Prof. Dr. Jens Fielitz
Research Areas: molecular cardiology
Research focus
Jens Fielitz is a DZHK professor for molecular cardiology and muscular proteostasis at the Ernst-Moritz-Arndt University Greifswald. One focus of his studies is the function of the ubiquitin proteasome system (UPS) and its role in different cardiac diseases.
With his translational research group, he focuses on disease mechanisms, which might eventually be useful to develop novel treatment strategies. In particular, he is studying mechanisms of pathological cardiac remodeling and inflammation-dependent skeletal muscle failure.
Ausgewählte Publikationen
Li Y, Dörmann N, Brinschwitz B, Kny M, Martin E, Bartels K, Li N, Giri PV, Schwanz S, Boschmann M, Hille S, Fielitz B, Wollersheim T, Grunow J, Felix SB, Weber-Carstens S, Luft FC, Müller OJ, Fielitz J. SPSB1-mediated inhibition of TGF-β receptor-II impairs myogenesis in inflammation. J Cachexia Sarcopenia Muscle. 2023. 14:1721-1736. PMID: 37209006
Wundersitz S, Pablo Tortola C, Schmidt S, Oliveira Vidal R, Kny M, Hahn A, Zanders L, Katus HA, Sauer S, Butter C, Luft FC, Müller OJ, Fielitz J. The Transcription Factor EB (TFEB) Sensitizes the Heart to Chronic Pressure Overload. Int J Mol Sci. 2022. 23:5943. PMID: 35682624
Zanders L, Kny M, Hahn A, Schmidt S, Wundersitz S, Todiras M, Lahmann I, Bandyopadhyay A, Wollersheim T, Kaderali L, Luft FC, Birchmeier C, Weber-Carstens S, Fielitz J. Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting. J Cachexia Sarcopenia Muscle. 2022. 13:713-727. PMID: 34821076
Busch K, Kny M, Huang N, Klassert TE, Stock M, Hahn A, Graeger S, Todiras M, Schmidt S, Chamling B, Willenbrock M, Groß S, Biedenweg D, Heuser A, Scheidereit C, Butter C, Felix SB, Otto O, Luft FC, Slevogt H, Fielitz J. Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy. J Cachexia Sarcopenia Muscle. 2021. 12:1653-1668. PMID: 34472725
Hahn A, Kny M, Pablo-Tortola C, Todiras M, Willenbrock M, Schmidt S, Schmoeckel K, Jorde I, Nowak M, Jarosch E, Sommer T, Bröker BM, Felix SB, Scheidereit C, Weber-Carstens S, Butter C, Luft FC, Fielitz J. Serum amyloid A1 mediates myotube atrophy via Toll-like receptors. J Cachexia Sarcopenia Muscle. 2020. 11:103-119. PMID: 31441598
Nowak M, Suenkel B, Porras P, Migotti R, Schmidt F, Kny M, Zhu X, Wanker EE, Dittmar G, Fielitz J. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy .Sommer T. J Cell Sci. 2019. 132:jcs233395. PMID: 31391242
Wollersheim T, Grunow JJ, Carbon NM, Haas K, Malleike J, Ramme SF, Schneider J, Spies CD, Märdian S, Mai K, Spuler S, Fielitz J., Weber-Carstens S. Muscle wasting and function after muscle activation and early protocol-based physiotherapy: an explorative trial. J Cachexia Sarcopenia Muscle. 2019, 10:734-747. PMID: 31016887
Huang N, Kny M, Riediger F, Busch K, Schmidt S, Luft FC, Slevogt H, Fielitz J. Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy. Intensive Care Med Exp. 2017. 5:3. PMID: 28097512
Zhu X, Kny M, Schmidt F, Hahn A, Wollersheim T, Kleber C, Weber-Carstens S, Fielitz J. Secreted Frizzled-Related Protein 2 and Inflammation-Induced Skeletal Muscle Atrophy. Crit Care Med. 2017 45:e169-e183. PMID: 27661566
Du Bois P, Pablo Tortola C, Lodka D, Kny M, Schmidt F, Song K, Schmidt S, Bassel-Duby R, Olson EN, Fielitz J. Angiotensin II Induces Skeletal Muscle Atrophy by Activating TFEB-Mediated MuRF1 Expression. Circ Res. 2015. 117:424-36. PMID: 26137861
