The majority of patients with obesity develop type 2 diabetes. This study shows that insulin resistance in obesity arises not only in classic metabolic organs, but is also decisively mediated by the vascular endothelium. Treating mice with adrenomedullin mimicked the effect of obesity and induced endothelial and systemic insulin resistance. Endothelial loss or blockade of the adrenomedullin receptor improved obesity-induced insulin resistance. These findings identify a mechanism underlying obesity-induced systemic insulin resistance and suggest approaches to treat obesity-associated type 2 diabetes.
Link to the Publication: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes (Cho et al., Science, 2025)
