From channelopathies to clinical arrhythmias


Förderkennzeichen

81Z2500201

Projektnummer

464

Institution
Ruprecht-Karls-Universität Heidelberg
Projektleiter
Martin Borggrefe
Standort
Heidelberg/Mannheim
Kurzbeschreibung

Investigation of underlying mechanisms and identification of new therapeutic targets: hiPSC-CMs possess characteristics similar to that of native human cardiomyocytes and can model the … 

Investigation of underlying mechanisms and identification of new therapeutic targets: hiPSC-CMs possess characteristics similar to that of native human cardiomyocytes and can model the main features of some heart diseases. They provide a new platform to study the disease pathology and screen drugs. The aim of our study is to use the hiPSC-CMs modeling the arrhythmogenic heart diseases (SQTs, LQTs, Brugada syndrome, ARVC, HCM and DCM) for studying the underlying mechanisms and identifying new therapeutic targets for the treatment of the diseases. In addition, we will test effects of drugs on the “diseased” hiPSC-CMs and design better drug treatments for the diseases

Projektart
Standortprojekt
Stichwörter
iPS, arrhythmias, Patch-clamp
Topic
iPSC
Fördersumme
€ 587.627,67
Beginn
01.01.2015
Ende
31.12.2018