Projects

DZHK Publishing Policy

Publications are an essential criterion for the success and visibility of researchers and organizations. Our Publishing Policy regulates the handling of affiliation, acknowledgment and the citation of authorship. It applies to all DZHK-funded projects as well as to projects based on the DZHK Heart Bank.

DZHK Publishing Policy


Contact

DZHK Use and Access Office
Alexandra Klatt
Tel: 030 3465 529-10
use.access(at)dzhk.de

All research projects that work with data and biosamples from the DZHK Heart Bank and that have been approved to date can be found here. You can search for the resource you are using or do a full text search.

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A genomic perspective on the spread of farming to Germany

The adoption of farming by Neolithic populations is one of the most dramatic and influential ecological shifts in the recent history of our species. Recent ancient DNA (aDNA) studies have clarified longstanding questions concerning the Neolithization of Western Eurasia. By sequencing the genomes of early farmers ...

Principal Investigators
Joachim Burger, Yoan Diekmann (Johannes Gutenberg-Universität Mainz, Institute of Organismic and Molecular Evolution, Palaeogenetics Group)
dzhkomics-resource

Proteomic exploration of disease mechanisms related to the novel biomarker CCN1 for prediction of death in patients with dilated cardiomyopathy

Phenotyping in heart failure using a proteomic approach constitutes the next frontier and may enable the identification of novel biomarkers and new therapeutic targets.

Principal Investigators
Roland Klingenberg, Marcus Dörr (Kerckhoff Clinic, Dept. of Cardiology, Klinik & Greifswald University Medicine, Clinic and Polyclinic for Internal Medicine B)
resource-liquid-samples-image-data

Epigenetic and RNA-based biomarker validation in Cardiomypathies

Diseases of the heart muscle (cardiomyopathies) are common heart diseases that often have a severe course, up to and including heart failure.

Principal Investigators
Jan Haas, Benjamin Meder (University Hospital Heidelberg, Analysezentrum III)
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Proteogenomic discovery of endothelium-derived microproteins in cardiovascular disease

We have identified a unique set of thousands of microproteins (miPs, shorter than 100 amino acids) encoded by previously unannotated small open reading frames (smORFs) in human and murine endothelial cells.

Principal Investigators
Mauro Siragusa (Goethe Universität Frankfurt a Main, Institute for Vascular Signalling, Zentrum für Molekulare Medizin)
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Cardiac disease causative mutations in the Eph/ephrin signalling pathway

This project will study patients with dilated or hypertrophic cardiomyopathy that present mutations in the Eph/ephrin signaling pathway.

Principal Investigators
Guillermo Luxán (Goethe-University Frankfurt a Main, Institute of Cardiovascular Regeneration)
resource-liquid-samples-image-data

Identification of circulatory proteins reflecting myocardial processes relevant to disease progression in heart failure

Exploration of molecular fingerprints of patients with heart failure provides a promising approach to better understand mechanisms relevant for the development and progression of the disease.

Principal Investigators
Jürgen Prochaska, Philipp Wild (University Medical Center of the Johannes Gutenberg-University Mainz, Preventive Cardiology and Preventive Medicine, Department of Cardiology)
resource-tissue-samples

The role of urinary Dickkopf-3 in cardiorenal syndrome

Impaired renal function is common in patients with heart failure. Up to 50 percent of patients show chronic kidney disease (CKD), associated with worse outcomes and complicates pharmacological management.

Principal Investigators
Manuel Wallbach, Michael Koziolek (University Medical Center Göttingen, Nephrology and Rheumatology)
resource-liquid-samples-image-data

Computational assessment of genetic regulatory effects on RNA life using the DZHKomics resource

Genome-wide association studies (GWAS) have revealed tens of thousands of genomic loci associated with numerous traits and diseases; however, the underlying causal mechanism often remains poorly understood.

