DZHK Studies and Associated Studies

Do you want to associate your clinical trial with us?

Clinical studies that are not DZHK-financed can receive the status "DZHK-associated" if their objectives match our research interest. By associating, we support the study ideally, for example, by promoting recruitment through our network.

Application for Association

Study Participation

Would you like to participate in a DZHK study or learn more about our clinical studies? The Patient Information Platform (PIP) informs patients, relatives and interested individuals about our clinical studies.

Learn more (German only)

Contact:

Alexandra Klatt
Coordinator Clinical Research
Phone: +49 (0)30 3465 529 10
alexandra.klatt@dzhk.de

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Cyclosporine in Takotsubo syndrome (CIT-DZHK29)

In the DZHK-funded CIT-DZHK29 study, researchers from Heidelberg are investigating for the first time whether an anti-inflammatory drug can alleviate myocardial damage in broken heart syndrome.

Recruiting status
Recruiting planned
Principal Investigators
Principal investigator: Norbert Frey (Heidelberg), Co-PI: Bastian Bruns (Heidelberg)
11/2024 204 EUR 2.228.540,47 Frühe klinische Studie Herzmuskelerkrankungen, Herzschwäche

A first-in-human feasibility study to evaluate the safety (and short term effectiveness) of the autologous GrOwnValve transcatheter pulmonary heart valve (GECT-DZHK28)

In the GECT-DZHK28 study of the German Center for Cardiovascular Research, scientists are testing a heart valve replacement made of the patient's own tissue in humans, which is unique worldwide according to the current state of knowledge.

Recruiting status
Recruiting ongoing
Principal Investigators
Principal investigator: Boris Schmitt (Berlin)
12/2023 7 EUR 418.966,14 EUR Berlin Frühe klinische Studie Herzklappenerkrankungen

CAtheter-Based Ablation of atrial fibrillation compared to conventional treatment in patients with Heart Failure with Preserved Ejection Fraction (CABA-HFPEF-DZHK27)

CABA-HFPEF-DZHK27 is a large, multicenter study investigating whether catheter ablation achieves better results than drug treatment in heart failure patients with atrial fibrillation.

Recruiting status
Recruiting ongoing
Principal Investigators
Principal investigator: Abdul S. Parwani (Berlin), Co-PI: Paulus Kirchhof (Hamburg), Stefan Kääb (München), Roland R Tilz (Lübeck), Tim Friede (Göttingen), Burkert Pieske
03/2023 1548 EUR 3.267.048,00 Berlin,Bernau,Hennigsdorf,Rostock,Hamburg,Lübeck,Magdeburg,Düsseldorf,Wuppertal,Essen,Köln,Leverkusen,Lüdenscheid,Frankfurt am Main,Bad Nauheim,Schwetzingen,Heidelberg,Stuttgart,Tübingen,Bad Friedrichshall,München,Halle (Saale),Rangsdorf,Kiel,Göttingen,Recklinghausen,Erlangen,Coburg,Leipzig Leitlinien-relevante Studie Herzschwäche, Vorhofflimmern

A multicenter, randomized, double-blind, placebo-controlled trial evaluating immunosuppressive treatment in patients with chronic virus-negative inflammatory cardiomyopathy (TRINITY-DZHK26)

The multicenter, randomized, double-blind, placebo-controlled TRINITY-DZHK26 trial is testing the success of immunosuppressive treatment in patients with chronic virus-negative inflammatory cardiomyopathy.

Recruiting status
Recruiting ongoing
Principal Investigators
Principal investigator: Ulrich Grabmaier (München), Co-PI: Steffen Massberg (München)
03/2023 130 EUR 1.633.012,21 Berlin,Göttingen,Essen,Bad Nauheim,Heidelberg,Freiburg,München Frühe klinische Studie Herzmuskelerkrankungen

Tricuspid Intervention in Heart Failure (TRICI-HF-DZHK24)

The DZHK study TRICI-HF-DZHK24 is investigating whether patients with a leaking tricuspid valve benefit from a catheter-assisted repair of the heart valve.

