impacts on the Heart After COVID-19 Infection and Vaccination: Insights From Cardiovascular Magnetic Resonance. Groschel, J., Bhoyroo, Y., Blaszczyk, E., Trauzeddel, R. F., Viezzer, D., Saad, H., Fenski, M. & Schulz-Menger, J. Front Cardiovasc Med 9, 916922 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35911510  

Congestion in heart failure: a circulating biomarker-based perspective. A review from the Biomarkers Working Group of the Heart Failure Association, European Society of Cardiology. Nunez, J., de la Espriella, R., Rossignol, P., Voors, A. A., Mullens, W., Metra, M., Chioncel, O., Januzzi, J. L., Mueller, C., Richards, A. M., de Boer, R. A., Thum, T., Arfsten, H., Gonzalez, A., Abdelhamid, M., Adamopoulos, S., Anker, S. D., Gal, T. B., Biegus, J., Cohen-Solal, A. et al. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/36039656  

A review of protocols for human iPSC culture, cardiac differentiation, subtype-specification, maturation, and direct reprogramming. Lyra-Leite, D. M., Gutierrez-Gutierrez, O., Wang, M., Zhou, Y., Cyganek, L. & Burridge, P. W. STAR Protoc 3, 101560 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36035804  

Putting the puzzle together: SGLT2 inhibitors from prevention to treatment of heart failure. Harrington, J., Anker, S. & Butler, J. Eur Heart J 43, 4433-4435 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36036745  

Attaining sinus rhythm mediates improved outcome with early rhythm control therapy of atrial fibrillation: the EAST - AFNET 4 trial. Eckardt, L., Sehner, S., Suling, A., Borof, K., Breithardt, G., Crijns, H., Goette, A., Wegscheider, K., Zapf, A., Camm, A. J., Metzner, A. & Kirchhof, P. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/36036648  

Sodium-glucose cotransporter 2 inhibitor treatment lowers serum uric acid in patients with heart failure with reduced ejection fraction - lessons from clinical trials. Letter regarding the article 'Dapagliflozin reduces uric acid concentration, an independent predictor of adverse outcomes in DAPA-HF'. Doehner, W. & Packer, M. Eur J Heart Fail (2022).

[Hypertrophic cardiomyopathies and ATTR amyloidosis - a current review for clinical practice]. Tschope, C., Elsanhoury, A., Diekmann, S. & Kuhl, U. Dtsch Med Wochenschr 147, 1127-1134 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36030786  

Smartphone-based screening for atrial fibrillation: a pragmatic randomized clinical trial. Rizas, K. D., Freyer, L., Sappler, N., von Stülpnagel, L., Spielbichler, P., Krasniqi, A., Schreinlechner, M., Wenner, F. N., Theurl, F., Behroz, A., Eiffener, E., Klemm, M. P., Schneidewind, A., Zens, M., Dolejsi, T., Mansmann, U., Massberg, S. & Bauer, A. Nature Medicine (2022).

Coronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry. Nowatzke, J., Guedeney, P., Palaskas, N., Lehmann, L., Ederhy, S., Zhu, H., Cautela, J., Francis, S., Courand, P. Y., Deswal, A., Ewer, S. M., Aras, M., Arangalage, D., Ghafourian, K., Fenioux, C., Finke, D., Peretto, G., Zaha, V., Itzhaki Ben Zadok, O., Tajiri, K. et al. Eur J Cancer 177, 197-205 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36030143  

'Normal Weight' Is Really Not Normal in Chronic Disease. Anker, S. D., Usman, M. S. & Butler, J. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/36029317  

Effect of Empagliflozin on Circulating Proteomics in Heart Failure: Mechanistic Insights from the EMPEROR Program. Zannad, F., Ferreira, J. P., Butler, J., Filippatos, G., Januzzi, J. L., Sumin, M., Zwick, M., Saadati, M., Pocock, S. J., Sattar, N., Anker, S. D. & Packer, M. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/36017745  

Retinol and Retinol Binding Protein 4 Levels and Cardiometabolic Disease Risk. Schiborn, C., Weber, D., Grune, T., Biemann, R., Jager, S., Neu, N., Muller von Blumencron, M., Fritsche, A., Weikert, C., Schulze, M. B. & Wittenbecher, C. Circ Res, 101161CIRCRESAHA122321295 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36017698  

High-sensitivity troponin I with or without ultra-sensitive copeptin for the instant rule-out of acute myocardial infarction. Ricci, F., Neumann, J. T., Rubsamen, N., Sorensen, N. A., Ojeda, F., Cataldo, I., Zeller, T., Schafer, S., Hartikainen, T. S., Golato, M., Palermi, S., Zimarino, M., Blankenberg, S., Westermann, D. & De Caterina, R. Front Cardiovasc Med 9, 895421 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36017085  

A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation. Reininghaus, N., Paisdzior, S., Hopfner, F., Jyrch, S., Cetindag, C., Scheerer, P., Kuhnen, P. & Biebermann, H. Biomolecules 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36009013  

AVNeo Improves Early Hemodynamics In Regurgitant Bicuspid Aortic Valves Compared To Aortic Valve Repair. Prinzing, A., Bohm, J., Sideris, K., Vitanova, K., Lange, R. & Krane, M. Interact Cardiovasc Thorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/36018270  

Harmful Impact of Tobacco Smoking and Alcohol Consumption on the Atrial Myocardium. Ohlrogge, A. H., Frost, L. & Schnabel, R. B. Cells 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36010652  

Mobile Access to Medical Records in Heart Transplantation Aftercare: Mixed-Methods Study Assessing Usability, Feasibility and Effects of a Mobile Application. Muller, J., Weinert, L., Svensson, L., Rivinius, R., Kreusser, M. M. & Heinze, O. Life (Basel) 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36013383  

Novel cryoballoon ablation system for pulmonary vein isolation: multicenter assessment of efficacy and safety-ANTARCTICA study. Heeger, C. H., Pott, A., Sohns, C., Riesinger, L., Sommer, P., Gasperetti, A., Tondo, C., Fassini, G., Moser, F., Lucas, P., Weinmann, K., Bohnen, J. E., Dahme, T., Rillig, A., Kuck, K. H., Wakili, R., Metzner, A. & Tilz, R. R. Europace 24, 1917-1925 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36026521  

Periostin Augments Vascular Smooth Muscle Cell Calcification via beta-Catenin Signaling. Alesutan, I., Henze, L. A., Boehme, B., Luong, T. T. D., Zickler, D., Pieske, B., Eckardt, K. U., Pasch, A. & Voelkl, J. Biomolecules 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36009051  

Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly. Tas, K., Volta, B. D., Lindner, C., El Bounkari, O., Hille, K., Tian, Y., Puig-Bosch, X., Ballmann, M., Hornung, S., Ortner, M., Prem, S., Meier, L., Rammes, G., Haslbeck, M., Weber, C., Megens, R. T. A., Bernhagen, J. & Kapurniotu, A. Nat Commun 13, 5004 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36008417  

Neointimal hyperplasia in systemic-to-pulmonary shunts of children with complex cyanotic congenital heart disease. Kottmann, P., Cleuziou, J., Lemmer, J., Eildermann, K., Vitanova, K., von-Stumm, M., Lehmann, L., Horer, J., Ewert, P., Sigler, M. & Wolf, C. M. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/36005853  

Inverse relationship between IL-6 and sodium levels in patients with COVID-19 and other respiratory tract infections: data from the COVIVA study. Atila, C., Monnerat, S., Bingisser, R., Siegemund, M., Lampart, M., Rueegg, M., Zellweger, N., Osswald, S., Rentsch, K., Christ-Crain, M. & Twerenbold, R. Endocr Connect 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36006851  

Intravascular molecular imaging: translating pathophysiology of atherosclerosis into human disease conditions. Seguchi, M., Aytekin, A., Lenz, T., Nicol, P., Klosterman, G. R., Beele, A., Sabic, E., Utsch, L., Alyaqoob, A., Gorpas, D., Ntziachristos, V., Jaffer, F. A., Rauschendorfer, P. & Joner, M. Eur Heart J Cardiovasc Imaging 24, e1-e16 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36002376  

NGS-driven molecular diagnosis of heterogeneous hereditary neurological disorders reveals novel and known variants in disease-causing genes. Khan, A., Tian, S., Tariq, M., Khan, S., Safeer, M., Ullah, N., Akbar, N., Javed, I., Asif, M., Ahmad, I., Ullah, S., Satti, H. S., Khan, R., Naeem, M., Ali, M., Rendu, J., Faure, J., Dieterich, K., Latypova, X., Baig, S. M. et al. Mol Genet Genomics (2022). https://www.ncbi.nlm.nih.gov/pubmed/36002593  

ADAR1 Prevents Autoinflammatory Processes in the Heart Mediated by IRF7. Garcia-Gonzalez, C., Dieterich, C., Maroli, G., Wiesnet, M., Wietelmann, A., Li, X., Yuan, X., Graumann, J., Stellos, K., Kubin, T., Schneider, A. & Braun, T. Circ Res, 101161CIRCRESAHA122320839 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36000401  

Association of In-Hospital Hemoglobin Drop With Decreased Myocardial Salvage and Increased Long-Term Mortality in Patients With Acute ST-Segment-Elevation Myocardial Infarction. Dutsch, A., Graesser, C., Voll, F., Novacek, S., Eggerstedt, R., Armbruster, N. L., Laugwitz, K. L., Cassese, S., Schunkert, H., Ndrepepa, G., Kastrati, A., Kessler, T. & Sager, H. B. J Am Heart Assoc, e024857 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36000430  

Left ventricular assist device related infections and the risk of cerebrovascular accidents: a EUROMACS study. Zijderhand, C. F., Antonides, C. F. J., Veen, K. M., Verkaik, N. J., Schoenrath, F., Gummert, J., Nemec, P., Merkely, B., Musumeci, F., Meyns, B., de By, T., Bogers, A. & Caliskan, K. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35997578  

ARDS in the Time of Corona: Context and Perspective. Voelkel, N. F., Bogaard, H. J. & Kuebler, W. M. Am J Physiol Lung Cell Mol Physiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35997290  

Boosters for adeno-associated virus vector (AAV) (r)evolution. Szumska, J. & Grimm, D. Cytotherapy (2022). https://www.ncbi.nlm.nih.gov/pubmed/35999132  

The sound of drug delivery: optoacoustic imaging in pharmacology. Liu, N., Mishra, K., Stiel, A. C., Gujrati, V. & Ntziachristos, V. Adv Drug Deliv Rev, 114506 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35998826  

Recovery of reduced thiol groups by superoxide-mediated denitrosation of nitrosothiols. Schildknecht, S., von Kriegsheim, A., Vujacic-Mirski, K., Di Lisa, F., Ullrich, V. & Daiber, A. Redox Biol 56, 102439 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35995009  

Repolarization indicates electrical instability in ventricular arrhythmia originating from papillary muscle. Munkler, P., Klatt, N., Scherschel, K., Kuklik, P., Jungen, C., Cavus, E., Eickholt, C., Christoph, J., Lemoine, M. D., Christ, T., Willems, S., Riedel, R., Kirchhof, P. & Meyer, C. Europace (2022). https://www.ncbi.nlm.nih.gov/pubmed/35989424  

Two-Faced Janus: CCR2-Expressing Macrophages and Their Dual Role in Allograft Rejection of the Transplanted Heart. Farina, F. M., Santovito, D. & Weber, C. Circulation 146, 639-642 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35994560  

Use of intravascular ultrasound for optimal vessel sizing in chronic total occlusion percutaneous coronary intervention. Blessing, R., Buono, A., Ahoopai, M., Geyer, M., Knorr, M., Brandt, M., Steven, S., Drosos, I., Muenzel, T., Wenzel, P., Gori, T. & Dimitriadis, Z. Front Cardiovasc Med 9, 922366 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35990972  

Effective high-density lipoprotein cholesterol is associated with carotid intima-media thickness and vascular events after acute ischemic stroke. Schwedhelm, E., Tiedt, S., Lezius, S., Wolfer, T. A., Jensen, M., Schulz, R., Boger, R., Gerloff, C., Thomalla, G. & Choe, C. U. Atherosclerosis 357, 9-13 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35988315  

Genetic and modifiable risk factors combine multiplicatively in common disease. Pang, S., Yengo, L., Nelson, C. P., Bourier, F., Zeng, L., Li, L., Kessler, T., Erdmann, J., Magi, R., Lall, K., Metspalu, A., Mueller-Myhsok, B., Samani, N. J., Visscher, P. M. & Schunkert, H. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35987817  

Quality of life of patients with coronary heart disease treated with the bioresorbable vascular scaffold (ABSORB): 2-year results from the GABI-R-registry. Pahmeier, K., Neusser, S., Hamm, C., Kastner, J., Wohrle, J., Zahn, R., Achenbach, S., Mehilli, J., Gori, T., Naber, C., Nef, H., Neumann, T., Richardt, G., Schmermund, A., Claas, C., Riemer, T., Biermann-Stallwitz, J. & Group, G.-R. S. BMC Cardiovasc Disord 22, 379 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35987601  

Venting during venoarterial extracorporeal membrane oxygenation. Lusebrink, E., Binzenhofer, L., Kellnar, A., Muller, C., Scherer, C., Schrage, B., Joskowiak, D., Petzold, T., Braun, D., Brunner, S., Peterss, S., Hausleiter, J., Zimmer, S., Born, F., Westermann, D., Thiele, H., Schafer, A., Hagl, C., Massberg, S. & Orban, M. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35986750   

Blinded sample size recalculation in adaptive enrichment designs. Placzek, M. & Friede, T. Biom J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35983952  

Prognostic value of De Ritis ratio in patients with acute myocardial infarction. Ndrepepa, G., Holdenrieder, S. & Kastrati, A. Clin Chim Acta 535, 75-81 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35985502  

Inflammation in Children with CKD Linked to Gut Dysbiosis and Metabolite Imbalance. Holle, J., Bartolomaeus, H., Lober, U., Behrens, F., Bartolomaeus, T. U. P., Anandakumar, H., Wimmer, M. I., Vu, D. L., Kuhring, M., Bruning, U., Maifeld, A., Geisberger, S., Kempa, S., Schumacher, F., Kleuser, B., Bufler, P., Querfeld, U., Kitschke, S., Engler, D., Kuhrt, L. D. et al. J Am Soc Nephrol 33, 2259-2275 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35985814  

Biventricular strain assessment indicates progressive impairment of myocardial contractility in phenotypically negative patients with Fabry's disease. Halfmann, M. C., Benz, S., Schoepf, U. J., Hennermann, J. B., Kreitner, K. F., Lollert, A., Dueber, C., Altmann, S., Varga-Szemes, A., Kampmann, C. & Emrich, T. Eur J Radiol 155, 110471 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35985091  

Concomitant mitral regurgitation in patients with low-gradient aortic stenosis: an analysis from the German Aortic Valve Registry. Alushi, B., Ensminger, S., Herrmann, E., Balaban, U., Bauer, T., Beckmann, A., Bleiziffer, S., Mollmann, H., Walther, T., Bekeredjian, R., Hamm, C., Beyersdorf, F., Baldus, S., Boening, A., Falk, V., Thiele, H., Frerker, C. & Lauten, A. Clin Res Cardiol 111, 1377-1386 (2022). www.ncbi.nlm.nih.gov/pubmed/35984497

Thromboinflammation in cardiovascular disease: lessons learned for the management of hypertension, heart failure, and aortic valve stenosis. Wenzel, P. Eur Heart J 43, 4611-4613 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35979817  

Multi-omics assessment of dilated cardiomyopathy using non-negative matrix factorization. Tappu, R., Haas, J., Lehmann, D. H., Sedaghat-Hamedani, F., Kayvanpour, E., Keller, A., Katus, H. A., Frey, N. & Meder, B. PLoS One 17, e0272093 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35980883  

Ticagrelor with and without aspirin in patients with a prior coronary artery bypass graft undergoing percutaneous coronary intervention: the TWILIGHT-CABG study. Sardella, G., Beerkens, F. J., Dangas, G., Cao, D., Baber, U., Sartori, S., Cohen, D. J., Briguori, C., Gil, R., Nicolas, J., Zhang, Z., Dudek, D., Kunadian, V., Kornowski, R., Weisz, G., Claessen, B., Marx, S. O., Escaned, J., Huber, K., Collier, T. et al. EuroIntervention (2022). https://www.ncbi.nlm.nih.gov/pubmed/35979636  

Nitric oxide metabolites: associations with cardiovascular biomarkers and clinical parameters in patients with HFpEF. Piatek, K., Feuerstein, A., Zach, V., Rozados da Conceicao, C., Beblo, A., Belyavskiy, E., Pieske-Kraigher, E., Krannich, A., Schwedhelm, E., Hinz, S., Pieske, B. & Edelmann, F. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/35979962  

COVID-19 infection and its impact on case-fatality in patients with pulmonary embolism. Hobohm, L., Sagoschen, I., Barco, S., Farmakis, I. T., Fedeli, U., Koelmel, S., Gori, T., Espinola-Klein, C., Munzel, T., Konstantinides, S. & Keller, K. Eur Respir J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35981745  

Why do we climb mountains? An exploration of features of behavioural addiction in mountaineering and the association with stress-related psychiatric disorders. Habelt, L., Kemmler, G., Defrancesco, M., Spanier, B., Henningsen, P., Halle, M., Sperner-Unterweger, B. & Hufner, K. Eur Arch Psychiatry Clin Neurosci (2022). https://www.ncbi.nlm.nih.gov/pubmed/35980451

Impact of genetic deletion of MrgD or Mas receptors in depressive-like behavior in mice. Becari, L., Fonseca, M. L. A., Goncalves, S. C. A., Bader, M., Santos, R. A. S., Campagnole-Santos, M. J. & Kangussu, L. M. Acta Neuropsychiatr, 1-24 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35979816  

PrEdictive value of coMbined pre-test proBability and blOod gas anaLysis In pulmonary emboliSM-the EMBOLISM study. Meusel, M., Patz, T., Gruber, K., Kupp, S., Jensch, P. J., Saraei, R., Furschke, A., Sayk, F., Eitel, I. & Wolfrum, S. Intern Emerg Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/35976533  

Inhibitory Effect of Epigallocatechin Gallate-Silver Nanoparticles and Their Lysozyme Bioconjugates on Biofilm Formation and Cytotoxicity. Meesaragandla, B., Hayet, S., Fine, T., Janke, U., Chai, L. & Delcea, M. ACS Appl Bio Mater (2022). https://www.ncbi.nlm.nih.gov/pubmed/35977081  

Clinical characteristics, causes and predictors of outcomes in patients with in-hospital cardiac arrest: results from the SURVIVE-ARREST study. Hannen, L. E. M., Toprak, B., Weimann, J., Mahmoodi, B., Fluschnik, N., Schrage, B., Roedl, K., Soffker, G., Kluge, S., Issleib, M., Blankenberg, S., Kirchhof, P., Clemmensen, P., Sinning, C., Zengin-Sahm, E. & Becher, P. M. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/35978110  

Clonal hematopoiesis confers an increased mortality risk in orthotopic heart transplant recipients. Scolari, F. L., Brahmbhatt, D. H., Abelson, S., Medeiros, J. J. F., Anker, M. S., Fung, N. L., Otsuki, M., Calvillo-Arguelles, O., Lawler, P. R., Ross, H. J., Luk, A. C., Anker, S., Dick, J. E. & Billia, F. Am J Transplant 22, 3078-3086 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35971851  

Imaging of heart disease in women: review and case presentation. Mikail, N., Rossi, A., Bengs, S., Haider, A., Stahli, B. E., Portmann, A., Imperiale, A., Treyer, V., Meisel, A., Pazhenkottil, A. P., Messerli, M., Regitz-Zagrosek, V., Kaufmann, P. A., Buechel, R. R. & Gebhard, C. Eur J Nucl Med Mol Imaging 50, 130-159 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35974185  

Dataset of ileum bacterial diversity in mice after heart failure due to pressure overload. Spehlmann, M. E., Dhotre, D. P., Schmiedel, N., Chavan, N., Bang, C. & Rangrez, A. Y. Data Brief 44, 108498 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35966944  

Outcomes of aortic valve repair: early results from the German Aortic Valve Registry. Girdauskas, E., Petersen, J., Balaban, U., Herrmann, E., Bauer, T., Beckmann, A., Bekeredjian, R., Ensminger, S., Frerker, C., Mollmann, H., Walther, T. & Bleiziffer, S. Eur J Cardiothorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/35962722  

Thyroid hormones as a disease modifier and therapeutic target in nonalcoholic steatohepatitis. Wirth, E. K., Puengel, T., Spranger, J. & Tacke, F. Expert Rev Endocrinol Metab 17, 425-434 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35957531  

Cornuside Is a Potential Agent against Alzheimer's Disease via Orchestration of Reactive Astrocytes. Shi, J. Z., Zheng, X. M., Zhou, Y. F., Yun, L. Y., Luo, D. M., Hao, J. J., Liu, P. F., Zhang, W. K., Xu, J. K., Yan, Y., Xie, X. M., He, Y. Y. & Pang, X. B. Nutrients 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35956355  

Regulation of APD and Force by the Na(+)/Ca(2+) Exchanger in Human-Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue. Ismaili, D., Gurr, K., Horvath, A., Yuan, L., Lemoine, M. D., Schulz, C., Sani, J., Petersen, J., Reichenspurner, H., Kirchhof, P., Jespersen, T., Eschenhagen, T., Hansen, A., Koivumaki, J. T. & Christ, T. Cells 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35954268  

Serum of Post-COVID-19 Syndrome Patients with or without ME/CFS Differentially Affects Endothelial Cell Function In Vitro. Flaskamp, L., Roubal, C., Uddin, S., Sotzny, F., Kedor, C., Bauer, S., Scheibenbogen, C. & Seifert, M. Cells 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35954219  

Functional Characterization of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells. Fan, X., Cyganek, L., Nitschke, K., Uhlig, S., Nuhn, P., Bieback, K., Duerschmied, D., El-Battrawy, I., Zhou, X. & Akin, I. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35955642  

Time's up: mutation rate and lifespan. Cremer, A., Abplanalp, W. T. & Rieger, M. A. Signal Transduct Target Ther 7, 282 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35961971  

The beneficial therapeutic effects of plant-derived natural products for the treatment of sarcopenia. Bagherniya, M., Mahdavi, A., Shokri-Mashhadi, N., Banach, M., Von Haehling, S., Johnston, T. P. & Sahebkar, A. J Cachexia Sarcopenia Muscle 13, 2772-2790 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35961944  

Limited evidence for blood eQTLs in human sexual dimorphism. Porcu, E., Claringbould, A., Weihs, A., Lepik, K., Consortium, B., Richardson, T. G., Volker, U., Santoni, F. A., Teumer, A., Franke, L., Reymond, A. & Kutalik, Z. Genome Med 14, 89 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35953856  

Identification of novel genes whose expression in adipose tissue affects body fat mass and distribution: an RNA-Seq and Mendelian Randomization study. Konigorski, S., Janke, J., Patone, G., Bergmann, M. M., Lippert, C., Hubner, N., Kaaks, R., Boeing, H. & Pischon, T. Eur J Hum Genet (2022). https://www.ncbi.nlm.nih.gov/pubmed/35953519  

The multifaceted actions of the lncRNA H19 in cardiovascular biology and diseases. Busscher, D., Boon, R. A. & Juni, R. P. Clin Sci (Lond) 136, 1157-1178 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35946958  

Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI. Yang, Y., Knol, M. J., Wang, R., Mishra, A., Liu, D., Luciano, M., Teumer, A., Armstrong, N., Bis, J. C., Jhun, M. A., Li, S., Adams, H. H. H., Aziz, N. A., Bastin, M. E., Bourgey, M., Brody, J. A., Frenzel, S., Gottesman, R. F., Hosten, N., Hou, L. et al. Brain (2022). https://www.ncbi.nlm.nih.gov/pubmed/35943854  

Safety and usefulness of left ventricular endomyocardial biopsy in new- onset acute heart failure requiring mechanical support by an Impella(R) device. Tschope, C., Nelki, V., Trippel, T. D., Klingel, K., Abawi, D. & Alogna, A. Int J Cardiol 368, 49-52 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35944774  

Hypverventilation strain CMR imaging in patients with acute chest pain. Siry, D., Riffel, J. H., Salatzki, J., Andre, F., Ochs, M., Weberling, L. D., Giannitsis, E., Katus, H. A. & Friedrich, M. G. Sci Rep 12, 13584 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35945332  

Impact of metabolic stress induced by diets, aging and fasting on tissue oxygen consumption. Mackert, O., Wirth, E. K., Sun, R., Winkler, J., Liu, A., Renko, K., Kunz, S., Spranger, J. & Brachs, S. Mol Metab 64, 101563 (2022).

