Heart regeneration
The heart has only a minimal ability to recover from damage. This area of research focuses on how heart tissue can be repaired or replaced, with the ultimate goal of restoring lost pumping function and improving patients’ quality of life.
Why this area matters
After a heart attack or in cases of progressive heart failure, heart muscle cells die and are replaced by non-functional scar tissue. As the heart regenerates very little on its own, cardiac function deteriorates permanently. For patients, this means reduced physical capacity, frequent hospitalisations and a high risk of death. New therapies that enable the renewal or replacement of heart tissue are therefore urgently needed.
Our research approach
We explore different ways to restore function to damaged heart tissue. These include activating the body’s own regenerative mechanisms, reprogramming cells, and developing heart tissue in the laboratory. Such approaches are initially tested in experimental models before being translated into clinical studies.
Another key focus is ensuring the safe application of regenerative therapies. We investigate how replacement tissue integrates into the heart, how therapies can be delivered and what risks they may pose. In this way, we are laying the foundation for the long-term integration of innovative approaches into patient care.
Spokespersons
- Alessandra Moretti, Munich
- Arica Beisaw, Heidelberg/Mannheim
- Malte Tiburcy, Lower Saxony
Are you conducting research within or outside the DZHK and would like to connect with this focus area? Please contact: