Secondary Use Projects
All research projects that work with data and biosamples from the DZHK Heart Bank and that have been approved to date can be found here. You can search for the resource you are using or do a full text search.
1 - 10 (out of 19)
A genomic perspective on the spread of farming to Germany
The adoption of farming by Neolithic populations is one of the most dramatic and influential ecological shifts in the recent history of our species. Recent ancient DNA (aDNA) studies have clarified longstanding questions concerning the Neolithization of Western Eurasia. By sequencing the genomes of early farmers ...
| Principal Investigators |
|---|
Proteomic exploration of disease mechanisms related to the novel biomarker CCN1 for prediction of death in patients with dilated cardiomyopathy
Phenotyping in heart failure using a proteomic approach constitutes the next frontier and may enable the identification of novel biomarkers and new therapeutic targets.
| Principal Investigators |
|---|
Epigenetic and RNA-based biomarker validation in Cardiomypathies
Diseases of the heart muscle (cardiomyopathies) are common heart diseases that often have a severe course, up to and including heart failure.
| Principal Investigators |
|---|
Proteogenomic discovery of endothelium-derived microproteins in cardiovascular disease
We have identified a unique set of thousands of microproteins (miPs, shorter than 100 amino acids) encoded by previously unannotated small open reading frames (smORFs) in human and murine endothelial cells.
| Principal Investigators |
|---|
Cardiac disease causative mutations in the Eph/ephrin signalling pathway
This project will study patients with dilated or hypertrophic cardiomyopathy that present mutations in the Eph/ephrin signaling pathway.
| Principal Investigators |
|---|
Identification of circulatory proteins reflecting myocardial processes relevant to disease progression in heart failure
Exploration of molecular fingerprints of patients with heart failure provides a promising approach to better understand mechanisms relevant for the development and progression of the disease.
| Principal Investigators |
|---|
The role of urinary Dickkopf-3 in cardiorenal syndrome
Impaired renal function is common in patients with heart failure. Up to 50 percent of patients show chronic kidney disease (CKD), associated with worse outcomes and complicates pharmacological management.
| Principal Investigators |
|---|
Computational assessment of genetic regulatory effects on RNA life using the DZHKomics resource
Genome-wide association studies (GWAS) have revealed tens of thousands of genomic loci associated with numerous traits and diseases; however, the underlying causal mechanism often remains poorly understood.
| Principal Investigators |
|---|
Characterisation and risk stratification of patient subgroups in dilated cardiomyopathy by utilisation of an inflammatory 47-plex-biomarker panel
Inflammation plays a role in the development of heart failure and dilated cardiomyopathy and cytokines are involved in these processes.
| Principal Investigators |
|---|
Methylation profile of circulating cell-free DNA as a diagnostic tool for heart disease stratification
Circulating cell-free DNA (ccfDNA) is released to the plasma after cell death and therefore can be used to evaluate the extension of tissue damage.
| Principal Investigators |
|---|