Impact of moderate or severe left ventricular outflow tract calcification on clinical outcomes of patients with severe aortic stenosis undergoing transcatheter aortic valve implantation with self- and balloon-expandable valves: a post hoc analysis from the SOLVE-TAVI trial. Farhan, S., Stachel, G., Desch, S., Kurz, T., Feistritzer, H. J., Hartung, P., Eitel, I., Nef, H., Doerr, O., Lauten, A., Landmesser, U., Sandri, M., Holzhey, D., Borger, M., Ince, H., Oner, A., Meyer-Saraei, R., Wienbergen, H., Fach, A., Frey, N. et al. EuroIntervention (2022). https://www.ncbi.nlm.nih.gov/pubmed/35942626  

Magnetic resonance imaging in a patient with cardiac resynchronization therapy-defibrillator and two abandoned leads. Lusebrink, E., Kaab, S. & Fichtner, S. J Arrhythm 38, 672-673 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35936043  

Transcatheter Aortic Valve Replacement in a Patient With Criss-Cross Heart. Lewin, D., Van Praet, K. M., Nersesian, G., Kelm, M., Kofler, M., Baumgartner, M., Kempfert, J., Falk, V., Klein, C. & Unbehaun, A. JACC Case Rep 4, 934-940 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35935152  

The effect of probiotic and synbiotic supplementation on lipid parameters among patients with cardiometabolic risk factors: a systematic review and meta-analysis of clinical trials. Ghorbani, Z., Kazemi, A., Bartolomaeus, T. U. P., Martami, F., Noormohammadi, M., Salari, A., Lober, U., Balou, H. A., Forslund, S. K. & Mahdavi-Roshan, M. Cardiovasc Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/35934838  

Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency. Sundaram, S. M., Arrulo Pereira, A., Muller-Fielitz, H., Kopke, H., De Angelis, M., Muller, T. D., Heuer, H., Korbelin, J., Krohn, M., Mittag, J., Nogueiras, R., Prevot, V. & Schwaninger, M. Brain 145, 4264-4274 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35929549  

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. Ramdas, S., Judd, J., Graham, S. E., Kanoni, S., Wang, Y., Surakka, I., Wenz, B., Clarke, S. L., Chesi, A., Wells, A., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H., Ntalla, I., Hui, Q., Klarin, D. et al. Am J Hum Genet 109, 1366-1387 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35931049  

Plasma levels of thrombin and activated protein C in patients with acute myocardial Infarction: An observational study. Becher, T., Schimanski, R., Muller, J., Baumann, S., Klenantz, S., Potzsch, B. & Lossnitzer, D. Int J Cardiol Heart Vasc 42, 101097 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35928794  

Atrial functional assessment at rest and during exercise stress in left ventricular diastolic dysfunction. Backhaus, S. J. & Schuster, A. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35929610  

Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies. Reichart, D., Lindberg, E. L., Maatz, H., Miranda, A. M. A., Viveiros, A., Shvetsov, N., Gartner, A., Nadelmann, E. R., Lee, M., Kanemaru, K., Ruiz-Orera, J., Strohmenger, V., DeLaughter, D. M., Patone, G., Zhang, H., Woehler, A., Lippert, C., Kim, Y., Adami, E., Gorham, J. M. et al. Science 377, eabo1984 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35926050  

Coronary Access Following Redo TAVR: Impact of THV Design, Implant Technique, and Cell Misalignment. Meier, D., Akodad, M., Landes, U., Barlow, A. M., Chatfield, A. G., Lai, A., Tzimas, G., Tang, G. H. L., Puehler, T., Lutter, G., Leipsic, J. A., Sondergaard, L., Wood, D. A., Webb, J. G., Sellers, S. L. & Sathananthan, J. JACC Cardiovasc Interv 15, 1519-1531 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35926919  

Neuro-oncological Ventral Antigen 2 Regulates Splicing of Vascular Endothelial Growth Factor Receptor 1 and Is Required for Endothelial Function. Kremer, V., Oppelaar, J. J., Gimbel, T., Koziarek, S., Ganzevoort, W., van Pampus, M. G., van den Born, B. J., Vogt, L., de Groot, C. & Boon, R. A. Reprod Sci (2022). https://www.ncbi.nlm.nih.gov/pubmed/35927413  

Activation of an accessory pathway of glucose metabolism to treat dilated cardiomyopathy. Eschenhagen, T. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35923092  

Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. Specker, E., Matthes, S., Wesolowski, R., Schutz, A., Grohmann, M., Alenina, N., Pleimes, D., Mallow, K., Neuenschwander, M., Gogolin, A., Weise, M., Pfeifer, J., Ziebart, N., Heinemann, U., von Kries, J. P., Nazare, M. & Bader, M. J Med Chem 65, 11126-11149 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35921615  

Advanced diagnostics in inflammatory cardiomyopathy for personalized therapeutic decision-making. Schultheiss, H. P. & Escher, F. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35920154  

A biomathematical model of atherosclerosis in mice. Schirm, S., Haghikia, A., Brack, M., Ahnert, P., Nouailles, G., Suttorp, N., Loeffler, M., Witzenrath, M. & Scholz, M. PLoS One 17, e0272079 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35921269  

Le Coeur en Sabot: shape associations with adverse events in repaired tetralogy of Fallot. Mira, A., Lamata, P., Pushparajah, K., Abraham, G., Mauger, C. A., McCulloch, A. D., Omens, J. H., Bissell, M. M., Blair, Z., Huffaker, T., Tandon, A., Engelhardt, S., Koehler, S., Pickardt, T., Beerbaum, P., Sarikouch, S., Latus, H., Greil, G., Young, A. A. & Hussain, T. J Cardiovasc Magn Reson 24, 46 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35922806  

Cardiac sarcoidosis: growing evidence in risk stratification. Meder, B. & Koelemen, J. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/35920166  

Muscular myostatin gene expression and plasma concentrations are decreased in critically ill patients. Grunow, J. J., Reiher, K., Carbon, N. M., Engelhardt, L. J., Mai, K., Koch, S., Schefold, J. C., Z'Graggen, W., Schaller, S. J., Fielitz, J., Spranger, J., Weber-Carstens, S. & Wollersheim, T. Crit Care 26, 237 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35922829  

Genome-wide associations of aortic distensibility suggest causality for aortic aneurysms and brain white matter hyperintensities. Francis, C. M., Futschik, M. E., Huang, J., Bai, W., Sargurupremraj, M., Teumer, A., Breteler, M. M. B., Petretto, E., Ho, A. S. R., Amouyel, P., Engelter, S. T., Bulow, R., Volker, U., Volzke, H., Dorr, M., Imtiaz, M. A., Aziz, N. A., Lohner, V., Ware, J. S., Debette, S. et al. Nat Commun 13, 4505 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35922433  

Follow-up of Patients With Stroke, Based on Opt-Out Choice Potential Approach for Acute Care Quality Registries or Observational Studies. Napierkowski, I., Lorenz-Meyer, I., Hille, A., Ebinger, M., Freitag, E., Harmel, P., Endres, M., Hagemann, G., Koennecke, H. C., Mackert, B. M., Siegerink, B., Audebert, H. J. & Berlin - Specific Acute Treatment in Ischemic or hAemorrhagic Stroke with Long-term follow-up, r. Neurology (2022). https://www.ncbi.nlm.nih.gov/pubmed/35918161  

Integrated analyses of growth differentiation factor-15 concentration and cardiometabolic diseases in humans. Lemmela, S., Wigmore, E. M., Benner, C., Havulinna, A. S., Ong, R. M. Y., Kempf, T., Wollert, K. C., Blankenberg, S., Zeller, T., Peters, J. E., Salomaa, V., Fritsch, M., March, R., Palotie, A., Daly, M., Butterworth, A. S., Kinnunen, M., Paul, D. S. & Matakidou, A. Elife 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35916366  

Association of immune cell recruitment and BPD development. Heydarian, M., Schulz, C., Stoeger, T. & Hilgendorff, A. Mol Cell Pediatr 9, 16 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35917002  

Percutaneous left atrial appendage occlusion in a frail, high-risk, octogenarian patient population, after having undergone transcatheter aortic valve implantation. Drosos, I., De Rosa, R., Cremer, S., Seppelt, P. C., Hemmann, K., Oppermann, J., Blessing, R., Mas-Peiro, S., Vasa-Nicotera, M., Zeiher, A. M. & Dimitriadis, Z. BMC Cardiovasc Disord 22, 349 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35918658  

Beta-secretase-1 antisense RNA is associated with vascular ageing and atherosclerotic cardiovascular disease. Bampatsias, D., Mavroeidis, I., Tual-Chalot, S., Vlachogiannis, N. L., Bonini, F., Sachse, M., Mavraganis, G., Mareti, A., Kritsioti, C., Laina, A., Delialis, D., Ciliberti, G., Sopova, K., Gatsiou, A., Martelli, F., Georgiopoulos, G., Stellos, K. & Stamatelopoulos, K. Thromb Haemost (2022). https://www.ncbi.nlm.nih.gov/pubmed/35915966  

Role of plant-based diets in promoting health and longevity. Herpich, C., Muller-Werdan, U. & Norman, K. Maturitas 165, 47-51 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35914402  

Bail-Out Implantation of an Embolized Balloon-Expandable Transcatheter Heart Valve in the Aortic Arch Using Self-Expandable Stents. Dreger, H., Sundermann, S., Niehues, S. M. & Landmesser, U. Am J Cardiol 180, 163-164 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35914970

Using different geometries to modulate the cardiac fibroblast phenotype and the biomechanical properties of engineered connective tissues. Santos, G. L., DeGrave, A. N., Rehman, A., Al Disi, S., Xhaxho, K., Schroder, H., Bao, G., Meyer, T., Tiburcy, M., Dworatzek, E., Zimmermann, W. H. & Lutz, S. Biomater Adv 139, 213041 (2022). https://www.ncbi.nlm.nih.gov/pubmed/35909053


September

(Epi)transcriptomics in cardiovascular and neurological complications of COVID-19. Jusic, A., Stellos, K., Ferreira, L., Baker, A. H. & Devaux, Y. J Mol Cell Cardiol Plus 1, 100013 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36164464  

Effect of transcatheter edge-to-edge repair device position on diastolic hemodynamic parameters: An echocardiography-based simulation study. Vellguth, K., Barbieri, F., Reinthaler, M., Kasner, M., Landmesser, U., Kuehne, T., Hennemuth, A., Walczak, L. & Goubergrits, L. Front Cardiovasc Med 9, 915074 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36093164  

Spinal Stroke: Outcome Attenuation by Erythropoietin and Carbamylated Erythropoietin and Its Prediction by Sphingosine-1-Phosphate Serum Levels in Mice. Koepke, L. G., Schwedhelm, E., Ibing, W., Oberhuber, A., Daum, G., Vcelar, B., Schelzig, H. & Simon, F. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36076955  

SGLT2 Inhibitor Empagliflozin Modulates Ion Channels in Adult Zebrafish Heart. Karpushev, A. V., Mikhailova, V. B., Klimenko, E. S., Kulikov, A. N., Ivkin, D. Y., Kaschina, E. & Okovityi, S. V. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36076956  

Cardiovascular magnetic resonance imaging patterns of acute COVID-19 mRNA vaccine-associated myocarditis in young male patients: A first single-center experience. Evertz, R., Schulz, A., Lange, T., Backhaus, S. J., Vollmann, D., Kowallick, J. T., von Haehling, S., Hasenfuss, G. & Schuster, A. Front Cardiovasc Med 9, 965512 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36082124  

Assessment of the Consistency of Categorical Features Within the DZHK Biobanking Basic Set. Yusuf, K., Tahar, K., Sax, U., Hoffmann, W. & Krefting, D. Stud Health Technol Inform 296, 98-106 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36073494  

Right ventricular dysfunction predicts outcome after transcatheter mitral valve repair for primary mitral valve regurgitation. Doldi, P. M., Stolz, L., Kalbacher, D., Koll, B., Geyer, M., Ludwig, S., Orban, M., Braun, D., Weckbach, L. T., Stocker, T. J., Nabauer, M., Higuchi, S., Ruf, T., Da Rocha, E. S. J., Wild, M., Tence, N., Unterhuber, M., Schofer, N., Petrescu, A., Thiele, H. et al. Eur J Heart Fail 24, 2162-2171 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36054557  

Reference Interval for Serum L-Homoarginine Determined with Enzyme-Linked Immunosorbent Assay in the Population-Based Study of Health in Pomerania. Schwedhelm, E., Cordts, K., Moritz, E., Wesemann, R., Choe, C. U., Boger, R., Ittermann, T., Dorr, M., Friedrich, N. & Bahls, M. J Appl Lab Med 7, 1272-1282 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36172979  

Aging-regulated TUG1 is dispensable for endothelial cell function. Gimbel, A. T., Koziarek, S., Theodorou, K., Schulz, J. F., Stanicek, L., Kremer, V., Ali, T., Günther, S., Kumar, S., Jo, H., Hübner, N., Maegdefessel, L., Dimmeler, S., van Heesch, S. & Boon, R. A. PLoS One 17, e0265160 (2022).

The developing epicardium regulates cardiac chamber morphogenesis by promoting cardiomyocyte growth. Boezio, G. L. M., Zhao, S., Gollin, J., Priya, R., Mansingh, S., Guenther, S., Fukuda, N., Gunawan, F. & Stainier, D. Y. R. Dis Model Mech 16 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36172839  

Temperature Control After In-Hospital Cardiac Arrest: A Randomized Clinical Trial. Wolfrum, S., Roedl, K., Hanebutte, A., Pfeifer, R., Kurowski, V., Riessen, R., Daubmann, A., Braune, S., Soffker, G., Bibiza-Freiwald, E., Wegscheider, K., Schunkert, H., Thiele, H., Kluge, S. & Hypothermia After In-Hospital Cardiac Arrest Study, G. Circulation 146, 1357-1366 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36168956  

Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations. Thareja, G., Belkadi, A., Arnold, M., Albagha, O. M. E., Graumann, J., Schmidt, F., Grallert, H., Peters, A., Gieger, C., Consortium, T. & Suhre, K. Hum Mol Genet (2022).

Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes. Mendez, P. L., Obendorf, L., Jatzlau, J., Burdzinski, W., Reichenbach, M., Nageswaran, V., Haghikia, A., Stangl, V., Hiepen, C. & Knaus, P. BMC Biol 20, 210 (2022).

Engineered CRISPR prime editors with compact, untethered reverse transcriptases. Grünewald, J., Miller, B. R., Szalay, R. N., Cabeceiras, P. K., Woodilla, C. J., Holtz, E. J. B., Petri, K. & Joung, J. K. Nat Biotechnol (2022).

Short-term effects of ultrafine particles on heart rate variability: A systematic review and meta-analysis. Zhang, S., Breitner, S., Pickford, R., Lanki, T., Okokon, E., Morawska, L., Samoli, E., Rodopoulou, S., Stafoggia, M., Renzi, M., Schikowski, T., Zhao, Q., Schneider, A. & Peters, A. Environ Pollut 314, 120245 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36162563  

D(3) -Creatine dilution for body composition assessment: A direct take on the matter. Prado, C. M. & von Haehling, S. J Cachexia Sarcopenia Muscle 13, 2593-2594 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36156465  

Characteristics of immune checkpoint inhibitor-induced encephalitis and comparison with HSV-1 and anti-LGI1 encephalitis: A retrospective multicentre cohort study. Müller-Jensen, L., Zierold, S., Versluis, J. M., Boehmerle, W., Huehnchen, P., Endres, M., Mohr, R., Compter, A., Blank, C. U., Hagenacker, T., Meier, F., Reinhardt, L., Gesierich, A., Salzmann, M., Hassel, J. C., Ugurel, S., Zimmer, L., Banks, P., Spain, L., Soon, J. A. et al. European Journal of Cancer 175, 224-235 (2022).

[Use of a hypoglossal nerve stimulator during analgosedation in transcatheter aortic valve implantation]. Mayr, N. P., Pellegrini, C., Rheude, T. & Joner, M. Anaesthesiologie 71, 945-948 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36156159  

Comparison of the predictive value of four insulin resistance surrogates for the prevalence of hypertension: a population-based study. Cheng, W., Kong, F. & Chen, S. Diabetology & Metabolic Syndrome 14, 137 (2022).

Sensitivity analyses for data missing at random versus missing not at random using latent growth modelling: a practical guide for randomised controlled trials. Staudt, A., Freyer-Adam, J., Ittermann, T., Meyer, C., Bischof, G., John, U. & Baumann, S. BMC Medical Research Methodology 22, 250 (2022).

The marantic kiss: potential novel pathognomonic echocardiographic sign of non-bacterial thrombotic endocarditis. Schneider, M., Frydas, A., Grubitzsch, H., Pieske, B. & Morris, D. A. Eur Heart J Cardiovasc Imaging 24, e19 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36151865  

Methionine restriction - Association with redox homeostasis and implications on aging and diseases. Jelleschitz, J., Zhang, Y., Grune, T., Chen, W., Zhao, Y., Jia, M., Wang, Y., Liu, Z. & Hohn, A. Redox Biol 57, 102464 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36152485  

Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT and is associated with pulmonary hypertension. Tian, S., Cai, Z., Sen, P., van Uden, D., van de Kamp, E., Thuillet, R., Tu, L., Guignabert, C., Boomars, K., Van der Heiden, K., Brandt, M. M. & Merkus, D. Am J Physiol Heart Circ Physiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36149769  

Cardiovalve in mitral valve position-Additional solution for valve replacement. Sherif, M., Sundermann, S. H., Maisano, F., Pieske-Kraigher, E., Riess, J., Reinthaler, M., Mai, G. & Trippel, T. D. Front Cardiovasc Med 9, 960849 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36148056  

Temporal trends in patients with peripheral artery disease influenced by diabetes mellitus in Germany. Schmitt, V. H., Hobohm, L., Vosseler, M., Brochhausen, C., Münzel, T., Espinola-Klein, C. & Keller, K. J Diabetes 14, 670-684 (2022).

In Vivo Skin Regeneration and Wound Healing Using Cell Micro-Transplantation. Nanic, L., Cedilak, A., Vidacek, N. S., Gruber, F., Huzak, M., Bader, M. & Rubelj, I. Pharmaceutics 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36145701  

SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA. Maharana, S., Kretschmer, S., Hunger, S., Yan, X., Kuster, D., Traikov, S., Zillinger, T., Gentzel, M., Elangovan, S., Dasgupta, P., Chappidi, N., Lucas, N., Maser, K. I., Maatz, H., Rapp, A., Marchand, V., Chang, Y. T., Motorin, Y., Hubner, N., Hartmann, G. et al. Mol Cell (2022). https://www.ncbi.nlm.nih.gov/pubmed/36150385  

Saturated Fatty Acid Blood Levels and Cardiometabolic Phenotype in Patients with HFpEF: A Secondary Analysis of the Aldo-DHF Trial. Lechner, K., von Schacky, C., Scherr, J., Lorenz, E., Bock, M., Lechner, B., Haller, B., Krannich, A., Halle, M., Wachter, R., Duvinage, A. & Edelmann, F. Biomedicines 10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36140396  

Effects of Chronic Kidney Disease on Nanomechanics of the Endothelial Glycocalyx Are Mediated by the Mineralocorticoid Receptor. Fels, B., Beyer, A., Cazana-Perez, V., Giraldez, T., Navarro-Gonzalez, J. F., de la Rosa, D. A., Schaefer, F., Bayazit, A. K., Obrycki, L., Ranchin, B., Holle, J., Querfeld, U. & Kusche-Vihrog, K. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36142571  

Performance of Marmoset Monkeys as Embryo Donors Is Reflected by Different Stress-Related Parameters. Drummer, C., Munzker, J., Heistermann, M., Becker, T., Missbach, S. & Behr, R. Animals (Basel) 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36139275  

Association between the fatty liver index and chronic kidney disease: the population-based KORA study. Cai, X., Thorand, B., Hohenester, S., Koenig, W., Rathmann, W., Peters, A. & Nano, J. Nephrol Dial Transplant (2022). https://www.ncbi.nlm.nih.gov/pubmed/36150717  

Albuminuria as a marker of systemic congestion in patients with heart failure. Boorsma, E. M., Ter Maaten, J. M., Damman, K., van Essen, B. J., Zannad, F., van Veldhuisen, D. J., Samani, N. J., Dickstein, K., Metra, M., Filippatos, G., Lang, C. C., Ng, L., Anker, S. D., Cleland, J. G., Pellicori, P., Gansevoort, R. T., Heerspink, H. J. L., Voors, A. A. & Emmens, J. E. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/36148485  

Identification of the Transcription Factor ATF3 as a Direct and Indirect Regulator of the LDLR. Bauer, S., Eigenmann, J., Zhao, Y., Fleig, J., Hawe, J. S., Pan, C., Bongiovanni, D., Wengert, S., Ma, A., Lusis, A. J., Kovacic, J. C., Bjorkegren, J. L. M., Maegdefessel, L., Schunkert, H. & von Scheidt, M. Metabolites 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36144244  

Impact of Elevated LDH on Cystatin C-Based Glomerular Filtration Rate Estimates in Patients with Cancer. Aydilek, E., Wallbach, M., Koziolek, M., Wulf, G. G. & Brokers, N. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36143104  

Rotational Atherectomy or Balloon-Based Techniques to Prepare Severely Calcified Coronary Lesions. Rheude, T., Fitzgerald, S., Allali, A., Mashayekhi, K., Gori, T., Cuculi, F., Kufner, S., Hemetsberger, R., Sulimov, D. S., Rai, H., Ayoub, M., Bossard, M., Xhepa, E., Fusaro, M., Toelg, R., Joner, M., Byrne, R. A., Richardt, G., Kastrati, A., Cassese, S. et al. JACC Cardiovasc Interv 15, 1864-1874 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36137691  

Obesity and cardiovascular disease: beyond body weight and energy balance. Lechner, K. & Krauss, R. M. Eur J Prev Cardiol 29, 2216-2217 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36136860  

Incidence and impact of venous thromboembolism in hospitalized patients with Crohn's disease. Keller, K., Sivanathan, V., Schmitt, V. H., Ostad, M. A., Munzel, T., Espinola-Klein, C. & Hobohm, L. Thromb Res 219, 77-85 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36137330  

No Matter How Slowly You Go as Long as You Do Not Stop. Kastrati, A. & Dibra, A. JACC Cardiovasc Interv 15, 1861-1863 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36137690  

Fatigue and cognitive impairment after COVID-19: A prospective multicentre study. Hartung, T. J., Neumann, C., Bahmer, T., Chaplinskaya-Sobol, I., Endres, M., Geritz, J., Haeusler, K. G., Heuschmann, P. U., Hildesheim, H., Hinz, A., Hopff, S., Horn, A., Krawczak, M., Krist, L., Kudelka, J., Lieb, W., Maetzler, C., Mehnert-Theuerkauf, A., Montellano, F. A., Morbach, C. et al. EClinicalMedicine 53, 101651 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36133318  

Conundrum of Classifying Subtypes of Pulmonary Hypertension-Introducing a Novel Approach to Classify "Borderline" Patients in a Population with Severe Aortic Stenosis Undergoing TAVI. Boxhammer, E., Gharibeh, S. X., Wernly, B., Kelm, M., Franz, M., Kretzschmar, D., Hoppe, U. C., Lauten, A. & Lichtenauer, M. J Cardiovasc Dev Dis 9 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36135439  

Lack of L-type amino acid transporter 2 in murine thyroid tissue induces autophagy. Venugopalan, V., Rehders, M., Weber, J., Rodermund, L., Al-Hashimi, A., Bargmann, T., Golchert, J., Reinecke, V., Homuth, G., Volker, U., Verrey, F., Kirstein, J., Heuer, H., Schweizer, U., Braun, D., Wirth, E. K. & Brix, K. J Mol Endocrinol 70 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36129170  

Permanent pacemaker implantation and left bundle branch block with self-expanding valves - a SCOPE 2 subanalysis. Pellegrini, C., Garot, P., Morice, M. C., Tamburino, C., Bleiziffer, S., Thiele, H., Scholtz, S., Schramm, R., Cockburn, J., Cunnington, M., Wolf, A., Barbanti, M., Tchetche, D., Pagnotta, P., Gilard, M., Bedogni, F., Van Belle, E., Vasa-Nicotera, M., Chieffo, A., Bogaerts, K. et al. EuroIntervention (2022). https://www.ncbi.nlm.nih.gov/pubmed/36128956  

Pulsed-field ablation-based pulmonary vein isolation: acute safety, efficacy and short-term follow-up in a multi-center real world scenario. Lemoine, M. D., Fink, T., Mencke, C., Schleberger, R., My, I., Obergassel, J., Bergau, L., Sciacca, V., Rottner, L., Moser, J., Kany, S., Moser, F., Munkler, P., Dinshaw, L., Kirchhof, P., Reissmann, B., Ouyang, F., Sommer, P., Sohns, C., Rillig, A. et al. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36131138  

Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders. El Andari, J., Renaud-Gabardos, E., Tulalamba, W., Weinmann, J., Mangin, L., Pham, Q. H., Hille, S., Bennett, A., Attebi, E., Bourges, E., Leborgne, C., Guerchet, N., Fakhiri, J., Kramer, C., Wiedtke, E., McKenna, R., Guianvarc'h, L., Toueille, M., Ronzitti, G., Hebben, M. et al. Sci Adv 8, eabn4704 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36129972  

Catheter Ablation of Atrial Fibrillation in Patients With Heart Failure and Preserved Ejection Fraction. Zylla, M. M., Leiner, J., Rahm, A. K., Hoffmann, T., Lugenbiel, P., Schweizer, P., Scholz, E., Mereles, D., Kronsteiner, D., Kieser, M., Katus, H. A., Frey, N. & Thomas, D. Circ Heart Fail 15, e009281 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36126143  

Atrial Functional Tricuspid Regurgitation: Novel Definition and Impact on Prognosis. Schlotter, F., Dietz, M. F., Stolz, L., Kresoja, K. P., Besler, C., Sannino, A., Rommel, K. P., Unterhuber, M., von Roeder, M., Delgado, V., Thiele, H., Hausleiter, J., Bax, J. J. & Lurz, P. Circ Cardiovasc Interv 15, e011958 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36126130  

Modulatory role of gut microbiota in cholesterol and glucose metabolism: Potential implications for atherosclerotic cardiovascular disease. Roessler, J., Leistner, D. M., Landmesser, U. & Haghikia, A. Atherosclerosis 359, 1-12 (2022).

