Translational Research Projects

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SMASH Splice Modulation Approach to suppress HFpEF

SMASH Splice Modulation Approach to suppress HFpEF

Targeted inhibition of the titin splice factor RBM20 using antisense oligonucleotides (ASOs) offers a novel approach for treating heart failure with preserved ejection fraction (HFpEF) and is being advanced through preclinical studies.

Principal Investigators Michael Gotthardt, Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft; Alessio Alogna, Deutsches Herzzentrum der Charité
Project status