Recruiting status
Recruiting ongoing
Principal Investigators
Principal investigator: Jörg Hausleiter (München), Co-PI: Thomas Stocker, Daniel Braun, Steffen Massberg (München)
03/2022 360 EUR 1.767.773,93 München,Bad Oeynhausen,Leipzig,Freiburg,Hamburg,Gießen,Essen,Bad Krozingen,Berlin,Bernau,Lübeck,Kiel,Bremen,Siegburg,Tübingen,Erfurt,Ulm,Frankfurt am Main,Mainz,Stuttgart,Köln,Düsseldorf,Wuppertal Leitlinien-relevante Studie Herzklappenerkrankungen

Effect of anti-fibrotic therapy on regression of myocardial fibrosis after transcatheter aortic valve implantation (TAVI) in aortic stenosis patients with high fibrotic burden (Reduce-MFA-DZHK25)

The REDUCE-MFA-DZHK25 trial is testing whether antifibrotic drugs can reduce cardiac scarring after TAVI and improve patient prognosis.

Recruiting status
Recruiting ongoing
Principal Investigators
Principal investigator: Miriam Puls (Göttingen), Co-PI: Elisabeth Zeisberg (Göttingen)
03/2022 300 EUR 1.857.298,61 Berlin,Göttingen,Frankfurt am Main,Bad Nauheim,Heidelberg,München,Hamburg,Karlsruhe,Lübeck Frühe klinische Studie Herzmuskelerkrankungen

Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for >60 Year-olds (PRIMARY)

The PRIMARY study investigates whether a surgical or catheter-based approach is better for repairing mitral valve prolapse.

Recruiting status
Recruiting ongoing
Principal Investigators
Principal investigator for Germany: Volkmar Falk (Berlin), PI (Sponsor): Annetine C. Gelijns (Icahn School of Medicine at Mount Sinai, NY, USA), Co-PI for Germany: Stefan Blankenberg (Hamburg), Michael Borger (Leipzig)
03/2023 113 EUR 1.364.596 Berlin Leitlinien-relevante Studie Herzklappenerkrankungen

Munich Remote SpO2 and Heart Rate Assessment in Covid-19 patients (COVID SMART formerly MR SPOC)

In the COVID SMART trial, modern smartwatches continuously measure ECG, pulse, and oxygen saturation in the blood of COVID-19 patients and transfer these data into the hospital to get treatment advice.

Recruiting status
Study completed
Principal Investigators
Principal investigator: Moritz Sinner (München)
09/2020 600 EUR 146.031,56 München Frühe klinische Studie Herzmuskelerkrankungen

Stopping ACE-inhibitors in COVID-19 (ACEI-COVID-19)

The study investigates the effects on the course of COVID-19 disease when ACE inhibitors are paused or replaced by antihypertensives with a different mechanism of action in COVID-19 patients.

Recruiting status
Study completed
Principal Investigators
Principal investigator: Steffen Massberg (München), Co-PI: Konstantinos Rizas (München)
04/2020 208 EUR 179.861,00 München,Innsbruck,Weilheim,Bad Tölz,Memmingen,Weiden,Augsburg,Zams,Hall,Schwaz,Kufstein,St. Johann,Klagenfurt Leitlinien-relevante Studie Herzmuskelerkrankungen

Effect of anticoagulation therapy on clinical outcomes in COVID-19 (COVID-PREVENT)

The Germany-wide COVIDPREVENT trial is investigating whether the administration of the blood thinner Rivaroxaban can reduce thrombotic events such as heart attack, pulmonary embolism or stroke in CoVID-19 patients.

Recruiting status
Study completed
Principal Investigators
Principal investigator: Ulf Landmesser (Berlin)
11/2020 400 EUR 499.994,00 Berlin,Heidelberg,Neuperlach,Dresden,München,Herne,Greifswald,Frankfurt am Main,Oberhavel,Göttingen Leitlinien-relevante Studie Herzmuskelerkrankungen

Cardiac Magnetic Resonance guidance of Implantable Cardioverter Defibrillator implantation in non-ischaemic dilated cardiomyopathy (CMR-ICD-DZHK23)

The CMR-ICD-DZHK23 study wants to optimise the implantation of a defibrillator in patients with non-ischemic cardiomyopathy based on fibrosis on cardiac MRI.

