Publications 2025
Here you will find the publications of the DZHK. Please also inform yourself about further publications on the websites of the research institutions involved in the DZHK.
To the DZHK Papers of the Month
January
Paper of the Month
Combined endurance and resistance exercise training in heart failure with preserved ejection fraction: a randomized controlled trial
DZHK authors : Frank Edelmann, Rolf Wachter, Stephan Müller, Isabel Fegers-Wustrow, Marcus Dörr, Hans-Dirk Düngen, Christoph Herrm
Taming the flame: SerpinB1 suppression of pyroptosis in pathological cardiac hypertrophy. Bartelds, B. & Merkus, D. Cardiovasc Res (2025). https://www.ncbi.nlm.nih.gov/pubmed/39745929
From Ca(2)(+) dysregulation to heart failure: beta-adrenoceptor activation by RKIP postpones molecular damages and subsequent cardiac dysfunction in mice carrying mutant PLN(R9C) by correction of aberrant Ca(2+)-handling. Brand, T., Baumgarten, B. T., Denzinger, S., Reinders, Y., Kleindl, M., Schanbacher, C., Funk, F., Gedik, N., Jabbasseh, M., Kleinbongard, P., Dudek, J., Szendroedi, J., Tolstik, E., Schuh, K., Kruger, M., Dobrev, D., Cuello, F., Sickmann, A., Schmitt, J. P. & Lorenz, K. Pharmacol Res 211, 107558 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39742932
CD63 as novel target for nanoemulsion-based (19)F MRI imaging and drug delivery to activated cardiac fibroblasts. Euan Martinez, A. A., Bergmann, A. K., Tellkamp, F., Schott-Verdugo, S., Bouvain, P., Steinhausen, J., Bahr, J., Kmietczyk, V., Bencun, M., Flogel, U., Distler, J. H. W., Krueger, M., Volkers, M., Czekelius, C., Gohlke, H., Temme, S., Hesse, J. & Schrader, J. Theranostics 15, 1-18 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39744226
Cardiac fibroblast BAG3 regulates TGFBR2 signaling and fibrosis in dilated cardiomyopathy. Wang, B. Z., Morsink, M. A., Kim, S. W., Luo, L. J., Zhang, X., Soni, R. K., Lock, R. I., Rao, J., Kim, Y., Zhang, A., Neyazi, M., Gorham, J. M., Kim, Y., Brown, K., DeLaughter, D. M., Zhang, Q., McDonough, B., Watkins, J. M., Cunningham, K. M., Oudit, G. Y., Fine, B. M., Seidman, C. E., Seidman, J. G. & Vunjak-Novakovic, G. J Clin Invest 135 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39744939
Global alignment and local curvature of microtubules in mouse fibroblasts are robust against perturbations of vimentin and actin. Blob, A., Ventzke, D., Rolleke, U., Nies, G., Munk, A., Schaedel, L. & Koster, S. Soft Matter 21, 641-651 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39749806
Association of mental health in childhood, adolescence and young adulthood with cardiovascular risk factors and carotid remodeling below age 30 - results from the KiGGS cohort study. Buschges, J. C., Beyer, A. K., Schmidt-Trucksass, A., Berger, K. & Neuhauser, H. Eur J Epidemiol 40, 17-26 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39751700
Combined endurance and resistance exercise training in heart failure with preserved ejection fraction: a randomized controlled trial. Edelmann, F., Wachter, R., Duvinage, A., Mueller, S., Fegers-Wustrow, I., Schwarz, S., Christle, J. W., Pieske-Kraigher, E., Seyfarth, M., Knapp, M., Dorr, M., Nolte, K., Dungen, H. D., Herrmann-Lingen, C., Esefeld, K., Hagendorff, A., Haykowsky, M. J., Hasenfuss, G., Holzendorf, V., Prettin, C., Mende, M., Pieske, B. & Halle, M. Nat Med 31, 306-314 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39747684
Long non-coding RNAs direct the SWI/SNF complex to cell type-specific enhancers. Oo, J. A., Warwick, T., Palfi, K., Lam, F., McNicoll, F., Prieto-Garcia, C., Gunther, S., Cao, C., Zhou, Y., Gavrilov, A. A., Razin, S. V., Cabrera-Orefice, A., Wittig, I., Pullamsetti, S. S., Kurian, L., Gilsbach, R., Schulz, M. H., Dikic, I., Muller-McNicoll, M., Brandes, R. P. & Leisegang, M. S. Nat Commun 16, 131 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39747144
Coupling metabolomics and exome sequencing reveals graded effects of rare damaging heterozygous variants on gene function and human traits. Scherer, N., Fassler, D., Borisov, O., Cheng, Y., Schlosser, P., Wuttke, M., Haug, S., Li, Y., Telkamper, F., Patil, S., Meiselbach, H., Wong, C., Berger, U., Sekula, P., Hoppmann, A., Schultheiss, U. T., Mozaffari, S., Xi, Y., Graham, R., Schmidts, M., Kottgen, M., Oefner, P. J., Knauf, F., Eckardt, K. U., Grunert, S. C., Estrada, K., Thiele, I., Hertel, J. & Kottgen, A. Nat Genet 57, 193-205 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39747595
Risk scoring systems for early prediction of short-term mortality in resuscitated out-of-hospital cardiac arrest patients. Thevathasan, T., Landmesser, U., Freund, A., Poss, J., Skurk, C., Thiele, H. & Desch, S. Expert Rev Cardiovasc Ther 23, 5-13 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39750003
Intertwined destinies - Acute ischemic stroke and neurogenic stress cardiomyopathy. Kruska, M., Alonso, A., Akin, I. & Fastner, C. J Stroke Cerebrovasc Dis, 108222 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39753186
Thrombosis and Haemostasis 2024 Editors' Choice Papers. Weber, C., Rigby, A. & Lip, G. Y. H. Thromb Haemost 125, 85-91 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39753144
Aging oocytes: exploring apoptosis and its impact on embryonic development in common carp (Cyprinus carpio). Konar, E. S. M., Brachs, S., Mai, K., Waghmare, S. G., Policar, T., Samarin, A. M. & Samarin, A. M. J Anim Sci 103 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39761344
