Facilitating International Clinical Trials

Supporting multinational clinical trials is a focus of the newly established Global Cardiovascular Research Funders Forum (GCRFF). The Initiative is a sub-group of 7 of the 12 national funders.

It aims to facilitate multinational clinical trials by bringing all potential funders to the table right from the start. Scientists simply submit an "Expression of Interest" (EOI) - the initiative coordinates the matching of national funders.

The process has clear advantages for scientists and funders:

  • All funding organisations can get involved in the study design from the beginning. Until now, it has usually been the case that other funding organisations are only brought on board once the study has already been started with one funding organisation.
  • The study can be coordinated and started simultaneously in different countries: this increases the chances of success.
  • Reduce the risk to the funder(s) because there is greater assurance that the trial will be deliverable and costs are spread.

Want to submit an expression of interest (EOI)?

How it Works

Applicants from Germany do not necessarily have to be members of the DZHK.

> Not a DZHK member?

If you are not a member of the DZHK, and are therefore not eligible to apply for funding from the DZHK, you should plan to apply for national funding for the German component of your study, for example from the Federal Ministry of Education and Research (BMBF) or the German Research Foundation (DFG).

The EOI is submitted via the Grants Management System der British Heart Foundation (BHF).

> Member of the DZHK?

DZHK PIs, DZHK scientists, members of the Young DZHK, and scientists who are members of one of the Cardiological Competence Networks associated with the DZHK are eligible to apply for funding from the DZHK. (The funding recipient should be the respective DZHK partner institution, or one of the registered associations of the Cardiological Competence Networks.)

3 steps to promote the German component of the study

If you are applying to the DZHK for funding for the German component of the study, please proceed as follows:
> Submit a short application to the Clinical Study Group (CSG)
> Only submit the EOI to the GCRFF after the CSG advises you to do so
> Submit funding application to the DZHK

This way, it is more likely that DZHK will agree to funding of the German part. Please note, that your application for the German component of the study needs to follow the rules outlined in the DZHK funding scheme for guideline relevant studies.

What must be included in the EOI?

> Please note, the EOI must include co-applicants from the countries of the national funders who have been named in the funding request. Co-applicants should have been fully engaged in the development of the study and should have inputted into the EOI.
> If you have already secured funding for elements of the study, please provide details (funders name, amount awarded, date of award) in the EOI.
> Also, outline any formal applications for funding that have been submitted, where a result is awaited. Give the details of the funder, funding scheme and the date when a decision will be reached.

The EOI is submitted via the Grants Management System der British Heart Foundation (BHF).

Detailed information on the process and criteria can be found on the British Heart Foundation website: 

How it works
Criteria for submitting an Expression of Interest
How to apply

Deadlines & Panel Dates 2022/2023

29th September 2022, 18:00 (CET): Submit EOI
29th November 2022: Expert Advisory Panel meeting

27th January 2023, 10:00 (CET): Submit EOI
23rd March 2023: Expert Advisory Panel meeting

26th May 2023, 10:00 (CET): Submit EOI
20th July 2023: Expert Advisory Panel meeting

29th September 2023, 10:00 (CET): Submit EOI
29th November 2023: Expert Advisory Panel meeting

The EOI is submitted via the Grants Management System der British Heart Foundation (BHF):

Please Note

The GCRFF Multinational Clinical Trials Initiative provides a mechanism to support better coordination of consideration of multinational trial funding. It does not fund trials directly, nor does it guarantee funding by individual funders.

Global Cardiovascular Research Funders Forum (GCRFF)

We've joined forces with leading cardiovascular research funders in a new global partnership. The Global Cardiovascular Research Funders Forum (GCRFF) aims to accelerate the pace of progress by creating opportunities for cross-border coordination and collaboration between world-leading cardiovascular researchers and organisations. Its members will initially collaborate by sharing information on research funding priorities, strategic initiatives, and clinical trials.

The Forum includes many of the biggest independent funders of cardiovascular research in the world, which together support more than US$600 million in research annually.

The 12 members are:

Australia - National Heart Foundation of Australia
Canada - The Heart and Stroke Foundation of Canada; Institute of Circulatory and Respiratory Health, Canadian Institutes of Health Research, Canada
Denmark - Danish Heart Foundation (Hjerteforeningen)
France - Leducq Foundation
Germany - German Centre for Cardiovascular Research
Great Britain - British Heart Foundation
Netherlands - Dutch Heart Foundation (Hartstichting)
New Zealand - National Heart Foundation of New Zealand
Sweden - Swedish Heart Lung Foundation (Hjärt-Lungfonden)
USA - American Heart Association; National Heart, Lung and Blood Institute
Despite the astonishing progress that cardiovascular research has made in recent decades, cardiovascular diseases remain the biggest cause of death and disability globally, meaning urgent progress is needed.

International funders aim to improve global heart health (22.06.2021) press release