Recruiting status
Recruiting ongoing
Principal Investigators
Principal investigator: Ingo Eitel (Lübeck)
01/2021 760 EUR 3.159.483,84 Leipzig,Berlin,Hennigsdorf,Greifswald,Hamburg,Lübeck,Kiel,Bad Bevensen,Bad Oeynhausen,Göttingen,Düsseldorf,Essen,Münster,Neuwied,Frankfurt am Main,Bad Nauheim,Heidelberg,Freiburg,Ulm,Nürnberg,Coburg,Erfurt,Bonn,Mainz,Bad Krozingen,München Leitlinien-relevante Studie Herzschwäche

First prospective randomized trial to examine a differential therapeutic response in symptomatic patients with non-obstructive coronary artery disease after coronary physiological testing (EXAMINE-CAD-DZHK22)

The EXAMINE-CAD-DZHK22 study is investigating which drugs help with circulatory disorders of small heart vessels.

Recruiting status
Recruiting permanently stopped, after recruiting started
Principal Investigators
Principal investigator: Ulf Landmesser (Berlin), Co-PI: Barbara Stähli (Berlin)
03/2022 132 EUR 1.286.229,50 Leipzig,Berlin,Hamburg,Kiel,Bad Oeynhausen,Frankfurt am Main,Bad Nauheim,Mannheim,Heidelberg,Stuttgart,München,Erlangen,Mainz Frühe klinische Studie Durchblutungsstörungen des Herzmuskels

TranslatiOnal Registry for CardiomyopatHies-Plus (TORCH-Plus-DZHK21)

TORCH-Plus is a large-scale prospective data & biospecimen repository of patients with non-ischemic cardiomyopathies.

Recruiting status
Recruiting ongoing
Principal Investigators
Principal investigator: Benjamin Meder (Heidelberg)
08/2020 4340 EUR 3.169.463,16 Berlin,Greifswald,Hamburg,Lübeck,Kiel,Hannover,Göttingen,Mainz,Frankfurt am Main,Bad Nauheim,Mannheim,Heidelberg,München Register Herzmuskelerkrankungen

Safety and Efficacy of Induced Pluripotent Stem Cell-derived Engineered Human Myocardium as Biological Ventricular Assist Tissue in Terminal Heart Failure (BioVAT-DZHK20)

BioVAT-HF-DZHK20 trial is investigating under which conditions engineered human myocardium is safe to use in the treatment of patients with end-stage heart failure.

Recruiting status
Recruiting ongoing
Principal Investigators
Principal investigator: Wolfram-Hubertus Zimmermann (Göttingen)
02/2021 53 EUR 1.185.446,65 Lübeck,Bad Oeynhausen,Göttingen Frühe klinische Studie Herzschwäche

Prediction of Acute Coronary Syndrome in Acute Ischemic Stroke (PRAISE-DZHK19 I DZNEB001)

The aim of the study PRAISE-DZHK19 I DZNEB001 is to establish a clinical algorithm that enables the prediction of acute coronary syndrome or heart attack in stroke patients.

Recruiting status
Study completed
Principal Investigators
Principal investigator: Matthias Endres (Berlin), Co-PI: Ulf Landmesser, Christian Nolte (Berlin)
10/2018 251 EUR 542.644,91 Berlin,Leipzig,Greifswald,Hamburg,Lübeck,Fulda,Göttingen,Osnabrück,Bonn,Frankfurt am Main,Mannheim,Heidelberg,Tübingen,München,Erlangen,Celle,Bad Neustadt,Dresden Frühe klinische Studie Durchblutungsstörungen des Herzmuskels

Effect of Metformin in insulin resistant patients with heart failure with reduced ejection fraction (METRIS-HF-DZHK18)

The METRIS-HF-DZHK18 trial aims to find out whether improved energy metabolism can increase heart efficiency in patients with cardiac insufficiency.

Recruiting status
Recruiting complete, follow-up continuing
Principal Investigators
Principal Investigator: Wolfram Döhner (Berlin), Co-PI: Burkert Pieske, Tim Friede (Göttingen)
09/2018 144 EUR 992.572,24 Berlin Frühe klinische Studie Herzschwäche

Home-Based Screening for Early Detection of Atrial Fibrillation in Primary Care Patients Aged 75 Years and Older (SCREEN AF-DZHK15)

The SCREEN-AF study aims to improve the early detection of atrial fibrillation using a new “rhythm patch” with an integrated ECG recording unit which is applied to the patient’s chest.

