Projects

DZHK Publishing Policy

Publications are an essential criterion for the success and visibility of researchers and organizations. Our Publishing Policy regulates the handling of affiliation, acknowledgment and the citation of authorship. It applies to all DZHK-funded projects as well as to projects based on the DZHK Heart Bank.

DZHK Publishing Policy


Contact

DZHK Use and Access Office
Alexandra Klatt
Tel: 030 3465 529-10
use.access(at)dzhk.de

All research projects that work with data and biosamples from the DZHK Heart Bank and that have been approved to date can be found here. You can search for the resource you are using or do a full text search.

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A genomic perspective on the spread of farming to Germany

The adoption of farming by Neolithic populations is one of the most dramatic and influential ecological shifts in the recent history of our species. Recent ancient DNA (aDNA) studies have clarified longstanding questions concerning the Neolithization of Western Eurasia. By sequencing the genomes of early farmers ...

Principal Investigators
Burger, Joachim and Diekmann, Yoan (Johannes Gutenberg-Universität Mainz, Institute of Organismic and Molecular Evolution, Palaeogenetics Group)
dzhkomics-resource

Proteomic exploration of disease mechanisms related to the novel biomarker CCN1 for prediction of death in patients with dilated cardiomyopathy

Phenotyping in heart failure using a proteomic approach constitutes the next frontier and may enable the identification of novel biomarkers and new therapeutic targets.

Principal Investigators
Klingenberg, Roland and Dörr, Marcus (Kerckhoff-Klinik, Dept. of Cardiology and Klinik und Poliklinik für Innere Medizin B, Universitätsmedizin Greifswald)
resource-liquid-samples-image-data

Epigenetic and RNA-based biomarker validation in Cardiomypathies

Diseases of the heart muscle (cardiomyopathies) are common heart diseases that often have a severe course, up to and including heart failure.

Principal Investigators
Haas, Jan and Meder, Benjamin (University Hospital Heidelberg, Analysezentrum III)
resource-liquid-samples-image-data

Proteogenomic discovery of endothelium-derived microproteins in cardiovascular disease

Principal Investigators
Siragusa, Mauro (Goethe Universität Frankfurt a Main, Institute for Vascular Signalling, Zentrum für Molekulare Medizin)
resource-liquid-samples-image-data

Cardiac disease causative mutations in the Eph/ephrin signalling pathway

This project will study patients with dilated or hypertrophic cardiomyopathy that present mutations in the Eph/ephrin signaling pathway.

Principal Investigators
Luxán, Guillermo (Goethe-University Frankfurt a Main, Institute of Cardiovascular Regeneration)
resource-liquid-samples-image-data

Identification of circulatory proteins reflecting myocardial processes relevant to disease progression in heart failure

Principal Investigators
Prochaska, Jürgen and Wild, Philipp (University Medical Center of the Johannes Gutenberg-University Mainz, Preventive Cardiology and Preventive Medicine, Department of Cardiology)
resource-tissue-samples

The role of urinary Dickkopf-3 in cardiorenal syndrome

Impaired renal function is common in patients with heart failure. Up to 50 percent of patients show chronic kidney disease (CKD), associated with worse outcomes and complicates pharmacological management.

Principal Investigators
Wallbach, Manuel and Koziolek, Michael (University Medical Center Göttingen, Nephrology and Rheumatology)
resource-liquid-samples-image-data

Computational assessment of genetic regulatory effects on RNA life using the DZHK OMICS resource

Principal Investigators
Dieterich, Christoph and Szymczak, Silke (Klaus Tschira Institute for Integrative Computational Cardiology and Institut für Medizinische Biometrie und Statistik)
dzhkomics-resource

Characterisation and risk stratification of patient subgroups in dilated cardiomyopathy by utilisation of an inflammatory 47-plex-biomarker panel

Principal Investigators
Lehnert, Kristin and Ameling, Sabine (Klinik und Poliklinik für Innere Medizin B, Universitätsmedizin Greifswald und Abteilung für Funktionelle Genomforschung)
resource-liquid-samples-image-data

Methylation profile of circulating cell-free DNA as a diagnostic tool for heart disease stratification

Principal Investigators
Landmesser, Ulf and Kratzer, Adelheid (Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin (CBF), Department of Cardiology) in collaboration with Dr. Altuna Akalin (BIMSB, Bioinformatics, MDC Berlin)
resource-liquid-samples-image-data

Characterization of lipidome dynamics in anthracycline-induced cardiotoxicity

Principal Investigators
Beyhoff, Niklas (Charité – Universitätsmedizin Berlin, Institute of Pharmacology)
resource-tissue-samples

Principal Investigators
Nazari-Shafti, Timo and Neuber, Sebastian (Deutsches Herzzentrum Berlin)
resource-tissue-samples

Discovery and systematical characterization of Splicing Variation in Coronary Artery Disease

Genome-wide association studies (GWAS) have successfully identified over 300 gene loci contributing to the risk of coronary artery disease (CAD).

Principal Investigators
Schunkert, Heribert and Chen, Zhifen (Deutsches Herzzentrum München)
dzhkomics-resource

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