26 - 48 (out of 48)
Ultrasound evaluation of the inferior vena cava in addition to clinical assessment to guide decongestion in acute decompensated heart failure: a pilot study (CAVA-ADHF-DZHK10)
This trial is examining whether an ultrasound evaluation of the inferior vena cava in acute decompensated heart failure (ADHF) with congestion can be implemented in hospitals’ everyday routine in a large number of patients.
| Recruiting status | Study completed |
|---|---|
| Principal Investigators | Principal investigator: Alexander Jobs (Lübeck), Co-PI: Holger Thiele (Leipzig) |
| Main publication | JACC Heart Fail. 2025;13(10):102578 |
Evaluating the benefit of concurrent tricuspid valve repair during mitral surgery (CTSN-TVR-DZHK14)
The aim of the study is to clarify whether it is beneficial to operate the tricuspid valve in the right heart at the same time if the mitral valve is defective, even if the right heart valve is not yet very leaky.
| Recruiting status | Study completed |
|---|---|
| Principal Investigators | Principal investigator for Germany: Volkmar Falk (Berlin), PI (Sponsor): Annetine C. Gelijns (Icahn School of Medicine at Mount Sinai, NY, USA) |
| Main publication | N Engl J Med. 2022;386(4):327-339 |
Randomized Trial of TAVI versus SAVR in Patients with Symptomatic Severe Aortic Valve Stenosis and Intermediate Risk of Mortality (DEDICATE-DZHK6)
The DEDICATE-DZHK6 study is investigating whether surgical or transcatheter aortic valve implantation is the superior long-term treatment option for patients with severe aortic valve stenosis.
| Recruiting status | Recruiting complete, follow-up continuing |
|---|---|
| Principal Investigators | Principal investigator: Stefan Blankenberg (Hamburg), Co-PI: Moritz Seiffert (Hamburg) |
| Main publication | N Engl J Med. 2024;390(17):1572-1583. |
Intravenous iron in patients with systolic heart failure and iron deficiency to improve morbidity and mortality (FAIR-HF2-DZHK5)
The FAIR-HF2 study will be assessing whether treatment with intravenously administered ferric carboxymaltose improves the chances of survival and helps to reduce the number of hospitalisations of heart failure patients diagnosed with iron deficiency.
| Recruiting status | Study completed |
|---|---|
| Principal Investigators | Principal investigator; Mahir Karakas (Hamburg), Co-PI: Stefan Anker (Berlin) |
| Main publication | JAMA. 2025:e253833. doi: 10.1001/jama.2025.3833 |
Immediate unselected coronary angiography versus delayed triage in survivors of out-of-hospital cardiac arrest without ST-segment elevation (TOMAHAWK-DZHK4)
TOMAHAWK compares the effects of immediate coronary angiography to delayed intervention in survivors of cardiac arrest who occurred outside a hospital and without ST elevation.
| Recruiting status | Study completed |
|---|---|
| Principal Investigators | Principal investigator: Steffen Desch (Lübeck und Leipzig), Co-PI: Holger Thiele (Leipzig) |
| Main publication | N Engl J Med. 2021;385(27):2544-2553 |
Apixaban versus Phenprocoumon: oral anticoagulation plus antiplatelet therapy in patients with acute coronary syndrome and atrial fibrillation (APPROACH-ACS-AF-DZHK7)
DZHK researchers compare two therapies in patients with atrial fibrillation, who have also had a heart attack in order to find out which therapy leads to less bleedings.
| Recruiting status | Study completed |
|---|---|
| Principal Investigators | Principal investigator: Reza Wakili (München und Frankfurt), Co-PI: Steffen Massberg (München) |
Implantable cardiac monitors in high-risk post-infarction patients with cardiac autonomic dysfunction (SMART-MI-DZHK9)
DZHK researchers from Munich test whether the use of implantable cardiac monitors with home monitoring function is more effective than conventional follow-up for detecting serious arrhythmic events in a newly identified high-risk group of patients.