Recruiting status
Recruiting complete, follow-up continuing
Principal Investigators
Principal investigator for Germany: Rolf Wachter (Göttingen und Leipzig), Co-PI: Eva Hummers (Göttingen), Jeff Healey, David Gladstone (Canadian Stroke Prevention Intervention Network, Kanada)
12/2017 267 EUR 554.819,62 Göttingen,Hamburg Leitlinien-relevante Studie Vorhofflimmern

Evaluating the benefit of concurrent tricuspid valve repair during mitral surgery (CTSN-TVR-DZHK14)

The aim of the study is to clarify whether it is beneficial to operate the tricuspid valve in the right heart at the same time if the mitral valve is defective, even if the right heart valve is not yet very leaky.

Recruiting status
Recruiting complete, follow-up continuing
Principal Investigators
Principal investigator for Germany: Volkmar Falk (Berlin), PI (Sponsor): Annetine C. Gelijns (Icahn School of Medicine at Mount Sinai, NY, USA)
06/2017 76 EUR 722.862,79 Berlin,Leipzig,Jena,Hamburg,Lübeck,Bad Oeynhausen,Göttingen,Frankfurt am Main,Bad Krozingen,München Leitlinien-relevante Studie Herzklappenerkrankungen

Validation of Cardiovascular Magnetic Resonance against Invasive Haemodynamics in Patients with Heart Failure with Preserved Ejection Fraction (Decipher HFpEF-DZHK12)

The DECIPHER HFpEF-DZHK12 study investigates whether diastolic heart failure can be better diagnosed and its causes clarified with the help of cardiovascular magnetic resonance imaging (CMR).

Recruiting status
Recruiting complete
Principal Investigators
Principal investigator: Eike Nagel (Frankfurt)
01/2018 185 EUR 794.443,70 Leipzig,Berlin,Göttingen,Mainz,Frankfurt am Main,Bad Nauheim,Heidelberg Frühe klinische Studie Herzschwäche

Exercise Training in Patients with Left Ventricular Assist Device (Ex-VAD-DZHK11)

This study is examining whether a tailored physical exercise can improve the fitness and quality of life of patients with an artificial heart.

Recruiting status
Study completed
Principal Investigators
Principal investigator: Frank Edelmann (Berlin), Co-PI: Burkert Pieske, Martin Halle (München), Volkmar Falk (Berlin)
12/2017 66 EUR 613.531,61 Berlin,Leipzig,Hamburg,Düsseldorf,München Frühe klinische Studie Herzschwäche

Randomized Trial of TAVI versus SAVR in Patients with Symptomatic Severe Aortic Valve Stenosis and Intermediate Risk of Mortality (DEDICATE-DZHK6)

The DEDICATE-DZHK6 study is investigating whether surgical or transcatheter aortic valve implantation is the superior long-term treatment option for patients with severe aortic valve stenosis.

Recruiting status
Recruiting complete, follow-up continuing
Principal Investigators
Principal investigator: Stefan Blankenberg (Hamburg), Co-PI: Moritz Seiffert (Hamburg)
05/2017 1403 EUR 3.707.316,61 Dresden,Leipzig,Halle (Saale),Jena,Berlin,Brandenburg,Bernau,Greifswald,Karlsburg,Hamburg,Lübeck,Kiel,Hannover,Bad Oeynhausen,Gießen,Göttingen,Magdeburg,Düsseldorf,Bochum,Münster,Köln,Aachen,Koblenz,Frankfurt am Main,Bad Nauheim,Heidelberg,Stuttgart,Freiburg,Bad Krozingen,München,Ulm,Erlangen,Regensburg,Bad Neustadt Leitlinien-relevante Studie Herzklappenerkrankungen

Ultrasound evaluation of the inferior vena cava in addition to clinical assessment to guide decongestion in acute decompensated heart failure: a pilot study (CAVA-ADHF-DZHK10)

This trial is examining whether an ultrasound evaluation of the inferior vena cava in acute decompensated heart failure (ADHF) with congestion can be implemented in hospitals’ everyday routine in a large number of patients.

