Vascular end organ damage


Förderkennzeichen

81Z1700105

Projektnummer

445

Institution
Universität zu Lübeck
Projektleiter
Markus Schwaninger
Standort
Hamburg/Kiel/Lübeck
Kurzbeschreibung

Our project investigates vascular pruning and remodeling in mouse models of disease. We focus on (i) diabetes and (ii) incontinentia pigmenti, a genetic disease that leads to vascular … 

Our project investigates vascular pruning and remodeling in mouse models of disease. We focus on (i) diabetes and (ii) incontinentia pigmenti, a genetic disease that leads to vascular pathology in the brain. Although diverse in etiology, the two conditions share an involvement of the proinflammatory transcription factor NF-?B. To explore whether interfering with NF-?B signaling offers therapeutic opportunities, we employ classical small-molecule pharmacology as well as gene therapy approaches. Optical coherence tomography and various physiological or morphological techniques are used to evaluate the vasculature.

Projektart
Standortprojekt
Stichwörter
optical coherence tomography, diabetic complications, diabetic microvascular pathology, incontinentia pigmenti, small vessel diseases, NF-kB, gene therapy
Topic
endothelial cells/vascular function
Fördersumme
€ 250.009,05
Beginn
01.01.2015
Ende
31.12.2018