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Heart failure: early detection can save lives

The initial results of the ‘HerzCheck’ innovation fund project show this: A mobile care approach tailored to regional needs with cardiac MRI examinations can detect asymptomatic heart failure around seven years earlier than with conventional diagnostic procedures. This finding could significantly optimise the future care of heart patients.

Patient examination - © AdobeStock

Innovative cardiac MRI screening enables the early detection of heart failure, often years before the first symptoms appear. Initial results from the G-BA-funded ‘HerzCheck’ project show that almost fully automated, telemedically monitored cardiac MRIs can identify asymptomatic heart failure at an early stage and provide targeted treatment. This improves the prognosis and quality of life of patients, while reducing hospitalisation and follow-up costs.

On 30th of March 2025, the ‘HerzCheck’ team from Charité's German Heart Centre (DHZC) presented these findings at the ACC Congress in Chicago. More than 4,500 patients in rural regions were examined in the study. Almost a quarter were diagnosed with subclinical heart failure using state-of-the-art MRI diagnostics - on average almost seven years earlier than in the control group using conventional diagnostic methods. The full evaluation results are expected in summer 2025.

‘Our results show that early detection is crucial in order to avoid serious courses of heart failure,’ says “HerzCheck” consortium leader Prof. Sebastian Kelle, Head of Cardiovascular Imaging at the German Heart Centre of the Charité (DHZC), Virchow-Klinikum campus. ‘Modern early detection methods such as ‘HerzCheck’ could therefore be integrated into standard care. In particular, the possibility of recognising cardiac insufficiency independently of examiners, mobile, telemedically monitored, needs-based and with established measurement methods offers many opportunities - also as a template for other organ systems. We also need more valid data and targeted research into preventive measures in order to find out which therapies can effectively prevent the progression of asymptomatic heart failure and how the need for care can be estimated in the coming years.’

 

In the innovation fund project, 4,509 symptom-free people aged 40 to 69 with risk factors for cardiovascular disease were examined. The MRI examinations took place from June 2021 to April 2023 at 12 locations in Brandenburg and Mecklenburg-Western Pomerania in mobile trailers and were analysed using telemedicine. ‘HerzCheck’ cooperated with 100 medical practices, and a follow-up examination was carried out one year after the initial examination to scientifically evaluate the success of the therapy.

The ‘HerzCheck’ physicians used an innovative, telemedical procedure that utilises the left ventricular global longitudinal strain (GLS) to precisely assess the function of the left ventricle. Patients with an exceeded GLS threshold were considered to have subclinical heart failure and were compared with a control group in which symptomatic heart failure was diagnosed using conventional methods.

 

The key results of ‘HerzCheck’ at a glance:

  • Around a quarter of patients with cardiovascular risk factors who live in rural areas have asymptomatic heart failure. Such subclinical heart failure was diagnosed in 22.7 per cent of ‘HerzCheck’ participants.
  • Men with cardiovascular risk factors have a higher risk (37 per cent) of developing subclinical heart failure than women with corresponding risk factors (12 per cent).
  • The probability of developing heart failure in this risk group increases with age. The prevalence among the 40 to 49-year-olds studied was 21 per cent, while it was 25 per cent among the 60 to 69-year-olds.
  • The cardiovascular risk factors of smoking, obesity and diabetes in particular increase the risk of developing subclinical heart failure.
  • The cardiac MRI examinations carried out in ‘HerzCheck’ can detect heart failure on average almost seven years earlier than standard medical care examinations. This is shown by a comparison of the ‘HerzCheck’ participants with a historical control cohort: the ‘HerzCheck’ participants were 60.9 years old on average at the time of diagnosis, while the participants in the control cohort were 67.5 years old on average.

‘HerzCheck’ shows that modern MRI diagnostics can detect people at high risk of heart failure much earlier. Mobile, needs-based care in rural areas, in collaboration between local doctors and expert centres, enables early treatment, reduces hospital stays and lowers follow-up costs.

The project, funded with over seven million euros from the Federal Joint Committee, brings modern diagnostics to regions without adequate medical care and was carried out under the leadership of the German Heart Centre at Charité.


Read the full report at the German Heart Centre of the Charité