Recruiting status
Study completed
Principal Investigators
Principal investigator: Alexander Jobs (Lübeck), Co-PI: Holger Thiele (Leipzig)
07/2017 388 EUR 1.026.185,44 Lübeck,Leipzig,Berlin,Greifswald,Hamburg,Kiel,Göttingen,Mainz,Frankfurt am Main,Mannheim,München,Würzburg Frühe klinische Studie Herzschwäche

Cardiovascular magnetic resonance real time exercise stress testing in heart failure with preserved ejection fraction (HFpEF-stress-DZHK17)

Researchers will test in this trial whether the newly developed real-time CMR technology is suitable for the early and safe diagnosis of HFpEF.

Recruiting status
Study completed
Principal Investigators
Principal investigator: Andreas Schuster (Göttingen)
08/2017 70 EUR 316.183,18 Göttingen Frühe klinische Studie Herzschwäche

Left atrial appendage CLOSURE in patients with Atrial Fibrillation at high risk of stroke and bleeding compared to medical therapy (CLOSURE-AF-DZHK16)

The DZHK study CLOSURE-AF compares the benefit of the left atrial appendage closure with the best possible drug therapy for high-risk patients with atrial fibrillation.

Recruiting status
Recruiting ongoing
Principal Investigators
Principal investigator: Ulf Landmesser (Berlin), Co-PI: Ingo Eitel (Lübeck), Leif-Hendrik Boldt (Berlin)
03/2018 1000 EUR 7.121.219,24 Dresden,Leipzig,Halle (Saale),Jena,Zwickau,Berlin,Brandenburg,Hennigsdorf,Greifswald,Rostock,Hamburg,Lübeck,Kiel,Heide,Bremen,Göttingen,Köln,Mainz,Frankfurt am Main,Mannheim,Heidelberg,Tübingen,Bad Krozingen,München,Dachau,Ulm,Coburg,Würzburg,Erfurt Leitlinien-relevante Studie Vorhofflimmern

SPIRonolactone In the Treatment for Heart Failure (SPIRIT-HF-DZHK8)

The SPIRIT-HF-DZHK8 study investigates whether the drug spironolactone can reduce the number of people with preserved ejection fraction who end up in hospital and the number of people who die from heart failure.

Recruiting status
Recruiting ongoing
Principal Investigators
Principal investigator: Frank Edelmann (Berlin) (vormals Burkert Pieske)
11/2018 1300 EUR 7.068.795,31 Dresden,Leipzig,Elsterwerda,Halle (Saale),Jena,Berlin,Potsdam,Brandenburg,Greifswald,Schwerin,Hamburg,Lübeck,Kiel,Bremen,Hannover,Bad Oeynhausen,Gießen,Göttingen,Mainz,Bad Nauheim,Bad Homburg,Mannheim,Heidelberg,Schwäbisch Hall,München,Ulm,Frankfurt am Main Leitlinien-relevante Studie Herzschwäche

Implantable cardiac monitors in high-risk post-infarction patients with cardiac autonomic dysfunction (SMART-MI-DZHK9)

DZHK researchers from Munich test whether the use of implantable cardiac monitors with home monitoring function is more effective than conventional follow-up for detecting serious arrhythmic events in a newly identified high-risk group of patients.

Recruiting status
Study completed
Principal Investigators
Principal investigator: Axel Bauer (München und Insbruck, AT), Co-PI: Stefan Kääb, Steffen Massberg (München)
05/2016 400 EUR 2.126.096,51 München,Kiel,Tübingen,Leipzig,Berlin,Greifswald,Hamburg,Lübeck,Göttingen,Homburg,Karlsruhe,Regensburg,Wuppertal,Dresden,Essen,Münster,Aachen,Mainz,Wiesbaden,Mannheim,Heidelberg,Bernried,Füssen,Nürnberg,Weiden i.d. O Frühe klinische Studie Durchblutungsstörungen des Herzmuskels

Apixaban versus Phenprocoumon: oral anticoagulation plus antiplatelet therapy in patients with acute coronary syndrome and atrial fibrillation (APPROACH-ACS-AF-DZHK7)

DZHK researchers compare two therapies in patients with atrial fibrillation, who have also had a heart attack in order to find out which therapy leads to less bleedings.