Non-invasive assessment of pulmonary vein isolation durability using late gadolinium enhancement magnetic resonance imaging. Padilla-Cueto, D., Ferro, E., Garre, P., Prat, S., Guichard, J. B., Perea, R. J., Tolosana, J. M., Guasch, E., Arbelo, E., Porta-Sanchez, A., Roca-Luque, I., Sitges, M., Brugada, J., Mont, L. & Althoff, T. F. Europace (2022). https://www.ncbi.nlm.nih.gov/pubmed/36125227  

Role of Cardiac Contractility Modulation in Heart Failure with a Higher Ejection Fraction. Talha, K. M., Anker, S. D., Burkhoff, D., Filippatos, G., Lam, C. S. P., Stone, G., Wazni, O. & Butler, J. J Card Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/36122819  

Challenges of the newer generation of resorbable magnesium scaffolds: Lessons from failure mechanisms of the past generation. Seguchi, M., Aytekin, A., Lenz, T., Nicol, P., Alvarez-Covarrubias, H. A., Xhepa, E., Klosterman, G. R., Beele, A., Sabic, E., Utsch, L., Alyaqoob, A. & Joner, M. J Cardiol 81, 179-188 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36122642  

Association of Carotid Plaque and Flow Velocity With White Matter Integrity in a Middle-aged to Elderly Population. Rimmele, D. L., Petersen, E. L., Schlemm, E., Kessner, S. S., Petersen, M., Mayer, C., Cheng, B., Zeller, T., Waldeyer, C., Behrendt, C. A., Gerloff, C. & Thomalla, G. Neurology (2022). https://www.ncbi.nlm.nih.gov/pubmed/36123124  

Distribution of Pupil Size and Associated Factors: Results from the Population-Based Gutenberg Health Study. Kiel, M., Grabitz, S. D., Hopf, S., Koeck, T., Wild, P. S., Schmidtmann, I., Lackner, K. J., Munzel, T., Beutel, M. E., Pfeiffer, N. & Schuster, A. K. J Ophthalmol 2022, 9520512 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36119137  

Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement. Kapadia, S. R., Makkar, R., Leon, M., Abdel-Wahab, M., Waggoner, T., Massberg, S., Rottbauer, W., Horr, S., Sondergaard, L., Karha, J., Gooley, R., Satler, L., Stoler, R. C., Messe, S. R., Baron, S. J., Seeger, J., Kodali, S., Krishnaswamy, A., Thourani, V. H., Harrington, K. et al. N Engl J Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/36121045   

No evidence for age-related alterations in the marmoset retina. Haverkamp, S., Reinhard, K., Peichl, L. & Mietsch, M. Front Neuroanat 16, 945295 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36120100  

Sex-specific impact of anthropometric parameters on outcomes after transcatheter edge-to-edge repair for secondary mitral regurgitation. Higuchi, S., Orban, M., Adamo, M., Giannini, C., Melica, B., Karam, N., Praz, F., Kalbacher, D., Lubos, E., Stolz, L., Braun, D., Nabauer, M., Wild, M., Doldi, P., Neuss, M., Butter, C., Kassar, M., Ruf, T., Petrescu, A., Schofer, N. et al. Int J Cardiol 371, 312-318 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36115443  

Calcium in peroxisomes: An essential messenger in an essential cell organelle. Sargsyan, Y., Kalinowski, J. & Thoms, S. Front Cell Dev Biol 10, 992235 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36111338  

Heart failure during the COVID-19 pandemic: clinical, diagnostic, management, and organizational dilemmas. Palazzuoli, A., Metra, M., Collins, S. P., Adamo, M., Ambrosy, A. P., Antohi, L. E., Ben Gal, T., Farmakis, D., Gustafsson, F., Hill, L., Lopatin, Y., Tramonte, F., Lyon, A., Masip, J., Miro, O., Moura, B., Mullens, W., Radu, R. I., Abdelhamid, M., Anker, S. et al. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/36111511  

Cross-sectional study on the association of periodontitis with arterial hypertension in the Hamburg City Health Study. Konnecke, H., Schnabel, R. B., Walther, C., Lamprecht, R., Heydecke, G., Seedorf, U., Jagodzinski, A., Borof, K., Zeller, T., Beikler, T., Smeets, R., Gosau, M., Behrendt, C. A., Wenzel, U., Borschel, C. S., Karakas, M., Blankenberg, S. & Aarabi, G. Eur J Med Res 27, 181 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36114562  

Sex-specific associations of cardiorespiratory fitness and galectin-3 in the general population. Haid, M. E., Zylla, S., Paulista Markus, M. R., Friedrich, N., Ewert, R., Glaser, S., Felix, S. B., Dorr, M. & Bahls, M. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/36113868  

Comparison of hemodynamics in biological surgical aortic valve replacement and transcatheter aortic valve implantation - an in-silico study. Franke, B., Schlief, A., Walczak, L., Sundermann, S., Unbehaun, A., Kempfert, J., Solowjowa, N., Kuhne, T. & Goubergrits, L. Artif Organs (2022). www.ncbi.nlm.nih.gov/pubmed/36114598

A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes. Seibertz, F., Rapedius, M., Fakuade, F. E., Tomsits, P., Liutkute, A., Cyganek, L., Becker, N., Majumder, R., Clauss, S., Fertig, N. & Voigt, N. Commun Biol 5, 969 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36109584  

Photon-counting detector CT improves quality of arterial phase abdominal scans: A head-to-head comparison with energy-integrating CT. Graafen, D., Muller, L., Halfmann, M., Duber, C., Hahn, F., Yang, Y., Emrich, T. & Kloeckner, R. Eur J Radiol 156, 110514 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36108479  

Association between periodontitis and heart failure in the general population. Walther, C., Wenzel, J. P., Schnabel, R. B., Heydecke, G., Seedorf, U., Beikler, T., Borof, K., Nikorowitsch, J., Schrage, B., Blankenberg, S., Twerenbold, R., Zeller, T., Magnussen, C. & Aarabi, G. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/36101477  

Early effect of thrombolysis on structural brain network organisation after anterior-circulation stroke in the randomized WAKE-UP trial. Schlemm, E., Jensen, M., Kuceyeski, A., Jamison, K., Ingwersen, T., Mayer, C., Konigsberg, A., Boutitie, F., Ebinger, M., Endres, M., Fiebach, J. B., Fiehler, J., Galinovic, I., Lemmens, R., Muir, K. W., Nighoghossian, N., Pedraza, S., Puig, J., Simonsen, C. Z., Thijs, V. et al. Hum Brain Mapp 43, 5053-5065 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36102287  

Percutaneous Left Atrial Appendage Closure with the LAmbre Device Protected by a Cerebral Protection System in a 76-Year-Old Man with Persistent Left Atrial Appendage Thrombus. Popescu, S. S., Heeger, C. H., Keelani, A. & Tilz, R. R. Am J Case Rep 23, e937063 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36101478  

The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function. Nitz, K., Lacy, M., Bianchini, M., Wichapong, K., Kucukgoze, I. A., Bonfiglio, C. A., Migheli, R., Wu, Y., Burger, C., Li, Y., Forne, I., Ammar, C., Janjic, A., Mohanta, S., Duchene, J., Heemskerk, J. W. M., Megens, R. T. A., Schwedhelm, E., Huveneers, S., Lygate, C. A. et al. Circ Res, 101161CIRCRESAHA122321094 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36102188  

Pro-oxidative priming but maintained cardiac function in a broad spectrum of murine models of chronic kidney disease. Wollenhaupt, J., Frisch, J., Harlacher, E., Wong, D. W. L., Jin, H., Schulte, C., Vondenhoff, S., Moellmann, J., Klinkhammer, B. M., Zhang, L., Baleanu-Curaj, A., Liehn, E. A., Speer, T., Kazakov, A., Werner, C., van der Vorst, E. P. C., Selejan, S. R., Hohl, M., Bohm, M., Kramann, R. et al. Redox Biol 56, 102459 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36099852  

How to optimize the adherence to a guideline-directed medical therapy in the secondary prevention of cardiovascular diseases: a clinical consensus statement from the European Association of Preventive Cardiology (EAPC). Pedretti, R. F. E., Hansen, D., Ambrosetti, M., Back, M., Berger, T., Ferreira, M. C., Cornelissen, V., Davos, C. H., Doehner, W., de Pablo, Y. Z. C., Frederix, I., Greco, A., Kurpas, D., Michal, M., Osto, E., Pedersen, S., Salvador, R. E., Simonenko, M., Steca, P., Thompson, D. R. et al. Eur J Prev Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36098041  

Discrepancy of echocardiography and computed tomography in initial assessment and 2-year follow-up for monitoring Marfan syndrome and related disorders. Beetz, N. L., Trippel, T. D., Philipp, K., Maier, C., Walter-Rittel, T., Shnayien, S. & Gehle, P. Sci Rep 12, 15333 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36097197  

Comparison of cine cardiac magnetic resonance and echocardiography derived diameters of the aortic root in a large population-based cohort. Wenzel, J. P., Nikorowitsch, J., Bei der Kellen, R., Dohm, L., Girdauskas, E., Lund, G., Bannas, P., Blankenberg, S., Kolbel, T., Cavus, E., Mullerleile, K., Kaul, M. G., Adam, G. & Weinrich, J. M. Sci Rep 12, 15307 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36096919  

CXCR4 and CD74 together enhance cell survival in response to macrophage migration-inhibitory factor in chronic lymphocytic leukemia. Thavayogarajah, T., Sinitski, D., El Bounkari, O., Torres-Garcia, L., Lewinsky, H., Harjung, A., Chen, H. R., Panse, J., Vankann, L., Shachar, I., Bernhagen, J. & Koschmieder, S. Exp Hematol 115, 30-43 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36096455  

Temporal trends in incidence, patient characteristics, microbiology and in-hospital mortality in patients with infective endocarditis: a contemporary analysis of 86,469 cases between 2007 and 2019. Becher, P. M., Gossling, A., Fluschnik, N., Schrage, B., Seiffert, M., Schofer, N., Blankenberg, S., Kirchhof, P., Westermann, D. & Kalbacher, D. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36094574  

Insulin-like growth factor binding protein 7 (IGFBP7), a link between heart failure and senescence. Bracun, V., van Essen, B., Voors, A. A., van Veldhuisen, D. J., Dickstein, K., Zannad, F., Metra, M., Anker, S., Samani, N. J., Ponikowski, P., Filippatos, G., Cleland, J. G. F., Lang, C. C., Ng, L. L., Shi, C., de Wit, S., Aboumsallem, J. P., Meijers, W. C., Klip, I. T., van der Meer, P. et al. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/36088651  

Heart failure outcomes according to heart rate and effects of empagliflozin in patients of the EMPEROR-Preserved Trial. Bohm, M., Butler, J., Mahfoud, F., Filippatos, G., Ferreira, J. P., Pocock, S. J., Slawik, J., Brueckmann, M., Linetzky, B., Schuler, E., Wanner, C., Zannad, F., Packer, M., Anker, S. D., Committees, E. M.-P. T. & Investigators. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/36087309  

PCSK9 Inhibitor Wars: How Does Inclisiran Fit in with Current Monoclonal Antibody Inhibitor Therapy? Considerations for Patient Selection. Arnold, N. & Koenig, W. Curr Cardiol Rep (2022). https://www.ncbi.nlm.nih.gov/pubmed/36087240  

ACTN2 Mutant Causes Proteopathy in Human iPSC-Derived Cardiomyocytes. Zech, A. T. L., Prondzynski, M., Singh, S. R., Pietsch, N., Orthey, E., Alizoti, E., Busch, J., Madsen, A., Behrens, C. S., Meyer-Jens, M., Mearini, G., Lemoine, M. D., Kramer, E., Mosqueira, D., Virdi, S., Indenbirken, D., Depke, M., Salazar, M. G., Volker, U., Braren, I. et al. Cells 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36078153  

Distress-Mediated Remodeling of Cardiac Connexin-43 in a Novel Cell Model for Arrhythmogenic Heart Diseases. Wahl, C. M., Schmidt, C., Hecker, M. & Ullrich, N. D. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36077591  

European Stroke Organisation (ESO) guideline on screening for subclinical atrial fibrillation after stroke or transient ischaemic attack of undetermined origin. Rubiera, M., Aires, A., Antonenko, K., Lemeret, S., Nolte, C. H., Putaala, J., Schnabel, R. B., Tuladhar, A. M., Werring, D. J., Zeraatkar, D. & Paciaroni, M. Eur Stroke J 7, VI (2022). https://www.ncbi.nlm.nih.gov/pubmed/36082257  

Quantitative Phosphoproteomics of the Angiotensin AT(2)-Receptor Signaling Network Identifies HDAC1 (Histone-Deacetylase-1) and p53 as Mediators of Antiproliferation and Apoptosis. Peluso, A. A. B., Kempf, S. J., Verano-Braga, T., Rodrigues-Ribeiro, L., Johansen, L. E., Hansen, M. R., Kitlen, G., Haugaard, A. H., Sumners, C., Ditzel, H. J., Santos, R. A., Bader, M., Larsen, M. R. & Steckelings, U. M. Hypertension, 101161hypertensionaha12118620 (2022).

Reciprocal abrogation of PKM isoforms: contradictory outcomes and differing impact of splicing signal on CRISPR/Cas9 mediates gene editing in keratinocytes. Nold, S. P., Sych, K., Imre, G., Fuhrmann, D. C., Pfeilschifter, J., Vutukuri, R., Schnutgen, F., Wittig, I., Meisterknecht, J., Frank, S. & Goren, I. FEBS J (2022). https://www.ncbi.nlm.nih.gov/pubmed/36083715  

Mediterranean Diet and Atrial Fibrillation: Lessons Learned from the AFHRI Case-Control Study. Neumann, F. A., Jagemann, B., Makarova, N., Borschel, C. S., Aarabi, G., Gutmann, F., Schnabel, R. B. & Zyriax, B. C. Nutrients 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36079872  

Direct proteomic and high-resolution microscopy biopsy analysis identifies distinct ventricular fates in severe aortic stenosis. Brandenburg, S., Drews, L., Schonberger, H. L., Jacob, C. F., Paulke, N. J., Beuthner, B. E., Topci, R., Kohl, T., Neuenroth, L., Kutschka, I., Urlaub, H., Kuck, F., Leha, A., Friede, T., Seidler, T., Jacobshagen, C., Toischer, K., Puls, M., Hasenfuss, G., Lenz, C. et al. J Mol Cell Cardiol 173, 1-15 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36084744  

Exercise for Primary and Secondary Prevention of Cardiovascular Disease: JACC Focus Seminar 1/4. Tucker, W. J., Fegers-Wustrow, I., Halle, M., Haykowsky, M. J., Chung, E. H. & Kovacic, J. C. J Am Coll Cardiol 80, 1091-1106 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36075680  

Contractile Force of Transplanted Cardiomyocytes Actively Supports Heart Function After Injury. Studemann, T., Rossinger, J., Manthey, C., Geertz, B., Srikantharajah, R., von Bibra, C., Shibamiya, A., Kohne, M., Wiehler, A., Wiegert, J. S., Eschenhagen, T. & Weinberger, F. Circulation, 101161CIRCULATIONAHA122060124 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36073365  

Individual Patient Data Meta-analysis of Drug-eluting Versus Bare-metal Stents for Percutaneous Coronary Intervention in Chronic Versus Acute Coronary Syndromes. Piccolo, R., Bonaa, K. H., Efthimiou, O., Varenne, O., Baldo, A., Urban, P., Kaiser, C., de Belder, A., Lemos, P. A., Wilsgaard, T., Reifart, J., Ribeiro, E. E., Serruys, P. W., Byrne, R. A., de la Torre Hernandez, J. M., Esposito, G., Wijns, W., Juni, P., Windecker, S., Valgimigli, M. et al. Am J Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36075755  

Fractal Analysis of Dynamic Stress CT-Perfusion Imaging for Detection of Hemodynamically Relevant Coronary Artery Disease. Michallek, F., Nakamura, S., Kurita, T., Ota, H., Nishimiya, K., Ogawa, R., Shizuka, T., Nakashima, H., Wang, Y., Ito, T., Sakuma, H., Dewey, M. & Kitagawa, K. JACC Cardiovasc Imaging 15, 1591-1601 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36075619  

Propensity matched comparison of TAVI and SAVR in intermediate-risk patients with severe aortic stenosis and moderate-to-severe chronic kidney disease: a subgroup analysis from the German Aortic Valve Registry. Mas-Peiro, S., Faerber, G., Bon, D., Herrmann, E., Bauer, T., Bleiziffer, S., Bekeredjian, R., Boning, A., Frerker, C., Beckmann, A., Mollmann, H., Ensminger, S., Hamm, C. W., Beyersdorf, F., Fichtlscherer, S., Walther, T. & Board, G. A.-E. Clin Res Cardiol 111, 1387-1395 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36074270  

Protein Tyrosine Phosphatase 1B Deficiency in Vascular Smooth Muscle Cells Promotes Perivascular Fibrosis following Arterial Injury. Gogiraju, R., Gachkar, S., Velmeden, D., Bochenek, M. L., Zifkos, K., Hubert, A., Munzel, T., Offermanns, S. & Schafer, K. Thromb Haemost 122, 1814-1826 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36075234  

Biomarkers in heart failure clinical trials. A review from the Biomarkers Working Group of the Heart Failure Association of the European Society of Cardiology. Bayes-Genis, A., Aimo, A., Jhund, P., Richards, M., de Boer, R. A., Arfsten, H., Fabiani, I., Lupon, J., Anker, S. D., Gonzalez, A., Castiglione, V., Metra, M., Mueller, C., Nunez, J., Rossignol, P., Barison, A., Butler, J., Teerlink, J., Filippatos, G., Ponikowski, P. et al. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/36073112  

Multimodality Imaging to Assess Leaflet Height in Mitral Bioprosthetic Valves: Implications for Mitral Valve-in-Valve Procedure. Akodad, M., Sathananthan, J., Tzimas, G., Salcudean, H., Hensey, M., Gulsin, G. S., Meier, D., Anthony Chuang, M. Y., Chatfield, A. G., Landes, U., Blanke, P., Sondergaard, L., Payne, G. W., Lutter, G., Puehler, T., Wood, D. A., Webb, J. G., Leipsic, J. A. & Sellers, S. L. JACC Cardiovasc Imaging 15, 1663-1665 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36075626  

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention. Wang, Z., Emmerich, A., Pillon, N. J., Moore, T., Hemerich, D., Cornelis, M. C., Mazzaferro, E., Broos, S., Ahluwalia, T. S., Bartz, T. M., Bentley, A. R., Bielak, L. F., Chong, M., Chu, A. Y., Berry, D., Dorajoo, R., Dueker, N. D., Kasbohm, E., Feenstra, B., Feitosa, M. F. et al. Nat Genet 54, 1332-1344 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36071172  

Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults. Li, X., Delerue, T., Schottker, B., Holleczek, B., Grill, E., Peters, A., Waldenberger, M., Thorand, B. & Brenner, H. Nat Commun 13, 5269 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36071044  

Survival benefit of overweight patients undergoing MitraClip(R) procedure in comparison to normal-weight patients. Keller, K., Geyer, M., Hobohm, L., Tamm, A. R., Kreidel, F., Ruf, T. F., Hell, M., Schmitt, V. H., Bachmann, K., Born, S., Schulz, E., Munzel, T. & von Bardeleben, R. S. Clin Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36070481  

Evaluation of the HFA-PEFF Score: results from the prospective DIAST-CHF cohort. Hashemi, D., Mende, M., Trippel, T. D., Petutschnigg, J., Hasenfuss, G., Nolte, K., Herrmann-Lingen, C., Feuerstein, A., Langhammer, R., Tschope, C., Pieske, B., Wachter, R. & Edelmann, F. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/36070881  

European Society of Cardiology Quality Indicators for the Cardiovascular Preoperative Assessment and Management of patients considered for non-cardiac surgery. Developed in collaboration with the European Society of Anaesthesiology & Intensive Care. Gencer, B., Gale, C. P., Aktaa, S., Halvorsen, S., Beska, B., Abdelhamid, M., Mueller, C., Tutarel, O., McGreavy, P., Schirmer, H., Geissler, T., Sillesen, H., Niessner, A., Zacharowski, K., Mehilli, J. & Potpara, T. Eur Heart J Qual Care Clin Outcomes (2022). https://www.ncbi.nlm.nih.gov/pubmed/36069905  

Targeting innate immunity-driven inflammation in CKD and cardiovascular disease. Speer, T., Dimmeler, S., Schunk, S. J., Fliser, D. & Ridker, P. M. Nat Rev Nephrol 18, 762-778 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36064794  

In vivo adenine base editing reverts C282Y and improves iron metabolism in hemochromatosis mice. Rovai, A., Chung, B., Hu, Q., Hook, S., Yuan, Q., Kempf, T., Schmidt, F., Grimm, D., Talbot, S. R., Steinbruck, L., Gotting, J., Bohne, J., Krooss, S. A. & Ott, M. Nat Commun 13, 5215 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36064805  

Tachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions. Paulus, M. G., Renner, K., Nickel, A. G., Brochhausen, C., Limm, K., Zugner, E., Baier, M. J., Pabel, S., Wallner, S., Birner, C., Luchner, A., Magnes, C., Oefner, P. J., Stark, K. J., Wagner, S., Maack, C., Maier, L. S., Streckfuss-Bomeke, K., Sossalla, S. & Dietl, A. Basic Res Cardiol 117, 45 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36068416   

Dyskalemia in people at increased risk for heart failure: findings from the heart 'OMics' in AGEing (HOMAGE) trial. Monzo, L., Ferreira, J. P., Cleland, J. G. F., Pellicori, P., Mariottoni, B., Hazebroek, M. R., Collier, T. J., Cuthbert, J. J., Pieske, B., Petutschnigg, J., Ahmed, F. Z., Girerd, N., Clark, A. L., Cosmi, F., Staessen, J. A., Heymans, S., Rossignol, P. & Zannad, F. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/36065795  

Chronic cigarette smoking is associated with increased arterial stiffness in men and women: evidence from a large population-based cohort. Hahad, O., Schmitt, V. H., Arnold, N., Keller, K., Prochaska, J. H., Wild, P. S., Schulz, A., Lackner, K. J., Pfeiffer, N., Schmidtmann, I., Michal, M., Schattenberg, J. M., Tuscher, O., Daiber, A. & Munzel, T. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36068365  

Forebrain corticosteroid receptors promote post-myocardial infarction depression and mortality. Bruns, B., Daub, R., Schmitz, T., Hamze-Sinno, M., Spaich, S., Dewenter, M., Schwale, C., Gass, P., Vogt, M., Katus, H., Herzog, W., Friederich, H. C., Frey, N., Schultz, J. H. & Backs, J. Basic Res Cardiol 117, 44 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36068417  

The Role of Sex and Age in Moderating the Outcome of In-Person and Computer-Based Brief Alcohol Interventions at General Hospitals: Reanalysis of a Brief Intervention Study. Baumann, S., Gaertner, B., Bischof, G., Krolo, F., John, U. & Freyer-Adam, J. Eur Addict Res, 1-7 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36067728  

A head-to-head comparison of fast-SENC and feature tracking to LV long axis strain for assessment of myocardial deformation in chest pain patients. Siry, D., Riffel, J., Salatzki, J., Andre, F., Weberling, L. D., Ochs, M., Atia, N. A., Hillier, E., Albert, D., Katus, H. A., Giannitsis, E., Frey, N. & Friedrich, M. G. BMC Med Imaging 22, 159 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36064332  

Long-term cardiac pathology in individuals with mild initial COVID-19 illness. Puntmann, V. O., Martin, S., Shchendrygina, A., Hoffmann, J., Ka, M. M., Giokoglu, E., Vanchin, B., Holm, N., Karyou, A., Laux, G. S., Arendt, C., De Leuw, P., Zacharowski, K., Khodamoradi, Y., Vehreschild, M., Rohde, G., Zeiher, A. M., Vogl, T. J., Schwenke, C. & Nagel, E. Nat Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/36064600  

Paediatric familial hypercholesterolaemia screening in Europe: public policy background and recommendations. Gidding, S. S., Wiegman, A., Groselj, U., Freiberger, T., Peretti, N., Dharmayat, K. I., Daccord, M., Bedlington, N., Sikonja, J., Ray, K. K., Santos, R. D., Halle, M., Tokgozoglu, L., Gutierrez-Ibarluzea, I., Pinto, F. J. & Geanta, M. Eur J Prev Cardiol 29, 2301-2311 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36059237  

Sleep apnea predicts cardiovascular death in patients with Marfan syndrome: a cohort study. Gessler, N., Wohlmuth, P., Anwar, O., Debus, E. S., Eickholt, C., Gunawardene, M. A., Hakmi, S., Heitmann, K., Rybczynski, M., Schueler, H., Sheikhzadeh, S., Tigges, E., Wiest, G. H., Willems, S., Adam, E. & von Kodolitsch, Y. EPMA J 13, 451-460 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36061830  

Cardiac screening prior to return to play after SARS-CoV-2 infection: focus on the child and adolescent athlete: A Clinical Consensus Statement of the Task Force for Childhood Health of the European Association of Preventive Cardiology. D'Ascenzi, F., Castelletti, S., Adami, P. E., Cavarretta, E., Sanz-de la Garza, M., Maestrini, V., Biffi, A., Kantor, P., Pieles, G., Verhagen, E., Tiberi, M., Hanssen, H., Papadakis, M., Niebauer, J. & Halle, M. Eur J Prev Cardiol 29, 2120-2124 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36059208  

Circadian cardiac NAD(+) metabolism, from transcriptional regulation to healthy aging. Carpenter, B. J. & Dierickx, P. Am J Physiol Cell Physiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36062878  

Stroke-Heart Syndrome: Recent Advances and Challenges. Scheitz, J. F., Sposato, L. A., Schulz-Menger, J., Nolte, C. H., Backs, J. & Endres, M. J Am Heart Assoc 11, e026528 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36056731  

Identification of risk loci for primary aldosteronism in genome-wide association studies. Le Floch, E., Cosentino, T., Larsen, C. K., Beuschlein, F., Reincke, M., Amar, L., Rossi, G. P., De Sousa, K., Baron, S., Chantalat, S., Saintpierre, B., Lenzini, L., Frouin, A., Giscos-Douriez, I., Ferey, M., Abdellatif, A. B., Meatchi, T., Empana, J. P., Jouven, X., Gieger, C. et al. Nat Commun 13, 5198 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36057693  

Should HFrEF patients with NYHA class II expect benefit from CCM therapy? Results from the MAINTAINED observational study. Fastner, C., Yuecel, G., Hetjens, S., Rudic, B., Schmiel, G., Toepel, M., Liebe, V., Kruska, M., Borggrefe, M., Burkhoff, D., Akin, I., Duerschmied, D. & Kuschyk, J. Clin Res Cardiol 111, 1286-1294 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36056955  

Looking into the future of ACS patients through the small OCT window. Aytekin, A. & Kastrati, A. Rev Esp Cardiol (Engl Ed) (2022). https://www.ncbi.nlm.nih.gov/pubmed/36057426  

The dawn has come for new therapeutics to treat atherosclerosis: Targeting neuroimmune cardiovascular interfaces in artery brain circuits. Mohanta, S. K., Weber, C., Yin, C. & Habenicht, A. J. R. Clin Transl Med 12, e1040 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36052959  

Bi-allelic LETM1 variants perturb mitochondrial ion homeostasis leading to a clinical spectrum with predominant nervous system involvement. Kaiyrzhanov, R., Mohammed, S. E. M., Maroofian, R., Husain, R. A., Catania, A., Torraco, A., Alahmad, A., Dutra-Clarke, M., Gronborg, S., Sudarsanam, A., Vogt, J., Arrigoni, F., Baptista, J., Haider, S., Feichtinger, R. G., Bernardi, P., Zulian, A., Gusic, M., Efthymiou, S., Bai, R. et al. Am J Hum Genet 109, 1692-1712 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36055214  

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways. Young, W. J., Lahrouchi, N., Isaacs, A., Duong, T., Foco, L., Ahmed, F., Brody, J. A., Salman, R., Noordam, R., Benjamins, J. W., Haessler, J., Lyytikainen, L. P., Repetto, L., Concas, M. P., van den Berg, M. E., Weiss, S., Baldassari, A. R., Bartz, T. M., Cook, J. P., Evans, D. S. et al. Nat Commun 13, 5144 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36050321    

Cathepsin S Levels and Survival Among Patients With Non-ST-Segment Elevation Acute Coronary Syndromes. Stamatelopoulos, K., Mueller-Hennessen, M., Georgiopoulos, G., Lopez-Ayala, P., Sachse, M., Vlachogiannis, N. I., Sopova, K., Delialis, D., Bonini, F., Patras, R., Ciliberti, G., Vafaie, M., Biener, M., Boeddinghaus, J., Nestelberger, T., Koechlin, L., Tual-Chalot, S., Kanakakis, I., Gatsiou, A., Katus, H. et al. J Am Coll Cardiol 80, 998-1010 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36049808  

Mammalian Target of Rapamycin Inhibition in Patients With ST-Segment Elevation Myocardial Infarction. Stahli, B. E., Klingenberg, R., Heg, D., Branca, M., Manka, R., Kapos, I., Muggler, O., Denegri, A., Kesterke, R., Berger, F., Stehli, J., Candreva, A., von Eckardstein, A., Carballo, D., Hamm, C., Landmesser, U., Mach, F., Moccetti, T., Jung, C., Kelm, M. et al. J Am Coll Cardiol 80, 1802-1814 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36049557  

Monitoring for atrial fibrillation prior to patent foramen ovale closure after cryptogenic stroke. Diener, H. C., Wachter, R., Wong, A., Thijs, V., Schnabel, R. B., Ntaios, G., Kasner, S., Rothwell, P. M., Passman, R., Saver, J. L., Albers, B. A. & Bernstein, R. A. Int J Stroke, 17474930221124412 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36050817  

