Myocardial RNA Therapy


Förderkennzeichen

81Z3600431

Projektnummer

493

Institution
Technische Universität München
Projektleiter
Stefan Engelhardt
Standort
München
Kurzbeschreibung

This project aims to develop RNA-based therapeutics that interfere with myocardial damage. For this purpose several cardiovascular microRNAs have been identified and functionally … 

This project aims to develop RNA-based therapeutics that interfere with myocardial damage. For this purpose several cardiovascular microRNAs have been identified and functionally characterized with regard to their capacity to regulate key cellular signaling pathways. A subset of these miRNAs are being validated in mouse models of disease and approaches for their therapeutic manipulation are being developed. This involves studies that aim to optimize the pharmacokinetics and pharmacodynamics of miRNA inhibitor molecules.

Projektart
Standortprojekt
Stichwörter
miRNA-based therapy, microRNA, AntagomiR, anti-miR, AAV
Topic
DNA/RNA based, protein based therapy
Fördersumme
€ 1.966.524,12
Beginn
15.10.2011
Ende
31.12.2018