| Recruiting status | Study completed |
|---|---|
| Principal Investigators | Principal investigator: Axel Bauer (München und Insbruck, AT), Co-PI: Stefan Kääb, Steffen Massberg (München) |
| Main publication | Lancet Digit Health. 2022;4(2):e105-e116 |
Stress testing and echocardiography to identify significant DYNAMIC Mitral valve Regurgitation amenable to MitraClip mitral valve repair in patients with heart failure with reduced ejection fraction (DYNAMIC-MR)
| Recruiting status | Recruiting permanently stopped, after recruiting started |
|---|---|
| Principal Investigators | Burkert Pieske (Berlin) |
Early versus emergency left ventricular assist device implantation in patients awaiting cardiac transplantation (VAD-DZHK3)
This study is expected to deliver guideline-relevant findings for the future treatment of patients with terminal heart failure.
| Recruiting status | Study completed |
|---|---|
| Principal Investigators | Principal investigator: Volkmar Falk, Co-PI: Christoph Knosalla (Berlin), Gerd Hasenfuß, Tim Friede (Göttingen) |
Systolic dysfunction to congestive heart failure cohort study (TransitionCHF-DZHK2)
This cohort study explores ways of predicting when decreased cardiac performance without symptoms will develop into a clinically manifest disease.
| Recruiting status | Recruiting complete, follow-up continuing |
|---|---|
| Principal Investigators | Principal investigator: Karl Toischer (Göttingen) (vormals Gerd Hasenfuß, Co-PI: Rolf Wachter (Leipzig), Anja Sandek (Göttingen), Frank Edelmann (Berlin) |
Translational registry for cardiomyopathies (TORCH-DZHK1)
As a translational registry for cardiomyopathies, TORCH-DZHK1 collects data and biosamples from 2,300 patients with heart muscle diseases.
| Recruiting status | Study completed |
|---|---|
| Principal Investigators | Principal investigator: Hugo Katus (Heidelberg), Co-PI: Wolfgang Hoffmann (Greifswald) |
| Main publication | SC Heart Fail. 2017;4(3):209-215 |
Prospective, randomized trial of ticagrelor versus prasugrel in patients with acute coronary syndrome (ISAR-REACT 5)
This study compares two agents used to inhibit blood clotting - ticagrelor and prasugrel. The hypothesis that ticagrelor is superior to prasugrel for the treatment of patients with acute coronary syndrome will be examined in relation to clinical outcomes.
| Recruiting status | Study completed |
|---|---|
| Principal Investigators | Principal investigator: Adnan Kastrati (München), Co-PI: Stefanie Schüpke (München) |
| Main publication | N Engl J Med. 2019;381(16):1524-1534 |
Phosphodiesterase-5 inhibition in patients with combined pre- and postcapillary pulmonary hypertension due to heart failure with preserved ejection fraction (PASSION)
The DZHK associated study PASSION investigates whether the drug Tadalafil can reduce cardiac-related hospital admissions and mortality of patients with pulmonary hypertension due to heart failure.
| Recruiting status | Recruiting stopped |
|---|---|
| Principal Investigators | Marius Hoeper (Hannover), Stephan Rosenkranz (Köln) |
| Main publication | Circulation. 2024;150(8):600-610 |
Diagnostic Imaging Strategies for Patients with Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE)
The DZHK-associated study DISCHARGE compares whether cardiac CT or cardiac catheterization is better for the evaluation of coronary artery disease.
| Recruiting status | Study completed |
|---|---|
| Principal Investigators | Marc Dewey (Berlin) |
| Main publication | Radiology. 2024;310(2):e230591 |
Randomised placebo controlled clinical trial of efficacy of MYOcardial protection in patients with postacute inFLAMmatory cardiac involvEment due to COVID-19 (MYOFLAME-19)
The DZHK-associated MYOFLAME-19 study is investigating the long-term consequences of Covid19 in relation to the cardiovascular system.
