Cell Therapy


Förderkennzeichen

81Z1200102

Projektnummer

429

Institution
Johann Wolfgang Goethe-Universität Frankfurt am Main - Klinikum - Medizinische Klinik III
Projektleiter
Andreas Zeiher
Standort
RheinMain
Kurzbeschreibung

Intracoronary therapy using autologous bone-marrow derived  cells (BMCs) has been shown to moderately improve left ventricular function in patients with acute myocardial infarction and … 

Intracoronary therapy using autologous bone-marrow derived  cells (BMCs) has been shown to moderately improve left ventricular function in patients with acute myocardial infarction and chronic heart failure. One of the key factors influencing the efficacy of the application is certainly the heterogeneity of the cell products which varies depending on the genetic determinants and risk factors of the individual patients. Focus of this project is the establishment of fast and easy-to-perform in vitro methods to analyze the functionality of BMCs already before the re-application in the patient. Identification of factors determining the functionality of the applied cellular product might also enable ex-vivo modification by drugs or small molecules in order to further enhance the efficacy of cell therapy in patients with cardiovascular diseases.

Projektart
Standortprojekt
Stichwörter
acute myocardial infarction, heart failure, stem cell therapy
Topic
stem cells/cardiac regeneration
Fördersumme
€ 239.999,80
Beginn
01.01.2015
Ende
31.12.2018