Recruiting status
Study completed
Principal Investigators
Principal investigator: Reza Wakili (München und Frankfurt), Co-PI: Steffen Massberg (München)
07/2016 400 EUR 838.617,69 München,Coburg,Berlin,Greifswald,Rostock,Göttingen,Mainz,Heidelberg,Kiel,Essen,Aachen,Mannheim,Lüdenscheid Leitlinien-relevante Studie Durchblutungsstörungen des Herzmuskels

Intravenous iron in patients with systolic heart failure and iron deficiency to improve morbidity and mortality (FAIR-HF2-DZHK5)

The FAIR-HF2 study will be assessing whether treatment with intravenously administered ferric carboxymaltose improves the chances of survival and helps to reduce the number of hospitalisations of heart failure patients diagnosed with iron deficiency.

Recruiting status
Recruiting complete, follow-up continuing
Principal Investigators
Principle investigator; Mahir Karakas (Hamburg), Co-PI: Stefan Anker (Berlin)
03/2017 1200 EUR 7.328.760,30 Dresden,Leipzig,Borna,Halle (Saale),Jena,Berlin,Bernau,Greifswald,Rostock,Hamburg,Lübeck,Kiel,Bremen,Göttingen,Remscheid,Essen,Mainz,Frankfurt am Main,Bad Nauheim,Homburg,Kaiserslautern,Mannheim,Heidelberg,Bad Friedrichshall,München,Ulm,Nürnberg,Zwickau Leitlinien-relevante Studie Herzschwäche

Immediate unselected coronary angiography versus delayed triage in survivors of out-of-hospital cardiac arrest without ST-segment elevation (TOMAHAWK-DZHK4)

TOMAHAWK compares the effects of immediate coronary angiography to delayed intervention in survivors of cardiac arrest who occurred outside a hospital and without ST elevation.

Recruiting status
Study completed
Principal Investigators
Principal investigator: Steffen Desch (Lübeck und Leipzig), Co-PI: Holger Thiele (Leipzig)
11/2016 545 EUR 1.675.125,71 Lübeck,Leipzig,Jena,Berlin,Greifswald,Buchholz,Kiel,Flensburg,Schwalmstadt,Göttingen,Mönchengladbach,Herne,Mainz,Frankfurt am Main,Bad Nauheim,Langen,Limburg,Ludwigshafen,Mannheim,Heidelberg,Bad Krozingen,München,Neumarkt,Regensburg,Würzburg,Erfurt,Bad Berka,Essen,Tübingen Leitlinien-relevante Studie Herzstillstand

Early versus emergency left ventricular assist device implantation in patients awaiting cardiac transplantation (VAD-DZHK3)

This study is expected to deliver guideline-relevant findings for the future treatment of patients with terminal heart failure.

Recruiting status
Recruiting suspended on temporary hold
Principal Investigators
Principal investigator: Volkmar Falk, Co-PI: Christoph Knosalla (Berlin), Gerd Hasenfuß, Tim Friede (Göttingen)
07/2015 200 EUR 2.160.404,61 Leipzig,Jena,Berlin,Hamburg,Kiel,Hannover,Bad Oeynhausen,Göttingen,Magdeburg,Düsseldorf,Bad Nauheim,Heidelberg,Bad Krozingen,München,Erlangen Leitlinien-relevante Studie Herzschwäche

Systolic dysfunction to congestive heart failure cohort study (TransitionCHF-DZHK2)

This cohort study explores ways of predicting when decreased cardiac performance without symptoms will develop into a clinically manifest disease.

Recruiting status
Recruiting complete, follow-up continuing
Principal Investigators
Principal investigator: Gerd Hasenfuß (Göttingen), Co-PI: Rolf Wachter (Leipzig), Anja Sandek (Göttingen), Frank Edelmann (Berlin)
12/2014 1000 EUR 1.786.872,27 Leipzig,Jena,Berlin,Greifswald,Hamburg,Kiel,Göttingen,Mainz,Frankfurt am Main,Bad Nauheim,Mannheim,Heidelberg,München,Regensburg,Würzburg Kohorte Herzschwäche

Translational registry for cardiomyopathies (TORCH-DZHK1)

As a translational registry for cardiomyopathies, TORCH-DZHK1 collects data and biosamples from 2,300 patients with heart muscle diseases.