Principal Investigators
Christoph Dieterich, Silke Szymczak (Klaus Tschira Institute for Integrative Computational Cardiology, Institute for Medical Biometry and Statistics)
dzhkomics-resource

Characterisation and risk stratification of patient subgroups in dilated cardiomyopathy by utilisation of an inflammatory 47-plex-biomarker panel

Inflammation plays a role in the development of heart failure and dilated cardiomyopathy and cytokines are involved in these processes.

Principal Investigators
Kristin Lehnert, Sabine Ameling (Greifswald University Medicine and Institute Functional Genomics, Clinic and Polyclinic for Internal Medicine B)
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Methylation profile of circulating cell-free DNA as a diagnostic tool for heart disease stratification

Circulating cell-free DNA (ccfDNA) is released to the plasma after cell death and therefore can be used to evaluate the extension of tissue damage.

Principal Investigators
Ulf Landmesser, Adelheid Kratzer (Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin (CBF), Department of Cardiology) in collaboration with Dr. Altuna Akalin (BIMSB, Bioinformatics, MDC Berlin)
resource-liquid-samples-image-data

Characterization of lipidome dynamics in anthracycline-induced cardiotoxicity

Principal Investigators
Niklas Beyhoff (Charité – Universitätsmedizin Berlin, Institute of Pharmacology)
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Transition from acute to terminal heart failure - Activation of cardiac fibroblasts in non-infarcted areas of the heart

Principal Investigators
Timo Nazari-Shafti, Sebastian Neuber (German Heart Center Berlin)
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Discovery and systematical characterization of Splicing Variation in Coronary Artery Disease

Genome-wide association studies (GWAS) have successfully identified over 300 gene loci contributing to the risk of coronary artery disease (CAD).

Principal Investigators
Heribert Schunkert, Zhifen Chen (German Heart Centre Munich)
dzhkomics-resource

Association of single nucleotide polymorphism (SNPs) within the MAP3K12 gene with cardiovascular risk factors

The mitogen-activated protein 3 kinase 12 (MAP3K12) alias dual leucine zipper kinase (DLK) is mainly involved in the pathogenesis of neurodegenerative diseases.

Principal Investigators
Elke Oetjen (University Medical Center Hamburg- Eppendorf, Institute of Clinical Pharmacology and Toxicology)
dzhkomics-resource

Genetics of autoimmune encephalitis

Autoimmune brain inflammations are a group of rare, serious brain diseases caused mainly by auto-antibodies, which have only been known for about 15 years and lead to neurological and psychiatric symptoms.

Principal Investigators
Gregor Kuhlenbäumer, Anja Tietz, Frank Leypoldt (Kiel University and University Hospital Schleswig Holstein Kiel, Dept. of Neurology)
dzhkomics-resource

Exercise testing in patients with asymptomatic systolic heart failure

The project will further investigate two factors related to exercise capacity in NYHA I patients: the influence of the right heart and quality of life/mental health.

Principal Investigators
Gerd Hasenfuß, Anja Sandek, Hannah Bräunig (University Medical Center Göttingen, Clinic for Cardiology and Pneumology)
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Molecular markers and new therapeutic targets in patients with inflammatory cardiomyopathy

The exact pathomechanisms of inflammatory cardiomyopathy continue to be relevant to current cardiovascular science.

Principal Investigators
Bettina Heidecker, Benjamin Meder (Charité Universitätsmedizin Berlin, Campus Benjamin Franklin (CBF), Department of Cardiology and University Hospital Heidelberg, Institute for Cardiomyopathies)
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Exercise capacity and systolic and diastolic dysfunction in patients with NYHA I

While systolic dysfunction can be easily identified on echocardiography by using ejection fraction (EF), the diagnosis of diastolic dysfunction requires multiple criteria in echocardiography.

Principal Investigators
Gerd Hasenfuß, Anja Sandek, Moritz Peters (University Medical Center Göttingen, Clinic for Cardiology and Pneumology)
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Mass spectrometric detection of complex lipids in calcified aortic valves

Calcific aortic valve disease (CAVD) is the most common valvular heart disease requiring treatment in the western world.

Principal Investigators
Elias Rawish, Christian Frerker (Medical Clinic II, UKSH Lübeck Campus)
resource-tissue-samples

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