Brolucizumab and Platelet Activation and Reactivity. Sobolewska, B., Poeschel, S., Kalbacher, H., Bieber, K., Paczulla Stanger, A. M., Stellos, K. & Ziemssen, F. Curr Eye Res, 1-10 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39760267
A novel approach to modeling acute cardiac decompensation in rats. Thiele, A., Bartolomaeus, H., Anandakumar, H., Haase, N., Heuser, A., Muller, D. N., Dechend, R. & Wilck, N. Cardiovasc Res (2025). https://www.ncbi.nlm.nih.gov/pubmed/39760685
Clinical Outcomes According to the Extent of Atherosclerotic Disease in Female Patients Undergoing Transcatheter Aortic Valve Replacement: An Analysis From the WIN-TAVI Registry. Bay, B., Gitto, M., Sartori, S., Vogel, B., Tchetche, D., Petronio, A. S., Mehilli, J., Di Muro, F. M., Lefevre, T., Presbitero, P., Capranzano, P., Oliva, A., Iadanza, A., Leone, P. P., Sardella, G., van Mieghem, N. M., Kim, C. J., Meliga, E., Feng, Y., Dumonteil, N., Fraccaro, C., Trabattoni, D., Mikhail, G., Ferrer-Gracia, M. C., Naber, C., Sharma, S. K., Watanabe, Y., Morice, M. C., Dangas, G. D., Chieffo, A. & Mehran, R. Catheter Cardiovasc Interv (2025). https://www.ncbi.nlm.nih.gov/pubmed/39776285
Liver T1 mapping in Fontan patients and patients with biventricular congenital heart disease - insights into the effects of venous congestions on diffuse liver disease. Ide, Y., Gabbert, D. D., Hansen, J. H., Uebing, A. & Voges, I. Int J Cardiovasc Imaging 41, 347-358 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39776323
The High Stakes of High Decibels: The Cardiovascular Fallout From Aircraft Noise. Munzel, T., Kuntic, M., Stamm, P., Schmidt, F., Rajagopalan, S. & Daiber, A. J Am Coll Cardiol 85, 470-472 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39772366
Mechanisms and pharmacotherapy of cancer cachexia-associated anorexia. Sato, R., da Fonseca, G. W. P., das Neves, W. & von Haehling, S. Pharmacol Res Perspect 13, e70031 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39776294
A perfusion-independent high-throughput method to isolate liver sinusoidal endothelial cells. Babin-Ebell Goncalves, A., Mao, Y., Baljkas, T., Wiedmann, F., Eis, L., Pilz, F., Winkler, M., Kurschner-Zacharias, S. W., Hoffarth, M., Funaya, C., Shahidi, R., Geraud, C., Wu, C. C., Schmidt, C., Goerdt, S., Reiners-Koch, P. S. & Singhal, M. Commun Biol 8, 22 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39779980
Sepsis-induced NET formation requires MYD88 but is independent of GSDMD and PAD4. Englert, H., Rangaswamy, C., Kullik, G. A., Divivier, M., Gobel, J., Hermans-Borgmeyer, I., Borgmeyer, U., Mowen, K. A., Beerens, M., Frye, M., Mailer, R. K., Gelderblom, M., Stavrou, E. X., Preston, R. J. S., Schneider, S. W., Fuchs, T. A. & Renne, T. FASEB J 39, e70301 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39777764
Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression. Jin, Y. J., Liang, G., Li, R., Wang, S., Alnouri, M. W., Bentsen, M., Kuenne, C., Gunther, S., Yan, Y., Li, Y., Wettschureck, N. & Offermanns, S. Nat Cardiovasc Res 4, 180-196 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39779823
Cardiovascular MRI-derived Right Atrial Strain for Improved Risk Stratification in Patients with Severe Aortic Stenosis. Lange, T., Beuthner, B. E., Schulz, A., Backhaus, S. J., Evertz, R., Rigorth, K. R., Toischer, K., Kowallick, J. T., Hasenfuss, G., Puls, M. & Schuster, A. Radiol Cardiothorac Imaging 7, e230380 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39785675
The Role of Atrial Fibrillation and Oral Anticoagulation Status in Health-Related Quality of Life 12 Months After Ischemic Stroke or TIA. Olma, M. C., Steindorf-Sabath, L., Tutuncu, S., Kunze, C., Fiessler, C., Kirchhof, P., Dietzel, J., Schurig, J., Oschmann, P., Niehaus, L., Urbanek, C., Thomalla, G., Nabavi, D. G., Rother, J., Laufs, U., Veltkamp, R., Heuschmann, P. U., Haeusler, K. G., Endres, M. & Mon, D. I. Brain Behav 15, e70248 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39779216
Predictors and outcomes in patients undergoing surgery for acute type A aortic dissection requiring concomitant venoarterial extracorporeal membrane oxygenation support-a retrospective multicentre cohort study. Pitts, L., Gasser, S., Uzdenov, M., Gaisendrees, C., Bartkevics, M., Kreibich, M., Luehr, M., Kempfert, J., Schoenhoff, F., Falk, V. & Dumfarth, J. Eur J Cardiothorac Surg 67 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39786547
C-reactive protein levels and outcomes in infarct-related cardiogenic shock: data from the ECLS-SHOCK trial. Schupp, T., Thiele, H., Rassaf, T., Mahabadi, A. A., Lehmann, R., Eitel, I., Skurk, C., Clemmensen, P., Hennersdorf, M., Voigt, I., Linke, A., Tigges, E., Nordbeck, P., Jung, C., Lauten, P., Feistritzer, H. J., Buske, M., Poss, J., Ouarrak, T., Schneider, S., Behnes, M., Duerschmied, D., Desch, S., Freund, A., Zeymer, U. & Akin, I. Eur Heart J Acute Cardiovasc Care 14, 59-70 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39786552
Pyopericardium with cardiac tamponade caused by pyogenic liver abscess: a case report. Steffen, C., Sagmuller, J., Schoneburg, D., Goncz, E., Mockel, M., Ott, S., Ungur, A. L. & B, O. B. J Med Case Rep 19, 7 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39780178
Left atrial appendage occlusion: trends in demographics and in-hospital outcomes-a German nationwide analysis. Voran, J. C., Seoudy, H., Leye, M., Kolbrink, B., Schulte, K., Dempfle, A., Frank, D. & Kreidel, F. Clin Res Cardiol (2025). https://www.ncbi.nlm.nih.gov/pubmed/39777541
