Metabolomics


Förderkennzeichen

81Z7400171

Projektnummer

523

Institution
Universitätsmedizin Greifswald
Projektleiter
Matthias Nauck
Standort
Greifswald
Kurzbeschreibung

Changes in individual metabolic profiles can give hints on subcliinical deseases and might be a source for the discovery of new biomarkers. Furthermore, metabolic profiles can provide … 

Changes in individual metabolic profiles can give hints on subcliinical deseases and might be a source for the discovery of new biomarkers. Furthermore, metabolic profiles can provide information on specific food consumption habits or environmental exposures. Therefore, measurements of metabolic profiles are the basis for individualized diagnostics and therapy in patients. NMR and mass pectroscopy provide deep insights into metabolom changes in urine or blood plasma samples. The major aim of this project is to provide a platform for investigating metabolic changes due to prevention measure in cardiovascular diseases and to generate new hypotheses for the investigation and development of new diagnostic and theraputic approaches. Data from population-based studies like SHIP or Inter99 will complement these investigations by comparing patient cohorts to the general population. Furthermore, metabolic profiles that can be used as intervention (e.g. exercise training) monitoring tools will be investigated. Finally, a comprehensive data analysis of transcriptome, proteome and metabolome data will be carried out for risk stratification and therapeutic prognosis in DCM and heart failure.

Projektart
Standortprojekt
Stichwörter
metabolomics, metabolic profiles, risk stratification, molecular intervention monitoring
Topic
genetics of cardiovascular diseases
Fördersumme
€ 833.867,20
Beginn
01.01.2013
Ende
31.12.2018