Recruiting status
Study completed
Principal Investigators
Principal investigator: Hugo Katus (Heidelberg), Co-PI: Wolfgang Hoffmann (Greifswald)
12/2014 2300 EUR 1.286.691,72 Heidelberg,Berlin,Greifswald,Hamburg,Lübeck,Göttingen,Mainz,Frankfurt am Main,Bad Nauheim,Mannheim,München,Hannover,Kiel Register Herzmuskelerkrankungen

Revacept, a novel inhibitor of platelet adhesion in patients with stable coronary artery disease undergoing elective percutaneous coronary intervention (ISAR-PLASTER)

The study objective is to evaluate the efficacy and safety of treatment of the drug Revacept versus placebo in patients with stable coronary artery disease undergoing PCI.

Recruiting status
Study completed
Principal Investigators
Principal investigator: Adnan Kastrati (München), Co-PI: Steffen Massberg (München)
11/2017 332 EUR 975.353.08 München,Frankfurt am Main,Mainz,Berlin,Tübingen Frühe klinische Studie

Prospective, randomized trial of ticagrelor versus prasugrel in patients with acute coronary syndrome (ISAR-REACT 5)

This study compares two agents used to inhibit blood clotting - ticagrelor and prasugrel. The hypothesis that ticagrelor is superior to prasugrel for the treatment of patients with acute coronary syndrome will be examined in relation to clinical outcomes.

Recruiting status
Study completed
Principal Investigators
Principal investigator: Adnan Kastrati (München), Co-PI: Stefanie Schüpke (München)
09/2013 4000 EUR 1.099.168,82 München Leitlinien-relevante Studie

Phosphodiesterase-5 inhibition in patients with combined pre- and postcapillary pulmonary hypertension due to heart failure with preserved ejection fraction (PASSION)

The DZHK associated study PASSION investigates whether the drug Tadalafil can reduce cardiac-related hospital admissions and mortality of patients with pulmonary hypertension due to heart failure.

Recruiting status
Recruiting stopped
Principal Investigators
Marius Hoeper (Hannover), Stephan Rosenkranz (Köln)
10/2018 356 DZHK-assoziierte Studie (keine finanzielle Förderung) Hannover,Köln,Marburg,Heidelberg,Dresden,Leipzig,Würzburg,Berlin,Gießen,Greifswald,Homburg/Saar,Mainz,Regensburg,München,Immenhausen,Großhansdorf,Magdeburg,Mönchengladbach,Konstanz,Bremen,Bonn,Erfurt,Ulm,Donaueschingen Leitlinien-relevante Studie

Diagnostic Imaging Strategies for Patients with Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE)

The DZHK-associated study DISCHARGE compares whether cardiac CT or cardiac catheterization is better for the evaluation of coronary artery disease.

Recruiting status
Recruiting complete, follow-up continuing
Principal Investigators
Marc Dewey (Berlin)
10/2015 3546 DZHK-assoziierte Studie (keine finanzielle Förderung) Berlin Leitlinien-relevante Studie

Randomised placebo controlled clinical trial of efficacy of MYOcardial protection in patients with postacute inFLAMmatory cardiac involvEment due to COVID-19 (MYOFLAME-19)

The DZHK-associated MYOFLAME-19 study is investigating the long-term consequences of Covid19 in relation to the cardiovascular system.

Recruiting status
Recruiting ongoing
Principal Investigators
Principal investigator: Valentina Puntmann (Frankfurt), Co-PI: Eike Nagel (Frankfurt), Inga Voges (Kiel), Marcus Dörr (Greifswald), Dietrich Beitzke (Wien)
09/2022 280 DZHK-assoziierte Studie (keine finanzielle Förderung) Frankfurt am Main

Continuation of the cohort “inflammatory cardiomyopathy” of the collaborative research centre transregio 19 (SFB/TR19) as “SFB/TR19 Plus”

The cohort study SFB/TR 19 plus investigates new diagnostic and treatment approaches for inflammatory cardiomyopathies.

Principal Investigators
Principal investigator: Marcus Dörr (Greifswald)
06/2015 500 0 Greifswald Kohorte Herzmuskelerkrankungen

Culprit Lesion Only PCI Versus Multivessel PCI in Cardiogenic Shock (CULPRIT-SHOCK)

Prospective randomized multicenter study comparing immediate multivessel revascularization by PCI versus culprit lesion PCI with staged non-culprit lesion revascularization in patients with acute myocardial infarction complicated by cardiogenic shock.