European Research Council-funded grant: programming the epicardium to cure broken hearts. Dorn, T. & Moretti, A. Eur Heart J (2025). https://www.ncbi.nlm.nih.gov/pubmed/39791536
Sex hormone-dependent host-microbiome interactions and cardiovascular risk (XCVD): design of a longitudinal multi-omics cohort study. Franz, K., Marko, L., Mahler, A., Chakaroun, R., Heinitz, S., Schlogl, H., Sacher, J., Steckhan, N., Dechend, R., Adams, N., Andersen, M., Glintborg, D., Viehweger, M., Bahr, L. S. & Forslund-Startceva, S. K. BMJ Open 15, e087982 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39788783
A new hypothesis to explain disease dominance. Juvik, B., Falcucci, L., Lundegaard, P. R. & Stainier, D. Y. R. Trends Genet (2025). https://www.ncbi.nlm.nih.gov/pubmed/39788833
Sonogenetics is a novel antiarrhythmic mechanism. Li, Y., Wang, X., Guo, J., Wang, Y., Zykov, V., Bodenschatz, E. & Gao, X. Chaos 35 (2025). www.ncbi.nlm.nih.gov/pubmed/39792701
Targeting P21-Activated Kinase 2 as a Novel Therapeutic Approach to Mitigate Endoplasmic Reticulum Stress in Heart Failure With Preserved Ejection Fraction. Zhang, H., Xu, H., Zhou, F., Azam, T., Samman, S., Binder, P., Nguyen, B., Cartwright, E. J., Muller, O. J., Hille, S. S., Pu, F., Green, D., Liu, Y., Zi, M. & Wang, X. J Am Heart Assoc 14, e035302 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39791428
Personalized management of tricuspid valve regurgitation. Lurz, P., Zancanaro, E. & Kresoja, K. P. Eur Heart J (2025). https://www.ncbi.nlm.nih.gov/pubmed/39797420
Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats. Steinfeldt, J., Wild, B., Buergel, T., Pietzner, M., Upmeier Zu Belzen, J., Vauvelle, A., Hegselmann, S., Denaxas, S., Hemingway, H., Langenberg, C., Landmesser, U., Deanfield, J. & Eils, R. Nat Commun 16, 585 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39794311
Large Variations in Phenylalanine Concentrations Associate Adverse Cardiac Remodelling in Adult Patients With Phenylketonuria-A Long-Term CMR Study. Tanacli, R., Doeblin, P., Faragli, A., Hassel, J. H., Stehning, C., Plockinger, U., Ziagaki, A. & Kelle, S. J Cachexia Sarcopenia Muscle 16, e13667 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39797500
Intestinal interstitial fluid isolation provides novel insight into the human host-microbiome interface. Avery, E. G., Haag, L. M., McParland, V., Kedziora, S. M., Zigra, G. J., Valdes, D. S., Kirchner, M., Popp, O., Geisberger, S., Nonn, O., Karlsen, T. V., N'Diaye, G., Yarritu, A., Bartolomaeus, H., Bartolomaeus, T. U. P., Tagiyeva, N. A., Wimmer, M. I., Haase, N., Zhang, Y. D., Wilhelm, A., Grutz, G., Tenstad, O., Wilck, N., Forslund, S. K., Klopfleisch, R., Kuhl, A. A., Atreya, R., Kempa, S., Mertins, P., Siegmund, B., Wiig, H. & Muller, D. N. Cardiovasc Res (2025). https://www.ncbi.nlm.nih.gov/pubmed/39804196
ADAMTS4-Specific MR Peptide Probe for the Assessment of Atherosclerotic Plaque Burden in a Mouse Model. Mangarova, D. B., Kaufmann, J. O., Brangsch, J., Kader, A., Mockel, J., Heyl, J. L., Verlemann, C., Adams, L. C., Ludwig, A., Reimann, C., Poller, W. C., Niehaus, P., Karst, U., Taupitz, M., Hamm, B., Weller, M. G. & Makowski, M. R. Invest Radiol (2025). https://www.ncbi.nlm.nih.gov/pubmed/39804796
Focusing on microvascular function in heart failure with preserved ejection fraction. Velollari, O., Rommel, K. P., Kresoja, K. P., Lurz, P. & Gori, T. Heart Fail Rev (2025). https://www.ncbi.nlm.nih.gov/pubmed/39804445
Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis. Cicuendez, B., Mora, A., Lopez, J. A., Curtabbi, A., Perez-Garcia, J., Porteiro, B., Jimenez-Blasco, D., Latorre-Muro, P., Vo, P., Jerome, M., Gomez-Santos, B., Romero-Becerra, R., Leiva, M., Rodriguez, E., Leon, M., Leiva-Vega, L., Gomez-Lado, N., Torres, J. L., Hernandez-Cosido, L., Aguiar, P., Marcos, M., Jastroch, M., Daiber, A., Aspichueta, P., Bolanos, J. P., Spinelli, J. B., Puigserver, P., Enriquez, J. A., Vazquez, J., Folgueira, C. & Sabio, G. Nat Commun 16, 229 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39805849
Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms. Fonseca, D. L. M., Japel, M., Gyamfi, M. A., Filgueiras, I. S., Baiochi, G. C., Ostrinski, Y., Halpert, G., Lavi, Y. B., Vojdani, E., Silva-Sousa, T., Usuda, J. N., JCS, E. S., Freire, P. P., Nobile, A. L., Adri, A. S., Barcelos, P. M., Correa, Y. L. G., do Vale, F. Y. N., Lopes, L. O., Schmidt, S. L., Wang, X., Vahldieck, C., Fels, B., Schimke, L. F., Cabral-Miranda, G., Hirata, M. H., TA, A. K., Yu, Y. A., Dalmolin, R. J., Amital, H., Vojdani, A., Dias, H. D., Nakaya, H., Ochs, H. D., Silverberg, J. I., Zimmerman, J., Zyskind, I., Rosenberg, A. Z., Schulze-Forster, K., Heidecke, H., Catar, R., Moll, G., Hackel, A., Kusche-Vihrog, K., Shoenfeld, Y., Riemekasten, G., Akbarzadeh, R., Marques, A. H. C. & Cabral-Marques, O. NPJ Syst Biol Appl 11, 7 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39805853
Explainable AI associates ECG aging effects with increased cardiovascular risk in a longitudinal population study. Hempel, P., Ribeiro, A. H., Vollmer, M., Bender, T., Dorr, M., Krefting, D. & Spicher, N. NPJ Digit Med 8, 25 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39806125
The non-canonical proteome: a novel contributor to cancer proliferation. Ruiz-Orera, J. & Hubner, N. Cell Res (2025). https://www.ncbi.nlm.nih.gov/pubmed/39806169
Asymptomatic Severe Aortic-Valve Stenosis - To Wait or Not to Wait. Blankenberg, S. N Engl J Med 392, 278-279 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39813648
