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Prediction of Acute Coronary Syndrome in Acute Ischemic Stroke (PRAISE-DZHK19 I DZNE 001)
The aim of the study PRAISE-DZHK19 I DZNE B001 is to establish a clinical algorithm that enables the prediction of acute coronary syndrome or heart attack in stroke patients.
Effect of Metformin in insulin resistant patients with heart failure with reduced ejection fraction (METRIS-HF-DZHK18)
The METRIS-HF-DZHK18 trial aims to find out whether improved energy metabolism can increase heart efficiency in patients with cardiac insufficiency.
Home-Based Screening for Early Detection of Atrial Fibrillation in Primary Care Patients Aged 75 Years and Older (SCREEN AF-DZHK15)
The SCREEN-AF study aims to improve the early detection of atrial fibrillation using a new “rhythm patch” with an integrated ECG recording unit which is applied to the patient’s chest.
Evaluating the benefit of concurrent tricuspid valve repair during mitral surgery (CTSN-TVR-DZHK14)
The aim of the study is to clarify whether it is beneficial to operate the tricuspid valve in the right heart at the same time if the mitral valve is defective, even if the right heart valve is not yet very leaky.
Validation of Cardiovascular Magnetic Resonance against Invasive Haemodynamics in Patients with Heart Failure with Preserved Ejection Fraction (Decipher HFpEF-DZHK12)
The DECIPHER HFpEF-DZHK12 study investigates whether diastolic heart failure can be better diagnosed and its causes clarified with the help of cardiovascular magnetic resonance imaging (CMR).
Exercise Training in Patients with Left Ventricular Assist Device (Ex-VAD-DZHK11)
- This study is examining whether a tailored physical exercise can improve the fitness and quality of life of patients with an artificial heart.
Randomized Trial of TAVI versus SAVR in Patients with Symptomatic Severe Aortic Valve Stenosis and Intermediate Risk of Mortality (DEDICATE-DZHK6)
The DEDICATE-DZHK6 study is investigating whether surgical or transcatheter aortic valve implantation is the superior long-term treatment option for patients with severe aortic valve stenosis.
Ultrasound evaluation of the inferior vena cava in addition to clinical assessment to guide decongestion in acute decompensated heart failure: a pilot study (CAVA-ADHF-DZHK10)
This trial is examining whether an ultrasound evaluation of the inferior vena cava in acute decompensated heart failure (ADHF) with congestion can be implemented in hospitals’ everyday routine in a large number of patients.
Cardiovascular magnetic resonance real time exercise stress testing in heart failure with preserved ejection fraction (HFpEF-stress-DZHK17)
Researchers will test in this trial whether the newly developed real-time CMR technology is suitable for the early and safe diagnosis of HFpEF.
Left atrial appendage CLOSURE in patients with Atrial Fibrillation at high risk of stroke and bleeding compared to medical therapy (CLOSURE-AF-DZHK16)
The DZHK study CLOSURE-AF compares the benefit of the left atrial appendage closure with the best possible drug therapy for high-risk patients with atrial fibrillation.
SPIRonolactone In the Treatment for Heart Failure (SPIRIT-HF-DZHK8)
The SPIRIT-HF-DZHK8 study investigates whether the drug spironolactone can reduce the number of people with preserved ejection fraction who end up in hospital and the number of people who die from heart failure.
Implantable cardiac monitors in high-risk post-infarction patients with cardiac autonomic dysfunction (SMART-MI-DZHK9)
DZHK researchers from Munich test whether the use of implantable cardiac monitors with home monitoring function is more effective than conventional follow-up for detecting serious arrhythmic events in a newly identified high-risk group of patients.
Apixaban versus Phenprocoumon: oral anticoagulation plus antiplatelet therapy in patients with acute coronary syndrome and atrial fibrillation (APPROACH-ACS-AF-DZHK7)
DZHK researchers compare two therapies in patients with atrial fibrillation, who have also had a heart attack in order to find out which therapy leads to less bleedings.
Intravenous iron in patients with systolic heart failure and iron deficiency to improve morbidity and mortality (FAIR-HF2-DZHK5)
The FAIR-HF2 study will be assessing whether treatment with intravenously administered ferric carboxymaltose improves the chances of survival and helps to reduce the number of hospitalisations of heart failure patients diagnosed with iron deficiency.
Immediate unselected coronary angiography versus delayed triage in survivors of out-of-hospital cardiac arrest without ST-segment elevation (TOMAHAWK-DZHK4)
TOMAHAWK compares the effects of immediate coronary angiography to delayed intervention in survivors of cardiac arrest who occurred outside a hospital and without ST elevation.
Early versus emergency left ventricular assist device implantation in patients awaiting cardiac transplantation (VAD-DZHK3)
This study is expected to deliver guideline-relevant findings for the future treatment of patients with terminal heart failure.
Systolic dysfunction to congestive heart failure cohort study (TransitionCHF-DZHK2)
This cohort study explores ways of predicting when decreased cardiac performance without symptoms will develop into a clinically manifest disease.
Translational registry for cardiomyopathies (TORCH)
Revacept, a novel inhibitor of platelet adhesion in patients with stable coronary artery disease undergoing elective percutaneous coronary intervention: a randomized, double-blind, placebo-controlled, phase II trial (REVACEPT-PCI in CAD)
Continuation of the cohort “inflammatory cardiomyopathy” of the collaborative research centre transregio 19 (SFB/TR19) as “SFB/TR19 Plus”
Prospective, randomized trial of ticagrelor versus prasugrel in patients with acute coronary syndrome (ISAR-REACT 5)
Prospective randomized multicenter study comparing immediate multivessel revascularization by PCI versus culprit lesion PCI with staged non-culprit lesion revascularization in patients with acute myocardial infarction complicated by cardiogenic shock
SORT - AF Supervised Obesity Reduction Trial for AF Ablation Patients (SORT-AF)
Evaluation of the safety and efficacy of the OPTIMIZER ® system in subjects with moderate-to-severe heart failure (FIX-HF-5C)
Non-vitamin K antagonist oral anticoagulants in patients with atrial high rate episodes (NOAH-AFNET 6)
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