Recruiting status
Study completed
Principal Investigators
Principal investigator: Holger Thiele (Lübeck und Leipzig)
04/2013 706 DZHK-assoziierte Studie (keine finanzielle Förderung) Lübeck,Erfurt,Lippe-Detmold,München,Langen-Seligenstadt,Leipzig,Magdeburg,Göttingen,Coburg,Mannheim,Greifswald,Bremen,Bambek,Würzburg,Düsseldorf,Regensburg,Wiesbaden Leitlinien-relevante Studie

SORT-AF Supervised Obesity Reduction Trial for AF Ablation Patients (SORT-AF)

Prospective randomized multicenter study to evaluate the impact of weight reduction on AF recurrence after AF ablation in obese patients.

Recruiting status
Study completed
Principal Investigators
Stephan Willems (Hamburg), Daniel Steven (Köln)
01/2014 140 DZHK-assoziierte Studie (keine finanzielle Förderung) Lübeck,Köln,Hamburg Leitlinien-relevante Studie

German Aortic valve RegistrY (GARY)

Prospective, controlled, multicenter registry study to evaluate the variability in structural requirements, processes, andresults for different aortic valve therapies (e.g. surgical AVR and TAVI,different prosthetic valve devices).

Recruiting status
Recruiting ongoing
Principal Investigators
Christian Hamm (Bad Nauheim), Friedhelm Beyersdorf (Freiburg), Eva Herrmann (Frankfurt)
07/2010 0 575.915,01 Register Herzklappenerkrankungen

Evaluation of the safety and efficacy of the OPTIMIZER ® system in subjects with moderate-to-severe heart failure (FIX-HF-5C)

The study was designed to evaluate both safety and efficacy of the OPTIMIZER system in patients with moderate to severe heart failure.

Recruiting status
Study completed
Principal Investigators
Gerd Hasenfuß (Göttingen)
10/2014 160 DZHK-assoziierte Studie (keine finanzielle Förderung) Göttingen,Essen,Bad Bevensen,Berlin,Hamburg,Mannheim,München Leitlinien-relevante Studie

Non-vitamin K antagonist oral anticoagulants in patients with atrial high rate episodes (NOAH-AFNET 6)

NOAH-AFNET 6 evaluates the potential benefit of oral anticoagulation treatment in patients with atrial high rate episodes.

Recruiting status
Study completed
Principal Investigators
Paulus Kirchhof (Birmingham, Münster)
06/2016 2538 0 Münster Leitlinien-relevante Studie

Early treatment of atrial fibrillation for stroke prevention trial (EAST – AFNET 4)

In the EAST – AFNET 4 study, atrial fibrillation shall be detected early on.

Recruiting status
Study completed
Principal Investigators
Paulus Kirchhof (Birmingham, Münster)
07/2011 2789 0 Leitlinien-relevante Studie

National register for congenital heart defects (NRCHD)

The person-based register records data from patients of all age groups and with all kinds of congenital heart defects across Germany.

Recruiting status
Recruiting ongoing
Principal Investigators
Ulrike Bauer, Thomas Pickardt (Berlin)
2000 70000 0 Berlin,Aachen,augsburg,Bad Oeynhausen,Bochum,Bonn,Bremen,Chemnitz,Coesfeld,Datteln,Dortmund,Dresden,Duisburg,Düsseldorf,Eichwalde,Erfurt,Erlangen,Frankfurt am Main,Freiburg,Fulda,Fürth,Gelsenkirchen,Greifswald,Gießen,Göttingen,Hagen,Halle (Saale),Hamburg,Hannover,Heidelberg,Homburg,Ibbenbüren,Jena,Kaiserslautern,Karlsruhe,Kassel,Kempten,Kiel,Krefeld,Köln,Landshut,Leipzig,Lingen,Wittenberg,Lübeck,Mainz,Mannheim,Memmingen,München,Münster,Oberhausen,Oldenburg,Pinneberg,Ravensburg,Regensburg,Rheinfelden-Herten,Rosenheim,Rothenburg,Saalfeld,Sainkt Augustin,Stuttgart,Traunstein,Tübingen,Ulm,Vechta,Weimar,Wuppertal,Würzburg Register

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