Correction: Periodontitis and systemic inflammation as independent and interacting risk factors for mortality: evidence from a prospective cohort study. Pink, C., Holtfreter, B., Volzke, H., Nauck, M., Dorr, M. & Kocher, T. BMC Med23, 16 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39810226
Phenotypes linked to duplication upstream of SOX9: New insights into presentation and diagnosis. Unal, E., Tekmenuray-Unal, A., Cayir, A., Papatya Cakir, E. D., Beyazit, N., Kolbasi, B., Gurpinar Tosun, B., Yigit, G., Zibat, A., Wollnik, B., Demirbilek, H. & Guran, T. J Clin Endocrinol Metab (2025). https://www.ncbi.nlm.nih.gov/pubmed/39812180
Clinical Characteristics and Outcomes of Patients Undergoing 3 Aortic Valve Interventions: The THIRD Multicenter Registry. Tarantini, G., Tang, G. H. L., Pilgrim, T., Kim, W. K., Greenbaum, A., Castriota, F., Webb, J. G., Nombela Franco, L., De Backer, O., Hartikainen, T., Codner, P., Koren, O., Patel, V., Meier, D., Tomii, D., Ueyama, H. A., Paredes-Vazquez, J. G., Arturi, F., Kornowski, R., Makkar, R. R., Cardaioli, F., Nai Fovino, L. & Investigators, T. R. JACC Cardiovasc Interv 18, 103-115 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39814484
Cardiopulmonary exercise testing as a prognosis-assessing tool in heart failure with preserved ejection fraction. da Conceicao, C. R., Krannich, A., Zach, V., Pinto, R., Deichl, A., Feuerstein, A., Schleussner, L. & Edelmann, F. ESC Heart Fail (2025). https://www.ncbi.nlm.nih.gov/pubmed/39823134
Incidence and predictors of weaning failure from veno-arterial extracorporeal membrane oxygenation therapy in patients with cardiogenic shock. Dettling, A., Kellner, C., Sundermeyer, J., Beer, B. N., Besch, L., Bertoldi, L. F., Blankenberg, S., Dauw, J., Eckner, D., Eitel, I., Graf, T., Horn, P., Jozwiak-Nozdrzykowska, J., Kirchhof, P., Kluge, S., Krais, J., von Lewinski, D., Linke, A., Luedike, P., Lusebrink, E., Nordbeck, P., Pappalardo, F., Pauschinger, M., Proudfoot, A., Rassaf, T., Reichenspurner, H., Sag, C. M., Scherer, C., Schulze, P. C., Schwinger, R. H. G., Skurk, C., Sramko, M., Tavazzi, G., Thiele, H., Morici, N., Winzer, E. B., Westermann, D., Schrage, B. & Mangner, N. Eur J Heart Fail (2025). https://www.ncbi.nlm.nih.gov/pubmed/39823252
App-Based Coaching to Prevent Addictive Behaviors in Vocational School Students: A Cluster Randomized Trial. Guertler, D., Schmidt, H., Neumann, M., Brandt, D., Dreissigacker, A., Blasing, D., Mohring, A., Meyer, C., Bischof, A., Bischof, G., Surig, S., Rehbein, F., Hohls, L., Borgwardt, S., Wurm, S., Haug, S. & Rumpf, H. J. J Adolesc Health 76, 499-508 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39818651
Gut-derived metabolites as treatment targets in chronic kidney disease-an avenue toward personalized medicine. Holle, J. & Bartolomaeus, H. Pediatr Nephrol (2025). https://www.ncbi.nlm.nih.gov/pubmed/39820506
Occupational exposures and coronary heart disease in the Hamburg City Health Study (HCHS) - a cross-sectional study. Labe, F., Twerenbold, R., Toprak, B., Koch, P., Zyriax, B. C., Affolderbach, S., Damerau, L., Hoven, H., Zeeb, H., Herold, R. & Harth, V. BMC Public Health 25, 180 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39819445
Efficacy and safety of finerenone in patients with chronic kidney disease and type 2 diabetes by diuretic use: A FIDELITY analysis. Mentz, R. J., Anker, S. D., Pitt, B., Rossing, P., Ruilope, L. M., Gebel, M., Kolkhof, P., Lawatscheck, R., Rohwedder, K., Bakris, G. L., on behalf of the, F.-D. & Investigators, F.-D. Eur J Heart Fail (2025). https://www.ncbi.nlm.nih.gov/pubmed/39823276
Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy. Raj Murthi, S., Petry, A., Shashikadze, B., Stockl, J. B., Schmid, M., Santamaria, G., Klingel, K., Kracun, D., Chen, X., Bauer, S., Schmitt, J. P., Flenkenthaler, F., Gorham, J., Toepfer, C. N., Potesil, D., Hruska, P., Zdrahal, Z., Mayer, Z., Klop, M., Lehmann, L., Qin, Y., Papanakli, L., Spielmann, N., Moretti, A., Frohlich, T., Ewert, P., Holdenrieder, S., Seidman, J. G., Seidman, C. E., Gorlach, A. & Wolf, C. M. Sci Rep 15, 2132 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39820339
Long-term pulse pressure trajectories and risk of incident atrial fibrillation: the Tromso Study. Sharashova, E., Gerdts, E., Ball, J., Schnabel, R. B., Stylidis, M., Tiwari, S., Mathiesen, E. B., Wilsgaard, T. & Lochen, M. L. Eur Heart J (2025). https://www.ncbi.nlm.nih.gov/pubmed/39820670
Rationale and design of the HERZCHECK trial: Detection of early heart failure using telemedicine and cardiovascular magnetic resonance in structurally weak regions (NCT05122793). Kelle, S., Nolden, A. C., Muller, M. L., Beyer, R. E., Steen, H., Remppis, B. A., Wieditz, J., Kentenich, H., Tuit, A., Cvetkovic, M., Witt, U. E., Andre, F., Schmidt, S., Huppertz, A., Simic, D., Muller, D., Shukri, A., Issing, M., Glardon, A., Reber, K. C., Landmesser, U., Frey, N., Pieske, B., Stock, S., Falk, V., Friede, T. & Thiede, G. J Cardiovasc Magn Reson 27, 101841 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39824461
Outcome and complications in postcardiotomy cardiogenic shock treated with extracorporeal life support - a systematic review and meta-analysis. Kienlein, R. M., Trauzeddel, R. F., Akbari, N., Avalli, L., Biancari, F., Dini, C. S., Guenther, S., Hagl, C., Heringlake, M., Kruppa, J., Makikallio, T., Martins, R., de Chambrun, M. P., Rastan, A. J., Rubino, A., van den Brink, F., Nordine, M. & Treskatsch, S. BMC Anesthesiol 25, 29 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39825250
