Proteomic exploration of disease mechanisms related to the novel biomarker CCN1 for prediction of death in patients with dilated cardiomyopathy

We have identified CCN1 as a novel circulating biomarker in cardiovascular patients with Acute Coronary Syndromes and patients with Dilated Cardiomyopathy. In both clinical settings, CCN1 constitutes an independent prognostic biomarker to predict death. We now aim to replicate our findings on the prognostic value of CCN1 in a validation cohort from the DZHK Heart Bank. To gain novel insights into what disease process this biomarker reflects and how this impacts mortality, we aim to perform a comprehensive analysis of the proteins involved. Detailed insights into the pathophysiology are a prerequisite to identify potential targets amenable to future therapies.

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