| Recruiting status | Recruiting complete |
|---|---|
| Principal Investigators | Principal investigator: Valentina Puntmann (Frankfurt), Co-PI: Eike Nagel (Frankfurt), Inga Voges (Kiel), Marcus Dörr (Greifswald), Dietrich Beitzke (Wien) |
Continuation of the cohort “inflammatory cardiomyopathy” of the collaborative research centre transregio 19 (SFB/TR19) as “SFB/TR19 Plus”
The cohort study SFB/TR 19 plus investigates new diagnostic and treatment approaches for inflammatory cardiomyopathies.
| Recruiting status | Recruiting complete, follow-up complete |
|---|---|
| Principal Investigators | Principal investigator: Marcus Dörr (Greifswald) |
Culprit Lesion Only PCI Versus Multivessel PCI in Cardiogenic Shock (CULPRIT-SHOCK)
Prospective randomized multicenter study comparing immediate multivessel revascularization by PCI versus culprit lesion PCI with staged non-culprit lesion revascularization in patients with acute myocardial infarction complicated by cardiogenic shock.
| Recruiting status | Study completed |
|---|---|
| Principal Investigators | Principal investigator: Holger Thiele (Lübeck und Leipzig) |
| Main publication | Circ Cardiovasc Interv. 2020;13(9):e009562 |
SORT-AF Supervised Obesity Reduction Trial for AF Ablation Patients (SORT-AF)
Prospective randomized multicenter study to evaluate the impact of weight reduction on AF recurrence after AF ablation in obese patients.
| Recruiting status | Study completed |
|---|---|
| Principal Investigators | Stephan Willems (Hamburg), Daniel Steven (Köln) |
| Main publication | Europace. 2021;23(10):1548-1558 |
German Aortic valve RegistrY (GARY)
Prospective, controlled, multicenter registry study to evaluate the variability in structural requirements, processes, andresults for different aortic valve therapies (e.g. surgical AVR and TAVI,different prosthetic valve devices).
| Recruiting status | Recruiting ongoing |
|---|---|
| Principal Investigators | Christian Hamm (Bad Nauheim), Friedhelm Beyersdorf (Freiburg), Eva Herrmann (Frankfurt) |
| Main publication | JACC Cardiovasc Interv. 2020;13(22):2642-2654 |
Evaluation of the safety and efficacy of the OPTIMIZER ® system in subjects with moderate-to-severe heart failure (FIX-HF-5C)
The study was designed to evaluate both safety and efficacy of the OPTIMIZER system in patients with moderate to severe heart failure.
| Recruiting status | Study completed |
|---|---|
| Principal Investigators | Gerd Hasenfuß (Göttingen) |
| Main publication | ESC Heart Fail. 2019;6(6):1178-1187 |
Non-vitamin K antagonist oral anticoagulants in patients with atrial high rate episodes (NOAH-AFNET 6)
NOAH-AFNET 6 evaluates the potential benefit of oral anticoagulation treatment in patients with atrial high rate episodes.
| Recruiting status | Study completed |
|---|---|
| Principal Investigators | Paulus Kirchhof (Birmingham, Münster) |
| Main publication | J Am Heart Assoc. 2024;13(17):e036429. |
Early treatment of atrial fibrillation for stroke prevention trial (EAST – AFNET 4)
In the EAST – AFNET 4 study, atrial fibrillation shall be detected early on.
| Recruiting status | Study completed |
|---|---|
| Principal Investigators | Paulus Kirchhof (Birmingham, Münster) |
| Main publication | Eur Heart J. 2022;43(12):1219-1230 |
Nationales Register für angeborene Herzfehler (NRCHD)
The person-based register records data from patients of all age groups and with all kinds of congenital heart defects across Germany.
| Recruiting status | Recruiting ongoing |
|---|---|
| Principal Investigators | Ulrike Bauer, Thomas Pickardt (Berlin) |
| Main publication | Nat Genet. 2016;48(9):1060-1065 |