Haplotype Phasing of Biallelic WNT10B Variants Using Long-Read Sequencing in Split-Hand/Foot Malformation Syndrome. Pozojevic, J., Kakar, N., Sczakiel, H. L., Kruse, N., Handler, K., Balachandran, S., Sreenivasan, V., Mensah, M. A. & Spielmann, M. Clin Genet (2025). https://www.ncbi.nlm.nih.gov/pubmed/39825730
Repeat Procedures After Pulsed Field Ablation for Atrial Fibrillation: MANIFEST-REDO Study. Scherr, D., Turagam, M. K., Maury, P., Blaauw, Y., van der Voort, P., Neuzil, P., Reichlin, T., Metzner, A., Vijgen, J., Kautzner, J., Boveda, S., Anic, A., Hansen, J., Manninger, M., Sommer, P., Anselme, F., Willems, S., Deneke, T., Tilz, R., Steven, D., Wakili, R., Jais, P., Funasako, M., Arentz, T., Rollin, A., Mulder, B. A., Ouss, A., Petru, J., Kueffer, T., Lemoine, M. D., Koopman, P., Peichl, P., Adelino, R., Jurisic, Z., Ruwald, M., Eberl, A. S., Sohns, C., Savoure, A., Nentwich, K., Gunawardene, M., Heeger, C. H., Sultan, A., Bohnen, J. E., Kupusovic, J., Derval, N., Lehrmann, H., Ekanem, E. & Reddy, V. Y. Europace (2025). https://www.ncbi.nlm.nih.gov/pubmed/39824172
Author Correction: Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precision. Vromman, M., Anckaert, J., Bortoluzzi, S., Buratin, A., Chen, C. Y., Chu, Q., Chuang, T. J., Dehghannasiri, R., Dieterich, C., Dong, X., Flicek, P., Gaffo, E., Gu, W., He, C., Hoffmann, S., Izuogu, O., Jackson, M. S., Jakobi, T., Lai, E. C., Nuytens, J., Salzman, J., Santibanez-Koref, M., Stadler, P., Thas, O., Vanden Eynde, E., Verniers, K., Wen, G., Westholm, J., Yang, L., Ye, C. Y., Yigit, N., Yuan, G. H., Zhang, J., Zhao, F., Vandesompele, J. & Volders, P. J. Nat Methods 22, 448 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39825083
Accuracy of Established Prognostic Staging Systems for Cardiac Transthyretin Amyloidosis in the Tafamidis Era. Muller, M. L., Spethmann, S., Messroghli, D., Brand, A., Mattig, I., Hahn, K., Landmesser, U. & Heidecker, B. JACC Adv 4, 101568 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39826440
Divergent endothelial mechanisms drive arteriovenous malformations in Alk1 and SMAD4 loss-of-function. Oppenheim, O., Giese, W., Park, H., Baumann, E., Ivanov, A., Beule, D., Eichmann, A. & Gerhardt, H. bioRxiv (2025). https://www.ncbi.nlm.nih.gov/pubmed/39829872
Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study. Lai, L., Juntilla, D. L., Del, M., Del, C. G.-A. M., Grallert, H., Thorand, B., Farzeen, A., Rathmann, W., Winkelmann, J., Prokisch, H., Gieger, C., Herder, C., Peters, A. & Waldenberger, M. Cardiovasc Diabetol 24, 19 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39827095
Frailty impacts all-cause mortality after endovascular abdominal aortic aneurysm repair: a retrospective cohort study. Wang, Y. X., Zhao, W. X., Wang, Z. M., Zhao, N., Li, Z. L., Wu, Z. Y., Diao, Y. P. & Li, Y. J. J Nutr Health Aging 29, 100489 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39827699
Short Report - Birth Weight is Not Associated With Cataracts or Pseudophakia - Results from the Gutenberg Health Study. Fiess, A., Gissler, S., Grabitz, S., Wild, P. S., Lackner, K. J., Beutel, M. E., Urschitz, M. S., Tuscher, O., Munzel, T., Schattenberg, J. M., Konstantinides, S. V., Pfeiffer, N. & Schuster, A. K. Clin Ophthalmol 19, 153-156 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39834533
Time trends of catheter-directed treatment in acute pulmonary embolism in Germany. Keller, K., Schmidt, F. P., Farmakis, I. T., Barco, S., Fengler, K., Knorr, M., Gori, T., Munzel, T., Lurz, P. & Hobohm, L. Res Pract Thromb Haemost 9, 102651 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39834528
Risk factors for non-benefit of implantable cardioverter defibrillator therapy. Kreimer, F., Lewenhardt, M., El-Battrawy, I., Haghikia, A. & Gotzmann, M. Sci Rep 15, 2480 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39833338
Editorial: Insights in cardiovascular and smooth muscle pharmacology: 2023. Schildt, S., Reichart, D. & Lebek, S. Front Pharmacol 15, 1544594 (2024). https://www.ncbi.nlm.nih.gov/pubmed/39834824
Electrocoagulation-free strategy in minimally invasive direct coronary artery bypass with hybrid revascularisation - a case report. Schuering, C. L., Wert, L., von Mackensen, J. K. R., Zwaans, V. I. T., Kaemmel, J., Heck, R., Starck, C. T., Kempfert, J., Jacobs, S., Falk, V. & Al, A. A. E. J Cardiothorac Surg 20, 73 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39833866
The DIGIT-HF trial: Key amendments of study design. Bavendiek, U., Berliner, D., Thomas, N. H., Liu, X., Schwab, J., Rieth, A., Maier, L. S., Schallhorn, S., Angelini, E., Rathje, F., Sandu, M. A., Geller, W., Gaspar, T., Hambrecht, R., Zdravkovic, M., Philipp, S., Kosevic, D., Nickenig, G., Scheiber, D., Winkler, S., Becher, P. M., Lurz, P., Hulsmann, M., Schroder, C., Seltmann, A., von der Leyen, H., Veltmann, C., Stork, S., Bohm, M., Koch, A. & Bauersachs, J. Eur J Heart Fail (2025). https://www.ncbi.nlm.nih.gov/pubmed/39838553
The deubiquitinase USP5 prevents accumulation of protein aggregates in cardiomyocytes. Eibach, Y., Kreher, S., Poetsch, M. S., Kho, A. L., Gaertner, U., Clemen, C. S., Schroder, R., Guo, K., Milting, H., Meder, B., Potente, M., Richter, M., Schneider, A., Meiners, S., Gautel, M. & Braun, T. Sci Adv 11, eado3852 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39841822
Exposomic Determinants of Atherosclerosis: Recent Evidence. Hahad, O., Sagheer, U., Nasir, K., Kuntic, M., Daiber, A., Navas-Acien, A., Chen, K., Rajagopalan, S. & Al-Kindi, S. Curr Atheroscler Rep 27, 28 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39841313
Perinatal dysfunction of innate immunity in cystic fibrosis. Jaudas, F., Bartenschlager, F., Shashikadze, B., Santamaria, G., Reichart, D., Schnell, A., Stockl, J. B., Degroote, R. L., Cambra, J. M., Graeber, S. Y., Bahr, A., Kartmann, H., Stefanska, M., Liu, H., Naumann-Bartsch, N., Bruns, H., Berges, J., Hanselmann, L., Stirm, M., Krebs, S., Deeg, C. A., Blum, H., Schulz, C., Zawada, D., Janda, M., Caballero-Posadas, I., Kunzelmann, K., Moretti, A., Laugwitz, K. L., Kupatt, C., Saalmuller, A., Frohlich, T., Wolf, E., Mall, M. A., Mundhenk, L., Gerner, W. & Klymiuk, N. Sci Transl Med 17, eadk9145 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39841805
Deep Learning-Enabled Assessment of Right Ventricular Function Improves Prognostication After Transcatheter Edge-to-Edge Repair for Mitral Regurgitation. Lachmann, M., Fortmeier, V., Stolz, L., Tokodi, M., Kovacs, A., Hesse, A., Leipert, A., Rippen, E., Alvarez Covarrubias, H. A., von Scheidt, M., Tervooren, J., Roski, F., Fett, M., Gercek, M., Schuster, T., Harmsen, G., Yuasa, S., Mayr, N. P., Kastrati, A., Schunkert, H., Joner, M., Xhepa, E., Laugwitz, K. L., Hausleiter, J., Rudolph, V. & Trenkwalder, T. Circ Cardiovasc Imaging 18, e017005 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39836730
Clinical characteristics and BGA-optimized pretest probability of pulmonary embolism in the elderly. Patz, T., Gruber, K., Kupp, S., Schmidtke, G. M., Furschke, A., Sayk, F., Stiermaier, T., Eitel, I., Wolfrum, S. & Meusel, M. Med Klin Intensivmed Notfmed (2025). https://www.ncbi.nlm.nih.gov/pubmed/39841193
FFR-Negative Nonculprit High-Risk Plaques and Clinical Outcomes in High-Risk Populations: An Individual Patient-Data Pooled Analysis From COMBINE (OCT-FFR) and PECTUS-obs. Volleberg, R., Rroku, A., Mol, J. Q., Hermanides, R. S., van Leeuwen, M., Berta, B., Meuwissen, M., Alfonso, F., Wojakowski, W., Belkacemi, A., Roleder, T., Kedhi, E., van Royen, N., Combine & investigators, P. E.-o. Circ Cardiovasc Interv 18, e014667 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39840429
Elevated Neutrophil-to-Lymphocyte Ratio Predicts Prognosis in Acute Myocarditis. Cannata, A., Segev, A., Madaudo, C., Bobbio, E., Baggio, C., Schutze, J., Gentile, P., Sanguineti, M., Monzo, L., Schettino, M., Ferone, E., Elshanoury, A., Younis, A., Palazzini, M., Ferroni, A., Giani, V., Sadler, M., Di Lisi, D., Albarjas, M., Calo, L., Sado, D., Polte, C. L., Garascia, A., Scott, P. A., Shah, A. M., Giacca, M., Sinagra, G., Bollano, E., McDonagh, T., Tschope, C., Novo, G., Ammirati, E., Beigel, R., Grani, C., Merlo, M., Ameri, P. & Bromage, D. I. JACC Heart Fail (2025). https://www.ncbi.nlm.nih.gov/pubmed/39846908
BMAL1 is a Critical Regulator of Sex-Specific Gene Expression in the Heart. Dierickx, P. Function (Oxf) 6 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39844341
Artificial intelligence-based, non-invasive assessment of the central aortic pressure in adults after operative or interventional treatment of aortic coarctation. Freilinger, S., Bambul Heck, P., Dewald, O., Eicken, A., Ewert, P., Freiberger, A., Harig, F., Huntgeburth, M., Losch, M., Kaemmerer, H., Klawonn, F., Meierhofer, C., Mellert, F., Middeke, M., Nagdyman, N., Oberhoffer, R., von Scheidt, F., Ury, E., Wolfrum, N., Kaemmerer-Suleiman, A. S. & Suleiman, M. N. Open Heart12 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39842936
Differential effects of sound interventions tuned to 432 Hz or 443 Hz on cardiovascular parameters in cancer patients: a randomized cross-over trial. Hohneck, A., Rodriguez, A. M., Weingartner, S., Merx, K., Sarodnick, F., von Gagern, F., Mavratzas, A., Burkholder, I., Schumacher, G., Hofmann, W. K. & Hofheinz, R. D. BMC Complement Med Ther 25, 18 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39844155
Lateral Atrial Expression Patterns Provide Insights into Local Transcription Disequilibrium Contributing to Disease Susceptibility. Isaacs, A., Zeemering, S., Winters, J., Batlle, M., Bidar, E., Boukens, B., Casadei, B., Chua, W., Crijns, H., Fabritz, L., Guasch, E., Hatem, S. N., Hermans, B., Kaab, S., Kawczynski, M., Maesen, B., Maessen, J., Mont, L., Sinner, M. F., Wakili, R., Verheule, S., Kirchhof, P., Schotten, U. & Stoll, M. Circ Genom Precis Med 18, e004594 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39846178
Anonymize or synthesize? Privacy-preserving methods for heart failure score analytics. Johann, T. I., Otte, K., Prasser, F. & Dieterich, C. Eur Heart J Digit Health 6, 147-154 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39846076
Evaluating pulmonary stenosis and regurgitation impact on cardiac strain and strain rate in a porcine model via magnetic resonance feature tracking. Rosel, S. F., Backhaus, S. J., Lange, T., Schulz, A., Kowallick, J. T., Gowda, K., Treiber, J., Rolf, A., Sossalla, S. T., Hasenfuss, G., Kutty, S. & Schuster, A. Int J Cardiovasc Imaging 41, 257-268 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39843561
Altered retinal vasculature in childhood cancer survivors: Data from the German CVSS-study. Schuster, A. K., Voigt, A. M., Jager, T., Nickels, S., Schulz, A., Faber, J., Wingerter, A., Merzenich, H., Schmidtmann, I., Beutel, M. E., Munzel, T., Lackner, K. J., Pfeiffer, N. & Wild, P. S. Acta Ophthalmol (2025). https://www.ncbi.nlm.nih.gov/pubmed/39846480
