Reverse cardiac remodeling


Förderkennzeichen

81Z2710103

Projektnummer

480

Institution
Universitätsklinikum Hamburg-Eppendorf
Projektleiter
Heimo Ehmke
Standort
Hamburg/Kiel/Lübeck
Kurzbeschreibung

Cardiac mechanical unloading is associated with an increased risk of ventricular arrhythmias. Underlying pathophysiological mechanisms are still poorly understood. Recent studies indicate … 

Cardiac mechanical unloading is associated with an increased risk of ventricular arrhythmias. Underlying pathophysiological mechanisms are still poorly understood. Recent studies indicate that unloading causes a remodeling of Ca2+ homeostasis in ventricular cardiomyocytes leading to a reduced contribution of sarcoplasmic reticulum (SR) Ca2+ release to the systolic Ca2+ transient. Using pharmacological and genetic interventions in a rodent model of cardiac unloading, this project tests the hypothesis that reestablishing the dominance of SR Ca2+ release will stabilize cardiac repolarization and therefore reduce the occurrence of arrhythmias.

Projektart
Standortprojekt
Stichwörter
acute mechanical unloading, Ca2+ cycling, phospholamban, Ca2+ channel, cardiac arrhythmias, SERCA2, heart transplantation
Topic
cardiomyocyte function
Fördersumme
€ 308.000,00
Beginn
29.10.2014
Ende
31.12.2018