Endothelial versus pronephron fate decision is modulated by the transcription factors Cloche/Npas4l, Tal1, and Lmo2. Mattonet, K., Riemslagh, F. W., Guenther, S., Prummel, K. D., Kesavan, G., Hans, S., Ebersberger, I., Brand, M., Burger, A., Reischauer, S., Mosimann, C. & Stainier, D. Y. R. Sci Adv 8, eabn2082 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36044573  

Effects of homoarginine supplementation on heart and skeletal muscle of rats with heart failure with preserved ejection fraction. Buttner, P., Adams, V., Werner, S., Ossmann, S., Besler, C., Schwedhelm, E. & Thiele, H. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/36043453


Oktober

Cardiac Thrombogenicity in Stroke: Mechanisms and Evaluation. Back, M. & Doehner, W. Eur J Vasc Endovasc Surg 64, 150-152 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36309461  

The C1q-ApoE complex: A new hallmark pathology of viral hepatitis and nonalcoholic fatty liver disease. Habenicht, L. K. L., Wang, Z., Zhang, X., Li, Y., Mogler, C., Huspenina, J. S., Schmid, R. M., Weber, C., Mohanta, S. K., Ma, Z. & Yin, C. Front Immunol 13, 970938 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36304458  

Editorial: Cardiac optogenetics: Using light to observe and excite the heart. Bruegmann, T., Smith, G. L. & Lehnart, S. E. Front Physiol 13, 1031062 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36304575

Reduction in SOCE and Associated Aggregation in Platelets from Mice with Platelet-Specific Deletion of Orai1. Yang, L., Ottenheijm, R., Worley, P., Freichel, M. & Camacho Londono, J. E. Cells 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36291093  

Mobilization of CD11b(+)/Ly6c(hi) monocytes causes multi organ dysfunction syndrome in acute pancreatitis. Wilden, A., Glaubitz, J., Otto, O., Biedenweg, D., Nauck, M., Mack, M., Ribback, S., Broker, B. M., von Rheinbaben, S. F., Lerch, M. M., Aghdassi, A. A., Weiss, F. U. & Sendler, M. Front Immunol 13, 991295 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36300116  

Intraocular Pressure-Induced Endothelial Dysfunction of Retinal Blood Vessels Is Persistent, but Does Not Trigger Retinal Ganglion Cell Loss. Wang, M., Liu, H., Xia, N., Li, H., van Beers, T., Gericke, A. & Prokosch, V. Antioxidants (Basel) 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36290587  

High Temporal Resolution Dual-Source Photon-Counting CT for Coronary Artery Disease: Initial Multicenter Clinical Experience. Soschynski, M., Hagen, F., Baumann, S., Hagar, M. T., Weiss, J., Krauss, T., Schlett, C. L., von Zur Muhlen, C., Bamberg, F., Nikolaou, K., Greulich, S., Froelich, M. F., Riffel, P., Overhoff, D., Papavassiliu, T., Schoenberg, S. O., Faby, S., Ulzheimer, S., Ayx, I. & Krumm, P. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36294324  

Genotype Complements the Phenotype: Identification of the Pathogenicity of an LMNA Splice Variant by Nanopore Long-Read Sequencing in a Large DCM Family. Sedaghat-Hamedani, F., Rebs, S., Kayvanpour, E., Zhu, C., Amr, A., Muller, M., Haas, J., Wu, J., Steinmetz, L. M., Ehlermann, P., Streckfuss-Bomeke, K., Frey, N. & Meder, B. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36293084  

Left Ventricular Assist Device Implantation in Cancer-Therapy-Related Heart Failure. Mulzer, J., Muller, M., Schoenrath, F., Falk, V., Potapov, E. & Knierim, J. Life (Basel) 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36294920  

Blockade of Wnt Secretion Attenuates Myocardial Ischemia-Reperfusion Injury by Modulating the Inflammatory Response. Meyer, I. S., Li, X., Meyer, C., Voloshanenko, O., Pohl, S., Boutros, M., Katus, H. A., Frey, N. & Leuschner, F. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36293109  

COVID-19 Infections in Adults with Congenital Heart Disease-A Prospective Single-Center Study in an Outpatient Setting. Langes, N., Meierhofer, C., Nagdyman, N., Maurer, S. J., Bourier, F., Halle, M., Holdenrieder, S., Ewert, P. & Tutarel, O. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36294426   

Long-Term Psychosocial Consequences of Whole-Body Magnetic Resonance Imaging and Reporting of Incidental Findings in a Population-Based Cohort Study. Korbmacher-Bottcher, D., Bamberg, F., Peters, A., Linkohr, B., Ladwig, K. H., Schwettmann, L., Weckbach, S., Schlett, C. L. & Rospleszcz, S. Diagnostics (Basel) 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36292045  

Cluster Analysis Statistical Spectroscopy for the Identification of Metabolites in (1)H NMR Metabolomics. Heinzmann, S. S., Waldenberger, M., Peters, A. & Schmitt-Kopplin, P. Metabolites 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36295894  

Effects of an Omega-3 Supplemented, High-Protein Diet in Combination with Vibration and Resistance Exercise on Muscle Power and Inflammation in Old Adults: A Pilot Randomized Controlled Trial. Hass, U., Kochlik, B., Herpich, C., Rudloff, S. & Norman, K. Nutrients 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36296958  

Frequency, Risk Factors, and Clinical Outcomes of Late-Onset Atrial Flutter in Patients after Heart Transplantation. Rahm, A. K., Reinhardt, S., Helmschrott, M., Darche, F. F., Bruckner, T., Lugenbiel, P., Thomas, D., Ehlermann, P., Sommer, W., Warnecke, G., Frey, N. & Rivinius, R. J Cardiovasc Dev Dis 9 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36286289  

Iatrogenic atrial septal defects after transseptal puncture for percutaneous left atrial appendage occlusion and their hemodynamic effects. Drosos, I., Rosa, R., Seppelt, P. C., Cremer, S., Mas-Peiro, S., Hemmann, K., Oppermann, J., Blessing, R., Vasa-Nicotera, M., Zeiher, A. M. & Dimitriadis, Z. J Geriatr Cardiol 19, 675-684 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36284683   

High-throughput optical action potential recordings in hiPSC-derived cardiomyocytes with a genetically encoded voltage indicator in the AAVS1 locus. Zhang, F., Meier, A. B., Poch, C. M., Tian, Q., Engelhardt, S., Sinnecker, D., Lipp, P., Laugwitz, K. L., Moretti, A. & Dorn, T. Front Cell Dev Biol 10, 1038867 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36274846  

Microcephaly is associated with impaired educational development in children with congenital heart disease. Pfitzer, C., Sievers, L. K., Hutter, A., Khaliq, H. A., Poryo, M., Berger, F., Bauer, U. M. M., Helm, P. C. & Schmitt, K. R. L. Front Cardiovasc Med 9, 917507 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36277771  

Pulmonary hypertension: Linking inflammation and pulmonary arterial stiffening. Liu, S. F., Nambiar Veetil, N., Li, Q., Kucherenko, M. M., Knosalla, C. & Kuebler, W. M. Front Immunol 13, 959209 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36275740  

A mechanistic framework for cardiometabolic and coronary artery diseases. Koplev, S., Seldin, M., Sukhavasi, K., Ermel, R., Pang, S., Zeng, L., Bankier, S., Di Narzo, A., Cheng, H., Meda, V., Ma, A., Talukdar, H., Cohain, A., Amadori, L., Argmann, C., Houten, S. M., Franzen, O., Mocci, G., Meelu, O. A., Ishikawa, K. et al. Nat Cardiovasc Res 1, 85-100 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36276926  

Left-atrial long-axis shortening allows effective quantification of atrial function and optimized risk prediction following acute myocardial infarction. Backhaus, S. J., Rosel, S. F., Stiermaier, T., Schmidt-Rimpler, J., Evertz, R., Schulz, A., Lange, T., Kowallick, J. T., Kutty, S., Bigalke, B., Gutberlet, M., Hasenfuss, G., Thiele, H., Eitel, I. & Schuster, A. Eur Heart J Open 2, oeac053 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36268539  

Empagliflozin Preserves Skeletal Muscle Function in a HFpEF Rat Model. Winzer, E. B., Schauer, A., Langner, E., Augstein, A., Goto, K., Mannel, A., Barthel, P., Jannasch, A., Labeit, S., Mangner, N., Linke, A. & Adams, V. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36232292   

Distinct role of mitochondrial function and protein kinase C in intimal and medial calcification in vitro. Heuschkel, M. A., Babler, A., Heyn, J., van der Vorst, E. P. C., Steenman, M., Gesper, M., Kappel, B. A., Magne, D., Goueffic, Y., Kramann, R., Jahnen-Dechent, W., Marx, N., Quillard, T. & Goettsch, C. Front Cardiovasc Med 9, 959457 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36204585  

Developmental errors in the common marmoset retina. Haverkamp, S., Mietsch, M. & Briggman, K. L. Front Neuroanat 16, 1000693 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36204677  

Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues. Marttila, S., Tamminen, H., Rajic, S., Mishra, P. P., Lehtimaki, T., Raitakari, O., Kahonen, M., Kananen, L., Jylhava, J., Hagg, S., Delerue, T., Peters, A., Waldenberger, M., Kleber, M. E., Marz, W., Luoto, R., Raitanen, J., Sillanpaa, E., Laakkonen, E. K., Heikkinen, A. et al. Epigenomics 14, 1105-1124 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36200237  

Serial measurements of protein and microRNA biomarkers to specify myocardial infarction subtypes. Schulte, C., Singh, B., Theofilatos, K., Sorensen, N. A., Lehmacher, J., Hartikainen, T., Haller, P. M., Westermann, D., Zeller, T., Blankenberg, S., Neumann, J. T. & Mayr, M. J Mol Cell Cardiol Plus 1, None (2022). https://www.ncbi.nlm.nih.gov/pubmed/36185590  

Induced pluripotent stem cell-derived brain organoids as potential human model system for chemotherapy induced CNS toxicity. Scholz, S., Lewis, K., Saulich, F., Endres, M., Boehmerle, W. & Huehnchen, P. Front Mol Biosci 9, 1006497 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36188215  

Seizures, ataxia and parvalbumin-expressing interneurons respond to selenium supply in Selenop-deficient mice. Schweizer, U., Wirth, E. K., Klopstock, T., Holter, S. M., Becker, L., Moskovitz, J., Grune, T., Fuchs, H., Gailus-Durner, V., Hrabe de Angelis, M., Kohrle, J. & Schomburg, L. Redox Biol 57, 102490 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36182809

Integration of Hi-C with short and long-read genome sequencing reveals the structure of germline rearranged genomes. Schopflin, R., Melo, U. S., Moeinzadeh, H., Heller, D., Laupert, V., Hertzberg, J., Holtgrewe, M., Alavi, N., Klever, M. K., Jungnitsch, J., Comak, E., Turkmen, S., Horn, D., Duffourd, Y., Faivre, L., Callier, P., Sanlaville, D., Zuffardi, O., Tenconi, R., Kurtas, N. E. et al. Nat Commun 13, 6470 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36309531  

Effect of Mobile Stroke Unit Dispatch in all Patients with Acute Stroke or TIA. Rohmann, J. L., Piccininni, M., Ebinger, M., Wendt, M., Weber, J. E., Schwabauer, E., Geisler, F., Freitag, E., Harmel, P., Lorenz-Meyer, I., Rohrpasser-Napierkowski, I., Nolte, C. H., Nabavi, D. G., Schmehl, I., Ekkernkamp, A., Endres, M. & Audebert, H. J. Ann Neurol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36309933  

Optimized definition of right ventricular dysfunction on computed tomography for risk stratification of pulmonary embolism. Lerchbaumer, M. H., Aviram, G., Ebner, M., Ritter, C. O., Steimke, L., Rozenbaum, Z., Adam, S. Z., Granot, Y., Hasenfuss, G., Lotz, J., Hamm, B., Konstantinides, S. V. & Lankeit, M. Eur J Radiol 157, 110554 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36308850   

TAVI for patients with normal-flow low-gradient compared to high-gradient aortic stenosis. Steffen, J., Andreae, D., Nabauer, M., Reissig, N., Doldi, P. M., Haum, M., Orban, M., Theiss, H., Rizas, K., Braun, D., Peterss, S., Hausleiter, J., Massberg, S. & Deseive, S. Int J Cardiol 371, 299-304 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36306951  

Detection of apoptosis by [(18)F]ML-10 after cardiac ischemia-reperfusion injury in mice. Fischer, M., Zacherl, M. J., Olivier, J., Lindner, S., Massberg, S., Bartenstein, P., Grawe, F., Ziegler, S., Brendel, M., Lehner, S., Boening, G. & Todica, A. Ann Nucl Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/36306025  

Spironolactone effect on cardiac structure and function of patients with heart failure and preserved ejection fraction: a pooled analysis of three randomized trials. Ferreira, J. P., Cleland, J. G., Girerd, N., Bozec, E., Rossignol, P., Pellicori, P., Cosmi, F., Mariottoni, B., Solomon, S. D., Pitt, B., Pfeffer, M. A., Shah, A. M., Petutschnigg, J., Pieske, B., Edelmann, F. & Zannad, F. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/36303266  

First steps taken, but many more ahead. Beer, B. N. & Schrage, B. Eur Heart J Acute Cardiovasc Care 11, 904-905 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36306402  

Catheter ablation of supraventricular tachycardias-a success story. Althoff, T. F. & Mont, L. Europace (2022). https://www.ncbi.nlm.nih.gov/pubmed/36305555  

Fatty Acid Amide Hydrolase Deficiency Is Associated with Deleterious Cardiac Effects after Myocardial Ischemia and Reperfusion in Mice. Rajlic, S., Surmann, L., Zimmermann, P., Weisheit, C. K., Bindila, L., Treede, H., Velten, M., Daiber, A. & Duerr, G. D. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36293543  

Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation. Ortiz-Zapater, E., Bagley, D. C., Hernandez, V. L., Roberts, L. B., Maguire, T. J. A., Voss, F., Mertins, P., Kirchner, M., Peset-Martin, I., Woszczek, G., Rosenblatt, J., Gotthardt, M., Santis, G. & Parsons, M. Nat Commun 13, 6407 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36302767  

Patient-Reported Quality of Life After Intravenous Alteplase for Stroke in the WAKE-UP Trial. Jensen, M., Sehner, S., Cheng, B., Schlemm, E., Quandt, F., Barow, E., Wegscheider, K., Boutitie, F., Ebinger, M., Endres, M., Fiebach, J., Thijs, V., Lemmens, R., Muir, K., Nighoghossian, N., Pedraza, S., Simonsen, C. Z., Thomalla, G. & Gerloff, C. Neurology (2022). https://www.ncbi.nlm.nih.gov/pubmed/36302662  

Image Quality Improvement Techniques and Assessment Adequacy in Clinical Optoacoustic Imaging: A Systematic Review. Dimaridis, I., Sridharan, P., Ntziachristos, V., Karlas, A. & Hadjileontiadis, L. Biosensors (Basel) 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36291038  

Sequences and proteins that influence mRNA processing in Trypanosoma brucei: Evolutionary conservation of SR-domain and PTB protein functions. Waithaka, A., Maiakovska, O., Grimm, D., do Nascimento, L. M. & Clayton, C. PLoS Negl Trop Dis 16, e0010876 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36288402  

Targeted Temperature Management in Postresuscitation Care After Incorporating Results of the TTM2 Trial. Lusebrink, E., Binzenhofer, L., Kellnar, A., Scherer, C., Schier, J., Kleeberger, J., Stocker, T. J., Peterss, S., Hagl, C., Stark, K., Petzold, T., Fichtner, S., Braun, D., Kaab, S., Brunner, S., Theiss, H., Hausleiter, J., Massberg, S. & Orban, M. J Am Heart Assoc 11, e026539 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36285786  

Standard Transfemoral Transcatheter Aortic Valve Replacement. Van Praet, K. M., Nersesian, G., Kukucka, M., Heil, E., Kofler, M., Wert, L., Falk, V., Kempfert, J., Klein, C. & Unbehaun, A. Multimed Man Cardiothorac Surg 2022 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36282201   

Iron deficiency and cardiovascular disease. Savarese, G., von Haehling, S., Butler, J., Cleland, J. G., Ponikowski, P. & Anker, S. D. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/36282723  

Association of epicardial adipose tissue with coronary CT angiography plaque parameters on cardiovascular outcome in patients with and without diabetes mellitus. Tesche, C., Bauer, M. J., Straube, F., Rogowski, S., Baumann, S., Renker, M., Fink, N., Schoepf, U. J., Hoffmann, E. & Ebersberger, U. Atherosclerosis 363, 78-84 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36280469  

Early and late renal function changes with spironolactone in patients at risk of developing heart failure: findings from the HOMAGE trial. Ferreira, J. P., Cleland, J. G. F., Girerd, N., Pellicori, P., Hazebroek, M. R., Verdonschot, J., Collier, T. J., Petutschnigg, J., Clark, A. L., Staessen, J. A., Heymans, S., Zannad, F. & Rossignol, P. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36279002  

Subtype-specific plasma signatures of platelet-related protein releasate in acute pulmonary embolism. Baidildinova, G., Ten Cate, V., Nagler, M., Panova-Noeva, M., Rapp, S., Kock, T., Prochaska, J. H., Heitmeier, S., Gerdes, C., Schwers, S., Konstantinides, S. V., Munzel, T., Espinola-Klein, C., Lackner, K. J., Spronk, H. M. N., Ten Cate, H., van der Meijden, P. E. J., Leineweber, K., Wild, P. S. & Jurk, K. Thromb Res 220, 75-87 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36274391  

Angiotensin 1-7 increases fiber cross-sectional area and force in juvenile mouse skeletal muscle. Albadrani, H., Ammar, T., Rajgara, R., Bader, M., Wiper-Bergeron, N. & Renaud, J. M. Am J Physiol Cell Physiol 323, C1681-C1696 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36280388 

Neutrophil "plucking" on megakaryocytes drives platelet production and boosts cardiovascular disease. Petzold, T., Zhang, Z., Ballesteros, I., Saleh, I., Polzin, A., Thienel, M., Liu, L., Ul Ain, Q., Ehreiser, V., Weber, C., Kilani, B., Mertsch, P., Gotschke, J., Cremer, S., Fu, W., Lorenz, M., Ishikawa-Ankerhold, H., Raatz, E., El-Nemr, S., Gorlach, A. et al. Immunity 55, 2285-2299 e2287 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36272416   

Use of serial changes in biomarkers vs. baseline levels to predict left ventricular remodelling after STEMI. Klingenberg, R., Holtkamp, F., Grun, D., Frey, A., Jahns, V., Jahns, R., Gassenmaier, T., Hamm, C. W., Frantz, S. & Keller, T. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/36271665  

Fasting intervention and its clinical effects on the human host and microbiome. Forslund, S. K. J Intern Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/36271842  

D-dopachrome tautomerase in cardiovascular and inflammatory diseases-A new kid on the block or just another MIF? Zan, C., Yang, B., Brandhofer, M., El Bounkari, O. & Bernhagen, J. FASEB J 36, e22601 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36269019  

Role of CD40(L)-TRAF signaling in inflammation and resolution-a double-edged sword. Strohm, L., Ubbens, H., Münzel, T., Daiber, A. & Daub, S. Front Pharmacol 13, 995061 (2022).

Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals. Ripplinger, C. M., Glukhov, A. V., Kay, M. W., Boukens, B. J., Chiamvimonvat, N., Delisle, B. P., Fabritz, L., Hund, T. J., Knollmann, B. C., Li, N., Murray, K. T., Poelzing, S., Quinn, T. A., Remme, C. A., Rentschler, S. L., Rose, R. A. & Posnack, N. G. Am J Physiol Heart Circ Physiol 323, H1137-H1166 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36269644  

The mega COMBO collaboration: An individual patient data pooled analysis of patients undergoing PCI with COMBO stent. Nardin, M., Pivato, C. A., Cao, D., Sartori, S., Zhang, Z., Vogel, B., Nicolas, J., Chiarito, M., Qiu, H., Chandrasekhar, J., Spirito, A., Abizaid, A., Christiansen, E. H., Colombo, A., de Winter, R. J., Haude, M., Jakobsen, L., Jensen, L. O., Krucoff, M. W., Landmesser, U. et al. Int J Cardiol 370, 149-155 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36270496  

Genomic risk scores, biomolecules, and clinical conditions to predict atrial fibrillation: time to integrate what we can measure. Kaab, S., Holm, H. & Kirchhof, P. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/36269625  

Quadrivalvular nonbacterial thrombotic endocarditis in a patient with clear cell cervical cancer. Gabelmann, V., Grabs, F., Diestelmeier, S., Heindl, F., Vosseler, M., Münzel, T., Sagoschen, I. & Wild, J. Clin Case Rep 10, e6434 (2022).

Successful treatment of doxorubicin-induced cardiomyopathy with low-dose sacubitril/valsartan: a case report. Bell, E., Desuki, A., Karbach, S. & Göbel, S. Eur Heart J Case Rep 6, ytac396 (2022).

Comparison of Predicted and Confirmed Neo-Left Ventricular Outflow Tract After Transcatheter Mitral Valve Replacement. Puehler, T., Blanke, P., Seoudy, H., Sathananthan, J., Sellers, S. L., Meier, D., Both, M., Saad, M., Frank, D., Sondergaard, L. & Lutter, G. JACC Cardiovasc Interv 15, e219-e221 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36265952  

NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart. Muller, M., Eghbalian, R., Boeckel, J. N., Frese, K. S., Haas, J., Kayvanpour, E., Sedaghat-Hamedani, F., Lackner, M. K., Tugrul, O. F., Ruppert, T., Tappu, R., Martins Bordalo, D., Kneuer, J. M., Piekarek, A., Herch, S., Schudy, S., Keller, A., Grammes, N., Bischof, C., Klinke, A. et al. Nat Commun 13, 6209 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36266340  

3D model-based super-resolution motion-corrected cardiac T1 mapping. Hufnagel, S., Metzner, S., Kerkering, K. M., Aigner, C. S., Kofler, A., Schulz-Menger, J., Schaeffter, T. & Kolbitsch, C. Phys Med Biol 67 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36265478  

Diagnostic and prognostic value of the AST/ALT ratio in patients with sepsis and septic shock. Schupp, T., Weidner, K., Rusnak, J., Jawhar, S., Forner, J., Dulatahu, F., Brück, L. M., Hoffmann, U., Bertsch, T., Weiß, C., Akin, I. & Behnes, M. Scand J Gastroenterol, 1-11 (2022).

Sarcopenia and Frailty in Heart Failure: Is There a Biomarker Signature? Sato, R., Vatic, M., da Fonseca, G. W. P. & von Haehling, S. Curr Heart Fail Rep 19, 400-411 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36261756  

Hospital intervention volume affects outcomes of emergency transcatheter aortic valve implantations in Germany. Oettinger, V., Heidenreich, A., Kaier, K., Zehender, M., Bode, C., Duerschmied, D., von Zur Mühlen, C., Westermann, D. & Stachon, P. Sci Rep 12, 17483 (2022).

Artificial intelligence-enabled phenotyping of patients with severe aortic stenosis: on the recovery of extra-aortic valve cardiac damage after transcatheter aortic valve replacement. Lachmann, M., Rippen, E., Schuster, T., Xhepa, E., von Scheidt, M., Trenkwalder, T., Pellegrini, C., Rheude, T., Hesse, A., Stundl, A., Harmsen, G., Yuasa, S., Schunkert, H., Kastrati, A., Laugwitz, K. L., Joner, M. & Kupatt, C. Open Heart 9 (2022).

Pulsed field ablation in patients with complex consecutive atrial tachycardia in conjunction with ultra-high density mapping: proof of concept. Gunawardene, M. A., Schaeffer, B. N., Jularic, M., Eickholt, C., Akbulak, R., Hedenus, K., Wahedi, R., Anwar, O., Gessler, N., Hartmann, J. & Willems, S. J Cardiovasc Electrophysiol (2022).

Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage. Ercu, M., Mucke, M. B., Pallien, T., Marko, L., Sholokh, A., Schachterle, C., Aydin, A., Kidd, A., Walter, S., Esmati, Y., McMurray, B. J., Lato, D. F., Yumi Sunaga-Franze, D., Dierks, P. H., Flores, B. I. M., Walker-Gray, R., Gong, M., Merticariu, C., Zuhlke, K., Russwurm, M. et al. Circulation 146, 1758-1778 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36259389  

Development and External Validation of a Multivariable Prediction Model to Identify Nondiabetic Hyperglycemia and Undiagnosed Type 2 Diabetes: Diabetes Risk Assessment in Dentistry Score (DDS). Yonel, Z., Kocher, T., Chapple, I. L. C., Dietrich, T., Völzke, H., Nauck, M., Collins, G., Gray, L. J. & Holtfreter, B. J Dent Res, 220345221129807 (2022).

Riociguat and balloon pulmonary angioplasty improve prognosis in patients with inoperable chronic thromboembolic pulmonary Hypertension. Wiedenroth, C. B., Rolf, A., Steinhaus, K., Adameit, M. S. D., Kriechbaum, S. D., Haas, M., Roller, F., Hamm, C. W., Ghofrani, H. A., Mayer, E., Breithecker, A., Guth, S. & Liebetrau, C. J Heart Lung Transplant 42, 134-139 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36257870  

Engineered skeletal muscle recapitulates human muscle development, regeneration and dystrophy. Shahriyari, M., Islam, M. R., Sakib, S. M., Rinn, M., Rika, A., Kruger, D., Kaurani, L., Gisa, V., Winterhoff, M., Anandakumar, H., Shomroni, O., Schmidt, M., Salinas, G., Unger, A., Linke, W. A., Zschuntzsch, J., Schmidt, J., Bassel-Duby, R., Olson, E. N., Fischer, A. et al. J Cachexia Sarcopenia Muscle 13, 3106-3121 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36254806  

Ticagrelor or Prasugrel in Patients With Acute Coronary Syndrome and High Bleeding Risk. Lahu, S., Presch, A., Ndrepepa, G., Menichelli, M., Valina, C., Hemetsberger, R., Witzenbichler, B., Bernlochner, I., Joner, M., Xhepa, E., Hapfelmeier, A., Kufner, S., Rifatov, N., Sager, H. B., Mayer, K., Kessler, T., Laugwitz, K. L., Richardt, G., Schunkert, H., Neumann, F. J. et al. Circ Cardiovasc Interv 15, e012204 (2022).

Deep, deep learning with BART. Blumenthal, M., Luo, G., Schilling, M., Holme, H. C. M. & Uecker, M. Magn Reson Med 89, 678-693 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36254526  

Cardiac phase-resolved late gadolinium enhancement imaging. Weingärtner, S., Demirel Ö, B., Gama, F., Pierce, I., Treibel, T. A., Schulz-Menger, J. & Akçakaya, M. Front Cardiovasc Med 9, 917180 (2022).

Low ankle-brachial index and cognitive function after stroke-the PROSpective with Incident Stroke Berlin (PROSCIS-B). Stillfried, M. R. V., Sperber, P. S., Broersen, L. H. A., Huo, S., Piper, S. K., Heuschmann, P. U., Endres, M., Siegerink, B. & Liman, T. G. Front Neurol 13, 963262 (2022).