Autograft dilation after Ross procedure in children and young adults is mitigated by autograft reinforcement: A retrospective MRI study. Seiler, R., Stenzel, R., Weixler, V., Muiznieks, M., Gurtner, M., Berger, F., Kuhne, T., Cho, M. Y., Photiadis, J., Kelm, M. & Murin, P. Sci Rep 15, 2813 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39843611
The Legacy of ECPR - Bridging the Past, Shaping the Present, Defining the Future. Thevathasan, T., Hassager, C., Bartos, J., van de Poll, M. & Poss, J. Eur Heart J Acute Cardiovasc Care (2025). https://www.ncbi.nlm.nih.gov/pubmed/39842876
Simplified Outcome Prediction in Patients Undergoing Transcatheter Tricuspid Valve Intervention by Survival Tree-Based Modelling. Fortmeier, V., Lachmann, M., Stolz, L., von Stein, J., Rommel, K. P., Kassar, M., Gercek, M., Schober, A. R., Stocker, T. J., Omran, H., Fett, M., Tervooren, J., Korber, M. I., Hesse, A., Harmsen, G., Friedrichs, K. P., Yuasa, S., Rudolph, T. K., Joner, M., Pfister, R., Baldus, S., Laugwitz, K. L., Windecker, S., Praz, F., Lurz, P., Hausleiter, J. & Rudolph, V. JACC Adv 4, 101575 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39848099
Mechanistic insights into HPV-positivity in non-smokers and HPV-negativity in smokers with head and neck cancer. Hoffmann, M., Hille, S., Fazel, A., Laudien, M., Wiegand, S., Muller, M., Muller, O. J. & Quabius, E. S. Front Oncol 14, 1484319 (2024). https://www.ncbi.nlm.nih.gov/pubmed/39850816
Directed Evolution of AAV9 for Efficient Gene Expression in Cardiomyocytes In Vitro and In Vivo. Huttermann, L., Schroder, L. C., Shetty, P. M. V., Jonker, T., Hille, S. S., Kliesow Remes, A., Matzen, A., Boender, A. R., Grimm, D., Frank, D., Boink, G. J. J., Eschenhagen, T., Schade, D. & Muller, O. J. Hum Gene Ther 36, 101-115 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39850991
Adapting and Implementing a Blended Collaborative Care Intervention for Older Adults with Multimorbidity: Quantitative and Qualitative Results from the ESCAPE Pilot Study. Schulze, J., Luhmann, D., Nagel, J., Regner, C., Zelenak, C., Bersch, K., Herrmann-Lingen, C., Burg, M. M., Herbeck-Belnap, B. & Consortium, E. Behav Sci (Basel) 15 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39851883
Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2. Buttari, B., Tramutola, A., Rojo, A. I., Chondrogianni, N., Saha, S., Berry, A., Giona, L., Miranda, J. P., Profumo, E., Davinelli, S., Daiber, A., Cuadrado, A. & Di Domenico, F. Biomolecules 15 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39858508
Analysis of Calcium Patterns in the Thoracic Aorta and Clinical Outcomes of TAVR Patients Presenting with Porcelain Aorta. Campanella, C., Voss, S., Schreyer, J., Puluca, N., Amabile, A., Wirth, F., Krane, M. & Ruge, H. J Clin Med 14 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39860509
Interventions by Cardiovascular Drugs Against Aircraft Noise-Induced Cardiovascular Oxidative Stress and Damage. Kuntic, M., Kuntic, I., Zheng, J., Nardi, L., Oelze, M., Valar, A., Mihalikova, D., Strohm, L., Ubbens, H., Tang, Q., Zhang, L., Horta, G., Stamm, P., Hahad, O., Krueger-Burg, D., Li, H., Steven, S., Gericke, A., Schmeisser, M. J., Munzel, T. & Daiber, A. Antioxidants (Basel) 14 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39857393
Composite cardiac computed tomography angiography score for improved risk assessment in chronic coronary syndromes. Lee, S., Giesen, A., Mouselimis, D., Weichsel, L., Giannopoulos, A. A., Nunninger, M., Renker, M., Andre, F., Frey, N. & Korosoglou, G. Sci Rep15, 3089 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39856114
Diurnal timing of physical activity in relation to obesity and diabetes in the German National Cohort (NAKO). Stein, M. J., Weber, A., Bamberg, F., Baurecht, H., Berger, K., Bohmann, P., Brenner, H., Brummer, J., Dorr, M., Fischer, B., Gastell, S., Greiser, K. H., Harth, V., Hebestreit, A., Heise, J. K., Herbolsheimer, F., Ittermann, T., Karch, A., Keil, T., Kluttig, A., Krist, L., Michels, K. B., Mikolajczyk, R., Nauck, M., Nimptsch, K., Obi, N., Pischon, T., Pivovarova-Ramich, O., Schikowski, T., Schmidt, B., Schulze, M. B., Steindorf, K., Zylla, S. & Leitzmann, M. F. Int J Obes (Lond) (2025). https://www.ncbi.nlm.nih.gov/pubmed/39856244
Risk Stratification of QTc Prolongations in Hospitalized Cardiology and Gastroenterology Patients Using the Tisdale Score-A Retrospective Analysis. Steinbrech, J., Amann, U., Irlbeck, M., Clauss, S. & Strobach, D. J Clin Med 14 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39860345
Revealing microRNA regulation in single cells. Maji, R. K., Leisegang, M. S., Boon, R. A. & Schulz, M. H. Trends Genet (2025). https://www.ncbi.nlm.nih.gov/pubmed/39863489
Anticoagulation for patients with device-detected atrial fibrillation and a history of stroke. Sposato, L. A. & Wachter, R. Lancet Neurol 24, 92-94 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39862889
A novel uORF regulates folliculin to promote cell growth and lysosomal biogenesis during cardiac stress. Bencun, M., Spreyer, L., Boileau, E., Eschenbach, J., Frey, N., Dieterich, C. & Volkers, M. Sci Rep 15, 3319 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39865126
Two-pore channel regulators - Who is in control? Deutsch, R., Kudrina, V., Freichel, M. & Grimm, C. Front Physiol 15, 1534071 (2024). https://www.ncbi.nlm.nih.gov/pubmed/39867224
