Metabolic mechanisms of cardiovascular disease and the German Prevention Study


Förderkennzeichen

81Z5100251

Projektnummer

497

Institution
Charité - Universitätsmedizin Berlin
Projektleiter
Joachim Spranger
Standort
Berlin
Kurzbeschreibung

We aim to identify novel and further elucidate known endogenous metabolic modifiers of cardiovascular health. We analyze the interrelation between environment, novel metabolic targets … 

We aim to identify novel and further elucidate known endogenous metabolic modifiers of cardiovascular health. We analyze the interrelation between environment, novel metabolic targets and CVD in relation to age and pre-existing CVD to finally translate those findings into preventive practice. We use established mouse models of metabolic disease (obesity, insulin resistance, NAFLD) and analyse the role of specific molecular targets in rodents. We particularly test selected interventional strategies (incl. pharmacology). This is combined with clinical studies in cohorts with impaired metabolism and increased cardiovascular risk (e.g. obesity, diabetes, insulin resistance)

Projektart
Standortprojekt
Stichwörter
Metabolism, brain-heart axis, diabetes, NAFLD, prevention
Topic
arteriosclerosis
Fördersumme
€ 1.218.823,34
Beginn
01.01.2012
Ende
31.12.2018