Novel insights into mouse models of ectopic proplatelet release. Spindler, M., Bergmeier, W., Stradal, T. E. B., Zhang, J., Siminovitch, K. A., Nicolai, L., Reinhold, A. & Bender, M. Blood Adv 6, 6135-6139 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36251748  

ACURATE neo2 versus SAPIEN 3 Ultra for transcatheter aortic valve implantation. Pellegrini, C., Rheude, T., Renker, M., Wolf, A., Wambach, J. M., Alvarez-Covarrubias, H. A., Dörr, O., Singh, P., Charitos, E. I., Xhepa, E., Joner, M. & Kim, W. K. EuroIntervention (2022).

Lipoprotein(a) levels in a global population with established atherosclerotic cardiovascular disease. Nissen, S. E., Wolski, K., Cho, L., Nicholls, S. J., Kastelein, J., Leitersdorf, E., Landmesser, U., Blaha, M., Lincoff, A. M., Morishita, R., Tsimikas, S., Liu, J., Manning, B., Kozlovski, P., Lesogor, A., Thuren, T., Shibasaki, T., Matei, F., Silveira, F. S., Meunch, A. et al. Open Heart 9 (2022).

Assessing spatial learning and memory in mice: Classic radial maze versus a new animal-friendly automated radial maze allowing free access and not requiring food deprivation. Kohler, J., Mei, J., Banneke, S., Winter, Y., Endres, M. & Emmrich, J. V. Front Behav Neurosci 16, 1013624 (2022).

Patient Selection for Protected Percutaneous Coronary Intervention: Who Benefits the Most? Kim, S. H., Baumann, S., Behnes, M., Borggrefe, M. & Akin, I. Interv Cardiol Clin 11, 455-464 (2022).

A universal model of RNA.DNA:DNA triplex formation accurately predicts genome-wide RNA-DNA interactions. Warwick, T., Seredinski, S., Krause, N. M., Bains, J. K., Althaus, L., Oo, J. A., Bonetti, A., Dueck, A., Engelhardt, S., Schwalbe, H., Leisegang, M. S., Schulz, M. H. & Brandes, R. P. Brief Bioinform 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36239395  

Proportion of stroke types in Madagascar: A tertiary-level hospital-based case series. Riedmann, J., Solonavalona, A. F., Rakotozafy, A. R., Ralamboson, S., Endres, M., Siegerink, B., Siebert, E., Knauss, S. & Emmrich, J. V. PLoS One 17, e0276199 (2022).

Sphingolipids in Atherosclerosis: Chimeras in Structure and Function. Peters, L., Kuebler, W. M. & Simmons, S. Int J Mol Sci 23 (2022).

Vascular and Liver Homeostasis in Juvenile Mice Require Endothelial Cyclic AMP-Dependent Protein Kinase A. Nedvetsky, P. I., Cornelissen, I., Mathivet, T., Bouleti, C., Ou, P., Baatsen, P., Zhao, X., Schuit, F., Stanchi, F., Mostov, K. E. & Gerhardt, H. Int J Mol Sci 23 (2022).

Frequency of subclavian artery stenosis in patients with mammarian artery coronary bypass and suspected coronary artery disease progression. Müller, A. M., Bertram, J., Bradaric, C., Koppara, T., Cassese, S., Xhepa, E., Heilmeier, B., Ott, I., Kastrati, A., Laugwitz, K. L., Ibrahim, T. & Dirschinger, R. J. Clin Res Cardiol (2022).

Influence of Shear Stress, Inflammation and BRD4 Inhibition on Human Endothelial Cells: A Holistic Proteomic Approach. Jarausch, J., Neuenroth, L., Andag, R., Leha, A., Fischer, A., Asif, A. R., Lenz, C. & Eidizadeh, A. Cells 11 (2022).

The Effect of Dextrose or Protein Ingestion on Circulating Growth Differentiation Factor 15 and Appetite in Older Compared to Younger Women. Herpich, C., Lehmann, S., Kochlik, B., Kleinert, M., Klaus, S., Müller-Werdan, U. & Norman, K. Nutrients 14 (2022).

[New mapping tools for catheter ablation of atrial fibrillation]. Delgado-Lopez, M., Heeger, C. H. & Tilz, R. R. Herzschrittmacherther Elektrophysiol 33, 380-385 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36239817  

Transvenous lead extraction in patients with systemic cardiac device-related infection-Procedural outcome and risk prediction: A GALLERY subgroup-analysis. Chung, D. U., Burger, H., Kaiser, L., Osswald, B., Bärsch, V., Nägele, H., Knaut, M., Reichenspurner, H., Gessler, N., Willems, S., Butter, C., Pecha, S. & Hakmi, S. Heart Rhythm (2022).

Echocardiographic evaluation of left ventricular function using an automated analysis algorithm is feasible for beginners and experts: comparison with invasive and non-invasive methods. Nicol, P., Rank, A., Lenz, T., Schürmann, F., Syryca, F., Trenkwalder, T., Reinhard, W., Adolf, R., Hadamitzky, M., Kastrati, A., Joner, M., Schunkert, H. & Engel, L. C. J Echocardiogr (2022).

AntiSplodge: a neural-network-based RNA-profile deconvolution pipeline designed for spatial transcriptomics. Lund, J. B., Lindberg, E. L., Maatz, H., Pottbaecker, F., Hubner, N. & Lippert, C. NAR Genom Bioinform 4, lqac073 (2022). www.ncbi.nlm.nih.gov/pubmed/36225530

[MINOCA-myocardial infarction with nonobstructive coronary arteries]. Kowallick, J. T., Scholz, M., Schuster, A. & Lotz, J. Radiologie (Heidelb) 62, 912-919 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36227368  

Autoimmune activation and hypersensitization of the AT1 and ETA receptors contributes to vascular injury in scleroderma renal crisis. Hegner, B., Kretzschmar, T., Zhu, N., Kleinau, G., Zhao, H., Kamhieh-Milz, J., Hilger, J., Schindler, R., Scheerer, P., Riemekasten, G., Philippe, A. & Catar, R. Rheumatology (Oxford) (2022). https://pubmed.ncbi.nlm.nih.gov/36227102/   

A saturated map of common genetic variants associated with human height. Yengo, L., Vedantam, S., Marouli, E., Sidorenko, J., Bartell, E., Sakaue, S., Graff, M., Eliasen, A. U., Jiang, Y., Raghavan, S., Miao, J., Arias, J. D., Graham, S. E., Mukamel, R. E., Spracklen, C. N., Yin, X., Chen, S. H., Ferreira, T., Highland, H. H., Ji, Y. et al. Nature (2022). https://pubmed.ncbi.nlm.nih.gov/36224396/  

Sex-specific and hormone-related differences in vascular remodelling in atherosclerosis. Yerly, A., van der Vorst, E. P. C., Baumgartner, I., Bernhard, S. M., Schindewolf, M. & Doring, Y. Eur J Clin Invest 53, e13885 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36219492  

Identification and management of cancer cachexia in patients: Assessment of healthcare providers' knowledge and practice gaps. Baracos, V. E., Coats, A. J., Anker, S. D., Sherman, L., Klompenhouwer, T., International Advisory, B., Regional Advisory Boards for North America, E. & Japan. J Cachexia Sarcopenia Muscle 13, 2683-2696 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36218155  

Emergency TAVI for acute heart failure due to severe aortic stenosis in critically ill patients with or without cardiogenic shock. Steffen, J., Stocker, A., Scherer, C., Haum, M., Fischer, J., Doldi, P. M., Theiss, H., Braun, D., Rizas, K., Peterß, S., Hausleiter, J., Massberg, S., Orban, M. & Deseive, S. Eur Heart J Acute Cardiovasc Care (2022).

SGLT2 Inhibitors and Peripheral Vascular Events: A Review of the Literature. Marchiori, E., Rodionov, R. N., Peters, F., Magnussen, C., Nordanstig, J., Gombert, A., Spanos, K., Jarzebska, N. & Behrendt, C. A. Heart Fail Clin 18, 609-623 (2022).

Determination of AAV properties by single amino acids: Go(o)d is in the details. Maiakovska, O., Baumgartl, C. & Grimm, D. Mol Ther Methods Clin Dev 27, 93-95 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36212908  

Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease. Khera, A. V., Wang, M., Chaffin, M., Emdin, C. A., Samani, N. J., Schunkert, H., Watkins, H., McPherson, R., Erdmann, J., Elosua, R., Boerwinkle, E., Ardissino, D., Butterworth, A. S., Di Angelantonio, E., Naheed, A., Danesh, J., Chowdhury, R., Krumholz, H. M., Sheu, W. H., Rich, S. S. et al. Circ Genom Precis Med, 101161circgen121003598 (2022). https://pubmed.ncbi.nlm.nih.gov/36215124/  

Progressive and Simultaneous Right and Left Atrial Remodeling Uncovered by a Comprehensive Magnetic Resonance Assessment in Atrial Fibrillation. Gunturiz-Beltrán, C., Nuñez-Garcia, M., Althoff, T. F., Borràs, R., Figueras, I. V. R. M., Garre, P., Caixal, G., Prat-González, S., Perea, R. J., Benito, E. M., Tolosana, J. M., Arbelo, E., Roca-Luque, I., Brugada, J., Sitges, M., Mont, L. & Guasch, E. J Am Heart Assoc 11, e026028 (2022).

Prevention of Oxidative Damage in Spinal Cord Ischemia Upon Aortic Surgery: First-In-Human Results of Shock Wave Therapy Prove Safety and Feasibility. Graber, M., Nägele, F., Röhrs, B. T., Hirsch, J., Pölzl, L., Moriggl, B., Mayr, A., Troger, F., Kirchmair, E., Wagner, J. F., Nowosielski, M., Mayer, L., Voelkl, J., Tancevski, I., Meyer, D., Grimm, M., Knoflach, M., Holfeld, J. & Gollmann-Tepeköylü, C. J Am Heart Assoc 11, e026076 (2022).

A novel MAP3K20 mutation causing centronuclear myopathy-6 with fiber-type disproportion in a Pakistani family. Ahmad, I., Khan, A., Noor Ul Ayan, H., Budde, B., Altmüller, J., Korejo, A. A., Nürnberg, G., Thiele, H., Tariq, M., Nürnberg, P. & Erdmann, J. J Hum Genet (2022).

Exercise MR-proANP unmasks latent right heart failure in CTEPH. Kriechbaum, S. D., Birmes, J., Wiedenroth, C. B., Adameit, M. S. D., Gruen, D., Vietheer, J., Richter, M. J., Guth, S., Roller, F. C., Rademann, M., Fischer-Rasokat, U., Rolf, A., Liebetrau, C., Hamm, C. W., Keller, T. & Rieth, A. J. J Heart Lung Transplant 41, 1819-1830 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36210266   

Inflammatory plasma proteins predict short-term mortality in patients with an acute myocardial infarction. Schmitz, T., Harmel, E., Heier, M., Peters, A., Linseisen, J. & Meisinger, C. J Transl Med 20, 457 (2022).

Future temperature-related mortality considering physiological and socioeconomic adaptation: a modelling framework. Rai, M., Breitner, S., Wolf, K., Peters, A., Schneider, A. & Chen, K. Lancet Planet Health 6, e784-e792 (2022).

CODE-EHR best practice framework for the use of structured electronic healthcare records in clinical research. Kotecha, D., Asselbergs, F. W., Achenbach, S., Anker, S. D., Atar, D., Baigent, C., Banerjee, A., Beger, B., Brobert, G., Casadei, B., Ceccarelli, C., Cowie, M. R., Crea, F., Cronin, M., Denaxas, S., Derix, A., Fitzsimons, D., Fredriksson, M., Gale, C. P., Gkoutos, G. V. et al. Eur Heart J 43, 3578-3588 (2022).

Kinin B1 receptor modulates mitochondrial activity responsivity in fasting and voluntary exercise. Arruda, A. C., Budu, A., de Menezes, T. N., Bader, M., Araujo, R. C. & Freitas-Lima, L. C. Life Sci 309, 121034 (2022).

Serum dihydrotestosterone is associated with adverse myocardial remodeling in patients with Aortic Valve Stenosis before and after Aortic Valve Replacement. Schafstedde, M., Nordmeyer, J., Berger, F., Knosalla, C., Mertins, P., Regitz-Zagrosek, V., Kuehne, T., Kraus, M. & Nordmeyer, S. Am J Physiol Heart Circ Physiol (2022).

Integrated control of coronary blood flow in exercising swine by adenosine, nitric oxide, and K(ATP) channels. Duncker, D. J., Sorop, O., van de Wouw, J., Fen, G., de Beer, V. J., Taverne, Y. J., de Graaff, H. J. D. & Merkus, D. Am J Physiol Heart Circ Physiol 323, H1080-H1090 (2022). www.ncbi.nlm.nih.gov/pubmed/36206049

Impact of Different Training Modalities on Molecular Alterations in Skeletal Muscle of Patients With Heart Failure With Preserved Ejection Fraction: A Substudy of the OptimEx Trial. Winzer, E. B., Augstein, A., Schauer, A., Mueller, S., Fischer-Schaepmann, T., Goto, K., Hommel, J., van Craenenbroeck, E. M., Wisløff, U., Pieske, B., Halle, M., Linke, A. & Adams, V. Circ Heart Fail 15, e009124 (2022).

Machine learning evaluation of LV outflow obstruction in hypertrophic cardiomyopathy using three-chamber cardiovascular magnetic resonance. Sahota, M., Saraskani, S. R., Xu, H., Li, L., Majeed, A. W., Hermida, U., Neubauer, S., Desai, M., Weintraub, W., Desvigne-Nickens, P., Schulz-Menger, J., Kwong, R. Y., Kramer, C. M., Young, A. A., Lamata, P. & investigators, H. Int J Cardiovasc Imaging 38, 2695-2705 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36201099  

Psychosocial Characteristics of Patients Evaluated for Kidney, Liver, or Heart Transplantation. Gronewold, N., Schunn, F., Ihrig, A., Mayer, G., Wohnsland, S., Wagenlechner, P., Leuschner, M., Kreusser, M. M., Sommerer, C., Rupp, C., Friederich, H. C., Schultz, J. H. & Bruns, B. Psychosom Med 85, 98-105 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36201770  

Determinants of mammography screening participation-a cross-sectional analysis of the German population-based Gutenberg Health Study (GHS). Pokora, R. M., Büttner, M., Schulz, A., Schuster, A. K., Merzenich, H., Teifke, A., Michal, M., Lackner, K., Münzel, T., Zeissig, S. R., Wild, P. S., Singer, S. & Wollschläger, D. PLoS One 17, e0275525 (2022).

The impact of cell culture media on the interaction of biopolymer-functionalized gold nanoparticles with cells: mechanical and toxicological properties. Meesaragandla, B., Komaragiri, Y., Schlüter, R., Otto, O. & Delcea, M. Sci Rep 12, 16643 (2022).

ECG performance in simultaneous recordings of five wearable devices using a new morphological noise-to-signal index and Smith-Waterman-based RR interval comparisons. Bläsing, D., Buder, A., Reiser, J. E., Nisser, M., Derlien, S. & Vollmer, M. PLoS One 17, e0274994 (2022).

Extracellular Matrix Profiling and Disease Modelling in Engineered Vascular Smooth Muscle Cell Tissues. Reed, E., Fellows, A., Lu, R., Rienks, M., Schmidt, L., Yin, X., Duregotti, E., Brandt, M., Krasemann, S., Hartmann, K., Barallobre-Barreiro, J., Addison, O., Cuello, F., Hansen, A. & Mayr, M. Matrix Biol Plus 16, 100122 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36193159  

Prediction of activity-related energy expenditure under free-living conditions using accelerometer-derived physical activity. Jeran, S., Steinbrecher, A., Haas, V., Mähler, A., Boschmann, M., Westerterp, K. R., Brühmann, B. A., Steindorf, K. & Pischon, T. Sci Rep 12, 16578 (2022).

Data standards for transcatheter aortic valve implantation: the European Unified Registries for Heart Care Evaluation and Randomised Trials (EuroHeart). Aktaa, S., Batra, G., James, S. K., Blackman, D. J., Ludman, P. F., Mamas, M. A., Abdel-Wahab, M., Angelini, G. D., Czerny, M., Delgado, V., De Luca, G., Eustachio, A., Foldager, D., Hamm, C. W., Iung, B., Mangner, N., Mehilli, J., Murphy, G. J., Mylotte, D., Parma, R. et al. Eur Heart J Qual Care Clin Outcomes (2022).

Integrated single-cell analysis based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis. Zernecke, A., Erhard, F., Weinberger, T., Schulz, C., Ley, K., Saliba, A. E. & Cochain, C. Cardiovasc Res (2022).

Optimisation of individual cardiovascular risk assessment in a German coronary artery disease cohort using a commercial test for genetic polymorphisms - a pilot study. Krohn, J. B., Neubauer, C., Fischer, S., Oberkanins, C., Katus, H. A. & Gleissner, C. A. Acta Cardiol, 1-11 (2022).

Depression predicts equivalized income five years later, but not vice versa: Results from the prospective Gutenberg Health Study. Wicke, F. S., Schmidt, P., Petersen, J., Ernst, M., Krakau, L., Brahler, E., Tibubos, A. N., Otten, D., Reiner, I., Michal, M., Schulz, A., Munzel, T., Wild, P. S., Konig, J., Lackner, K. J., Pfeiffer, N. & Beutel, M. E. Soc Sci Med 313, 115395 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36183523  

Biomarker profiles in heart failure with preserved vs. reduced ejection fraction: results from the DIAST-CHF study. Eidizadeh, A., Schnelle, M., Leha, A., Edelmann, F., Nolte, K., Werhahn, S. M., Binder, L. & Wachter, R. ESC Heart Fail (2022).

Using pERK immunostaining to quantify neuronal activity induced by stress in zebrafish larvae. Corradi, L., Zaupa, M., Sawamiphak, S. & Filosa, A. STAR Protoc 3, 101731 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36183255  

NOX4 mRNA correlates with plaque stability in patients with carotid artery stenosis. Hofmann, A., Frank, F., Wolk, S., Busch, A., Klimova, A., Sabarstinski, P., Gerlach, M., Egorov, D., Kopaliani, I., Weinert, S., Hamann, B., Poitz, D. M., Brunssen, C., Morawietz, H., Schröder, K. & Reeps, C. Redox Biol 57, 102473 (2022).

Value of PET ECG gating in a cross-validation study of cardiac function assessment by PET/MR imaging. Villagran Asiares, A., Vitadello, T., Bogdanovic, B., Solari, E. L., McIntosh, L., Schachoff, S., Ibrahim, T. & Nekolla, S. G. J Nucl Cardiol (2022).

The Angiotensin AT(2) Receptor: From a Binding Site to a Novel Therapeutic Target. Steckelings, U. M., Widdop, R. E., Sturrock, E. D., Lubbe, L., Hussain, T., Kaschina, E., Unger, T., Hallberg, A., Carey, R. M. & Sumners, C. Pharmacol Rev 74, 1051-1135 (2022).

Systematic review and meta-analysis of intravenous iron-carbohydrate complexes in HFrEF patients with iron deficiency. Sindone, A., Doehner, W. & Comin-Colet, J. ESC Heart Fail (2022).

Association of general and abdominal adiposity with postural changes in systolic blood pressure: results from the NAKO pretest and MetScan studies. Moreno Velasquez, I., Jaeschke, L., Steinbrecher, A., Boeing, H., Keil, T., Janke, J. & Pischon, T. Hypertens Res 45, 1964-1976 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36180592  

Stroke genetics informs drug discovery and risk prediction across ancestries. Mishra, A., Malik, R., Hachiya, T., Jurgenson, T., Namba, S., Posner, D. C., Kamanu, F. K., Koido, M., Le Grand, Q., Shi, M., He, Y., Georgakis, M. K., Caro, I., Krebs, K., Liaw, Y. C., Vaura, F. C., Lin, K., Winsvold, B. S., Srinivasasainagendra, V., Parodi, L. et al. Nature 611, 115-123 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36180795  

Cardiovascular and metabolic determinants of quality of life in patients with cancer. Evertz, R., Gödde, K., Diehl, C., Valentova, M., Garfias-Veitl, T., Braulke, F., Wulf, G. G., Overbeck, T. R., Bleckmann, A., König, A. O., Weinländer, P., Potthoff, S., Hadzibegovic, S., Lena, A., Keller, U., Landmesser, U., Schuster, A., Anker, M. S., Hasenfuß, G. & von Haehling, S. ESC Heart Fail (2022).


November

Why Angiotensin II is a Poor Choice for Circulatory Support of Ventilated COVID-19 Patients Compared to Vasopressin. Speth, R. C. & Bader, M. Med Res Arch 10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36438606  

REACT DX registry: Real world REACTion to atrial high rate episodes detected in implantable cardioverter-defibrillator recipients with a DX lead. O'Connor, M., Kolb, C., Klein, N., Rauwolf, T., Kuster, S., Kaab, S., Tilz, R. R., Bansch, D., Ince, H., Belke, R., Hauser, T., Rietsch, K., Kramer, J. F., Wessel, N. & Lennerz, C. Technol Health Care (2022). https://www.ncbi.nlm.nih.gov/pubmed/36442163  

B lymphocyte-deficiency in mice promotes venous thrombosis. Hasselwander, S., Xia, N., Mimmler, M., Ascher, S., Knopp, T., Reifenberg, G., Karbach, S., Ruf, W., Reinhardt, C. & Li, H. Heliyon 8, e11740 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36439760  

Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus (AAV) Capsid Variants. Rapti, K., Maiakovska, O., Becker, J., Szumska, J., Zayas, M., Bubeck, F., Liu, J., Gerstmann, E., Kramer, C., Wiedtke, E. & Grimm, D. J Vis Exp (2022). https://www.ncbi.nlm.nih.gov/pubmed/36342179  

Treatment of advanced heart failure in adults with congenital heart disease: a narrative review and clinical cases. Sinning, C., Huntgeburth, M., Fukushima, N., Tompkins, R., Huh, J., Tataneo, S., Diller, G. P., Chen, Y. S., Zengin, E., Magnussen, C., Kaemmerer, A. S., Cho, Y. H., Blankenberg, S., Rickers, C., Harig, F., Weyand, M., Hubler, M., von Kodolitsch, Y., Oto, O., Zuckermann, A. et al. Cardiovasc Diagn Ther 12, 727-743 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36329959   

Hemodynamic markers of pulmonary vasculopathy for prediction of early right heart failure and mortality after heart transplantation. Rieth, A. J., Rivinius, R., Luhring, T., Grun, D., Keller, T., Grinninger, C., Schuttler, D., Bara, C. L., Helmschrott, M., Frey, N., Sandhaus, T., Schulze, C., Kriechbaum, S., Vietheer, J., Sindermann, J., Welp, H., Lichtenberg, A., Choi, Y. H., Richter, M., Tello, K. et al. J Heart Lung Transplant (2022). https://www.ncbi.nlm.nih.gov/pubmed/36333208  

SARS-CoV-2 infection causes prolonged cardiomyocyte swelling and inhibition of HIF1alpha translocation in an animal model COVID-19. Daems, M., Liesenborghs, L., Boudewijns, R., Simmonds, S. J., Kraisin, S., Van Wauwe, J., Cuijpers, I., Raman, J., Geuens, N., Buyten, T. V., Lox, M., Verhamme, P., Van Linthout, S., Martinod, K., Heymans, S., Tschope, C., Neyts, J. & Jones, E. A. V. Front Cardiovasc Med 9, 964512 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36324747  

Right ventricular function in transcatheter mitral and tricuspid valve edge-to-edge repair. Stolz, L., Doldi, P. M., Weckbach, L. T., Stocker, T. J., Braun, D., Orban, M., Wild, M. G., Hagl, C., Massberg, S., Nabauer, M., Hausleiter, J. & Orban, M. Front Cardiovasc Med 9, 993618 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36312295  

 

Verapamil inhibits Kir2.3 channels by binding to the pore and interfering with PIP(2) binding. Xynogalos, P., Rahm, A. K., Fried, S., Chasan, S., Scherer, D., Seyler, C., Katus, H. A., Frey, N. & Zitron, E. Naunyn Schmiedebergs Arch Pharmacol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36445385  

Defining terms commonly used in sarcopenia research: a glossary proposed by the Global Leadership in Sarcopenia (GLIS) Steering Committee. Cawthon, P. M., Visser, M., Arai, H., Avila-Funes, J. A., Barazzoni, R., Bhasin, S., Binder, E., Bruyere, O., Cederholm, T., Chen, L. K., Cooper, C., Duque, G., Fielding, R. A., Guralnik, J., Kiel, D. P., Kirk, B., Landi, F., Sayer, A. A., Von Haehling, S., Woo, J. et al. Eur Geriatr Med 13, 1239-1244 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36445639  

Higher Daily Air Temperature Is Associated with Shorter Leukocyte Telomere Length: KORA F3 and KORA F4. Ni, W., Wolf, K., Breitner, S., Zhang, S., Nikolaou, N., Ward-Caviness, C. K., Waldenberger, M., Gieger, C., Peters, A. & Schneider, A. Environ Sci Technol 56, 17815-17824 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36442845  

Association between Platelet Count and Treatment Effect of Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes. Koch, T., Lahu, S., Coughlan, J. J., Cassese, S., Voll, F., Ndrepepa, G., Menichelli, M., Valina, C. M., Hemetsberger, R., Witzenbichler, B., Bernlochner, I., Joner, M., Xhepa, E., Mayer, K., Kessler, T., Laugwitz, K. L., Richardt, G., Schunkert, H., Angiolillo, D., Sibbing, D. et al. Thromb Haemost (2022). https://www.ncbi.nlm.nih.gov/pubmed/36442805  

Septal myocardial scar burden predicts the response to cardiac contractility modulation in patients with heart failure. Ansari, U., Overhoff, D., Burkhoff, D., Fastner, C., Yucel, G., Roger, S., Rudic, B., Liebe, V., Borggrefe, M., Akin, I., Kuschyk, J., Papavassiliu, T. & Tulumen, E. Sci Rep 12, 20504 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36443407  

Repression of the iron exporter ferroportin may contribute to hepatocyte iron overload in individuals with type 2 diabetes. Qiu, R., Alikhanyan, K., Volk, N., Marques, O., Mertens, C., Agarvas, A. R., Singh, S., Pepperkok, R., Altamura, S. & Muckenthaler, M. U. Mol Metab, 101644 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36436807  

Fractal dimension of the aortic annulus: a novel predictor of paravalvular leak after transcatheter aortic valve implantation. Stachel, G., Abdel-Wahab, M., de Waha-Thiele, S., Desch, S., Feistritzer, H. J., Kitamura, M., Farhan, S., Eitel, I., Kurz, T. & Thiele, H. Int J Cardiovasc Imaging 38, 2469-2478 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36434335  

Improving Survival in Cardiogenic Shock-A Propensity Score-Matched Analysis of the Impact of an Institutional Allocation Protocol to Short-Term Mechanical Circulatory Support. Ott, S., Lewin, D., Nersesian, G., Stein, J., Just, I. A., Hommel, M., Schoenrath, F., Starck, C. T., O'Brien, B., Falk, V., Potapov, E. & Lanmueller, P. Life (Basel) 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36431066  

