Nutritional Pharmacology


Förderkennzeichen

81Z5100254

Projektnummer

498

Institution
Charité - Universitätsmedizin Berlin
Projektleiter
Ulrich Kintscher
Standort
Berlin
Kurzbeschreibung

This study aims to investigate the preventive actions of new lipid mediators on myocardial hypertrophy and heart failure. We could recently show that palmitoleic acid (C16:1n7) promotes … 

This study aims to investigate the preventive actions of new lipid mediators on myocardial hypertrophy and heart failure. We could recently show that palmitoleic acid (C16:1n7) promotes the development of physiological cardiac remodeling (Foryst-Ludwig A, J Biol Chem 2015). In continuation of this, we are now focusing on new ?-3 fatty acids. We will test the anti-hypertrophic/ anti-fibrotic potential of anti-inflammatory lipid mediators such as resolvins, protectins und maresins in different disease models such as TAC or isoprenalin injection.

Projektart
Standortprojekt
Stichwörter
lipids, metabolism, heart failure
Topic
cardiac hypertrophy/remodeling
Fördersumme
€ 564.362,01
Beginn
01.01.2015
Ende
31.12.2018