Prof. Dr. Eike Nagel
Research areas: cardiology, cardiac imaging, cardiovascular disease, magnetic resonance imaging, translational research
Eike Nagel is DZHK Professor for Cardiology and director of the DZHK Centre for Cardiovascular Imaging in Frankfurt. He is one of the founding members and Past President of the Society for Cardiovascular Magnetic Resonance (SCMR), lead of the Institute for Experimental and Translational Cardiovascular Imaging and the Interdisciplinary Cardiovascular Imaging Service and Consultant Cardiologist in the Departments of Cardiology and Radiology at the University Hospital Frankfurt am Main.
Research focus
Prof. Nagel is dedicated to translational clinical research of cardiovascular imaging biomarkers, aiming at generating a better understanding of the underlying pathophysiology of cardiovascular diseases. His research focuses on developing, validating and translating new diagnostic procedures into clinical routine, especially in the field of coronary heart disease, cardiomyopathy and heart failure (HF-REF, H-PEF).
Prof. Nagel has successfully established and translated several CMR applications and imaging techniques into clinical practice. His scientific achievements include the establishment of new methods for assessing the presence of myocardial ischemia by MRI, including stress myocardial perfusion using adenosine and regadenoson, as well as wall motion abnormality imaging by dobutamine (DSMR). Currently, Prof. Nagel investigates novel imaging parameters based on CMR for the characterization and classification of patients with heart failure with preserved ejection fraction (HFpEF) as well as establishing predictive associations for myocardial fingerprinting with the outcome to investigate the biomarker qualification pathway of these fingerprints in the characterization of diffuse myocardial disease.
Prof. Nagel has a longstanding history of research, teaching, and training in cardiovascular magnetic resonance. He has published over 500 imaging-related publications and has authored several clinical guidelines, for example on standardized image acquisition, standardized reporting and standardized quantification for cardiovascular magnetic resonance as well as diagnostic pathways for heart failure with preserved ejection fraction.
The Institute for Experimental and Translational Cardiovascular Imaging offers state-of-the-art clinical service as well as a wide range of courses and fellowships on CMR for clinicians, radiographers, CMR physicists, and engineers, aspiring to outline the role of CMR in diagnosis and clinical management of heart diseases.
Major achievements and awards
Awarding of the Gold Medal of the Society for Cardiovascular Magnetic Resonance (SCMR) for achievements in the field of science and the establishment of MRI for clinical applications (2016)
Key publications
Kim W.Y., Danias P.G., Stuber M., Flamm S.D., Plein S., Nagel E., Langerak S.E., Weber O.M., Pedersen E.M., Schmidt M., Botnar R.M., Manning W.J. Coronary magnetic resonance angiography for the detection of coronary stenoses . New England Journal of Medicine 2001: 345 (26): 1863-1869
Nagel E., Lehmkuhl H.B., Bocksch W., Klein C., Vogel U., Frantz E., Ellmer A., Dreysse S., and Fleck E. Noninvasive diagnosis of ischemia-induced wall motion abnormalities with the use of high-dose dobutamine stress MRI: comparison with dobutamine stress echocardiography. Circulation 1999: 99 (6): 763-770
Nagel E., Klein C., Paetsch I., Hettwer S., Schnackenburg B., Wegscheider K., Fleck E. Magnetic resonance perfusion measurements for the noninvasive detection of coronary artery disease. Circulation 2003: 108 (4): 432-437
Schulz-Menger J., Bluemke D.A., Bremerich J., Flamm S.D., Fogel M.A., Friedrich M.G., Kim R.J., von Knobelsdorff-Brenkenhoff F., Kramer C.M., Pennell D.J., Plein S., Nagel E. Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) board of trustees task force on standardized post processing. Resonance 2013: May 1: 15-35
Puntmann V.O., Isted A., Hinojar R., Foote L., Carr-White G., Nagel E. T1 and T2 mapping in recognition of early cardiac involvement in systemic sarcoidosis. Radiology 2017: 285(1): 63-72
Child N., Suna G., Dabir D., Yap M.L., Rogers T., Kathirgamanathan M., Arroyo-Ucar E., Hinojar R., Mahmoud I., Young C., Wendler O., Mayr M., Sandhu B., Morton G., Muhly-Reinholz M., Dimmeler S., Nagel E., Puntmann V.O. Comparison of MOLLI, shMOLLLI, and SASHA in discrimination between health and disease and relationship with histologically derived collagen volume fraction European Heart Journal - Cardiovascular Imaging 2018: Jul 1, 19(7): 768-776
Puntmann V.O., Carr-White G., Jabbour A., Yu C.-Y., Gebker R., Kelle S., Rolf A., Zitzmann S., Peker E., D’Angelo T., Pathan F., Elen, Valbuena S., Hinojar R., Arendt C., Narula J., Herrmann E., Zeiher A.M., Nagel E. Native T1 and ECV of noninfarcted myocardium and outcome in patients with coronary artery disease. Journal of the American College of Cardiology 2018: Feb 20, 71(7): 766-778
Puntmann V.O., Valbuena S., Hinojar R., Petersen S.E., Greenwood J.P., Kramer C.M., Kwong R.Y., McCann G.P., Berry C., Nagel E. Society for Cardiovascular Magnetic Resonance (SCMR) expert consensus for CMR imaging endpoints in clinical research: part I-analytical validation and clinical qualification. Journal of Cardiovascular Magnetic Resonance 2018: Sep 20; 20(1): 67