Coronary plaque characterization assessed by delayed enhancement dual-layer spectral CT angiography and optical coherence tomography. Nadjiri, J., Koppara, T., Kafka, A., Weis, F., Rasper, M., Gassert, F. G., von Schacky, C. E., Pfeiffer, D., Laugwitz, K. L., Makowski, M. R. & Ibrahim, T. Int J Cardiovasc Imaging 38, 2491-2500 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36434331  

Generation of induced pluripotent stem cells from three individuals with Huntington's disease. Miller, D. C., Lisowski, P., Lickfett, S., Mlody, B., Bunning, M., Genehr, C., Ulrich, C., Wanker, E. E., Diecke, S., Priller, J. & Prigione, A. Stem Cell Res 65, 102976 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36434993  

TREML2 Gene Expression and Its Missense Variant rs3747742 Associate with White Matter Hyperintensity Volume and Alzheimer's Disease-Related Brain Atrophy in the General Population. Kuhn, A. L., Frenzel, S., Teumer, A., Wittfeld, K., Garvert, L., Weihs, A., Homuth, G., Prokisch, H., Bulow, R., Nauck, M., Volker, U., Volzke, H., Grabe, H. J. & Van der Auwera, S. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36430248  

Association between Alcohol Consumption and Health-Related Quality of Life among Hospital and Ambulatory Care Patients with Past Year Depressive Symptoms. Krause, K., Guertler, D., Moehring, A., Batra, A., Eck, S., Rumpf, H. J., Bischof, G., Buchholz, M., John, U. & Meyer, C. Int J Environ Res Public Health 19 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36429382  

Transgenic rat with overproduction of ubiquitous angiotensin-(1-7) presents neuroprotection in a model of ischemia and reperfusion. Kangussu, L. M., Almeida-Santos, A. F., Fernandes, L. F., Alenina, N., Bader, M., Santos, R. A. S., Massensini, A. R. & Campagnole-Santos, M. J. Brain Res Bull 192, 184-191 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36435363  

Evolving Role of Catheter Ablation for Atrial Fibrillation: Early and Effective Rhythm Control. Chen, S., Yin, Y., Ling, Z., Meyer, C., Purerfellner, H., Martinek, M., Kiuchi, M. G., Futyma, P., Zhu, L., Schratter, A., Wang, J., Acou, W. J., Sommer, P., Ouyang, F., Liu, S., Chun, J. K. R. & Schmidt, B. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36431348  

The Effect of a Prasugrel- versus a Ticagrelor-based Strategy on Total Ischemic and Bleeding Events in Patients with Acute Coronary Syndromes. Aytekin, A., Coughlan, J. J., Ndrepepa, G., Cassese, S., Lahu, S., Kufner, S., Mayer, K., Xhepa, E., Gewalt, S., Joner, M., Hapfelmeier, A., Angiolillo, D. J., Menichelli, M., Richardt, G., Neumann, F. J., Schunkert, H. & Kastrati, A. Eur Heart J Cardiovasc Pharmacother (2022). https://www.ncbi.nlm.nih.gov/pubmed/36434779  

Genetic and phenotypic spectrum in the NONO-associated syndromic disorder. Roessler, F., Beck, A. E., Susie, B., Tobias, B., Begtrup, A., Biskup, S., Caluseriu, O., Delanty, N., Frohlich, C., Greally, M. T., Karnstedt, M., Klockner, C., Kurtzberg, J., Schubert, S., Schulze, M., Weidenbach, M., Westphal, D. S., White, M., Wolf, C. M., Zyskind, J. et al. Am J Med Genet A (2022). https://www.ncbi.nlm.nih.gov/pubmed/36426740  

Dataset of a retrospective multicenter cohort study on characteristics of immune checkpoint inhibitor-induced encephalitis and comparison with HSV-1 and anti-LGI1 encephalitis. Muller-Jensen, L., Zierold, S., Versluis, J. M., Boehmerle, W., Huehnchen, P., Endres, M., Mohr, R., Compter, A., Blank, C. U., Hagenacker, T., Meier, F., Reinhardt, L., Gesierich, A., Salzmann, M., Hassel, J. C., Ugurel, S., Zimmer, L., Banks, P., Spain, L., Soon, J. A. et al. Data Brief 45, 108649 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36426082  

Editorial: Extracellular vesicles in cardiovascular inflammation and calcification. Krohn, J. B., Aikawa, E., Aikawa, M., Hutcheson, J. D., Sahoo, S. & Fish, J. E. Front Cardiovasc Med 9, 1077124 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36426218  

Parental mutations influence wild-type offspring via transcriptional adaptation. Jiang, Z., El-Brolosy, M. A., Serobyan, V., Welker, J. M., Retzer, N., Dooley, C. M., Jakutis, G., Juan, T., Fukuda, N., Maischein, H. M., Balciunas, D. & Stainier, D. Y. R. Sci Adv 8, eabj2029 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36427314  

Case Fatality of Hospitalized Patients with COVID-19 Infection Suffering from Acute Respiratory Distress Syndrome in Germany. Sagoschen, I., Keller, K., Wild, J., Munzel, T. & Hobohm, L. Viruses 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36423124  

Integrating Mechanisms in Thrombotic Peripheral Arterial Disease. Nagy, M., van der Meijden, P. E. J., Glunz, J., Schurgers, L., Lutgens, E., Ten Cate, H., Heitmeier, S. & Spronk, H. M. H. Pharmaceuticals (Basel) 15 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36422558   

A New Laboratory Workflow Integrating the Free Light Chains Kappa Quotient into Routine CSF Analysis. Hannich, M. J., Abdullah, M. R., Budde, K., Petersmann, A., Nauck, M., Dressel, A. & Susse, M. Biomolecules 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36421703  

Atrial Fibrillation and Transvenous Lead Extraction-A Comprehensive Subgroup Analysis of the GermAn Laser Lead Extraction RegistrY (GALLERY). Chung, D. U., Pecha, S., Burger, H., Anwar, O., Eickholt, C., Nagele, H., Reichenspurner, H., Gessler, N., Willems, S., Butter, C., Hakmi, S. & Investigators, G. Medicina (Kaunas) 58 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36422224  

Hemodynamic force assessment by cardiovascular magnetic resonance in HFpEF: A case-control substudy from the HFpEF stress trial. Backhaus, S. J., Uzun, H., Rosel, S. F., Schulz, A., Lange, T., Crawley, R. J., Evertz, R., Hasenfuss, G. & Schuster, A. EBioMedicine 86, 104334 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36423376  

Myocardial extracellular volume is a non-invasive tissue marker of heart failure in patients with transposition of the great arteries and systemic right ventricle. Al-Wakeel-Marquard, N., Ferreira da Silva, T., Berger, F., Kuehne, T. & Messroghli, D. R. Frontiers in Pediatrics 10, 949078 (2022).

Changes in miRNA expression in patients with peripheral arterial vascular disease during moderate- and vigorous-intensity physical activity. Sieland, J., Niederer, D., Engeroff, T., Vogt, L., Troidl, C., Schmitz-Rixen, T., Banzer, W. & Troidl, K. Eur J Appl Physiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36418750  

Fin ray branching is defined by TRAP(+) osteolytic tubules in zebrafish. Cardeira-da-Silva, J., Bensimon-Brito, A., Tarasco, M., Brandao, A. S., Rosa, J. T., Borbinha, J., Almeida, P. J., Jacinto, A., Cancela, M. L., Gavaia, P. J., Stainier, D. Y. R. & Laize, V. Proc Natl Acad Sci U S A 119, e2209231119 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36417434  

E-cigarette exposure augments murine abdominal aortic aneurysm development: role of Chil1. Mulorz, J., Spin, J. M., Mulorz, P., Wagenhauser, M., Deng, A., Mattern, K., Rhee, Y. H., Toyama, K., Adam, M., Schelzig, H., Maegdefessel, L. & Tsao, P. S. Cardiovasc Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/36413508  

Impact of cryoballoon application abortion due to phrenic nerve injury on reconnection rates: a YETI subgroup analysis. Heeger, C. H., Popescu, S. S., Sohns, C., Pott, A., Metzner, A., Inaba, O., Straube, F., Kuniss, M., Aryana, A., Miyazaki, S., Cay, S., Ehrlich, J. R., El-Battrawy, I., Martinek, M., Saguner, A. M., Tscholl, V., Yalin, K., Lyan, E., Su, W., Papiashvili, G. et al. Europace (2022). https://www.ncbi.nlm.nih.gov/pubmed/36414239  

3 Tesla magnetic resonance imaging in patients with cardiac implantable electronic devices: a single centre experience. Fluschnik, N., Tahir, E., Erley, J., Mullerleile, K., Metzner, A., Wenzel, J. P., Guerreiro, H., Adam, G., Blankenberg, S., Kirchhof, P., Tonnis, T. & Nikorowitsch, J. Europace (2022). https://www.ncbi.nlm.nih.gov/pubmed/36413601  

Free-breathing myocardial T(1) mapping using inversion-recovery radial FLASH and motion-resolved model-based reconstruction. Wang, X., Rosenzweig, S., Roeloffs, V., Blumenthal, M., Scholand, N., Tan, Z., Holme, H. C. M., Unterberg-Buchwald, C., Hinkel, R. & Uecker, M. Magn Reson Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/36404631  

Impact of time between thrombolysis and endovascular thrombectomy on outcomes in patients with acute ischaemic stroke. Wagner, L., Mohrbach, D., Ebinger, M., Endres, M., Nolte, C. H., Harmel, P., Audebert, H. J., Rohmann, J. L. & Siegerink, B. Front Neurol 13, 1018630 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36408513  

Early myocardial oedema can predict subsequent cardiomyopathy in high-dose anthracycline therapy. Muehlberg, F., Kornfeld, M., Zange, L., Ghani, S., Reichardt, A., Reichardt, P. & Schulz-Menger, J. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/36404640  

Longitudinal associations between metabolites and long-term exposure to ambient air pollution: Results from the KORA cohort study. Yao, Y., Schneider, A., Wolf, K., Zhang, S., Wang-Sattler, R., Peters, A. & Breitner, S. Environ Int 170, 107632 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36402035  

A managed care system with telemedicine support for neurological emergencies. Erdur, H., Weber, J. E., Angermaier, A., Kinze, S., Sotoodeh, A., Gorski, C., Bollweg, K., Ernst, S., Kandil, F. I., Behrens, J., Ganeshan, R., Keysers, A., Kotlarz-Bottcher, M., Peters, D., Schlemm, L., Stangenberg-Gliss, K., Witt, C., Hennig, B., Reber, K. C., Schneider, U. et al. Ann Neurol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36401341  

Comparative single-cell analysis of the adult heart and coronary vasculature. Balachandran, S., Pozojevic, J., Sreenivasan, V. K. A. & Spielmann, M. Mamm Genome (2022). https://www.ncbi.nlm.nih.gov/pubmed/36401619  

Analysis of the adiponectin paradox in healthy older people. Walowski, C. O., Herpich, C., Enderle, J., Braun, W., Both, M., Hasler, M., Muller, M. J., Norman, K. & Bosy-Westphal, A. J Cachexia Sarcopenia Muscle (2022). https://www.ncbi.nlm.nih.gov/pubmed/36401062   

How slimming regulatory T cells limit atherosclerosis: Mechanistic insights into T cell lipid metabolism. van der Vorst, E. P. C. & Doring, Y. Atherosclerosis 362, 23-25 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36400604  

A specific new biomarker for atrial fibrillation and its sequelae? Sinner, M. F. & von Falkenhausen, A. S. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/36399389  

Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide). Zeidler, J. D., Chini, C. C. S., Kanamori, K. S., Kashyap, S., Espindola-Netto, J. M., Thompson, K., Warner, G., Cabral, F. S., Peclat, T. R., Gomez, L. S., Lopez, S. A., Wandersee, M. K., Schoon, R. A., Reid, K., Menzies, K., Beckedorff, F., Reid, J. M., Brachs, S., Meyer, R. G., Meyer-Ficca, M. L. et al. iScience 25, 105431 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36388973  

Enoxaparin for outpatients with COVID-19: 90-day results from the randomised, open-label, parallel-group, multinational, phase III OVID trial. Voci, D., Gotschi, A., Held, U., Bingisser, R., Colucci, G., Duerschmied, D., Fumagalli, R. M., Gerber, B., Hasse, B., Keller, D. I., Konstantinides, S. V., Mach, F., Rampini, S. K., Righini, M., Robert-Ebadi, H., Rosemann, T., Roth-Zetzsche, S., Sebastian, T., Simon, N. R., Spirk, D. et al. Thromb Res 221, 157-163 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36396519  

Preliminary results of the cross-sectional associations of sedentary behavior and physical activity with serum brain-derived neurotrophic factor in adults with coronary heart disease. Ullrich, A., Wenzel, K., Bahls, M., Voigt, L., Konemann, S., Dorr, M., Wurm, S. & Ulbricht, S. Sci Rep 12, 19685 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36385629  

Assessment of health-related quality of life in individuals with depressive symptoms: validity and responsiveness of the EQ-5D-3L and the SF-6D. Stolz, M., Albus, C., Beutel, M. E., Deter, H. C., Fritzsche, K., Herrmann-Lingen, C., Michal, M., Petrowski, K., Ronel, J., Schultz, J. H., Sollner, W., Weber, C., de Zwaan, M. & Krauth, C. Eur J Health Econ (2022). https://www.ncbi.nlm.nih.gov/pubmed/36385438

Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2. Oo, J. A., Palfi, K., Warwick, T., Wittig, I., Prieto-Garcia, C., Matkovic, V., Tomaskovic, I., Boos, F., Izquierdo Ponce, J., Teichmann, T., Petriukov, K., Haydar, S., Maegdefessel, L., Wu, Z., Pham, M. D., Krishnan, J., Baker, A. H., Gunther, S., Ulrich, H. D., Dikic, I. et al. Cell Rep 41, 111670 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36384122  

Discovery of novel eGFR-associated multiple independent signals using a quasi-adaptive method. Ghasemi, S., Becker, T., Grabe, H. J. & Teumer, A. Front Genet 13, 997302 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36386835  

Regularization approaches in clinical biostatistics: A review of methods and their applications. Friedrich, S., Groll, A., Ickstadt, K., Kneib, T., Pauly, M., Rahnenfuhrer, J. & Friede, T. Stat Methods Med Res, 9622802221133557 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36384320  

Incidence, recurrence and management of electrical storm in Brugada syndrome. El-Battrawy, I., Roterberg, G., Kowitz, J., Aweimer, A., Lang, S., Mugge, A., Zhou, X. & Akin, I. Front Cardiovasc Med 9, 981715 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36386327  

Development and validation of a prognostic model for the early identification of COVID-19 patients at risk of developing common long COVID symptoms. Deforth, M., Gebhard, C. E., Bengs, S., Buehler, P. K., Schuepbach, R. A., Zinkernagel, A. S., Brugger, S. D., Acevedo, C. T., Patriki, D., Wiggli, B., Twerenbold, R., Kuster, G. M., Pargger, H., Schefold, J. C., Spinetti, T., Wendel-Garcia, P. D., Hofmaenner, D. A., Gysi, B., Siegemund, M., Heinze, G. et al. Diagn Progn Res 6, 22 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36384641  

The relationship between Alzheimer's-related brain atrophy patterns and sleep macro-architecture. Weihs, A., Frenzel, S., Garvert, L., Kuhn, L., Wittfeld, K., Ewert, R., Fietze, I., Penzel, T., Stubbe, B., Szentkiralyi, A., Wulms, N., Volzke, H. & Grabe, H. J. Alzheimers Dement (Amst) 14, e12371 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36381559  

Lower levels of vWF are associated with lower risk of cardiovascular disease. van Paridon, P. C. S., Panova-Noeva, M., van Oerle, R., Schulz, A., Prochaska, J. H., Arnold, N., Schmidtmann, I., Beutel, M., Pfeiffer, N., Munzel, T., Lackner, K. J., Ten Cate, H., Wild, P. S. & Spronk, H. M. H. Res Pract Thromb Haemost 6, e12797 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36381288  

Frailty is characterized by biomarker patterns reflecting inflammation or muscle catabolism in multi-morbid patients. Kochlik, B., Franz, K., Henning, T., Weber, D., Wernitz, A., Herpich, C., Jannasch, F., Aykac, V., Muller-Werdan, U., Schulze, M. B., Grune, T. & Norman, K. J Cachexia Sarcopenia Muscle (2022). https://www.ncbi.nlm.nih.gov/pubmed/36377255  

Letter to the editor "Cardiac function in critically ill patients with severe COVID: A prospective cross-sectional study in mechanically ventilated patients". Dandel, M. J Crit Care 73, 154217 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36379138  

Replication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells. Zhang, T., Kunne, C., Ding, D., Gunther, S., Guo, X., Zhou, Y., Yuan, X. & Braun, T. Nat Commun 13, 6907 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36376321  

Atrial Fibrillation Risk Assessment after Embolic Stroke of Undetermined Source. von Falkenhausen, A. S., Feil, K., Sinner, M. F., Schonecker, S., Muller, J., Wischmann, J., Eiffener, E., Clauss, S., Poli, S., Poli, K., Zuern, C. S., Ziemann, U., Berrouschot, J., Kitsiou, A., Schabitz, W. R., Dieterich, M., Massberg, S., Kaab, S. & Kellert, L. Ann Neurol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36373166  

Pharmacologic treatment of delirium symptoms: A systematic review. Sadlonova, M., Duque, L., Smith, D., Madva, E. N., Amonoo, H. L., Vogelsang, J., Staton, S. C., von Arnim, C. A. F., Huffman, J. C. & Celano, C. M. Gen Hosp Psychiatry 79, 60-75 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36375344  

Cardiac fibroblasts and mechanosensation in heart development, health and disease. Pesce, M., Duda, G. N., Forte, G., Girao, H., Raya, A., Roca-Cusachs, P., Sluijter, J. P. G., Tschope, C. & Van Linthout, S. Nat Rev Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36376437  

Higher short-term mortality of Evolut versus Sapien 3: A piece of the puzzle? Kim, W. K. & Abdel-Wahab, M. Int J Cardiol 370, 351-352 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36375596  

Atrial fibrillation screening perspectives after STROKESTOP and LOOP. Freedman, B. & Schnabel, R. B. Nat Rev Cardiol 20, 1-2 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36376431  

Prediction of liver-related mortality in a community setting. Schneider, C. V., Gross, S. & Strnad, P. J Hepatol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36370952  

Prognostic value of De Ritis ratio with aspartate aminotransferase and alanine aminotransferase within the reference range. Ndrepepa, G., Holdenrieder, S. & Kastrati, A. Clinica Chimica Acta 538, 46-52 (2023).

Complete Left-Atrial Lesion Set versus Pulmonary Vein Isolation Only in Patients with Paroxysmal AF Undergoing CABG or AVR. Yildirim, Y., Petersen, J., Aydin, A., Alassar, Y., Reichenspurner, H. & Pecha, S. Medicina (Kaunas) 58 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36363563  

Small Molecule BRD4 Inhibitors Apabetalone and JQ1 Rescues Endothelial Cells Dysfunction, Protects Monolayer Integrity and Reduces Midkine Expression. Shahid, S., Pantakani, M., Binder, L., Fischer, A., Pantakani, K. & Asif, A. R. Molecules 27 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36364277  

Prevalence and Treatment Outcomes of Arrhythmias in Patients with Single Ventricle Physiology over the Age of 40 Years. Pujol, C., Hessling, G., Telishevska, M., Schiele, S., Deisenhofer, I., Ewert, P. & Tutarel, O. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36362800  

Deep phenotyping of two preclinical mouse models and a cohort of RBM20 mutation carriers reveals no sex-dependent disease severity in RBM20 cardiomyopathy. Lennermann, D. C., Pepin, M. E., Grosch, M., Konrad, L., Kemmling, E., Hartmann, J., Nolte, J. L., Clauder-Munster, S., Kayvanpour, E., Sedaghat-Hamedani, F., Haas, J., Meder, B., van den Boogaard, M., Amin, A. S., Dewenter, M., Kruger, M., Steinmetz, L. M., Backs, J. & van den Hoogenhof, M. M. G. Am J Physiol Heart Circ Physiol 323, H1296-H1310 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36367695  

Temporal Trends in Patients with Peripheral Artery Disease Influenced by COVID-19 Pandemic. Keller, K., Schmitt, V. H., Hobohm, L. M. A., Brochhausen, C., Munzel, T. & Espinola-Klein, C. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36362660  

Evaluation of Pharmacological Rescue of Melanocortin-4 Receptor Nonsense Mutations by Aminoglycoside. Hopfner, F., Paisdzior, S., Reininghaus, N., Sohail, I., Scheerer, P., Annibale, P., Biebermann, H. & Kuhnen, P. Life (Basel) 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36362948  

Acute Exposure to Simulated Nocturnal Train Noise Leads to Impaired Sleep Quality and Endothelial Dysfunction in Young Healthy Men and Women: A Sex-Specific Analysis. Hahad, O., Herzog, J., Roosli, M., Schmidt, F. P., Daiber, A. & Munzel, T. Int J Environ Res Public Health 19 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36360723  

Negative Impact of the UEFA European Soccer Championship on Central Hemodynamics and Arterial Stiffness: A Multicenter Study. Franzen, K. F., Mortensen, K., Ott, C., Herber, K., Busse, M., Soling, C., Schneppe, D., Lassig, S., Dorr, M., Tilz, R., Dromann, D., Schunkert, H. & Reppel, M. Life (Basel) 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36362851  

Cardiac Troponin I Reveals Diagnostic and Prognostic Superiority to Aminoterminal Pro-B-Type Natriuretic Peptide in Sepsis and Septic Shock. Forner, J., Schupp, T., Weidner, K., Rusnak, J., Jawhar, S., Dulatahu, F., Bruck, L. M., Behnes, M., Hoffmann, U., Bertsch, T., Kittel, M. & Akin, I. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36362826  

Effect of sulfasalazine on endothelium-dependent vascular response by the activation of Nrf2 signalling pathway. Sonmez, M. I., Shahzadi, A., Kose, C., Sonmez, H., Ozyazgan, S. & Akkan, A. G. Front Pharmacol 13, 979300 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36353481  

GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation. Guillamat-Prats, R., Hering, D., Derle, A., Rami, M., Hardtner, C., Santovito, D., Rinne, P., Bindila, L., Hristov, M., Pagano, S., Vuilleumier, N., Schmid, S., Janjic, A., Enard, W., Weber, C., Maegdefessel, L., Faussner, A., Hilgendorf, I. & Steffens, S. Nature Cardiovascular Research (2022).

The impact of the PCSK-9/VLDL-Receptor axis on inflammatory cell polarization. Barcena, M. L., Estepa, M., Marx, L., Breiter, A., Haritonow, N. & Stawowy, P. Cytokine 161, 156077 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36356495  

Sex differences in imaging and clinical characteristics of patients from the WAKE-UP trial. Wouters, A., Scheldeman, L., Liessens, H., Dupont, P., Boutitie, F., Cheng, B., Ebinger, M., Endres, M., Fiebach, J. B., Gerloff, C., Muir, K. W., Nighoghossian, N., Pedraza, S., Simonsen, C. Z., Thijs, V., Thomalla, G. & Lemmens, R. Eur J Neurol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36349887  

Pan-claudin family interactome analysis reveals shared and specific interactions. Suarez-Artiles, L., Breiderhoff, T., Girardello, R., Gonschior, H., Rodius, S., Lesur, A., Reimer, U., Ramberger, E., Perez-Hernandez, D., Muller, D., Mertins, P. & Dittmar, G. Cell Rep 41, 111588 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36351382  

Properdin (factor P) as a new target cleaved by factor XIa: Intrinsic coagulation at the crossroads with inflammation. Luo, Q. & Wenzel, P. Res Pract Thromb Haemost 6, e12835 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36349265  

Inducible over-expression of cardiac Nos1ap causes short QT syndrome in transgenic mice. Jansch, M., Lubomirov, L. T., Trum, M., Williams, T., Schmitt, J., Schuh, K., Qadri, F., Maier, L. S., Bader, M. & Ritter, O. FEBS Open Bio (2022). https://www.ncbi.nlm.nih.gov/pubmed/36352324  

The atypical beta-blocker S-oxprenolol reduces cachexia and improves survival in a rat cancer cachexia model. Yuan, L., Springer, J., Palus, S., Busquets, S., Jove, Q., Alves de Lima Junior, E., Anker, M. S., von Haehling, S., Alvarez Ladron, N., Millman, O., Oosterlee, A., Szymczyk, A., Lopez-Soriano, F. J., Anker, S. D., Coats, A. J. S. & Argiles, J. M. J Cachexia Sarcopenia Muscle (2022). https://www.ncbi.nlm.nih.gov/pubmed/36346141  

Phenotypic Discovery of Triazolo[1,5-c]quinazolines as a First-In-Class Bone Morphogenetic Protein Amplifier Chemotype. Wesseler, F., Lohmann, S., Riege, D., Halver, J., Roth, A., Pichlo, C., Weber, S., Takamiya, M., Muller, E., Ketzel, J., Flegel, J., Gihring, A., Rastegar, S., Bertrand, J., Baumann, U., Knippschild, U., Peifer, C., Sievers, S., Waldmann, H. & Schade, D. J Med Chem 65, 15263-15281 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36346705  

Magnetique: an interactive web application to explore transcriptome signatures of heart failure. Britto-Borges, T., Ludt, A., Boileau, E., Gjerga, E., Marini, F. & Dieterich, C. J Transl Med 20, 513 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36345035  

Mid-term performance of decellularized equine pericardium in congenital heart surgery. Weixler, V. H. M., Kuschnerus, K., Romanchenko, O., Ovroutski, S., Cho, M. Y., Berger, F., Sigler, M., Sinzobahamvya, N., Photiadis, J. & Murin, P. Interact Cardiovasc Thorac Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/36342192  

Morphological characteristics of lesions with thin cap fibroatheroma-a substudy from the COMBINE (OCT-FFR) trial. Roleder-Dylewska, M., Gasior, P., Hommels, T. M., Roleder, T., Berta, B., Ang, H. Y., Ng, J. C. K., Hermanides, R. S., Fabris, E., AJJ, I. J., Kauer, F., Alfonso, F., von Birgelen, C., Escaned, J., Camaro, C., Kennedy, M. W., Pereira, B., Magro, M., Nef, H., Reith, S. et al. Eur Heart J Cardiovasc Imaging (2022). https://www.ncbi.nlm.nih.gov/pubmed/36342269  

Brain network architecture constrains age-related cortical thinning. Petersen, M., Nagele, F. L., Mayer, C., Schell, M., Rimmele, D. L., Petersen, E., Kuhn, S., Gallinat, J., Hanning, U., Fiehler, J., Twerenbold, R., Gerloff, C., Thomalla, G. & Cheng, B. Neuroimage 264, 119721 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36341953  

Rapid estimation of 2D relative B1+ -maps from localizers in the human heart at 7T using deep learning. Krueger, F., Aigner, C. S., Hammernik, K., Dietrich, S., Lutz, M., Schulz-Menger, J., Schaeffter, T. & Schmitter, S. Magn Reson Med 89, 1002-1015 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36336877

Network reconstruction for trans acting genetic loci using multi-omics data and prior information. Hawe, J. S., Saha, A., Waldenberger, M., Kunze, S., Wahl, S., Muller-Nurasyid, M., Prokisch, H., Grallert, H., Herder, C., Peters, A., Strauch, K., Theis, F. J., Gieger, C., Chambers, J., Battle, A. & Heinig, M. Genome Med 14, 125 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36344995  

Unravelling the impact of aging on the human endothelial lncRNA transcriptome. Drekolia, M. K., Talyan, S., Cordellini Emidio, R., Boon, R. A., Guenther, S., Looso, M., Dumbovic, G. & Bibli, S. I. Front Genet 13, 1035380 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36338971  

A Randomized Controlled Trial Comparing Apixaban to the Vitamin K-antagonist Phenprocoumon in Patients on Chronic Hemodialysis: The AXADIA-AFNET 8 study. Reinecke, H., Engelbertz, C., Bauersachs, R., Breithardt, G., Echterhoff, H. H., Gerbeta, J., Haeusler, K. G., Hewing, B., Hoyer, J., Juergensmeyer, S., Klingenheben, T., Knapp, G., Rump, L. C., Schmidt-Guertler, H., Wanner, C., Kirchhof, P. & Goerlich, D. Circulation (2022). https://www.ncbi.nlm.nih.gov/pubmed/36335915  

Diagnostic and Therapeutic Decision-Making Problems Evoked by Mitral Regurgitation in Heart Failure With Preserved Left Ventricular Ejection Fraction. Dandel, M. Am J Cardiol 186, 244 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36336521  

Lamin A/C-dependent chromatin architecture safeguards naive pluripotency to prevent aberrant cardiovascular cell fate and function. Wang, Y., Elsherbiny, A., Kessler, L., Cordero, J., Shi, H., Serke, H., Lityagina, O., Trogisch, F. A., Mohammadi, M. M., El-Battrawy, I., Backs, J., Wieland, T., Heineke, J. & Dobreva, G. Nat Commun 13, 6663 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36333314  

Population-Level Implications of Sodium-Glucose Cotransporter-2 Inhibitors for Heart Failure With Preserved Ejection Fraction in the US. Talha, K. M., Butler, J., Greene, S. J., Aggarwal, R., Anker, S. D., Claggett, B. L., Solomon, S. D., McMurray, J. J. V., Vaduganathan, M. & Fonarow, G. C. JAMA Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36334258  

Inclisiran and cardiovascular events: a patient-level analysis of phase III trials. Ray, K. K., Raal, F. J., Kallend, D. G., Jaros, M. J., Koenig, W., Leiter, L. A., Landmesser, U., Schwartz, G. G., Lawrence, D., Friedman, A., Garcia Conde, L., Wright, R. S. & investigators, O. P. I. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/36331326   

Effect of inclisiran on lipids in primary prevention: the ORION-11 trial. Ray, K. K., Kallend, D., Leiter, L. A., Raal, F. J., Koenig, W., Jaros, M. J., Schwartz, G. G., Landmesser, U., Garcia Conde, L., Wright, R. S. & Investigators, O.-. Eur Heart J 43, 5047-5057 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36331315  

Minimal Clinically Important Difference for Six-minute Walk Test in Patients with HFrEF and Iron Deficiency. Khan, M. S., Anker, S. D., Friede, T., Jankowska, E. A., Metra, M., Pina, I. L., Coats, A. J., Rosano, G., Roubert, B., Goehring, U. M., Dorigotti, F., Comin-Colet, J., Van Veldhuisen, D. J., Filippatos, G. S., Ponikowski, P. & Butler, J. J Card Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/36332897  

Low-density lipoprotein cholesterol goal attainment in patients with clinical evidence of familial hypercholesterolemia and elevated Lp(a). Schwarz, A., Demuth, I., Landmesser, U., Haghikia, A., Konig, M. & Steinhagen-Thiessen, E. Lipids Health Dis 21, 114 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36324160  

HIF1alpha-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex. Leisegang, M. S., Bains, J. K., Seredinski, S., Oo, J. A., Krause, N. M., Kuo, C. C., Gunther, S., Senturk Cetin, N., Warwick, T., Cao, C., Boos, F., Izquierdo Ponce, J., Haydar, S., Bednarz, R., Valasarajan, C., Fuhrmann, D. C., Preussner, J., Looso, M., Pullamsetti, S. S., Schulz, M. H. et al. Nat Commun 13, 6563 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36323673  

Proteomics reveals antiviral host response and NETosis during acute COVID-19 in high-risk patients. Bauer, A., Pachl, E., Hellmuth, J. C., Kneidinger, N., Heydarian, M., Frankenberger, M., Stubbe, H. C., Ryffel, B., Petrera, A., Hauck, S. M., Behr, J., Kaiser, R., Scherer, C., Deng, L., Teupser, D., Ahmidi, N., Muenchhoff, M., Schubert, B. & Hilgendorff, A. Biochim Biophys Acta Mol Basis Dis 1869, 166592 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36328146  

Weight change and clinical outcomes in heart failure with reduced ejection fraction: insights from EMPEROR-Reduced. Anker, S. D., Khan, M. S., Butler, J., Ofstad, A. P., Peil, B., Pfarr, E., Doehner, W., Sattar, N., Coats, A. J. S., Filippatos, G., Ferreira, J. P., Zannad, F., Pocock, S. & Packer, M. Eur J Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/36325584  

Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis. Zhang, Y., Sun, C., Li, Y., Qin, J., Amancherla, K., Jing, Y., Hu, Q., Liang, K., Zhang, Z., Ye, Y., Huang, L. A., Nguyen, T. K., Egranov, S. D., Zhao, Z., Wu, A., Xi, Y., Yao, J., Hung, M. C., Calin, G. A., Cheng, J. et al. Sci Transl Med 14, eabo1981 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36322628  

Association of spermidine plasma levels with brain aging in a population-based study. Wortha, S. M., Frenzel, S., Bahls, M., Habes, M., Wittfeld, K., Van der Auwera, S., Bulow, R., Zylla, S., Friedrich, N., Nauck, M., Volzke, H., Grabe, H. J., Schwarz, C. & Floel, A. Alzheimers Dement (2022). https://www.ncbi.nlm.nih.gov/pubmed/36321615  

Left atrial strain correlates with severity of cardiac involvement in Anderson-Fabry disease. Halfmann, M. C., Altmann, S., Schoepf, U. J., Reichardt, C., Hennermann, J. B., Kreitner, K. F., Kloeckner, R., Hahn, F., Dueber, C., Varga-Szemes, A., Kampmann, C. & Emrich, T. Eur Radiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36322192  

[Treat calcified stenoses correctly]. Blessing, R. & Gori, T. Herz 47, 503-512 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36322196  

[Cardiac pacing – new devices, new techniques]. Reincke, S., Delgado, M., Vogler, J. & Tilz, R. R. Dtsch Med Wochenschr 147, 1469-1476 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36318910  

Protective behavior and SARS-CoV-2 infection risk in the population - Results from the Gutenberg COVID-19 study. Baumkotter, R., Yilmaz, S., Zahn, D., Fenzl, K., Prochaska, J. H., Rossmann, H., Schmidtmann, I., Schuster, A. K., Beutel, M. E., Lackner, K. J., Munzel, T. & Wild, P. S. BMC Public Health 22, 1993 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36316662  

Single-Center Experience With a Self-Expandable Venous Cannula During Minimally Invasive Cardiac Surgery. Van Praet, K. M., Kofler, M., Meyer, A., Sundermann, S. H., Hommel, M., Falk, V. & Kempfert, J. Innovations (Phila), 15569845221131534 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36314445  

Neutrophils in aging and aging-related pathologies. Van Avondt, K., Strecker, J. K., Tulotta, C., Minnerup, J., Schulz, C. & Soehnlein, O. Immunol Rev (2022). https://www.ncbi.nlm.nih.gov/pubmed/36315403  

Intermittent Chest Pain in a 46-Year-Old Patient. Plappert, C., Sherif, M. & Oeing, C. JAMA 328, 2058-2059 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36315193  

Mechanical recovery plug for left ventricular assist device explantation. Loforte, A., Gliozzi, G., Nersesian, G., Votano, D., Potapov, E. & Pacini, D. Multimed Man Cardiothorac Surg 2022 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36315037  

Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses. Gaziano, L., Sun, L., Arnold, M., Bell, S., Cho, K., Kaptoge, S. K., Song, R. J., Burgess, S., Posner, D. C., Mosconi, K., Robinson-Cohen, C., Mason, A. M., Bolton, T. R., Tao, R., Allara, E., Schubert, P., Chen, L., Staley, J. R., Staplin, N., Altay, S. et al. Circulation 146, 1507-1517 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36314129


Dezember

 

A multicenter evaluation of external outflow graft obstruction with a fully magnetically levitated left ventricular assist device. Wert, L., Stewart, G. C., Mehra, M. R., Milwidsky, A., Jorde, U. P., Goldstein, D. J., Selzman, C. H., Stehlik, J., Alshamdin, F. D., Khaliel, F. H., Gustafsson, F., Boschi, S., Loforte, A., Ajello, S., Scandroglio, A. M., Tucanova, Z., Netuka, I., Schloglhofer, T., Zimpfer, D., Zijderhand, C. F. et al. J Thorac Cardiovasc Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/36562497  

Pathophysiological Role and Diagnostic Potential of R-Loops in Cancer and Beyond. Khan, E. S. & Danckwardt, S. Genes (Basel) 13 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36553448  

Endothelial Cell GATA2 Modulates the Cardiomyocyte Stress Response through the Regulation of Two Long Non-Coding RNAs. Froese, N., Szaroszyk, M., Korf-Klingebiel, M., Koch, K., Schmitto, J. D., Geffers, R., Hilfiker-Kleiner, D., Riehle, C., Wollert, K. C., Bauersachs, J. & Heineke, J. Biology (Basel) 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36552246   

A Simplified Approach to Pulmonary Vein Visualization during Cryoballoon Ablation of Atrial Fibrillation. Anwar, O., Chung, D. U., Gunawardene, M. A., Jungen, C., Hartmann, J., Meyer, C., Gessler, N., Willems, S., Hakmi, S. & Eickholt, C. Medicina (Kaunas) 58 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36556902  

Targeting myeloid cell coagulation signaling blocks MAP kinase/TGF-beta1 driven fibrotic remodeling in ischemic heart failure. Garlapati, V., Molitor, M., Michna, T., Harms, G. S., Finger, S., Jung, R., Lagrange, J., Efentakis, P., Wild, J., Knorr, M., Karbach, S., Wild, S., Vujacic-Mirski, K., Munzel, T., Daiber, A., Brandt, M., Gori, T., Milting, H., Tenzer, S., Ruf, W. et al. J Clin Invest (2022). https://www.ncbi.nlm.nih.gov/pubmed/36548062  

Editorial: Nanodomain regulation of muscle physiology and alterations in disease. Louch, W. E., Ullrich, N. D., Navedo, M. F. & Macquaide, N. Front Physiol 13, 1092304 (2022). www.ncbi.nlm.nih.gov/pubmed/36523550

Hypothermia and its role in patients with ST-segment-elevation myocardial infarction and cardiac arrest. Keller, K., Sagoschen, I., Schmitt, V. H., Munzel, T., Gori, T. & Hobohm, L. Front Cardiovasc Med 9, 1051978 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36523354  

Editorial: Modeling of cardiovascular systems. Wang, Y., Majumder, R., Tian, F. B. & Gao, X. Front Physiol 13, 1094146 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36518103  

An electrochemical nitric oxide generator for in-home inhalation therapy in pulmonary artery hypertension. Liu, Y., Zhu, Y., Jiang, C., Su, Z., Yan, Y., Feng, B., Mao, W., Zhang, Y., Wang, X., Xu, Z. & Zhang, H. BMC Med 20, 481 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36522645  

Diagnostic and Prognostic Significance of the Prothrombin Time/International Normalized Ratio in Sepsis and Septic Shock. Schupp, T., Weidner, K., Rusnak, J., Jawhar, S., Forner, J., Dulatahu, F., Bruck, L. M., Hoffmann, U., Bertsch, T., Muller, J., Weiss, C., Akin, I. & Behnes, M. Clin Appl Thromb Hemost 28, 10760296221137893 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36503298  

Temperature-controlled ablation of the mitral isthmus line using the novel DiamondTemp ablation system. Rottner, L., My, I., Schleberger, R., Moser, F., Moser, J., Kirchhof, P., Ouyang, F., Rillig, A., Metzner, A. & Reissmann, B. Front Cardiovasc Med 9, 1046956 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36505349  

The burdens of poverty during the COVID-19 pandemic. Petersen, J., Hettich, N., Baumkotter, R., Wild, P. S., Pfeiffer, N., Munzel, T., Konig, J., Lackner, K. J. & Beutel, M. E. Front Sociol 7, 995318 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36505762  

Lack of correlation between hip osteoarthritis and anatomical spinopelvic parameters obtained in supine position on MRI. Maurer, E., Lorbeer, R., Hefferman, G., Schlett, C. L., Peters, A., Rospleszcz, S., Kiefer, L. S., Nikolaou, K., Bamberg, F. & Walter, S. S. Injury 54, 525-532 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36503838  

Fetal Bradycardia Caused by Monogenic Disorders-A Review of the Literature. Westphal, D. S., Hauser, M., Beckmann, B. M., Wolf, C. M., Hessling, G., Oberhoffer-Fritz, R. & Wacker-Gussmann, A. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36498454  

Subclinical Cardiovascular Disease Markers in Relation to Serum and Dietary Magnesium in Individuals from the General Population: The KORA-MRI Study. Shugaa Addin, N., Schlett, C. L., Bamberg, F., Thorand, B., Linseisen, J., Seissler, J., Peters, A. & Rospleszcz, S. Nutrients 14 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36500983  

Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammation. Mauersberger, C., Sager, H. B., Wobst, J., Dang, T. A., Lambrecht, L., Koplev, S., Stroth, M., Bettaga, N., Schlossmann, J., Wunder, F., Friebe, A., Björkegren, J. L. M., Dietz, L., Maas, S. L., van der Vorst, E. P. C., Sandner, P., Soehnlein, O., Schunkert, H. & Kessler, T. Nature Cardiovascular Research 1, 1174-1186 (2022). https://www.nature.com/articles/s44161-022-00175-w  

Safety and Feasibility of Catheter Ablation Procedures in Patients with Bleeding Disorders. Feher, M., Saguner, A. M., Kirstein, B., Vogler, J., Eitel, C., Phan, H. L., Keelani, A., Cimen, T., Hatahet, S., Trajanoski, D., Samara, O., Kuck, K. H., Tilz, R. R. & Heeger, C. H. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36498531  

Posttraumatic growth after childhood cancer: Psychometric evaluation of a five-item short form and associations with mental health. Ernst, M., Werner, A. M., Brahler, E., Wild, P. S., Faber, J., Merzenich, H. & Beutel, M. E. J Psychosom Res 164, 111099 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36481723  

Immuno-cardio-oncology: Killing two birds with one stone? Van Linthout, S. & Volk, H. D. Front Immunol 13, 1018772 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36466820  

Somatic mosaicism in STAG2-associated cohesinopathies: Expansion of the genotypic and phenotypic spectrum. Schmidt, J., Dreha-Kulaczewski, S., Zafeiriou, M. P., Schreiber, M. K., Wilken, B., Funke, R., Neuhofer, C. M., Altmuller, J., Thiele, H., Nurnberg, P., Biskup, S., Li, Y., Zimmermann, W. H., Kaulfuss, S., Yigit, G. & Wollnik, B. Front Cell Dev Biol 10, 1025332 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36467423  

 

Pregnancy and breast cancer in a patient with complicated Kawasaki Disease, as if one problem was not enough: a case report. Barzen, G., Stangl, K., Blohmer, J. U., Henrich, W., Dorner, T., Lembcke, A. & Stangl, V. Eur Heart J Case Rep 6, ytac435 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36451807https://www.ncbi.nlm.nih.gov/pubmed/36451807

Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19. Tran, F., Harris, D. M. M., Scharmacher, A., Grasshoff, H., Sterner, K., Schinke, S., Kading, N., Humrich, J. Y., Cabral-Marques, O., Bernardes, J. P., Mishra, N., Bahmer, T., Franzenburg, J., Hoyer, B. F., Gluck, A., Guggeis, M., Ossysek, A., Kuller, A., Frank, D., Lange, C. et al. ERJ Open Res 8 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36575710   

Early SARS-CoV-2 infection: platelet-neutrophil complexes and platelet function. Rieder, M., Baldus, N., Stallmann, D., Jeserich, M., Goller, I., Wirth, L., Pollmeier, L., Hofmann, M., Bode, C., Busch, H. J., Schmid, B., Gauchel, N., Scharf, R. E., Duerschmied, D., Lother, A. & Krauel, K. Res Pract Thromb Haemost, 100025 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36575689  

De Ritis ratio and long-term major cardiovascular adverse events in patients undergoing elective percutaneous coronary intervention. Ndrepepa, G., Holdenrieder, S. & Kastrati, A. Eur J Clin Invest, e13942 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36575818   

Brown adipose tissue is not associated with cachexia or increased mortality in a retrospective study of patients with cancer. Eljalby, M., Huang, X., Becher, T., Wibmer, A. G., Jiang, C. S., Vaughan, R., Schoder, H. & Cohen, P. Am J Physiol Endocrinol Metab (2022). https://www.ncbi.nlm.nih.gov/pubmed/36576355  

Expanding the spectrum of EEF1D neurodevelopmental disorders: Biallelic variants in the Guanine Exchange Domain. Averdunk, L., Al-Thihli, K., Surowy, H., Ludecke, H. J., Drechsler, M., Yigit, G., Smorag, L., Hallak, B. A., Li, Y., Altmuller, J., Guthoff, T., Wallot, M., Nurnberg, P., Wollnik, B., Abou Jamra, R., Al-Maawali, A. & Wieczorek, D. Clin Genet (2022). https://www.ncbi.nlm.nih.gov/pubmed/36576126  

Mirabegron-induced brown fat activation does not exacerbate atherosclerosis in mice with a functional hepatic ApoE-LDLR pathway. Ying, Z., van Eenige, R., Beerepoot, R., Boon, M. R., Kloosterhuis, N. J., van de Sluis, B., Bartelt, A., Rensen, P. C. N. & Kooijman, S. Pharmacol Res 187, 106634 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36574856  

Heart-Focused Anxiety Is Prevalent in Adults With Congenital Heart Disease and Associated With Reduced Exercise Capacity. Willinger, L., Hock, J., Hager, A., Oberhoffer-Fritz, R., Ewert, P. & Muller, J. J Cardiopulm Rehabil Prev (2022). https://www.ncbi.nlm.nih.gov/pubmed/36574070  

Have extraction patterns in German adults with severe periodontitis changed between 2000 and 2010? Results from two cohort studies. Rug, J., Holtfreter, B., Volzke, H. & Kocher, T. J Clin Periodontol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36574775  

A single-cell RNA labeling strategy for measuring stress response upon tissue dissociation. Neuschulz, A., Bakina, O., Badillo-Lisakowski, V., Olivares-Chauvet, P., Conrad, T., Gotthardt, M., Kettenmann, H. & Junker, J. P. Mol Syst Biol, e11147 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36573354   

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. Kanoni, S., Graham, S. E., Wang, Y., Surakka, I., Ramdas, S., Zhu, X., Clarke, S. L., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H., Ntalla, I., Hui, Q., Klarin, D., Hilliard, A. T., Wang, Z., Xue, C. et al. Genome Biol 23, 268 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36575460  

Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS. Hellbach, F., Sinke, L., Costeira, R., Baumeister, S. E., Beekman, M., Louca, P., Leeming, E. R., Mompeo, O., Berry, S., Wilson, R., Wawro, N., Freuer, D., Hauner, H., Peters, A., Winkelmann, J., Koenig, W., Meisinger, C., Waldenberger, M., Heijmans, B. T., Slagboom, P. E. et al. Eur J Nutr (2022). https://www.ncbi.nlm.nih.gov/pubmed/36571600  

Co-exposure to urban particulate matter and aircraft noise adversely impacts the cerebro-pulmonary-cardiovascular axis in mice. Kuntic, M., Kuntic, I., Krishnankutty, R., Gericke, A., Oelze, M., Junglas, T., Bayo Jimenez, M. T., Stamm, P., Nandudu, M., Hahad, O., Keppeler, K., Daub, S., Vujacic-Mirski, K., Rajlic, S., Strohm, L., Ubbens, H., Tang, Q., Jiang, S., Ruan, Y., Macleod, K. G. et al. Redox Biol 59, 102580 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36566737  

Impact of Empagliflozin in Heart Failure With Reduced Ejection Fraction in Patients With Ischemic Versus Nonischemic Cause. Khan, M. S., Butler, J., Anker, S. D., Filippatos, G., Ferreira, J. P., Pocock, S. J., Januzzi, J. L., Pina, I. L., Bohm, M., Ponikowski, P., Verma, S., Brueckmann, M., Vedin, O., Zeller, C., Zannad, F. & Packer, M. J Am Heart Assoc, e027652 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36565199  

Prognostic Impact of Different Types of Ventricular Tachyarrhythmias Stratified by Underlying Cardiac Disease. Schupp, T., Rusnak, J., Weidner, K., Bertsch, T., Mashayekhi, K., Tajti, P., Akin, I. & Behnes, M. J Pers Med 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36556245   

Impact of Lactate on 30-Day All-Cause Mortality in Patients with and without Out-of-Hospital Cardiac Arrest Due to Cardiogenic Shock. Rusnak, J., Schupp, T., Weidner, K., Ruka, M., Egner-Walter, S., Forner, J., Bertsch, T., Kittel, M., Mashayekhi, K., Tajti, P., Ayoub, M., Behnes, M. & Akin, I. J Clin Med 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36555911  

Right Ventricular Strain by Magnetic Resonance Feature Tracking Is Largely Afterload-Dependent and Does Not Reflect Contractility: Validation by Combined Volumetry and Invasive Pressure Tracings. Rolf, A., Keller, T., Wolter, J. S., Kriechbaum, S., Weferling, M., Guth, S., Wiedenroth, C., Mayer, E., Hamm, C. W., Fischer-Rasokat, U. & Treiber, J. Diagnostics (Basel) 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36553190  

Genetic Ablation of Ankrd1 Mitigates Cardiac Damage during Experimental Autoimmune Myocarditis in Mice. Rinkunaite, I., Simoliunas, E., Alksne, M., Bartkute, G., Labeit, S., Bukelskiene, V. & Bogomolovas, J. Biomolecules 12 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36551326  

Quo Vadis? Immunodynamics of Myeloid Cells after Myocardial Infarction. Moggio, A., Schunkert, H., Kessler, T. & Sager, H. B. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36555456  

Body surface scan anthropometrics are related to cardiorespiratory fitness in the general population. Kohler, A., Filges, B., Volzke, H., Felix, S. B., Ewert, R., Stubbe, B., Markus, M. R. P., Gross, S., Dorr, M., Ittermann, T. & Bahls, M. Sci Rep 12, 22185 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36564547  

Differential Regulation of MMPs, Apoptosis and Cell Proliferation by the Cannabinoid Receptors CB1 and CB2 in Vascular Smooth Muscle Cells and Cardiac Myocytes. Greiner, B., Sommerfeld, M., Kintscher, U., Unger, T., Kappert, K. & Kaschina, E. Biomedicines 10 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36552027  

tRNA-like Transcripts from the NEAT1-MALAT1 Genomic Region Critically Influence Human Innate Immunity and Macrophage Functions. Gast, M., Nageswaran, V., Kuss, A. W., Tzvetkova, A., Wang, X., Mochmann, L. H., Rad, P. R., Weiss, S., Simm, S., Zeller, T., Voelzke, H., Hoffmann, W., Volker, U., Felix, S. B., Dorr, M., Beling, A., Skurk, C., Leistner, D. M., Rauch, B. H., Hirose, T. et al. Cells 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36552736  

Effect of Metabolic Adaptation by Voluntary Running Wheel Activity and Aldosterone Inhibition on Renal Function in Female Spontaneously Hypertensive Rats. Atmanspacher, F., Schreckenberg, R., Wolf, A., Grgic, I. & Schluter, K. D. Cells 11 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36552716  

Effect of baroreflex activation therapy on dipping pattern in patients with resistant hypertension. Wallbach, M., Born, E., Schafer, A. K. & Koziolek, M. J. J Clin Hypertens (Greenwich) (2022). https://www.ncbi.nlm.nih.gov/pubmed/36545753  

Heart failure: an update from the last years and a look at the near future. Riccardi, M., Sammartino, A. M., Piepoli, M., Adamo, M., Pagnesi, M., Rosano, G., Metra, M., von Haehling, S. & Tomasoni, D. ESC Heart Fail 9, 3667-3693 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36546712  

Successful baroreflex activation therapy in a case of therapy-resistant renovascular hypertension. Nuhn, E. M., Wallbach, M., Elger, F. & Koziolek, M. J. Clin Res Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36547755  

Efficacy and Safety of Inclisiran in Patients with Polyvascular Disease: Pooled, Post Hoc Analysis of the ORION-9, ORION-10, and ORION-11 Phase 3 Randomized Controlled Trials. Koenig, W., Conde, L. G., Landmesser, U., Leiter, L. A., Ray, K. K., Schwartz, G. G., Wright, R. S., Han, J. & Raal, F. J. Cardiovasc Drugs Ther (2022). https://www.ncbi.nlm.nih.gov/pubmed/36550348  

Very high-power short-duration ablation for pulmonary vein isolation utilizing a very-close protocol-the FAST AND FURIOUS PVI study. Heeger, C. H., Sano, M., Popescu, S. S., Subin, B., Feher, M., Phan, H. L., Kirstein, B., Vogler, J., Eitel, C., Hatahet, S., Kuck, K. H. & Tilz, R. R. Europace (2022). https://www.ncbi.nlm.nih.gov/pubmed/36546582  

Human Macrophage Long Intergenic Noncoding RNA, SIMALR, Suppresses Inflammatory Macrophage Apoptosis via NTN1 (Netrin-1). Cynn, E., Li, D., O'Reilly, M. E., Wang, Y., Bashore, A. C., Jha, A., Foulkes, A., Zhang, H., Winter, H., Maegdefessel, L., Yan, H., Li, M., Ross, L., Xue, C. & Reilly, M. P. Arterioscler Thromb Vasc Biol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36546321   

A systematic review and evaluation of statistical methods for group variable selection. Buch, G., Schulz, A., Schmidtmann, I., Strauch, K. & Wild, P. S. Stat Med (2022). https://www.ncbi.nlm.nih.gov/pubmed/36546512  

Glucose-Induced Hemodynamic and Metabolic Response of Skeletal Muscle in Heart Failure Patients with Reduced vs. Preserved Ejection Fraction-A Pilot Study. Boschmann, M., Klug, L., Edelmann, F., Sandek, A., von Haehling, S., Dungen, H. D., Springer, J., Anker, S. D., Doehner, W. & Jauert, N. J Cardiovasc Dev Dis 9 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36547453  