Myocardial Inflammation in Cardiac Transthyretin Amyloidosis: Prevalence and Potential Prognostic Implications. Muller, M. L., Brand, A., Mattig, I., Spethmann, S., Messroghli, D., Hahn, K., Violano, M., Mitchell, J. D., Hare, J. M., Frustaci, A., Klingel, K., Luscher, T. F., Landmesser, U. & Heidecker, B. Circ Heart Fail 18, e012146 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39866106
Renal damage-induced hepcidin accumulation contributes to anemia in angiotensinogen-deficient mice. Rodrigues, A. F., Boreggio, L., Lahuta, T., Qadri, F., Alenina, N., Barros, C. C., Todiras, M. & Bader, M. Clin Sci (Lond) 139 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39869503
Strength of Genetic Associations with Thyrotropin Values Differs Between Populations with Similarity to African and European Reference Populations. Wade, A. N., Guare, L., Hayat, M., Straub, P., Gao, Z., Medici, M., Teumer, A., Davis, L. K., Ramsay, M., Ritchie, M. D., BioBank, P. M. & Cappola, A. R. Thyroid 35, 131-142 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39869013
Clinical impact of inappropriate DOAC dosing in atrial fibrillation: Insights from a real-world registry. Yildirim, M., Hund, H., Mueller-Hennessen, M., Katus, H. A., Frey, N., Giannitsis, E. & Salbach, C. Int J Cardiol Heart Vasc 56, 101598 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39867851
The European Registry for Patients with Mechanical Circulatory Support (EUROMACS) of the European Association for Cardio-Thoracic Surgery Fourth report: Focus on standardized outcome ratios. Veen, K. M., Ahmed, M., Stark, C., Botta, L., Anastasiadis, K., Bernhardt, A., Berchtold-Herz, M., Caliskan, K., Reineke, D., Damman, K., Fiane, A., Gkouziouta, A., Gollmann-Tepekoylu, C., Najjar, E., Hulman, M., Iacovoni, A., Loforte, A., Merkely, B., Musumeci, F., Comisso, M., Nemec, P., Netuka, I., Ozbaran, M., Potapov, E., Pya, Y., Rabago, G., Ramjankhan, F., Scandroglio, A. M., Pieri, M., Reichenspurner, H., Dashkevich, A., Stockman, B., Vanderheyden, M., Tops, L., Wahlers, T., Przybylowski, P., Zimpfer, D., Logstrup, B. B., Santer, D., Farber, G., Gummert, J., Meyns, B., de By, T. & Schoenrath, F. Eur J Cardiothorac Surg (2025). https://www.ncbi.nlm.nih.gov/pubmed/39874447
Rationale and design of the FAIR-HF2-DZHK05 trial: Ferric carboxymaltose assessment of morbidity and mortality in patients with iron deficiency and chronic heart failure. Anker, S. D., Friede, T., Butler, J., Talha, K. M., Diek, M., Nosko, A., Placzek, M., Hasenfuss, G., Ponikowski, P. & Karakas, M. Eur J Heart Fail (2025). https://www.ncbi.nlm.nih.gov/pubmed/39876699
Heart Failure in Atrial Fibrillation Subtypes in Women and Men in the Tromso Study. Espnes, H., Wilsgaard, T., Ball, J., Lochen, M. L., Njolstad, I., Schnabel, R. B., Gerdts, E. & Sharashova, E. JACC Adv 4, 101556 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39877667
Steatohepatitis-induced vascular niche alterations promote melanoma metastasis. Hoffmann, J., Schuler, J., Dietsch, B., Kurschner-Zacharias, S. W., Sticht, C., Trogisch, F. A., Schreitmuller, M., Baljkas, T., Schledzewski, K., Reinhart, M., Wohlfeil, S. A., Winkler, M., Schmid, C. D., Heineke, J., Geraud, C., Goerdt, S., Reiners-Koch, P. S. & Olsavszky, V. Cancer Metab 13, 5 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39875968
A 39-year-old women with newly diagnosed ALCAPA syndrome during pregnancy. Stolz, L., Schneider, J. J., Haum, M., Estner, H., Hausleiter, J., Massberg, S. & Thienel, M. Clin Res Cardiol (2025). https://www.ncbi.nlm.nih.gov/pubmed/39878852
Association of Year-to-Year Lipid Variability With Risk of Cognitive Decline and Dementia in Community-Dwelling Older Adults. Zhou, Z., Moran, C., Murray, A. M., Zoungas, S., Magnussen, C., Chong, T. T., Shah, R. C., Sheets, K. M., Nelson, M., Zhu, C., Tonkin, A. M., Talic, S., Ernst, M. E., Orchard, S. G., McNeil, J. J., Wolfe, R., Woods, R. L., Neumann, J. T., Qiu, P. & Ryan, J. Neurology104, e210247 (2025). https://www.ncbi.nlm.nih.gov/pubmed/39879572
A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis. Asare, Y., Yan, G., Schlegl, C., Prestel, M., van der Vorst, E. P. C., Teunissen, A. J. P., Aronova, A., Tosato, F., Naser, N., Caputo, J., Prevot, G., Azzun, A., Wefers, B., Wurst, W., Schneider, M., Forne, I., Bidzhekov, K., Naumann, R., van der Laan, S. W., Brandhofer, M., Cao, J., Roth, S., Malik, R., Tiedt, S., Mulder, W. J. M., Imhof, A., Liesz, A., Weber, C., Bernhagen, J. & Dichgans, M. Immunity (2025). https://www.ncbi.nlm.nih.gov/pubmed/39879983
Engineered heart muscle allografts for heart repair in primates and humans. Jebran, A. F., Seidler, T., Tiburcy, M., Daskalaki, M., Kutschka, I., Fujita, B., Ensminger, S., Bremmer, F., Moussavi, A., Yang, H., Qin, X., Missbach, S., Drummer, C., Baraki, H., Boretius, S., Hasenauer, C., Nette, T., Kowallick, J., Ritter, C. O., Lotz, J., Didie, M., Mietsch, M., Meyer, T., Kensah, G., Kruger, D., Sakib, M. S., Kaurani, L., Fischer, A., Dressel, R., Rodriguez-Polo, I., Stauske, M., Diecke, S., Maetz-Rensing, K., Gruber-Dujardin, E., Bleyer, M., Petersen, B., Roos, C., Zhang, L., Walter, L., Kaulfuss, S., Yigit, G., Wollnik, B., Levent, E., Roshani, B., Stahl-Henning, C., Strobel, P., Legler, T., Riggert, J., Hellenkamp, K., Voigt, J. U., Hasenfuss, G., Hinkel, R., Wu, J. C., Behr, R. & Zimmermann, W. H. Nature (2025). https://www.ncbi.nlm.nih.gov/pubmed/39880949
Comparative phenotyping of C57BL/6J substrains reveals distinctive patterns of cardiac aging. Walter, S., Baumgarten, P., Hegemann, N., Haseli, S. P., Deubel, S., Jelleschitz, J., Hohn, A., Berndt, N., Kuebler, W. M., Grune, J. & Ott, C. Geroscience (2025). https://www.ncbi.nlm.nih.gov/pubmed/39885113
