​ ​ ​ ​
​

April 2017

​
​
​
​
​
Overview
​ ​
​ ​
​
​

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function, J Clin Invest. 2017. doi:10.1172/JCI84840, DZHK authors: Wild, Schillert, Teumer, Völker, Edelmann, Friedrich, Peters, Wachter, Völzke, Ziegler, Münzel, Pieske, Schunkert, Blankenberg, Felix, Zeller, Dörr

​ ​

Understanding the genetic architecture of the heart may help to prevent and treat heart disease. An international consortium of investigators (EchoGen) led by DZHK researchers from the Greifswald and RheinMain sites performed a meta-analysis of 30 studies to explore which genetic variations are linked to the inter-individual variability of cardiac structure and function. The researchers identified ten new genetic variants associated with the structure and function of the heart. The results may help scientists to understand the complex pattern of hereditary and environmental factors underlying cardiovascular diseases and provide a basis for developing new therapies.

Link

​
​
​