Immature Platelet Fraction Predicts Adverse Events in Patients With Acute Coronary Syndrome: the ISAR-REACT 5 Reticulated Platelet Substudy. Bongiovanni, D., Schreiner, N., Gosetti, R., Mayer, K., Angiolillo, D. J., Sibbing, D., Holdenrieder, S., Anetsberger, A., von Scheidt, M., Schunkert, H., Laugwitz, K. L., Schupke, S., Kastrati, A., Fegers-Wustrow, I. & Bernlochner, I. Arterioscler Thromb Vasc Biol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36546322  

Sex-specific associations between serum lipids and hemostatic factors: the cross-sectional population-based KORA-fit study. von Falckenstein, J. V., Freuer, D., Peters, A., Heier, M., Teupser, D., Linseisen, J. & Meisinger, C. Lipids Health Dis 21, 143 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36544148   

Coronary artery perforation located in a coronary artery bypass graft treated with new-generation single-layer polytetrafluorethylene-covered stent: results from a multicenter Registry. Voll, F., Koch, T., Lenz, T., Cassese, S., Xhepa, E., Joner, M., Kastrati, A., Kufner, S. & Investigators, R. Coron Artery Dis (2022). https://www.ncbi.nlm.nih.gov/pubmed/36539951  

The molecular evolution of spermatogenesis across mammals. Murat, F., Mbengue, N., Winge, S. B., Trefzer, T., Leushkin, E., Sepp, M., Cardoso-Moreira, M., Schmidt, J., Schneider, C., Mossinger, K., Bruning, T., Lamanna, F., Belles, M. R., Conrad, C., Kondova, I., Bontrop, R., Behr, R., Khaitovich, P., Paabo, S., Marques-Bonet, T. et al. Nature (2022). https://www.ncbi.nlm.nih.gov/pubmed/36544022  

Mansoor's Self-Report Tool for Cardiovascular Risk Assessment predicts adverse in-hospital events in patients with pulmonary embolism. Keller, K., Schmitt, V. H., Ostad, M. A., Munzel, T., Hobohm, L. & Espinola-Klein, C. Clin Respir J (2022). https://www.ncbi.nlm.nih.gov/pubmed/36544042  

Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine. Wu, F., Li, X., Looso, M., Liu, H., Ding, D., Gunther, S., Kuenne, C., Liu, S., Weissmann, N., Boettger, T., Atzberger, A., Kolahian, S., Renz, H., Offermanns, S., Gartner, U., Potente, M., Zhou, Y., Yuan, X. & Braun, T. Nat Genet (2022). https://www.ncbi.nlm.nih.gov/pubmed/36539616  

The effect of probiotic and synbiotic supplementation on appetite-regulating hormones and desire to eat: A systematic review and meta-analysis of clinical trials. Noormohammadi, M., Ghorbani, Z., Lober, U., Mahdavi-Roshan, M., Bartolomaeus, T. U. P., Kazemi, A., Shoaibinobarian, N. & Forslund, S. K. Pharmacol Res 187, 106614 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36538981  

Single-cell transcriptomics for the assessment of cardiac disease. Miranda, A. M. A., Janbandhu, V., Maatz, H., Kanemaru, K., Cranley, J., Teichmann, S. A., Hubner, N., Schneider, M. D., Harvey, R. P. & Noseda, M. Nat Rev Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36539452  

Noise annoyance and risk of prevalent and incident atrial fibrillation-A sex-specific analysis. Hahad, O., Beutel, M. E., Gilan, D. A., Chalabi, J., Schuster, A. K., Gianicolo, E., Lackner, K. J., Lieb, K., Galle, P. R., Wild, P. S., Daiber, A. & Munzel, T. Front Public Health 10, 1061328 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36536776  

The impact of extra-valvular cardiac damage on mid-term clinical outcome following transcatheter aortic valve replacement in patients with severe aortic stenosis. Pellegrini, C., Duesmann, C., Rheude, T., Berg, A., Alvarez-Covarrubias, H. A., Trenkwalder, T., Mayr, N. P., Schurmann, F., Nicol, P., Xhepa, E. & Joner, M. Front Cardiovasc Med 9, 1039208 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36531697  

Timing of bioprosthetic valve fracture in transcatheter valve-in-valve intervention: impact on valve durability and leaflet integrity. Meier, D., Payne, G. W., Mostaco-Guidolin, L. B., Bouchareb, R., Rich, C., Lai, A., Chatfield, A. G., Akodad, M., Salcudean, H., Lutter, G., Puehler, T., Pibarot, P., Allen, K. B., Chhatriwalla, A. K., Sondergaard, L., Wood, D. A., Webb, J. G., Leipsic, J. A., Sathananthan, J. & Sellers, S. L. EuroIntervention (2022). https://www.ncbi.nlm.nih.gov/pubmed/36534495   

Efficient single copy integration via homology-directed repair (scHDR) by 5'modification of large DNA donor fragments in mice. Medert, R., Thumberger, T., Tavhelidse-Suck, T., Hub, T., Kellner, T., Oguchi, Y., Dlugosz, S., Zimmermann, F., Wittbrodt, J. & Freichel, M. Nucleic Acids Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/36533445  

Endothelial deletion of the cytochrome P450 reductase leads to cardiac remodelling. Lopez, M., Malacarne, P. F., Ramanujam, D. P., Warwick, T., Muller, N., Hu, J., Dewenter, M., Weigert, A., Gunther, S., Gilsbach, R., Engelhardt, S., Brandes, R. P. & Rezende, F. Front Physiol 13, 1056369 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36531184  

New prospectives on treatment opportunities in RASopathies. Gelb, B. D., Yohe, M. E., Wolf, C. & Andelfinger, G. Am J Med Genet C Semin Med Genet (2022). https://www.ncbi.nlm.nih.gov/pubmed/36533679  

3D modeling and printing for complex biventricular repair of double outlet right ventricle. Bruning, J., Kramer, P., Goubergrits, L., Schulz, A., Murin, P., Solowjowa, N., Kuehne, T., Berger, F., Photiadis, J. & Weixler, V. H. Front Cardiovasc Med 9, 1024053 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36531701  

Interferon-gamma drives macrophage reprogramming, cerebrovascular remodeling, and cognitive dysfunction in a zebrafish and a mouse model of ion imbalance and pressure overload. Apaydin, D. C., Zakarauskas-Seth, B. I., Carnevale, L., Apaydin, O., Perrotta, M., Carnevale, R., Kotini, M. P., Kotlar-Goldaper, I., Belting, H. G., Carnevale, D., Filosa, A. & Sawamiphak, S. Cardiovasc Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/36536484  

Straight to the Heart: T Cells That Specifically Target Cardiac Tissue. Abplanalp, W. T., Merten, M. & Dimmeler, S. Circulation 146, 1946-1949 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36534731   

Results of non-elective withdrawal of continuous-flow left ventricular assist devices in selected patients. Knierim, J., Tsyganenko, D., Stein, J., Mulzer, J., Muller, M., Hrytsyna, Y., Schoenrath, F., Falk, V. & Potapov, E. J Heart Lung Transplant (2022). https://www.ncbi.nlm.nih.gov/pubmed/36529649  

Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting. Anttila, V., Saraste, A., Knuuti, J., Hedman, M., Jaakkola, P., Laugwitz, K. L., Krane, M., Jeppsson, A., Sillanmaki, S., Rosenmeier, J., Zingmark, P., Rudvik, A., Garkaviy, P., Watson, C., Pangalos, M. N., Chien, K. R., Fritsche-Danielson, R., Collen, A. & Gan, L. M. Mol Ther (2022). https://www.ncbi.nlm.nih.gov/pubmed/36528793  

The '10 commandments' for the 2022 European Society of Cardiology guidelines on cardiovascular assessment and management of patients undergoing non-cardiac surgery. Mehilli, J. & Halvorsen, S. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/36527277  

Myocardial epigenetic modifications link chronic kidney disease to coronary microvascular disease. Sen, P., Sorop, O. & Merkus, D. Am J Physiol Heart Circ Physiol 324, H175-H176 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36525479  

Guts within guts: the microbiome of the intestinal helminth parasite Ascaris suum is derived but distinct from its host. Midha, A., Jarquin-Diaz, V. H., Ebner, F., Lober, U., Hayani, R., Kundik, A., Cardilli, A., Heitlinger, E., Forslund, S. K. & Hartmann, S. Microbiome 10, 229 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36527132   

Renal angiotensin I-converting enzyme-deficient mice are protected against aristolochic acid nephropathy. Juretzko, A., Steinbach, A., Witte, J., Hannemann, A., Miehe, B., Siegerist, F., Wolke, C., Stracke, S. & Rettig, R. Pflugers Arch (2022). https://www.ncbi.nlm.nih.gov/pubmed/36520238  

Macrophagic AMPKalpha1 orchestrates regenerative inflammation induced by glucocorticoids. Caratti, G., Desgeorges, T., Juban, G., Stiffel, U., Fessard, A., Koenen, M., Caratti, B., Theret, M., Skurk, C., Chazaud, B., Tuckermann, J. P. & Mounier, R. EMBO Rep, e55363 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36520372   

Berlin Registry of Neuroimmunological entities (BERLimmun): protocol of a prospective observational study. Sperber, P. S., Brandt, A. U., Zimmermann, H. G., Bahr, L. S., Chien, C., Rekers, S., Mahler, A., Bottcher, C., Asseyer, S., Duchow, A. S., Bellmann-Strobl, J., Ruprecht, K., Paul, F. & Schmitz-Hubsch, T. BMC Neurol 22, 479 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36517734  

Comment to the article: "Consensus statement on the definition of orthostatic hypertension endorsed by the American Autonomic Society and the Japanese Society of Hypertension" by Jordan and colleagues. Moreno Velasquez, I. & Pischon, T. Clin Auton Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/36517690  

Prior Myocardial Infarction and Treatment Effect of Ticagrelor Versus Prasugrel in Patients With Acute Coronary Syndromes - A Post-hoc Analysis of the ISAR-REACT 5 Trial. Lahu, S., Scalamogna, M., Ndrepepa, G., Menichelli, M., Valina, C., Hemetsberger, R., Witzenbichler, B., Bernlochner, I., Joner, M., Xhepa, E., Hapfelmeier, A., Kufner, S., Sager, H. B., Mayer, K., Kessler, T., Laugwitz, K. L., Richardt, G., Schunkert, H., Neumann, F. J., Kastrati, A. et al. J Am Heart Assoc 11, e027257 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36515247  

Early rhythm-control therapy for atrial fibrillation in patients with a history of stroke: a subgroup analysis of the EAST-AFNET 4 trial. Jensen, M., Suling, A., Metzner, A., Schnabel, R. B., Borof, K., Goette, A., Haeusler, K. G., Zapf, A., Wegscheider, K., Fabritz, L., Diener, H. C., Thomalla, G. & Kirchhof, P. Lancet Neurol 22, 45-54 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36517170  

Initial experience with transcatheter tricuspid valve repair in patients with cardiac amyloidosis. Hoerbrand, I. A., Volz, M. J., Aus dem Siepen, F., Aurich, M., Schlegel, P., Geis, N. A., Hegenbart, U., Konstandin, M. H., Frey, N. & Raake, P. W. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/36514259  

Furnishing the cachexia landscape: A year of research in JCSM. Frohlich, A. K., Diek, M., von Haehling, S. & Anker, M. S. J Cachexia Sarcopenia Muscle 13, 2763-2771 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36510825  

Long non-coding RNAs at the crossroad of vascular smooth muscle cell phenotypic modulation in atherosclerosis and neointimal formation. Fasolo, F., Paloschi, V. & Maegdefessel, L. Atherosclerosis (2022). https://www.ncbi.nlm.nih.gov/pubmed/36513554   

Comparison of calling pipelines for whole genome sequencing: an empirical study demonstrating the importance of mapping and alignment. Betschart, R. O., Thiery, A., Aguilera-Garcia, D., Zoche, M., Moch, H., Twerenbold, R., Zeller, T., Blankenberg, S. & Ziegler, A. Sci Rep 12, 21502 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36513709  

Single beta-blocker or combined amiodarone therapy in implantable cardioverter-defibrillator and cardiac resynchronization therapy defibrillator patients - insights from the German DEVICE-registry. Wiedmann, F., Ince, H., Stellbrink, C., Kleemann, T., Eckardt, L., Brachmann, J., Gonska, B. D., Kaab, S., Perings, C. A., Jung, W., Lugenbiel, P., Hochadel, M., Senges, J., Frey, N. & Schmidt, C. Heart Rhythm (2022). https://www.ncbi.nlm.nih.gov/pubmed/36509321  

Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide. O'Reilly, M., Sommerfeld, L. C., O'Shea, C., Broadway-Stringer, S., Andaleeb, S., Reyat, J. S., Kabir, S. N., Stastny, D., Malinova, A., Delbue, D., Fortmueller, L., Gehmlich, K., Pavlovic, D., Skryabin, B. V., Holmes, A. P., Kirchhof, P. & Fabritz, L. Europace (2022). https://www.ncbi.nlm.nih.gov/pubmed/36504385  

Impact of observer experience on multi-detector computed tomography aortic valve morphology assessment and valve size selection for transcatheter aortic valve replacement. Evertz, R., Hub, S., Kowallick, J. T., Seidler, T., Danner, B. C., Hasenfuss, G., Toischer, K. & Schuster, A. Sci Rep 12, 21430 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36509862  

Cardiac metabolism in HFpEF: from fuel to signalling. Capone, F., Sotomayor-Flores, C., Bode, D., Wang, R., Rodolico, D., Strocchi, S. & Schiattarella, G. G. Cardiovasc Res (2022). https://www.ncbi.nlm.nih.gov/pubmed/36504368   

Placental Transcriptome Profiling in Subtypes of Diabetic Pregnancies Is Strongly Confounded by Fetal Sex. Kedziora, S. M., Obermayer, B., Sugulle, M., Herse, F., Kraker, K., Haase, N., Langmia, I. M., Muller, D. N., Staff, A. C., Beule, D. & Dechend, R. Int J Mol Sci 23 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36499721  

Telemedical monitoring in patients with inborn cardiac disease - experience of a tertiary care centre. Westphal, D. S., Federle, D., Steger, A., Vodermeier, T., Scheiper-Welling, S., Jenewein, T., Beckmann, B. M., Kauferstein, S., Martens, E. & Hahn, F. Mamm Genome, 1-8 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36481846  

Pragmatic screening for heart failure in the general population using an electrocardiogram-based neural network. Surendra, K., Nurnberg, S., Bremer, J. P., Knorr, M. S., Uckert, F., Wenzel, J. P., Bei der Kellen, R., Westermann, D., Schnabel, R. B., Twerenbold, R., Magnussen, C., Kirchhof, P., Blankenberg, S., Neumann, J. & Schrage, B. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/36482800  

Diagnostic and prognostic role of platelets in patients with sepsis and septic shock. Schupp, T., Weidner, K., Rusnak, J., Jawhar, S., Forner, J., Dulatahu, F., Bruck, L. M., Hoffmann, U., Kittel, M., Bertsch, T., Akin, I. & Behnes, M. Platelets 34, 2131753 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36484263  

Muscle sodium content in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Petter, E., Scheibenbogen, C., Linz, P., Stehning, C., Wirth, K., Kuehne, T. & Kelm, M. J Transl Med 20, 580 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36494667  

Sex hormones in SARS-CoV-2 susceptibility: key players or confounders? Lott, N., Gebhard, C. E., Bengs, S., Haider, A., Kuster, G. M., Regitz-Zagrosek, V. & Gebhard, C. Nat Rev Endocrinol, 1-15 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36494595  

Impact of age on the prognosis of patients with ventricular tachyarrhythmias and aborted cardiac arrest. Weidner, K., Schupp, T., Rusnak, J., El-Battrawy, I., Ansari, U., Hoppner, J., Mueller, J., Kittel, M., Taton, G., Reiser, L., Bollow, A., Reichelt, T., Ellguth, D., Engelke, N., Grosse Meininghaus, D., Akin, M., Bertsch, T., Akin, I. & Behnes, M. Z Gerontol Geriatr (2022). https://www.ncbi.nlm.nih.gov/pubmed/36480051  

Frequency, associated variables, and outcomes of acute myocardial injury according to the fourth Universal Definition of Myocardial Infarction in patients with acute ischemic stroke. Stengl, H., Ganeshan, R., Hellwig, S., Klammer, M. G., von Rennenberg, R., Bohme, S., Audebert, H. J., Nolte, C. H., Endres, M. & Scheitz, J. F. Eur Stroke J 7, 413-420 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36478763  

Genetic diversity fuels gene discovery for tobacco and alcohol use. Saunders, G. R. B., Wang, X., Chen, F., Jang, S. K., Liu, M., Wang, C., Gao, S., Jiang, Y., Khunsriraksakul, C., Otto, J. M., Addison, C., Akiyama, M., Albert, C. M., Aliev, F., Alonso, A., Arnett, D. K., Ashley-Koch, A. E., Ashrani, A. A., Barnes, K. C., Barr, R. G. et al. Nature 612, 720-724 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36477530  

HeartWare to HeartMate 3 left ventricular assist device exchange via a left lateral thoracotomy. Nersesian, G., Montagner, M., Lanmueller, P., Lewin, D., Van Praet, K. M., Kofler, M., Ott, S., Falk, V. & Potapov, E. Multimed Man Cardiothorac Surg 2022 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36476648  

Fluorescence in situ hybridization and polymerase chain reaction to detect infections of cardiac implantable electronic devices. Just, I. A., Barthel, F., Moter, A., Kikhney, J., Friedrich, A., Wloch, A., Falk, V., Starck, C. & Schoenrath, F. Europace (2022). https://www.ncbi.nlm.nih.gov/pubmed/36477494  

Translational opportunities of single-cell biology in atherosclerosis. de Winther, M. P. J., Back, M., Evans, P., Gomez, D., Goncalves, I., Jorgensen, H. F., Koenen, R. R., Lutgens, E., Norata, G. D., Osto, E., Dib, L., Simons, M., Stellos, K., Yla-Herttuala, S., Winkels, H., Bochaton-Piallat, M. L. & Monaco, C. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/36478058  

Empagliflozin, irrespective of blood pressure, improves outcomes in heart failure with preserved ejection fraction: the EMPEROR-Preserved trial. Bohm, M., Anker, S., Mahfoud, F., Lauder, L., Filippatos, G., Ferreira, J. P., Pocock, S. J., Brueckmann, M., Saloustros, I., Schuler, E., Wanner, C., Zannad, F., Packer, M. & Butler, J. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/36478225  

Adipocytes control haematopoiesis and inflammation through CD40 signaling. Reiche, M. E., Poels, K., Bosmans, L. A., Vos, W. G., Van Tiel, C. M., Gijbels, M. J. J., Aarts, S., Den Toom, M., Beckers, L., Weber, C., Atzler, D., Rensen, P. C. N., Kooijman, S. & Lutgens, E. Haematologica (2022). https://www.ncbi.nlm.nih.gov/pubmed/36475519  

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants. Aragam, K. G., Jiang, T., Goel, A., Kanoni, S., Wolford, B. N., Atri, D. S., Weeks, E. M., Wang, M., Hindy, G., Zhou, W., Grace, C., Roselli, C., Marston, N. A., Kamanu, F. K., Surakka, I., Venegas, L. M., Sherliker, P., Koyama, S., Ishigaki, K., Asvold, B. O. et al. Nat Genet 54, 1803-1815 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36474045  

Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease. Widjaja, A. A., Viswanathan, S., Shekeran, S. G., Adami, E., Lim, W. W., Chothani, S., Tan, J., Goh, J. W. T., Chen, H. M., Lim, S. Y., Boustany-Kari, C. M., Hawkins, J., Petretto, E., Hubner, N., Schafer, S., Coffman, T. M. & Cook, S. A. Nat Commun 13, 7497 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36470928  

Leaflet-splitting device to prevent coronary artery obstruction in valve-in-valve transcatheter aortic valve implantation. Van Praet, K. M., Klein, C., Kukucka, M., Kempfert, J., Kofler, M., Gerckens, U., Dvir, D., Falk, V. & Unbehaun, A. Multimed Man Cardiothorac Surg 2022 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36468494  

Linking single nucleotide polymorphisms to signaling blueprints in abdominal aortic aneurysms. Lim, C., Pratama, M. Y., Rivera, C., Silvestro, M., Tsao, P. S., Maegdefessel, L., Gallagher, K. A., Maldonado, T. & Ramkhelawon, B. Sci Rep 12, 20990 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36470918  

JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study. Liberale, L., Puspitasari, Y. M., Ministrini, S., Akhmedov, A., Kraler, S., Bonetti, N. R., Beer, G., Vukolic, A., Bongiovanni, D., Han, J., Kirmes, K., Bernlochner, I., Pelisek, J., Beer, J. H., Jin, Z. G., Pedicino, D., Liuzzo, G., Stellos, K., Montecucco, F., Crea, F. et al. Eur Heart J (2022). https://www.ncbi.nlm.nih.gov/pubmed/36469488  

RNA modifications in cardiovascular health and disease. Gatsiou, A. & Stellos, K. Nat Rev Cardiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36471164  

Efficacy of empagliflozin in heart failure with preserved versus mid-range ejection fraction: a pre-specified analysis of EMPEROR-Preserved. Anker, S. D., Butler, J., Usman, M. S., Filippatos, G., Ferreira, J. P., Bocchi, E., Bohm, M., Rocca, H. P. B., Choi, D. J., Chopra, V., Chuquiure, E., Giannetti, N., Gomez-Mesa, J. E., Janssens, S., Januzzi, J. L., Gonzalez-Juanatey, J. R., Merkely, B., Nicholls, S. J., Perrone, S. V., Pina, I. L. et al. Nat Med 28, 2512-2520 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36471037  

White matter hyperintensities are an independent predictor of cognitive decline 3 years following first-ever stroke-results from the PROSCIS-B study. Ali, H. F., Fast, L., Khalil, A., Siebert, E., Liman, T., Endres, M., Villringer, K. & Kufner, A. J Neurol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36471099  

Interleukin-10 -1082 G/A polymorphism and its association with early or severe presentation of coronary artery disease: A systematic review and meta-analysis. Rai, H., Joner, M., Wilson, H., McGovern, L., Richards, G., Colleran, R. & Byrne, R. A. Cytokine 162, 156103 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36463660  

Anti-osteopontin therapy leads to improved edema and infarct size in a murine model of ischemic stroke. Spitzer, D., Puetz, T., Armbrust, M., Dunst, M., Macas, J., Croll, F., Plate, K. H., Reiss, Y., Liebner, S., Harter, P. N., Guerit, S. & Devraj, K. Sci Rep 12, 20925 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36463381  

Stent imaging on a clinical dual-source photon-counting detector CT system-impact of luminal attenuation and sharp kernels on lumen visibility. Decker, J. A., O'Doherty, J., Schoepf, U. J., Todoran, T. M., Aquino, G. J., Brandt, V., Baruah, D., Fink, N., Zsarnoczay, E., Flohr, T., Schmidt, B., Allmendinger, T., Risch, F., Varga-Szemes, A. & Emrich, T. Eur Radiol (2022). https://www.ncbi.nlm.nih.gov/pubmed/36462045   

Hemodynamic Comparison between the Avalus and the Perimount Magna Ease Aortic Bioprosthesis up to 5 Years. Burri, M., Bozini, N., Vitanova, K., Mayr, B., Lange, R. & Gunzinger, R. Thorac Cardiovasc Surg (2022). https://www.ncbi.nlm.nih.gov/pubmed/36462752  

Minimally invasive surgical aortic valve replacement via a partial upper ministernotomy. Van Praet, K. M., Nersesian, G., Kukucka, M., Kofler, M., Wert, L., Klein, C., Unbehaun, A., Kempfert, J. & Falk, V. Multimed Man Cardiothorac Surg 2022 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36458810  

DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal. Cattaneo, P., Hayes, M. G. B., Baumgarten, N., Hecker, D., Peruzzo, S., Aslan, G. S., Kunderfranco, P., Larcher, V., Zhang, L., Contu, R., Fonseca, G., Spinozzi, S., Chen, J., Condorelli, G., Dimmeler, S., Schulz, M. H., Heinz, S., Guimaraes-Camboa, N. & Evans, S. M. Nat Commun 13, 7444 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36460641    

ACC/AHA/HFSA 2022 and ESC 2021 guidelines on heart failure comparison. Behnoush, A. H., Khalaji, A., Naderi, N., Ashraf, H. & von Haehling, S. ESC Heart Fail (2022). https://www.ncbi.nlm.nih.gov/pubmed/36460629  

Targeting Mitochondrial Calcium Handling to Treat Atrial Fibrillation. Voigt, N., Maack, C. & Pronto, J. R. D. J Am Coll Cardiol 80, 2220-2223 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36456052  

Pre-procedural oral anticoagulant use is associated with cardiovascular events in women after transcatheter aortic valve replacement: An analysis from the WIN-TAVI cohort. van Bergeijk, K. H., Wykrzykowska, J. J., Sartori, S., Snyder, C., Vogel, B., Tchetche, D., Petronio, A. S., Mehilli, J., Lefevre, T., Presbitero, P., Capranzano, P., Iadanza, A., Sardella, G., Van Mieghem, N. M., Meliga, E., Dumonteil, N., Fraccaro, C., Trabattoni, D., Mikhail, G., Ferrer-Gracia, M. C. et al. Int J Cardiol 372, 40-45 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36455701  

Ten-year clinical outcomes of drug-eluting stents with different polymer coating strategies by degree of coronary calcification: a pooled analysis of the ISAR-TEST 4 and 5 randomised trials. Rheude, T., Koch, T., Joner, M., Lenz, T., Xhepa, E., Wiebe, J., Coughlan, J. J., Aytekin, A., Cassese, S., Laugwitz, K. L., Schunkert, H., Kastrati, A. & Kufner, S. EuroIntervention (2022). https://www.ncbi.nlm.nih.gov/pubmed/36453826  

Role of phase angle in older adults with focus on the geriatric syndromes sarcopenia and frailty. Norman, K., Herpich, C. & Muller-Werdan, U. Rev Endocr Metab Disord, 1-9 (2022). https://www.ncbi.nlm.nih.gov/pubmed/36456777  

Genome Editing in Dyslipidemia and Atherosclerosis. Chen, Z., Lehertshuber, C. & Schunkert, H. Adv Exp Med Biol 1396, 139-156 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36454465  

[ESC guidelines 2022 on cardiovascular assessment and management of patients undergoing non-cardiac surgery : What is new?]. Mehilli, J. & Winhard, M. Herz (2022). https://www.ncbi.nlm.nih.gov/pubmed/36449042

Late-stage C-H Functionalization of Tryptophan-Containing Peptides with Thianthrenium Salts: Conjugation and Ligation. Kaplaneris, N., Puet, A., Kallert, F., Pohlmann, J. & Ackermann, L. Angew Chem Int Ed Engl 62, e202216661 (2023). https://www.ncbi.nlm.nih.gov/pubmed/36581584