Immunocardiology
Inflammation plays a decisive role in many cardiovascular diseases, yet there are still very few targeted therapies available. This focus area investigates immune system mechanisms and develops strategies to identify and therapeutically influence misguided processes.
Why this area matters
Whether heart attack, heart failure, or arrhythmias, inflammatory processes often make a significant contribution to the onset and progression of disease. Current treatments, however, target these mechanisms only unspecifically, which makes both efficacy and side effects difficult to control. A better understanding of immune responses is therefore a prerequisite for new, targeted therapies.
Our research approach
We investigate how immune cells, signalling pathways, and inflammatory mediators impact the heart and blood vessels. Molecular analyses are combined with clinical data to identify disease-specific patterns. The goal is to pinpoint patient subgroups that could particularly benefit from immunomodulatory treatments.
In parallel, we develop models that realistically replicate immune reactions in the heart. These models enable the testing of promising drug candidates before they enter clinical trials. In this way, we lay the foundation for therapies that act with greater precision without weakening the body’s defences.
Spokespersons
- Florian Leuschner, Heidelberg/Mannheim
- Konstantin Stark, Munich
- Tanja Zeller, North
Are you conducting research within or outside the DZHK and would like to connect with this focus area? Please contact: