Publications 2022

Here you will find publications of the DZHK in chronological order. First authors in grey are members of the Young DZHK. For more publications, please also check out the websites of the individual research institutions that participate in the DZHK.

DZHK Papers of the Month


Sex disparities in patients with suspected COVID-19 presenting at an emergency department in Switzerland. Arslani, K., Eken, C., Tschudin-Sutter, S., Gebhard, C. E., Zellweger, N., Bassetti, S., Bingisser, R., Lampart, M., Osswald, S., Kuster, G. M., Twerenbold, R. & investigators, C. Swiss Med Wkly 152 (2022).  

Effect of Thrombin on the Metabolism and Function of Murine Macrophages. Ukan, U., Delgado Lagos, F., Kempf, S., Gunther, S., Siragusa, M., Fisslthaler, B. & Fleming, I. Cells 11 (2022).  

Structured, Harmonized, and Interoperable Integration of Clinical Routine Data to Compute Heart Failure Risk Scores. Sommer, K. K., Amr, A., Bavendiek, U., Beierle, F., Brunecker, P., Dathe, H., Eils, J., Ertl, M., Fette, G., Gietzelt, M., Heidecker, B., Hellenkamp, K., Heuschmann, P., Hoos, J. D. E., Kesztyus, T., Kerwagen, F., Kindermann, A., Krefting, D., Landmesser, U., Marschollek, M. et al. Life (Basel) 12 (2022).  

Atherosclerosis and Its Impact on the Outcomes of Patients with Deep Venous Thrombosis. Keller, K., Prochaska, J. H., Coldewey, M., Gobel, S., Schmitt, V. H., Hahad, O., Ullmann, A., Nagler, M., Lamparter, H., Espinola-Klein, C., Munzel, T. & Wild, P. S. Life (Basel) 12 (2022).  

Pulmonary Artery Pressure-Guided Telemonitoring Reduced Pulmonary Artery Pressure but Did Not Result in Higher Doses of Guideline-Directed Medical Therapy-Observations from an Advanced Elderly German Heart Failure Cohort. Herrmann, E. J., Raghavan, B., Eissing, N., Fichtlscherer, S., Hamm, C. W. & Assmus, B. Life (Basel) 12 (2022).  

Metabolomic Profiling in Patients with Heart Failure and Exercise Intolerance: Kynurenine as a Potential Biomarker. Bekfani, T., Bekhite, M., Neugebauer, S., Derlien, S., Hamadanchi, A., Nisser, J., Hilse, M. S., Haase, D., Kretzschmar, T., Wu, M. F., Lichtenauer, M., Kiehntopf, M., von Haehling, S., Schlattmann, P., Lehmann, G., Franz, M., Mobius-Winkler, S. & Schulze, C. Cells 11 (2022).  

Right Antero-Lateral Mini-Thoracotomy Surgical Aortic Valve Replacement. Van Praet, K. M., Nersesian, G., Kofler, M., Sundermann, S. H., Unbehaun, A., Falk, V. & Kempfert, J. Surg Technol Int 41 (2022).  

David Procedure as Valve-Sparing Root Replacement. Pitts, L., Van Praet, K. M., Montagner, M., Kofler, M., Falk, V. & Kempfert, J. Surg Technol Int 41 (2022).  

Rac1 regulates lipid droplets formation, nanomechanical, and nanostructural changes induced by TNF in vascular endothelium in the isolated murine aorta. Pacia, M. Z., Chorazy, N., Sternak, M., Fels, B., Pacia, M., Kepczynski, M., Kusche-Vihrog, K. & Chlopicki, S. Cell Mol Life Sci 79, 317 (2022).  

The Relationship Between Vitamin D and Postoperative Atrial Fibrillation: A Prospective Cohort Study. Ohlrogge, A. H., Brederecke, J., Ojeda, F. M., Pecha, S., Borschel, C. S., Conradi, L., Rimkus, V., Blankenberg, S., Zeller, T. & Schnabel, R. B. Front Nutr 9, 851005 (2022).  

Clinical utility of inflammatory biomarkers in COVID-19 in direct comparison to other respiratory infections-A prospective cohort study. Lampart, M., Zellweger, N., Bassetti, S., Tschudin-Sutter, S., Rentsch, K. M., Siegemund, M., Bingisser, R., Osswald, S., Kuster, G. M. & Twerenbold, R. PLoS One 17, e0269005 (2022).  

Understanding the Role of SERCA2a Microdomain Remodeling in Heart Failure Induced by Obesity and Type 2 Diabetes. Lai, P., Nikolaev, V. O. & De Jong, K. A. J Cardiovasc Dev Dis 9 (2022).  

Generalizability of the EAST-AFNET 4 Trial: Assessing Outcomes of Early Rhythm-Control Therapy in Patients With Atrial Fibrillation. Dickow, J., Kirchhof, P., Van Houten, H. K., Sangaralingham, L. R., Dinshaw, L. H. W., Friedman, P. A., Packer, D. L., Noseworthy, P. A. & Yao, X. J Am Heart Assoc 11, e024214 (2022).  

Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity. Batlle, D., Monteil, V., Garreta, E., Hassler, L., Wysocki, J., Chandar, V., Schwartz, R. E., Mirazimi, A., Montserrat, N., Bader, M. & Penninger, J. M. Cell 185, 1837-1839 (2022).  

Remote control of the heart and beyond. Zimmermann, W. H. Science 376, 917-918 (2022).  

Stand-alone Focal Impulse and Rotor Modulation (FIRM) ablation versus second-generation cryoballoon pulmonary vein isolation for paroxysmal atrial fibrillation. Tilz, R. R., Yalin, K., Lyan, E., Heeger, C. H., Schluter, M., Fink, T., Sciacca, V., Liosis, S., Kuck, K. H., Popescu, S. S., Mortensen, K., Meyer-Saraei, R., Eitel, C. & Vogler, J. J Cardiovasc Electrophysiol (2022).  

Hidden Agenda - The Involvement of Endoplasmic Reticulum Stress and Unfolded Protein Response in Inflammation-Induced Muscle Wasting. Kny, M. & Fielitz, J. Front Immunol 13, 878755 (2022).  

Population kinetics of homoarginine and optimized supplementation for cardiovascular risk reduction. Kleist, C. J., Choe, C. U., Atzler, D., Schonhoff, M., Boger, R., Schwedhelm, E. & Wicha, S. G. Amino Acids 54, 889-896 (2022).  

Gender Differences in Takotsubo Syndrome. Arcari, L., Nunez Gil, I. J., Stiermaier, T., El-Battrawy, I., Guerra, F., Novo, G., Musumeci, B., Cacciotti, L., Mariano, E., Caldarola, P., Parisi, G., Montisci, R., Vitale, E., Sclafani, M., Volpe, M., Corbi-Pasqual, M., Martinez-Selles, M., Almendro-Delia, M., Sionis, A., Uribarri, A. et al. J Am Coll Cardiol 79, 2085-2093 (2022).  

Implementation of a Clinical Trial Recruitment Support System Based on Fast Healthcare Interoperability Resources (FHIR) in a Cardiology Department. Scherer, C., Endres, S., Orban, M., Kaab, S., Massberg, S., Winter, A. & Lobe, M. Stud Health Technol Inform 294, 440-444 (2022).  

Patient Characteristics, Procedural Characteristics, and Outcomes in Patients Having Lead Extraction in a High-Volume Center. O'Connor, M., Schmidt, P., Knoll, K., Schaarschmidt, C., Bock, M., Bahlke, F., Georgi, M., Frohlich, R., Sonne, C., Kottmaier, M., Reents, T., Bourier, F., Hessling, G., Deisenhofer, I., Kolb, C. & Lennerz, C. Am J Cardiol 176, 51-57 (2022).  

The long non-coding RNA MEG8 induces an endothelial barrier through regulation of microRNA-370 and -494 processing. Kremer, V., Stanicek, L., van Ingen, E., Bink, D. I., Hilderink, S., Tijsen, A. J., Wittig, I., Magdefessel, L., Nossent, A. Y. & Boon, R. A. J Cell Sci 135 (2022).  

Serotonin limits generation of chromaffin cells during adrenal organ development. Kameneva, P., Melnikova, V. I., Kastriti, M. E., Kurtova, A., Kryukov, E., Murtazina, A., Faure, L., Poverennaya, I., Artemov, A. V., Kalinina, T. S., Kudryashov, N. V., Bader, M., Skoda, J., Chlapek, P., Curylova, L., Sourada, L., Neradil, J., Tesarova, M., Pasqualetti, M., Gaspar, P. et al. Nat Commun 13, 2901 (2022).  

Protective actions of nuclear factor erythroid 2-related factor 2 (NRF2) and downstream pathways against environmental stressors. Bayo Jimenez, M. T., Frenis, K., Hahad, O., Steven, S., Cohen, G., Cuadrado, A., Munzel, T. & Daiber, A. Free Radic Biol Med 187, 72-91 (2022).  

Virtual reality in cardiac interventions-New tools or new toys? Sundermann, S. H., Hennemuth, A. & Kempfert, J. J Card Surg (2022).  

Safety and performance of a novel cerebral embolic protection device for transcatheter aortic valve implantation: the PROTEMBO C Trial. Jagielak, D., Targonski, R., Frerker, C., Abdel-Wahab, M., Wilde, J., Werner, N., Lauterbach, M., Leick, J., Grygier, M., Misterski, M., Erglis, A., Narbute, I., Witkowski, A. R., Adam, M., Frank, D., Gatto, F., Schmidt, T. & Lansky, A. J. EuroIntervention (2022).  

Insulin-Like Growth Factor, Inflammation, and MRI Markers of Alzheimer's Disease in Predominantly Middle-Aged Adults. Wittfeld, K., Raman, M. R., Conner, S. C., Aslam, A., Teumer, A., Nauck, M., Hosten, N., Habes, M., DeCarli, C., Vasan, R. S., Beiser, A. S., Himali, J. J., Seshadri, S., Grabe, H. J. & Satizabal, C. L. J Alzheimers Dis (2022).  

Real-Time Electrocardiogram Monitoring during Treadmill Training in Mice. Tomsits, P., Sharma Chivukula, A., Raj Chataut, K., Simahendra, A., Weckbach, L. T., Brunner, S. & Clauss, S. J Vis Exp (2022).  

Drug-coated balloons in below-the-knee arteries. Stoll, F., Uslu, R., Blessing, E., Frey, N., Katus, H. A., Erbel, C., Heilmeier, B. & Muller, O. J. Vasa (2022).  

Lived experiences of patients implanted with left ventricular assist devices. Inyom, C., Haese, T., Schoenrath, F., Potapov, E. & Knierim, J. Heart Lung 55, 155-161 (2022).  

Inflammatory Mediators in Atherosclerotic Vascular Remodeling. Evans, B. R., Yerly, A., van der Vorst, E. P. C., Baumgartner, I., Bernhard, S. M., Schindewolf, M. & Doring, Y. Front Cardiovasc Med 9, 868934 (2022).  

Awareness of sex and gender dimensions among physicians: the European federation of internal medicine assessment of gender differences in Europe (EFIM-IMAGINE) survey. Biskup, E., Marra, A. M., Ambrosino, I., Barbagelata, E., Basili, S., de Graaf, J., Gonzalvez-Gasch, A., Kaaja, R., Karlafti, E., Lotan, D., Kautzky-Willer, A., Perticone, M., Politi, C., Schenck-Gustafsson, K., Vilas-Boas, A., Roeters van Lennep, J., Gans, E. A., Regitz-Zagrosek, V., Pilote, L., Proietti, M. et al. Intern Emerg Med 17, 1395-1404 (2022).  

Outcomes with empagliflozin in heart failure with preserved ejection fraction using DELIVER-like endpoint definitions. Anker, S. D., Siddiqi, T. J., Filippatos, G., Zannad, F., Ferreira, J. P., Pocock, S. J., Brueckmann, M., Zeller, C., Packer, M. & Butler, J. Eur J Heart Fail (2022).  

Maternal socioeconomic and lifestyle factors and life dissatisfaction associated with a small for gestational age infant. The Survey of Neonates in Pomerania (SNiP). Pierdant, G., Ittermann, T., Freyer-Adam, J., Siewert-Markus, U., Grabe, H. J., Dorr, M., Heckmann, M., Zygmunt, M., Lange, A. E. & Markus, M. R. P. Arch Gynecol Obstet (2022).  

Infective endocarditis due to Staphylococcus aureus in adults with congenital heart disease: The next challenge. Tutarel, O. Int J Cardiol 362, 74-75 (2022).  

Distinct pathophysiological pathways in women and men with heart failure. Ravera, A., Santema, B. T., de Boer, R. A., Anker, S. D., Samani, N. J., Lang, C. C., Ng, L., Cleland, J. G. F., Dickstein, K., Lam, C. S. P., Van Spall, H. G. C., Filippatos, G., van Veldhuisen, D. J., Metra, M., Voors, A. A. & Sama, I. E. Eur J Heart Fail (2022).  

Intranasal application of adeno-associated viruses: a systematic review. Gadenstaetter, A. J., Schmutzler, L., Grimm, D. & Landegger, L. D. Transl Res (2022).  

Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium. Siland, J. E., Geelhoed, B., Roselli, C., Wang, B., Lin, H. J., Weiss, S., Trompet, S., van den Berg, M. E., Soliman, E. Z., Chen, L. Y., Ford, I., Jukema, J. W., Macfarlane, P. W., Kornej, J., Lin, H., Lunetta, K. L., Kavousi, M., Kors, J. A., Ikram, M. A., Guo, X. et al. PLoS One 17, e0268768 (2022).  

Midterm Follow-up of the Transatrial-to-Left Ventricle Cannulation for Acute Type A Dissection. Puehler, T., Friedrich, C., Lutter, G., Frank, D., Saad, M., Seoudy, H., Salem, M., Schoettler, J., Cremer, J. & Haneya, A. Ann Thorac Surg (2022).  

Association of early electrical changes with cardiovascular outcomes in immune checkpoint inhibitor myocarditis. Power, J. R., Alexandre, J., Choudhary, A., Ozbay, B., Hayek, S. S., Asnani, A., Tamura, Y., Aras, M., Cautela, J., Thuny, F., Gilstrap, L., Arangalage, D., Ewer, S., Huang, S., Deswal, A., Palaskas, N. L., Finke, D., Lehmann, L. H., Ederhy, S., Moslehi, J. et al. Arch Cardiovasc Dis 115, 315-330 (2022).  

Empagliflozin in patients post myocardial infarction rationale and design of the EMPACT-MI trial. Harrington, J., Udell, J. A., Jones, W. S., Anker, S. D., Bhatt, D. L., Petrie, M. C., Vedin, O., Sumin, M., Zwiener, I., Hernandez, A. F. & Butler, J. Am Heart J (2022).  

Inflammation and remodeling pathways and risk of cardiovascular events in patients with ischemic heart failure and reduced ejection fraction. Girerd, N., Cleland, J., Anker, S. D., Byra, W., Lam, C. S. P., Lapolice, D., Mehra, M. R., van Veldhuisen, D. J., Bresso, E., Lamiral, Z., Greenberg, B. & Zannad, F. Sci Rep 12, 8574 (2022).  

Sodium Glucose Cotransporter-2 Inhibition for Acute Myocardial Infarction: JACC Review Topic of the Week. Udell, J. A., Jones, W. S., Petrie, M. C., Harrington, J., Anker, S. D., Bhatt, D. L., Hernandez, A. F. & Butler, J. J Am Coll Cardiol 79, 2058-2068 (2022).  

The erythropoietin-derived peptide ARA 284 reduces tissue wasting and improves survival in a rat model of cancer cachexia. Palus, S., Elkina, Y., Braun, T., von Haehling, S., Dohner, W., Anker, S. D., Cerami, A., Brines, M. & Springer, J. J Cachexia Sarcopenia Muscle (2022).  

Clinical Features and Natural History of Preadolescent Nonsyndromic Hypertrophic Cardiomyopathy. Norrish, G., Cleary, A., Field, E., Cervi, E., Boleti, O., Ziolkowska, L., Olivotto, I., Khraiche, D., Limongelli, G., Anastasakis, A., Weintraub, R., Biagini, E., Ragni, L., Prendiville, T., Duignan, S., McLeod, K., Ilina, M., Fernandez, A., Marrone, C., Bokenkamp, R. et al. J Am Coll Cardiol 79, 1986-1997 (2022).  

Characterization of critically ill patients with septic shock and sepsis-associated cardiomyopathy using cardiovascular MRI. Muehlberg, F., Blaszczyk, E., Will, K., Wilczek, S., Brederlau, J. & Schulz-Menger, J. ESC Heart Fail (2022).

Obesity and Its Impact on Adverse In-Hospital Outcomes in Hospitalized Patients With COVID-19. Keller, K., Sagoschen, I., Schmitt, V. H., Sivanathan, V., Espinola-Klein, C., Lavie, C. J., Munzel, T. & Hobohm, L. Front Endocrinol (Lausanne) 13, 876028 (2022).  

Adjunctive Left Atrial Posterior Wall Isolation in Treating Atrial Fibrillation: Insight From a Large Secondary Analysis. Jiang, X., Liao, J., Ling, Z., Meyer, C., Sommer, P., Futyma, P., Martinek, M., Schratter, A., Acou, W. J., Wang, J., Zhu, L., Kiuchi, M. G., Purerfellner, H., Schmidt, B., Chun, J. K. R., Yin, Y. & Chen, S. JACC Clin Electrophysiol 8, 605-618 (2022).  

Identification of adeno-associated virus variants for gene transfer into human neural cell types by parallel capsid screening. Flitsch, L. J., Borner, K., Stullein, C., Ziegler, S., Sonntag-Buck, V., Wiedtke, E., Semkova, V., Au Yeung, S. W. C., Schlee, J., Hajo, M., Mathews, M., Ludwig, B. S., Kossatz, S., Kessler, H., Grimm, D. & Brustle, O. Sci Rep 12, 8356 (2022).  

Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages' transition into a pro-inflammatory state. Bosmans, L. A., van Tiel, C. M., Aarts, S., Willemsen, L., Baardman, J., van Os, B. W., den Toom, M., Beckers, L., Ahern, D. J., Levels, J. H. M., Jongejan, A., Moerland, P. D., Verberk, S. G. S., van den Bossche, J., de Winther, M., Weber, C., Atzler, D., Monaco, C., Gerdes, N., Shami, A. et al. Cardiovasc Res (2022).  

Impact of cardiac amyloidosis on outcomes of patients hospitalized with heart failure. Sebastian, G., Lukas, H., Alexander, D., Tommaso, G., Thomas, M., Rapezzi, C., Philip, W. & Karsten, K. Eur J Intern Med (2022).  

Impact of cardiac amyloidosis on outcomes of patients hospitalized with heart failure. Gobel, S., Hobohm, L., Desuki, A., Gori, T., Munzel, T., Claudio, R., Wenzel, P. & Keller, K. Eur J Intern Med 102, 88-96 (2022).  

New remote cerebral microbleeds in acute ischemic stroke: an analysis of the randomized, placebo-controlled WAKE-UP trial. Braemswig, T. B., Vynckier, J., Jensen, M., Boutitie, F., Galinovic, I., Simonsen, C. Z., Cheng, B., Cho, T. H., Scheitz, J. F., Fiehler, J., Puig, J., Thijs, V., Fiebach, J. B., Muir, K. W., Nighoghossian, N., Ebinger, M., Pedraza, S., Thomalla, G., Gerloff, C., Endres, M. et al. J Neurol (2022).  

Epicutaneous application of Imiquimod to model psoriasis-like skin disease induces water-saving aestivation motifs and vascular inflammation. Wild, J., Ringen, J., Bieler, T., Knopp, T., Lagrange, J., Molitor, M., Sies, K., Kropp, A., Keller, K., Daiber, A., Munzel, T., Rauh, M., Waisman, A., Wenzel, P., Titze, J. & Karbach, S. J Invest Dermatol (2022).  

The interplay between genetic variation and gene expression of the glucocorticoid receptor gene NR3C1 and blood cortisol levels on verbal memory and hippocampal volumes. Van der Auwera, S., Klinger-Konig, J., Wittfeld, K., Terock, J., Hannemann, A., Bulow, R., Nauck, M., Volker, U., Volzke, H. & Grabe, H. J. Eur Arch Psychiatry Clin Neurosci (2022).  

The need for increased pragmatism in cardiovascular clinical trials. Usman, M. S., Van Spall, H. G. C., Greene, S. J., Pandey, A., McGuire, D. K., Ali, Z. A., Mentz, R. J., Fonarow, G. C., Spertus, J. A., Anker, S. D., Butler, J., James, S. K. & Khan, M. S. Nat Rev Cardiol, 1-14 (2022).  

Piezo2 is not an indispensable mechanosensor in murine cardiomyocytes. Kloth, B., Mearini, G., Weinberger, F., Stenzig, J., Geertz, B., Starbatty, J., Lindner, D., Schumacher, U., Reichenspurner, H., Eschenhagen, T. & Hirt, M. N. Sci Rep 12, 8193 (2022).

Carotid ultrasonography improves residual risk stratification in guidelines-defined high cardiovascular risk patients. Georgiopoulos, G., Mavraganis, G., Delialis, D., Georgiou, S., Aivalioti, E., Patras, R., Petropoulos, I., Dimopoulou, M. A., Angelidakis, L., Sianis, A., Bampatsias, D., Dimoula, A., Maneta, E., Kosmopoulos, M., Vardavas, C., Stellos, K. & Stamatelopoulos, K. Eur J Prev Cardiol (2022).  

Head-to-head comparison between recommendations by the ESC and ACC/AHA/HFSA heart failure guidelines. Bayes-Genis, A., Aimo, A., Metra, M., Anker, S., Seferovic, P., Rapezzi, C., Castiglione, V., Nunez, J., Emdin, M., Rosano, G. & Coats, A. J. S. Eur J Heart Fail (2022).  

Increased Concentrations of Circulating Interleukins following Non-Invasive Vagus Nerve Stimulation: Results from a Randomized, Sham-Controlled, Crossover Study in Healthy Subjects. Veiz, E., Kieslich, S. K., Czesnik, D., Herrmann-Lingen, C., Meyer, T. & Staab, J. Neuroimmunomodulation, 1-10 (2022).  

The Bidirectional Link Between RNA Cleavage and Polyadenylation and Genome Stability: Recent Insights From a Systematic Screen. Spada, S., Luke, B. & Danckwardt, S. Front Genet 13, 854907 (2022).  

Compensatory Upregulation of Anti-Beta-Adrenergic Receptor Antibody Levels Might Prevent Heart Failure Presentation in Pediatric Myocarditis. Seidel, F., Scheibenbogen, C., Heidecke, H., Opgen-Rhein, B., Pickardt, T., Klingel, K., Berger, F., Messroghli, D. & Schubert, S. Front Pediatr 10, 881208 (2022).  

RNA modification mapping with JACUSA2. Piechotta, M., Naarmann-de Vries, I. S., Wang, Q., Altmuller, J. & Dieterich, C. Genome Biol 23, 115 (2022).  

Very-high-power short-duration ablation for treatment of premature ventricular contractions - The FAST-AND-FURIOUS PVC study. Heeger, C. H., Popescu, S. S., Kirstein, B., Hatahet, S., Traub, A., Phan, H. L., Feher, M., G, D. A., Keelani, A., Schluter, M., Vogler, J., Eitel, C., Kuck, K. H. & Tilz, R. R. Int J Cardiol Heart Vasc 40, 101042 (2022).  

Case Report: Transient Increase of CMR T1 Mapping Indices in a Patient With COVID-19 mRNA Vaccine Induced Acute Myocarditis. Ansari, U., Britsch, S., Rogowski, S., Duerschmied, D. & Papavassiliu, T. Front Cardiovasc Med 9, 880717 (2022).

Gender-Specific Performance of One- Compared to Two-Catheter Concepts in Transradial Coronary Angiography - Insights From the Randomized UDDC-Radial-Trial. Schneider, V. S., Lubking, L., Stahli, B. E., Skurk, C., Lauten, A., Mochmann, H. C., Schauerte, P., Riedel, M., Steinbeck, L., Rauch-Krohnert, U., Klotsche, J., Landmesser, U., Frohlich, G. & Leistner, D. M. Cardiovasc Revasc Med 43, 49-54 (2022).  

Association between bone turnover markers and periodontitis: A population-based cross-sectional study. Reckelkamm, S. L., Hannemann, A., Kocher, T., Nauck, M., Volzke, H., Ehmke, B., Rauner, M., Alayash, Z., Baumeister, S. E., Nolde, M. & Holtfreter, B. J Clin Periodontol 49, 633-641 (2022).  

Whole blood transcriptomic profiling identifies molecular pathways related to cardiovascular mortality in heart failure. Nath, M., Romaine, S. P. R., Koekemoer, A., Hamby, S., Webb, T. R., Nelson, C. P., Castellanos-Uribe, M., Papakonstantinou, M., Anker, S. D., Lang, C. C., Metra, M., Zannad, F., Filippatos, G., van Veldhuisen, D. J., Cleland, J. G., Ng, L. L., May, S. T., Marelli-Berg, F., Voors, A. A., Timmons, J. A. et al. Eur J Heart Fail (2022).  

Heat shock protein A4 ablation leads to skeletal muscle myopathy associated with dysregulated autophagy and induced apoptosis. Elkenani, M., Barakat, A. Z., Held, T., Rodrigues, D. M., Mobarak, S., Swarnka, S., Adham, I. M. & Mohamed, B. A. J Transl Med 20, 229 (2022).  

Surgical aortic valve replacement in patients aged 50-69 years-insights from the German Aortic Valve Registry (GARY). Vogt, F., Santarpino, G., Fujita, B., Frerker, C., Bauer, T., Beckmann, A., Bekeredjian, R., Bleiziffer, S., Mollmann, H., Walther, T., Beyersdorf, F., Hamm, C., Boning, A., Baldus, S., Ensminger, S., Fischlein, T., Eckner, D. & Board, G. E. Eur J Cardiothorac Surg (2022).  

Behavioral Health Risk Factors and Motivation to Change among Cardiovascular General Hospital Patients Aged 50 to 79 Years. Siewert-Markus, U., Ulbricht, S., Gaertner, B., Zyriax, B. C., Dorr, M., Tobschall, S., Baumann, S., John, U. & Freyer-Adam, J. Nutrients 14 (2022).  

Comparable Analysis of Acute Changes in Vascular Tone after Coffee versus Energy Drink Consumption. Schuttler, D., Hamm, W., Kellnar, A., Brunner, S. & Stremmel, C. Nutrients 14 (2022).  

Peripheral Serotonin Deficiency Affects Anxiety-like Behavior and the Molecular Response to an Acute Challenge in Rats. Sbrini, G., Hanswijk, S. I., Brivio, P., Middelman, A., Bader, M., Fumagalli, F., Alenina, N., Homberg, J. R. & Calabrese, F. Int J Mol Sci 23 (2022).  

Overexpression of Renin-B Induces Warburg-like Effects That Are Associated with Increased AKT/mTOR Signaling. Golchert, J., Staar, D., Bennewitz, J., Hartmann, M., Hoffmann, N., Ameling, S., Volker, U., Peters, J. & Wanka, H. Cells 11 (2022).  

Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture-prone atherosclerotic plaques. Edsfeldt, A., Swart, M., Singh, P., Dib, L., Sun, J., Cole, J. E., Park, I., Al-Sharify, D., Persson, A., Nitulescu, M., Borges, P. D. N., Kassiteridi, C., Goddard, M. E., Lee, R., Volkov, P., Orho-Melander, M., Maegdefessel, L., Nilsson, J., Udalova, I., Goncalves, I. et al. Eur Heart J 43, 1864-1877 (2022).  

In vivo Visualization of M2 Macrophages in the Myocardium After Myocardial Infarction (MI) Using (68) Ga-NOTA-Anti-MMR Nb: Targeting Mannose Receptor (MR, CD206) on M2 Macrophages. Varasteh, Z., Braeuer, M., Mohanta, S., Steinsiek, A. L., Habenicht, A., Omidvari, N., Topping, G. J., Rischpler, C., Weber, W. A., Sager, H. B., Raes, G., Hernot, S. & Schwaiger, M. Front Cardiovasc Med 9, 889963 (2022).  

Anticoagulation for Percutaneous Ventricular Assist Device-Supported Cardiogenic Shock: JACC Review Topic of the Week. Vandenbriele, C., Arachchillage, D. J., Frederiks, P., Giustino, G., Gorog, D. A., Gramegna, M., Janssens, S., Meyns, B., Polzin, A., Scandroglio, M., Schrage, B., Stone, G. W., Tavazzi, G., Vanassche, T., Vranckx, P., Westermann, D., Price, S. & Chieffo, A. J Am Coll Cardiol 79, 1949-1962 (2022).  

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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Mahajan, A., Spracklen, C. N., Zhang, W., Ng, M. C. Y., Petty, L. E., Kitajima, H., Yu, G. Z., Rueger, S., Speidel, L., Kim, Y. J., Horikoshi, M., Mercader, J. M., Taliun, D., Moon, S., Kwak, S. H., Robertson, N. R., Rayner, N. W., Loh, M., Kim, B. J., Chiou, J. et al. Nat Genet 54, 560-572 (2022).  

Integrated care for optimizing the management of stroke and associated heart disease: a position paper of the European Society of Cardiology Council on Stroke. Lip, G. Y. H., Lane, D. A., Lenarczyk, R., Boriani, G., Doehner, W., Benjamin, L. A., Fisher, M., Lowe, D., Sacco, R. L., Schnabel, R., Watkins, C., Ntaios, G. & Potpara, T. Eur Heart J (2022).

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Paradigm shift: new concepts for HCN4 function in cardiac pacemaking. Hennis, K., Biel, M., Fenske, S. & Wahl-Schott, C. Pflugers Arch 474, 649-663 (2022).  

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The Increasing Role of Rhythm Control in Patients With Atrial Fibrillation: JACC State-of-the-Art Review. Camm, A. J., Naccarelli, G. V., Mittal, S., Crijns, H., Hohnloser, S. H., Ma, C. S., Natale, A., Turakhia, M. P. & Kirchhof, P. J Am Coll Cardiol 79, 1932-1948 (2022).  

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Molybdenum Cofactor Catabolism Unravels the Physiological Role of the Drug Metabolizing Enzyme Thiopurine S-Methyltransferase. Pristup, J., Schaeffeler, E., Arjune, S., Hofmann, U., Angel Santamaria-Araujo, J., Leuthold, P., Friedrich, N., Nauck, M., Mayr, S., Haag, M., Muerdter, T., Marner, F. J., Relling, M. V., Evans, W. E., Schwarz, G. & Schwab, M. Clin Pharmacol Ther (2022).  

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Reference Values for Pediatric Atrial Volumes Assessed by Steady-State Free-Precession Magnetic Resonance Imaging Using Monoplane and Biplane Area-Length Methods. Voges, I., Caliebe, A., Hinz, S., Boroni Grazioli, S., Gabbert, D. D., Wegner, P., Uebing, A. S., Daubeney, P. E. F., Pennell, D. J. & Krupickova, S. J Magn Reson Imaging (2022).  

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The splicing-regulatory lncRNA NTRAS sustains vascular integrity. Fouani, Y., Kirchhof, L., Stanicek, L., Luxan, G., Heumuller, A. W., Knau, A., Fischer, A., Devraj, K., John, D., Neumann, P., Bindereif, A., Boon, R. A., Liebner, S., Wittig, I., Mogler, C., Karimova, M., Dimmeler, S. & Jae, N. EMBO Rep 23, e54157 (2022).  

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Phenotypic screen identifies FOXO inhibitor to counteract maturation and promote expansion of human iPS cell-derived cardiomyocytes. Schade, D., Drowley, L., Wang, Q. D., Plowright, A. T. & Greber, B. Bioorg Med Chem 65, 116782 (2022).  

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Treatment of the aortic root in acute aortic dissection type A: insights from the German Registry for Acute Aortic Dissection Type A. Kallenbach, K., Busch, C., Rylski, B., Dohle, D. S., Kruger, T., Holubec, T., Brickwedel, J., Poling, J., Noack, T., Hagl, C., Jawny, P., Boning, A., Chalabi, K., Karck, M. & Arif, R. Eur J Cardiothorac Surg (2022).  

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Association Between the Acidemia, Lactic Acidosis, and Shock Severity With Outcomes in Patients With Cardiogenic Shock. Jentzer, J. C., Schrage, B., Patel, P. C., Kashani, K. B., Barsness, G. W., Holmes, D. R., Jr., Blankenberg, S., Kirchhof, P. & Westermann, D. J Am Heart Assoc 11, e024932 (2022).  

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Establishing a robotic-assisted PCI program: experiences at a large tertiary referral center. Brunner, F. J., Waldeyer, C., Zengin-Sahm, E., Kondziella, C., Schrage, B., Clemmensen, P., Westermann, D., Blankenberg, S. & Seiffert, M. Heart Vessels (2022).

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Neuroimmune cardiovascular interfaces control atherosclerosis. Mohanta, S. K., Peng, L., Li, Y., Lu, S., Sun, T., Carnevale, L., Perrotta, M., Ma, Z., Forstera, B., Stanic, K., Zhang, C., Zhang, X., Szczepaniak, P., Bianchini, M., Saeed, B. R., Carnevale, R., Hu, D., Nosalski, R., Pallante, F., Beer, M., Santovito, D., Erturk, A., Mettenleiter, T. C., Klupp, B. G., Megens, R. T. A., Steffens, S., Pelisek, J., Eckstein, H. H., Kleemann, R., Habenicht, L., Mallat, Z., Michel, J. B., Bernhagen, J., Dichgans, M., D'Agostino, G., Guzik, T. J., Olofsson, P. S., Yin, C., Weber, C., Lembo, G., Carnevale, D. & Habenicht, A. J. R. Nature 605, 152-159 (2022).  

A machine learning algorithm for electrocardiographic fQRS quantification validated on multi-center data. Villa, A., Vandenberk, B., Kentta, T., Ingelaere, S., Huikuri, H. V., Zabel, M., Friede, T., Sticherling, C., Tuinenburg, A., Malik, M., Van Huffel, S., Willems, R. & Varon, C. Sci Rep 12, 6783 (2022).  

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Serial Assessment of Right Ventricular Deformation in Patients With Hypoplastic Left Heart Syndrome: A Cardiovascular Magnetic Resonance Feature Tracking Study. Kanngiesser, L. M., Freitag-Wolf, S., Boroni Grazioli, S., Gabbert, D. D., Hansen, J. H., Uebing, A. S. & Voges, I. J Am Heart Assoc 11, e025332 (2022).  

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Stent Optimization Using Optical Coherence Tomography and Its Prognostic Implications After Percutaneous Coronary Intervention. Rai, H., Harzer, F., Otsuka, T., Abdelwahed, Y. S., Antuna, P., Blachutzik, F., Koppara, T., Raber, L., Leistner, D. M., Alfonso, F., Nef, H., Seguchi, M., Aytekin, A., Xhepa, E., Kufner, S., Cassese, S., Laugwitz, K. L., Byrne, R. A., Kastrati, A. & Joner, M. J Am Heart Assoc 11, e02393 (2022).  

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Treatment of Transthyretin Amyloid Cardiomyopathy: The Current Options, the Future, and the Challenges. Tschope, C. & Elsanhoury, A. J Clin Med 11 (2022).  

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Straightforward Analysis of Sulfated Glycosaminoglycans by MALDI-TOF Mass Spectrometry from Biological Samples. Kruger, L., Biskup, K., Karampelas, V., Ludwig, A., Kasper, A. S., Poller, W. C. & Blanchard, V. Biology (Basel) 11 (2022).  

Simultaneous Quantification and Pharmacokinetic Characterization of Doxapram and 2-Ketodoxapram in Porcine Plasma and Brain Tissue. Kraft, M., Foerster, K. I., Wiedmann, F., Sauter, M., Paasche, A., Blochberger, P. L., Yesilgoz, B., L'Hoste, Y., Frey, N., Haefeli, W. E., Burhenne, J. & Schmidt, C. Pharmaceutics 14 (2022).  

The Structural and the Functional Aspects of Intercellular Communication in iPSC-Cardiomyocytes. Kiss, E., Fischer, C., Sauter, J. M., Sun, J. & Ullrich, N. D. Int J Mol Sci 23 (2022).  

Introduction of Lazy Luna an automatic software-driven multilevel comparison of ventricular function quantification in cardiovascular magnetic resonance imaging. Hadler, T., Wetzl, J., Lange, S., Geppert, C., Fenski, M., Abazi, E., Groschel, J., Ammann, C., Wenson, F., Topper, A., Dauber, S. & Schulz-Menger, J. Sci Rep 12, 6629 (2022).  

Pooled Analysis of Complications with Transvenous ICD Compared to Subcutaneous ICD in Patients with Catecholaminergic Polymorphic Ventricular Arrhythmia. Eckert, H., El-Battrawy, I., Veith, M., Roterberg, G., Kowitz, J., Lang, S., Zhou, X., Akin, I., Mugge, A. & Aweimer, A. J Pers Med 12 (2022).   

Human UPF3A and UPF3B enable fault-tolerant activation of nonsense-mediated mRNA decay. Wallmeroth, D., Lackmann, J. W., Kueckelmann, S., Altmuller, J., Dieterich, C., Boehm, V. & Gehring, N. H. EMBO J, e109191 (2022).  

Definition, Classification and Diagnosis of Diabetes Mellitus. Schleicher, E., Gerdes, C., Petersmann, A., Muller-Wieland, D., Muller, U. A., Freckmann, G., Heinemann, L., Nauck, M. & Landgraf, R. Exp Clin Endocrinol Diabetes (2022).  

Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease. Paeslack, N., Mimmler, M., Becker, S., Gao, Z., Khuu, M. P., Mann, A., Malinarich, F., Regen, T. & Reinhardt, C. Amino Acids (2022).  

Assessment of Myocardial Microstructure in a Murine Model of Obesity-Related Cardiac Dysfunction by Diffusion Tensor Magnetic Resonance Imaging at 7T. Lohr, D., Thiele, A., Stahnke, M., Braun, V., Smeir, E., Spranger, J., Brachs, S., Klopfleisch, R., Foryst-Ludwig, A., Schreiber, L. M., Kintscher, U. & Beyhoff, N. Front Cardiovasc Med 9, 839714 (2022).  

Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK-STAT signaling in macrophages by perturbing lipid raft structures. Hammoud, M. K., Dietze, R., Pesek, J., Finkernagel, F., Unger, A., Bieringer, T., Nist, A., Stiewe, T., Bhagwat, A. M., Nockher, W. A., Reinartz, S., Muller-Brusselbach, S., Graumann, J. & Muller, R. Mol Oncol (2022).  

Background calcium influx in arrhythmia: lead actor or extra? Fakuade, F. E., Fauconnier, J. & Voigt, N. J Physiol (2022).  

Optical coherence tomography in coronary atherosclerosis assessment and intervention. Araki, M., Park, S. J., Dauerman, H. L., Uemura, S., Kim, J. S., Di Mario, C., Johnson, T. W., Guagliumi, G., Kastrati, A., Joner, M., Holm, N. R., Alfonso, F., Wijns, W., Adriaenssens, T., Nef, H., Rioufol, G., Amabile, N., Souteyrand, G., Meneveau, N., Gerbaud, E., Opolski, M. P., Gonzalo, N., Tearney, G. J., Bouma, B., Aguirre, A. D., Mintz, G. S., Stone, G. W., Bourantas, C. V., Raber, L., Gili, S., Mizuno, K., Kimura, S., Shinke, T., Hong, M. K., Jang, Y., Cho, J. M., Yan, B. P., Porto, I., Niccoli, G., Montone, R. A., Thondapu, V., Papafaklis, M. I., Michalis, L. K., Reynolds, H., Saw, J., Libby, P., Weisz, G., Iannaccone, M., Gori, T., Toutouzas, K., Yonetsu, T., Minami, Y., Takano, M., Raffel, O. C., Kurihara, O., Soeda, T., Sugiyama, T., Kim, H. O., Lee, T., Higuma, T., Nakajima, A., Yamamoto, E., Bryniarski, K. L., Di Vito, L., Vergallo, R., Fracassi, F., Russo, M., Seegers, L. M., McNulty, I., Park, S., Feldman, M., Escaned, J., Prati, F., Arbustini, E., Pinto, F. J., Waksman, R., Garcia-Garcia, H. M., Maehara, A., Ali, Z., Finn, A. V., Virmani, R., Kini, A. S., Daemen, J., Kume, T., Hibi, K., Tanaka, A., Akasaka, T., Kubo, T., Yasuda, S., Croce, K., Granada, J. F., Lerman, A., Prasad, A., Regar, E., Saito, Y., Sankardas, M. A., Subban, V., Weissman, N. J., Chen, Y., Yu, B., Nicholls, S. J., Barlis, P., West, N. E. J., Arbab-Zadeh, A., Ye, J. C., Dijkstra, J., Lee, H., Narula, J., Crea, F., Nakamura, S., Kakuta, T., Fujimoto, J., Fuster, V. & Jang, I. K. Nat Rev Cardiol (2022).  

Antiarrhythmic Effects of Vernakalant in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes from a Patient with Short QT Syndrome Type 1. Xu, Q., Huang, X., Meng, Z., Li, Y., Zhong, R., Li, X., Cyganek, L., El-Battrawy, I., Akin, I., Zhou, X. & Lan, H. J Cardiovasc Dev Dis 9 (2022).  

Heart failure in the general population and impact of the 2021 European Society of Cardiology Heart Failure Guidelines. Wenzel, J. P., Nikorowitsch, J., Bei der Kellen, R., Magnussen, C., Bonin-Schnabel, R., Westermann, D., Twerenbold, R., Kirchhof, P., Blankenberg, S. & Schrage, B. ESC Heart Fail (2022).  

Quantitative Flow Ratio or Angiography for the Assessment of Non-culprit Lesions in Acute Coronary Syndromes: Protocol of the Randomized Trial QUOMODO. Ullrich, H., Olschewski, M., Belhadj, K. A., Munzel, T. & Gori, T. Front Cardiovasc Med 9, 815434 (2022).  

Depressive symptoms predict the incidence of common chronic diseases in women and men in a representative community sample. Otten, D., Ernst, M., Werner, A. M., Tibubos, A. N., Reiner, I., Brahler, E., Wiltink, J., Michal, M., Nagler, M., Wild, P. S., Munzel, T., Konig, J., Lackner, K. J., Peiffer, N. & Beutel, M. E. Psychol Med, 1-9 (2022).  

Assessment of sex- and age-dependency of risk factors for intimal hyperplasia in heart transplant patients using the high resolution of optical coherence tomography. Orban, M., Dietl, M., Dischl, D., von Samson-Himmelstjerna, P., Neubarth-Mayer, J., Struven, A., Tengler, A., Jakob, A., Fischer, M., Rizas, K., Petzold, T., Orban, M., Braun, D., Hausleiter, J., Hagl, C., Haas, N. A., Mehilli, J., Pozza, R. D., Massberg, S. & Ulrich, S. Int J Cardiol (2022).  

Ablation Lesion Assessment with MRI. Mont, L., Roca-Luque, I. & Althoff, T. F. Arrhythm Electrophysiol Rev 11, e02 (2022).  

Lipopolysaccharide Modifies Sodium Current Kinetics through ROS and PKC Signalling in Induced Pluripotent Stem-Derived Cardiomyocytes from Brugada Syndrome Patient. Liao, Z., Li, Y., Fan, X., Yang, Z., El-Battrawy, I., Zhou, X. & Akin, I. J Cardiovasc Dev Dis 9 (2022).  

Tenascin-X Mediates Flow-Induced Suppression of EndMT and Atherosclerosis. Liang, G., Wang, S., Shao, J., Jin, Y., Xu, L., Yan, Y., Gunther, S., Wang, L. & Offermanns, S. Circ Res, 101161CIRCRESAHA121320694 (2022).  

NMR Metabolomics Reveal Urine Markers of Microbiome Diversity and Identify Benzoate Metabolism as a Mediator between High Microbial Alpha Diversity and Metabolic Health. Hertel, J., Fassler, D., Heinken, A., Weiss, F. U., Ruhlemann, M., Bang, C., Franke, A., Budde, K., Henning, A. K., Petersmann, A., Volker, U., Volzke, H., Thiele, I., Grabe, H. J., Lerch, M. M., Nauck, M., Friedrich, N. & Frost, F. Metabolites 12 (2022).  

Treatment of the Aortic Root in Acute Aortic Dissection Type A: Insights from the German Registry for Acute Aortic Dissection Type A (GERAADA) Registry. Kallenbach, K., Busch, C., Rylski, B., Dohle, D. S., Kruger, T., Holubec, T., Brickwedel, J., Poling, J., Noack, T., Hagl, C., Jawny, P., Boning, A., Chalabi, K., Karck, M. & Arif, R. Eur J Cardiothorac Surg (2022).  

Effects of renin-angiotensin system inhibitor type and dosage on survival after transcatheter aortic valve implantation. Fischer-Rasokat, U., Bansch, C., Renker, M., Rolf, A., Charitos, E. I., Weferling, M., Liebetrau, C., Herrmann, E., Choi, Y. H., Hamm, C. W. & Kim, W. K. Eur Heart J Cardiovasc Pharmacother (2022).  

Movement therapy in lung transplantation candidates assisted by a lightweight wearable robot. Just, I. A., Fries, D., Loewe, S., Falk, V., Cesarovic, N., Kemper, D., Edelmann, F., Feuerstein, A., Haufe, F. L., Xiloyannis, M., Riener, R. & Schoenrath, F. Assist Technol (2022).  

Frontiers in CardioVascular Biomedicine (FCVB) 2022 Budapest is on in person! The excellent programme proves that scientists won against COVID-19. Ferdinandy, P., Koller, Á., Weber, C., Wojta, J. & Waltenberger, J. Cardiovasc Res 118, e59-e61 (2022).

Frontiers of CardioVascular Biomedicine 2022 Budapest is on in person! The excellent program proves that scientists won against Covid-19. Ferdinandy, P., Koller, A., Weber, C., Wojta, J. & Waltenberger, J. Cardiovasc Res (2022).  

Ten-year patterns of stent thrombosis after percutaneous coronary intervention with new- versus early-generation drug-eluting stents: insights from the DECADE cooperation. Coughlan, J. J., Maeng, M., Raber, L., Brugaletta, S., Aytekin, A., Okkels Jensen, L., Bar, S., Ortega-Paz, L., Laugwitz, K. L., Madsen, M., Heg, D., Sabate, M., Kufner, S., Warnakula Olesen, K. K., Kastrati, A., Windecker, S. & Cassese, S. Rev Esp Cardiol (Engl Ed) (2022).  

Machine learning-based identification of risk-factor signatures for undiagnosed atrial fibrillation in primary prevention and post-stroke in clinical practice. Schnabel, R. B., Witt, H., Walker, J., Ludwig, M., Geelhoed, B., Kossack, N., Schild, M., Miller, R. & Kirchhof, P. Eur Heart J Qual Care Clin Outcomes (2022).  

Targeting Cell-Specific Molecular Mechanisms of Innate Immunity in Atherosclerosis. Sauter, M. & Langer, H. F. Front Physiol 13, 802990 (2022).  

Prognostic Power of Pulmonary Arterial Compliance Is Boosted by a Hemodynamic Unloading Test With Glyceryl Trinitrate in Heart Failure Patients With Post-capillary Pulmonary Hypertension. Rieth, A. J., Grun, D., Zarogiannis, G., Kriechbaum, S. D., Wolter, S., Richter, M. J., Tello, K., Kruger, U., Mitrovic, V., Rosenkranz, S., Hamm, C. W. & Keller, T. Front Cardiovasc Med 9, 838898 (2022).  

The AT1 Receptor Blocker Telmisartan Reduces Intestinal Mucus Thickness in Obese Mice. Nickel, L., Sunderhauf, A., Rawish, E., Stolting, I., Derer, S., Thorns, C., Matschl, U., Othman, A., Sina, C. & Raasch, W. Front Pharmacol 13, 815353 (2022).  

Micro-dislodgement of a self-expanding transcatheter heart valve: Incidence, predictors, and outcomes. Kim, W. K., Renker, M., Dorr, O., Nef, H., Fischer-Rasokat, U., Choi, Y. H., Hamm, C. W. & Charitos, E. Int J Cardiol (2022).  

Ruthenaelectro-catalyzed C-H acyloxylation for late-stage tyrosine and oligopeptide diversification. Hou, X., Kaplaneris, N., Yuan, B., Frey, J., Ohyama, T., Messinis, A. M. & Ackermann, L. Chem Sci 13, 3461-3467 (2022).   

Cellular Chitchatting: Exploring the Role of Exosomes as Cardiovascular Risk Factors. Germena, G., Zelarayan, L. C. & Hinkel, R. Front Cell Dev Biol 10, 860005 (2022).  

Transmitral Gradients Following Transcatheter Edge-to-Edge Repair: Are Mean Gradients Meaningful? Hahn, R. T. & Hausleiter, J. JACC Cardiovasc Interv (2022).  

Severe low-gradient aortic stenosis: impact of inadequate left ventricular responses to high afterload on diagnosis and therapeutic decision-making. Dandel, M. & Hetzer, R. Heart Fail Rev (2022).  

Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20. Vieira-Vieira, C. H., Dauksaite, V., Sporbert, A., Gotthardt, M. & Selbach, M. Mol Cell (2022).  

Clinical implications of low estimated protein intake in patients with heart failure. Streng, K. W., Hillege, H. L., Ter Maaten, J. M., van Veldhuisen, D. J., Dickstein, K., Ng, L. L., Samani, N. J., Metra, M., Ponikowski, P., Cleland, J. G., Anker, S. D., Romaine, S. P. R., Damman, K., van der Meer, P., Lang, C. C. & Voors, A. A. J Cachexia Sarcopenia Muscle (2022).  

Not the classical serendipity: does doxapram treat atrial fibrillation? Liutkute, A., Brundel, B. J. & Voigt, N. Cardiovasc Res (2022).  

Generation of heterozygous (MRli003-A-5) and homozygous (MRli003-A-6) voltage-sensing knock-in human iPSC lines by CRISPR/Cas9 editing of the AAVS1 locus. Zhang, F., Meier, A. B., Sinnecker, D., Engelhardt, S., Lipp, P., Laugwitz, K. L., Dorn, T. & Moretti, A. Stem Cell Res 61, 102785 (2022).  

Symptom burden, psychosocial distress and palliative care needs in heart failure - A cross-sectional explorative pilot study. Strangl, F., Ischanow, E., Ullrich, A., Oechsle, K., Fluschnik, N., Magnussen, C., Knappe, D., Grahn, H., Blankenberg, S., Bokemeyer, C., Kirchhof, P. & Rybczynski, M. Clin Res Cardiol (2022).  

Surgical Restoration of Antero-Apical Left Ventricular Aneurysms: Cardiac Computed Tomography for Therapy Planning. Solowjowa, N., Nemchyna, O., Hrytsyna, Y., Meyer, A., Hennig, F., Falk, V. & Knosalla, C. Front Cardiovasc Med 9, 763073 (2022).  

Four decades of experience of prosthetic valve endocarditis reflect a high variety of diverse pathogens. Oberbach, A., Schlichting, N., Hagl, C., Lehmann, S., Kullnick, Y., Friedrich, M., Kohl, U., Horn, F., Kumbhari, V., Loffler, B., Schmidt, F., Joskowiak, D., Born, F., Saha, S. & Bagaev, E. Cardiovasc Res (2022).  

Prediction of disability-free survival in healthy older people. Neumann, J. T., Thao, L. T. P., Murray, A. M., Callander, E., Carr, P. R., Nelson, M. R., Wolfe, R., Woods, R. L., Reid, C. M., Shah, R. C., Newman, A. B., Williamson, J. D., Tonkin, A. M., McNeil, J. J. & investigators, A. Geroscience 44, 1641-1655 (2022).  

Natural killer cells act as an extrinsic barrier for in vivo reprogramming. Melendez, E., Chondronasiou, D., Mosteiro, L., Martinez de Villarreal, J., Fernandez-Alfara, M., Lynch, C. J., Grimm, D., Real, F. X., Alcami, J., Climent, N., Pietrocola, F. & Serrano, M. Development 149 (2022).  

Targeting the adipose tissue: heart crosstalk in pressure overload-induced heart failure. Tual-Chalot, S. & Stellos, K. Cardiovasc Res 118, 1854-1856 (2022).  

The Polyscore of autonomic parameters predicts mortality and identifies low-risk individuals among diabetic survivors of acute myocardial infarction. Steger, A., Dommasch, M., Muller, A., Barthel, P., Sinnecker, D., Wieg, L., Hapfelmeier, A., Heidegger, H. H., Huster, K. M., Martens, E., Laugwitz, K. L., Schmidt, G. & Dirschinger, R. Sci Rep 12, 6069 (2022).   

CARMA: what goes around, comes around for the heart. Juni, R. P. & Boon, R. A. Cardiovasc Res (2022).  

Patient related outcomes of mechanical lead extraction techniques (PROMET) study: A comparison of two professions. Akhtar, Z., Gallagher, M. M., Elbatran, A. I., Starck, C. T., Gonzalez, E., Al-Razzo, O., Mazzone, P., Delnoy, P. P., Breitenstein, A., Steffel, J., Eulert-Grehn, J., Lanmuller, P., Melillo, F., Marzi, A., Leung, L. W., Domenichini, G. & Sohal, M. Pacing Clin Electrophysiol 45, 658-665 (2022).  

The Evolution of Complex Muscle Cell In Vitro Models to Study Pathomechanisms and Drug Development of Neuromuscular Disease. Zschuntzsch, J., Meyer, S., Shahriyari, M., Kummer, K., Schmidt, M., Kummer, S. & Tiburcy, M. Cells 11 (2022).

C-Reactive Protein to Albumin Ratio in Patients Undergoing Transcatheter Aortic Valve Replacement. Seoudy, H., Shamekhi, J., Voigtlander, L., Ludwig, S., Frank, J., Kujat, T., Bramlage, P., Al-Kassou, B., Sugiura, A., Rangrez, A. Y., Schofer, N., Puehler, T., Lutter, G., Seiffert, M., Nickenig, G., Conradi, L., Frey, N., Westermann, D., Sinning, J. M. & Frank, D. Mayo Clin Proc 97, 931-940 (2022).  

A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals. Rohling, M., Kempf, K., Banzer, W., Braumann, K. M., Fuhrer-Sakel, D., Halle, M., McCarthy, D., Martin, S., Scholze, J., Toplak, H., Berg, A., Predel, H. G. & Acoorh Study, G. Nutrients 14 (2022).  

Molecular Effects of Auto-Antibodies on Angiotensin II Type 1 Receptor Signaling and Cell Proliferation. Philippe, A., Kleinau, G., Gruner, J. J., Wu, S., Postpieszala, D., Speck, D., Heidecke, H., Dowell, S. J., Riemekasten, G., Hildebrand, P. W., Kamhieh-Milz, J., Catar, R., Szczepek, M., Dragun, D. & Scheerer, P. Int J Mol Sci 23 (2022).  

Interdependence of Angiogenesis and Arteriogenesis in Development and Disease. le Noble, F. & Kupatt, C. Int J Mol Sci 23 (2022).  

Elevation of cardiac biomarkers in stroke is associated with pathological findings on cardiac MRI-results of the HEart and BRain interfaces in Acute Stroke study. von Rennenberg, R., Herm, J., Krause, T., Hellwig, S., Stengl, H., Scheitz, J. F., Elgeti, T., Nagel, S. N., Endres, M., Haeusler, K. G. & Nolte, C. H. Int J Stroke, 17474930221095698 (2022).  

Combining 3D-Printing and Electrospinning to Manufacture Biomimetic Heart Valve Leaflets. Freystetter, B., Grab, M., Grefen, L., Bischof, L., Isert, L., Mela, P., Bezuidenhout, D., Hagl, C. & Thierfelder, N. J Vis Exp (2022).  

Validity of a multidimensional comprehensive psychosocial screening instrument based on the ESC cardiovascular prevention guidelines - Evidence from the general and cardiovascular patient population. van den Houdt, S., Albus, C., Herrmann-Lingen, C., Widdershoven, J. & Kupper, N. J Psychosom Res 157, 110791 (2022).  

TAVR - From inoperable to younger, lower-risk patients: A slippery slope? Unbehaun, A., Abdullah, M., Hooda, A., Gedela, M., Kempfert, J., Klein, C. & Tang, G. H. L. Prog Cardiovasc Dis (2022).  

Rapid shear stress-dependent ENaC membrane insertion is mediated by the endothelial glycocalyx and the mineralocorticoid receptor. Cosgun, Z. C., Sternak, M., Fels, B., Bar, A., Kwiatkowski, G., Pacia, M. Z., Herrnbock, L., Lindemann, M., Stegbauer, J., Hoges, S., Chlopicki, S. & Kusche-Vihrog, K. Cell Mol Life Sci 79, 235 (2022).  

Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno-Associated Viral Vector rAAV9P1. Bauer, A., Puglisi, M., Nagl, D., Schick, J. A., Werner, T., Klingl, A., El Andari, J., Hornung, V., Kessler, H., Gotz, M., Grimm, D. & Brack-Werner, R. Adv Sci (Weinh) 9, e2104979 (2022).  

UBTF::ATXN7L3 gene fusion defines novel B cell precursor ALL subtype with CDX2 expression and need for intensified treatment. Bastian, L., Hartmann, A. M., Beder, T., Hanzelmann, S., Kassens, J., Bultmann, M., Hoeppner, M. P., Franzenburg, S., Wittig, M., Franke, A., Nagel, I., Spielmann, M., Reimer, N., Busch, H., Schwartz, S., Steffen, B., Viardot, A., Dohner, K., Kondakci, M., Wulf, G., Wendelin, K., Renzelmann, A., Kiani, A., Trautmann, H., Neumann, M., Gokbuget, N., Bruggemann, M. & Baldus, C. D. Leukemia 36, 1676-1680 (2022).  

Matched comparison of 3 cerebral perfusion strategies in open zone-0 anastomosis for acute type A aortic dissection. Montagner, M., Kofler, M., Pitts, L., Heck, R., Buz, S., Kurz, S., Falk, V. & Kempfert, J. Eur J Cardiothorac Surg (2022).  

Generation of two human iPSC lines, HMGUi003-A and MRIi028-A, carrying pathogenic biallelic variants in the PPCS gene. Iuso, A., Zhang, F., Rusha, E., Campbell, B., Dorn, T., Zanuttigh, E., Haas, D., Anikster, Y., Lederer, G., Pertek, A., Nteli, P., Laugwitz, K. L. & Moretti, A. Stem Cell Res 61, 102773 (2022).  

Non-robotic minimally invasive mitral valve repair: a 20-year single-centre experience. Feirer, N., Kornyeva, A., Lang, M., Sideris, K., Voss, B., Krane, M., Lange, R. & Vitanova, K. Eur J Cardiothorac Surg (2022).  

Pediatric heart transplantation in infants and small children under 3 years of age: Single center experience - "Early and long-term results". Rosenthal, L. L., Ulrich, S. M., Zimmerling, L., Brenner, P., Muller, C., Michel, S., Horer, J., Netz, H., Haas, N. A. & Hagl, C. Int J Cardiol 356, 45-50 (2022).  

Mechano-signaling via Piezo1 prevents activation and p53-mediated senescence of muscle stem cells. Peng, Y., Du, J., Gunther, S., Guo, X., Wang, S., Schneider, A., Zhu, L. & Braun, T. Redox Biol 52, 102309 (2022).  

Cardiac remodeling in patients with centrifugal left ventricular assist devices assessed by serial echocardiography. Mulzer, J., Krastev, H., Hoermandinger, C., Merke, N., Alhaloush, M., Schoenrath, F., Falk, V., Potapov, E. & Knierim, J. Echocardiography 39, 667-677 (2022).  

Dysregulated diurnal cortisol patterns are associated with cardiovascular mortality: Findings from the KORA-F3 study. Karl, S., Johar, H., Ladwig, K. H., Peters, A. & Lederbogen, F. Psychoneuroendocrinology 141, 105753 (2022).   

Galectin-3 inhibitors as novel antithrombotic drugs with almost no bleeding risk: wishful thinking or a realistic vision? Jakobs, K. & Rauch, U. Eur Heart J (2022).  

Transcatheter implantation of covered stents serving as extravascular conduits-Proof of a CT-based approach in three cases. Ewert, P., Eicken, A., Tanase, D., Georgiev, S., Will, A., Pankalla, C., Nagdyman, N., Meierhofer, C. & Horer, J. Catheter Cardiovasc Interv 99, 2054-2063 (2022).  

Pharmacological Targeting of the CCL2/CCR2 Axis for Atheroprotection: A Meta-Analysis of Preclinical Studies. Zivkovic, L., Asare, Y., Bernhagen, J., Dichgans, M. & Georgakis, M. K. Arterioscler Thromb Vasc Biol 42, e131-e144 (2022).  

Biomarker changes as surrogate endpoints in early-phase trials in heart failure with reduced ejection fraction. Savarese, G., Uijl, A., Ouwerkerk, W., Tromp, J., Anker, S. D., Dickstein, K., Hage, C., Lam, C. S. P., Lang, C. C., Metra, M., Ng, L. L., Orsini, N., Samani, N. J., van Veldhuisen, D. J., Cleland, J. G. F., Voors, A. A. & Lund, L. H. ESC Heart Fail (2022).  

Endocrine and molecular factors of increased female reproductive performance in the Dummerstorf high-fertility mouse line FL1. Ludwig, C. L. M., Bohleber, S., Rebl, A., Wirth, E. K., Venuto, M. T., Langhammer, M., Schweizer, U., Weitzel, J. M. & Michaelis, M. J Mol Endocrinol 69, 285-298 (2022).  

Transmural myocardial repair with engineered heart muscle in a rat model of heterotopic heart transplantation - A proof-of-concept study. Jebran, A. F., Tiburcy, M., Biermann, D., Balfanz, P., Didie, M., Karikkineth, B. C., Schondube, F., Kutschka, I. & Zimmermann, W. H. J Mol Cell Cardiol 168, 3-12 (2022).   

A Family and a Genome-Wide Polygenic Risk Score Are Independently Associated With Stroke in a Population-Based Study. Hammerle, M., Forer, L., Schonherr, S., Peters, A., Grallert, H., Kronenberg, F., Gieger, C. & Lamina, C. Stroke 53, 2331-2339 (2022).  

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Feasibility, Acceptability, and Preliminary Efficacy of a Positive Psychology Intervention in Patients With Coronary Heart Disease: A Randomized Controlled Trial. Sadlonova, M., Kermani, M. B., Huffman, J. C., Nikrahan, G. R., Sadeghi, M. & Celano, C. M. J Acad Consult Liaison Psychiatry (2022).  

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Brugada Syndrome: Different Experimental Models and the Role of Human Cardiomyocytes From Induced Pluripotent Stem Cells. Li, Y., Lang, S., Akin, I., Zhou, X. & El-Battrawy, I. J Am Heart Assoc 11, e024410 (2022).  

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Movement therapy in advanced heart failure assisted by a lightweight wearable robot: a feasibility pilot study. Just, I. A., Fries, D., Loewe, S., Falk, V., Cesarovic, N., Edelmann, F., Feuerstein, A., Haufe, F. L., Xiloyannis, M., Riener, R. & Schoenrath, F. ESC Heart Fail (2022).  

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Challenges in the conduct of randomised controlled trials in cardiogenic shock complicating acute myocardial infarction. Freund, A., Desch, S. & Thiele, H. J Geriatr Cardiol 19, 125-129 (2022).  

In vivo and ex vivo electrophysiological study of the mouse heart to characterize the cardiac conduction system, including atrial and ventricular vulnerability. Hennis, K., Rotzer, R. D., Rilling, J., Wu, Y., Thalhammer, S. B., Biel, M., Wahl-Schott, C. & Fenske, S. Nat Protoc (2022).  

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Thyroid function, pernicious anemia, and erythropoiesis: a two-sample Mendelian randomization study. Kjaergaard, A. D., Teumer, A., Marouli, E., Deloukas, P., Kus, A., Sterenborg, R., Asvold, B. O., Medici, M. & Ellervik, C. Hum Mol Genet (2022).  



Impact of the 2009 ESC Guideline Change on Surgically Treated Infective Endocarditis. Weber, C., Luehr, M., Petrov, G., Misfeld, M., Akhyari, P., Tugtekin, S. M., Diab, M., Saha, S., Elderia, A., Lichtenberg, A., Hagl, C., Doenst, T., Matschke, K., Borger, M. A. & Wahlers, T. Ann Thorac Surg 114, 1349-1356 (2022).

Pre-admission antiplatelet therapy and treatment effect of ticagrelor vs. prasugrel in patients with acute coronary syndromes-a subgroup analysis of the ISAR-REACT 5 trial. Lahu, S., Ndrepepa, G., Neumann, F. J., Menichelli, M., Bernlochner, I., Richardt, G., Wöhrle, J., Witzenbichler, B., Hemetsberger, R., Mayer, K., Akin, I., Cassese, S., Gewalt, S., Xhepa, E., Kufner, S., Valina, C., Sager, H. B., Joner, M., Ibrahim, T., Laugwitz, K. L. et al. Eur Heart J Cardiovasc Pharmacother 8, 687-694 (2022).

Interventional Procedures for Left Ventricular Assist Device-Associated Complications. Lanmueller, P., Eulert-Grehn, J. J., Unbehaun, A., Klein, C., Hommel, M., Kofler, M., Kempfert, J., Hoermandinger, C., Kaufmann, F., Stawowy, P., Dreysse, S., Mulzer, J., Mueller, M., Falk, V., Schoenrath, F., Potapov, E. & Just, I. A. ASAIO J 68, 1332-1338 (2022). 

Changes in Endocan and Dermatan Sulfate Are Associated with Biomechanical Properties of Abdominal Aortic Wall during Aneurysm Expansion and Rupture. Metschl, S., Bruder, L., Paloschi, V., Jakob, K., Reutersberg, B., Reeps, C., Maegdefessel, L., Gee, M., Eckstein, H. H. & Pelisek, J. Thromb Haemost 122, 1513-1523 (2022). 

The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis. Fiorito, G., Pedron, S., Ochoa-Rosales, C., McCrory, C., Polidoro, S., Zhang, Y., Dugue, P. A., Ratliff, S., Zhao, W. N., McKay, G. J., Costa, G., Solinas, M. G., Harris, K. M., Tumino, R., Grioni, S., Ricceri, F., Panico, S., Brenner, H., Schwettmann, L., Waldenberger, M. et al. J Gerontol A Biol Sci Med Sci 77, 1750-1759 (2022). 


Synthesis and in vitro Study of Artemisinin/Synthetic Peroxide-Based Hybrid Compounds against SARS-CoV-2 and Cancer. Herrmann, L., Yaremenko, I. A., Çapcı, A., Struwe, J., Tailor, D., Dheeraj, A., Hodek, J., Belyakova, Y. Y., Radulov, P. S., Weber, J., Malhotra, S. V., Terent'ev, A. O., Ackermann, L. & Tsogoeva, S. B. ChemMedChem 17, e202200005 (2022).

Hypothalamic Galanin-producing neurons regulate stress in zebrafish through a peptidergic, self-inhibitory loop. Corradi, L., Bruzzone, M., Maschio, M. D., Sawamiphak, S. & Filosa, A. Curr Biol 32, 1497-1510 e1495 (2022).  

Cytokine Hemoadsorption During Cardiac Surgery Versus Standard Surgical Care for Infective Endocarditis (REMOVE): Results From a Multicenter Randomized Controlled Trial. Diab, M., Lehmann, T., Bothe, W., Akhyari, P., Platzer, S., Wendt, D., Deppe, A. C., Strauch, J., Hagel, S., Gunther, A., Faerber, G., Sponholz, C., Franz, M., Scherag, A., Velichkov, I., Silaschi, M., Fassl, J., Hofmann, B., Lehmann, S., Schramm, R. et al. Circulation 145, 959-968 (2022).  

Redox-dependent loss of flavin by mitochondria complex I is different in brain and heart. Yoval-Sanchez, B., Ansari, F., James, J., Niatsetskaya, Z., Sosunov, S., Filipenko, P., Tikhonova, I. G., Ten, V., Wittig, I., Rafikov, R. & Galkin, A. Redox Biol 51, 102258 (2022).

A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome. Widjaja, A. A., Shekeran, S. G., Adami, E., Ting, J. G. W., Tan, J., Viswanathan, S., Lim, S. Y., Tan, P. H., Hubner, N., Coffman, T. & Cook, S. A. J Am Soc Nephrol 33, 718-730 (2022).

Computed tomographic assessment of right ventricular long axis strain for prognosis after transcatheter aortic valve replacement. Aquino, G. J., Decker, J. A., Schoepf, U. J., Carson, L., Fiegel, M., Paladugu, N., Brandt, V., Yacoub, B., Emrich, A. L., Kroencke, T., Burt, J. R., Bayer, R., 2nd, Emrich, T. & Varga-Szemes, A. Eur J Radiol 149, 110212 (2022).  

Impact of the 2009 ESC Guideline Change on Surgically Treated Infective Endocarditis. Weber, C., Luehr, M., Petrov, G., Misfeld, M., Akhyari, P., Tugtekin, S. M., Diab, M., Saha, S., Elderia, A., Lichtenberg, A., Hagl, C., Doenst, T., Matschke, K., Borger, M. A., Wahlers, T. & Clinical, M. P. o. A. o. I. E. i. G. S. G. Ann Thorac Surg (2022).   

Interferon-beta Suppresses Transcriptionally Active Parvovirus B19 Infection in Viral Cardiomyopathy: A Subgroup Analysis of the BICC-Trial. Schultheiss, H. P., Bock, C. T., Aleshcheva, G., Baumeier, C., Poller, W. & Escher, F. Viruses 14 (2022).

A potential future Fontan modification: preliminary in vitro data of a pressure-generating tube from engineered heart tissue. Kohne, M., Behrens, C. S., Studemann, T., Bibra, C. V., Querdel, E., Shibamiya, A., Geertz, B., Olfe, J., Huners, I., Jockenhovel, S., Hubler, M., Eschenhagen, T., Sachweh, J. S., Weinberger, F. & Biermann, D. Eur J Cardiothorac Surg (2022).   

Phenotypic spectrum of BLM- and RMI1-related Bloom syndrome. Gonenc, II, Elcioglu, N. H., Martinez Grijalva, C., Aras, S., Grossmann, N., Praulich, I., Altmuller, J., Kaulfuss, S., Li, Y., Nurnberg, P., Burfeind, P., Yigit, G. & Wollnik, B. Clin Genet (2022).   

Symptom Severity and Health-Related Quality of Life in Patients with Atrial Fibrillation: Findings from the Observational ARENA Study. Sadlonova, M., Senges, J., Nagel, J., Celano, C., Klasen-Max, C., Borggrefe, M., Akin, I., Thomas, D., Schwarzbach, C. J., Kleeman, T., Schneider, S., Hochadel, M., Suselbeck, T., Schwacke, H., Alonso, A., Haass, M., Ladwig, K. H. & Herrmann-Lingen, C. J Clin Med 11 (2022).  

Improving adaptive seamless designs through Bayesian optimization. Richter, J., Friede, T. & Rahnenfuhrer, J. Biom J (2022).  

Being Overweight or Obese Is Associated with an Increased Platelet Reactivity Despite Dual Antiplatelet Therapy with Aspirin and Clopidogrel. Puccini, M., Rauch, C., Jakobs, K., Friebel, J., Hassanein, A., Landmesser, U. & Rauch, U. Cardiovasc Drugs Ther (2022).  

Of hypes and paradigms in the search of the ideal valved conduit in the young. Peterss, S., Hagl, C. & Pichlmaier, M. Eur J Cardiothorac Surg (2022).  

Reactive Oxygen Species Differentially Modulate the Metabolic and Transcriptomic Response of Endothelial Cells. Muller, N., Warwick, T., Noack, K., Malacarne, P. F., Cooper, A. J. L., Weissmann, N., Schroder, K., Brandes, R. P. & Rezende, F. Antioxidants (Basel) 11 (2022).  

Intracranial haemorrhage in adult patients on venoarterial extracorporeal membrane oxygenation. Lusebrink, E., Zimmer, S., Schrage, B., Dabboura, S., Majunke, N., Scherer, C., Aksoy, A., Krogmann, A., Hoffmann, S., Szczanowicz, L., Binzenhofer, L., Peterss, S., Kuhn, C., Hagl, C., Massberg, S., Schafer, A., Thiele, H., Westermann, D., Orban, M. & Group, I.-V.-E. I. Eur Heart J Acute Cardiovasc Care (2022).  

Polygenic risk score: a tool ready for clinical use? Kavousi, M. & Schunkert, H. Eur Heart J (2022).  

Polycystic ovarian syndrome increases prevalence of concentric hypertrophy in normotensive obese women. De Jong, K. A., Berisha, F., Naderpoor, N., Appelbe, A., Kotowicz, M. A., Cukier, K., McGee, S. L. & Nikolaev, V. O. PLoS One 17, e0263312 (2022).

Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility. Barc, J., Tadros, R., Glinge, C., Chiang, D. Y., Jouni, M., Simonet, F., Jurgens, S. J., Baudic, M., Nicastro, M., Potet, F., Offerhaus, J. A., Walsh, R., Choi, S. H., Verkerk, A. O., Mizusawa, Y., Anys, S., Minois, D., Arnaud, M., Duchateau, J., Wijeyeratne, Y. D. et al. Nat Genet 54, 232-239 (2022).

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection. Pekayvaz, K., Leunig, A., Kaiser, R., Joppich, M., Brambs, S., Janjic, A., Popp, O., Nixdorf, D., Fumagalli, V., Schmidt, N., Polewka, V., Anjum, A., Knottenberg, V., Eivers, L., Wange, L. E., Gold, C., Kirchner, M., Muenchhoff, M., Hellmuth, J. C., Scherer, C. et al. Nat Commun 13, 1018 (2022).  

Influence of ejection fraction on biomarker expression and response to spironolactone in people at risk of heart failure: findings from the HOMAGE trial. Ferreira, J. P., Verdonschot, J. A. J., Girerd, N., Bozec, E., Pellicori, P., Collier, T., Mariottoni, B., Cosmi, F., Hazebroek, M., Cuthbert, J., Petutschnigg, J., Heymans, S., Staessen, J. A., Pieske, B., Edelman, F., Clark, A. L., Diez, J., Gonzalez, A., Rossignol, P., Cleland, J. G. et al. Eur J Heart Fail (2022).  

Percutaneous coronary intervention for chronic total occlusion in octogenarians: a propensity score study. Blessing, R. R. L., Ahoopai, M., Geyer, M., Brandt, M., Zeiher, A. M., Vasa-Nicotera, M., Munzel, T., Wenzel, P., Gori, T. & Dimitriadis, Z. Sci Rep 12, 3073 (2022).  

Renin, aldosterone, the aldosterone-to-renin ratio, and incident hypertension among normotensive subjects from the general population. Arnold, N., Hermanns, I. M., Schulz, A., Hahad, O., Schmitt, V. H., Panova-Noeva, M., Prochaska, J. H., Binder, H., Pfeiffer, N., Beutel, M., Lackner, K. J., Munzel, T. & Wild, P. S. Cardiovasc Res (2022).  

Role of TRPC6 in kidney damage after acute ischemic kidney injury. Zheng, Z., Tsvetkov, D., Bartolomaeus, T. U. P., Erdogan, C., Krugel, U., Schleifenbaum, J., Schaefer, M., Nurnberg, B., Chai, X., Ludwig, F. A., N'Diaye, G., Kohler, M. B., Wu, K., Gollasch, M. & Marko, L. Sci Rep 12, 3038 (2022).  

Effects of Atrial Fibrillation on the Human Ventricle. Pabel, S., Knierim, M., Stehle, T., Alebrand, F., Paulus, M., Sieme, M., Herwig, M., Barsch, F., Kortl, T., Poppl, A., Wenner, B., Ljubojevic-Holzer, S., Molina, C. E., Dybkova, N., Camboni, D., Fischer, T. H., Sedej, S., Scherr, D., Schmid, C., Brochhausen, C. et al. Circ Res, CIRCRESAHA121319718 (2022).  

Late Gadolinium Enhancement Cardiac Magnetic Resonance Imaging: From Basic Concepts to Emerging Methods. Holtackers, R. J., Emrich, T., Botnar, R. M., Kooi, M. E., Wildberger, J. E. & Kreitner, K. F. Rofo (2022).  

Surgery for infective endocarditis following low-intermediate risk transcatheter aortic valve replacement-a multicentre experience. Saha, S., Joskowiak, D., Marin-Cuartas, M., Diab, M., Schwaiger, B. M., Sandoval-Boburg, R., Popov, A. F., Weber, C., Varghese, S., Martens, A., Cebotari, S., Scherner, M., Eichinger, W., Holzhey, D., Dohle, D. S., Wahlers, T., Doenst, T., Misfeld, M., Mehilli, J., Massberg, S. et al. Eur J Cardiothorac Surg (2022).   

Effect of Sunitinib Treatment on Skin Sodium Accumulation in Patients With Renal Cancer: a Pilot Study. Marko, L., Dorr, A., Linz, P., van den Meiracker, A. H., Garrelds, I. M., Kuehne, T., Dechend, R., Danser, A. H. J., Florcken, A. & Muller, D. N. Hypertension, HYPERTENSIONAHA12219079 (2022).  

Preadmission antiplatelet therapy and treatment effect of ticagrelor versus prasugrel in patients with acute coronary syndromes - a subgroup analysis of the ISAR-REACT 5 trial. Lahu, S., Ndrepepa, G., Neumann, F. J., Menichelli, M., Bernlochner, I., Richardt, G., Wohrle, J., Witzenbichler, B., Hemetsberger, R., Mayer, K., Akin, I., Cassese, S., Gewalt, S., Xhepa, E., Kufner, S., Valina, C., Sager, H. B., Joner, M., Ibrahim, T., Laugwitz, K. L. et al. Eur Heart J Cardiovasc Pharmacother (2022).  

Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study. Kaura, A., Hartley, A., Panoulas, V., Glampson, B., Shah, A. S. V., Davies, J., Mulla, A., Woods, K., Omigie, J., Shah, A. D., Thursz, M. R., Elliott, P., Hemmingway, H., Williams, B., Asselbergs, F. W., O'Sullivan, M., Lord, G. M., Trickey, A., Sterne, J. A., Haskard, D. O. et al. PLoS Med 19, e1003911 (2022).  

Predictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1). Berling-Ernst, A., Yahiaoui-Doktor, M., Kiechle, M., Engel, C., Lammert, J., Grill, S., Dukatz, R., Rhiem, K., Baumann, F. T., Bischoff, S. C., Erickson, N., Schmidt, T., Niederberger, U., Siniatchkin, M. & Halle, M. Sci Rep 12, 2907 (2022).  

QRS micro-fragmentation as a mortality predictor. Hnatkova, K., Andrsova, I., Novotny, T., Britton, A., Shipley, M., Vandenberk, B., Sprenkeler, D. J., Junttila, J., Reichlin, T., Schlogl, S., Vos, M. A., Friede, T., Bauer, A., Huikuri, H. V., Willems, R., Schmidt, G., Franz, M. R., Sticherling, C., Zabel, M. & Malik, M. Eur Heart J (2022).  


MRI-Detected Brain Lesions and Cognitive Function in Patients With Atrial Fibrillation Undergoing Left Atrial Catheter Ablation in the Randomized AXAFA-AFNET 5 Trial. Haeusler, K. G., Eichner, F. A., Heuschmann, P. U., Fiebach, J. B., Engelhorn, T., Blank, B., Callans, D., Elvan, A., Grimaldi, M., Hansen, J., Hindricks, G., Al-Khalidi, H. R., Mont, L., Nielsen, J. C., Piccini, J. P., Schotten, U., Themistoclakis, S., Vijgen, J., Di Biase, L. & Kirchhof, P. Circulation 145, 906-915 (2022).  

Neurofilament proteins as a potential biomarker in chemotherapy-induced polyneuropathy. Huehnchen, P., Schinke, C., Bangemann, N., Dordevic, A. D., Kern, J., Maierhof, S. K., Hew, L., Nolte, L., Kortvelyessy, P., Gopfert, J. C., Ruprecht, K., Somps, C. J., Blohmer, J. U., Sehouli, J., Endres, M. & Boehmerle, W. JCI Insight 7 (2022).  

Severe heart failure in the setting of inflammatory cardiomyopathy with likely pathogenic titin variant. Mueller, M., Zwinger, L., Klaassen, S., Poller, W., Monserrat Iglesias, L., Pablo Ochoa, J., Klingel, K., Landmesser, U. & Heidecker, B. Int J Cardiol Heart Vasc 39, 100969 (2022).  

Dopamine D1/D5 Receptor Signaling Is Involved in Arrhythmogenesis in the Setting of Takotsubo Cardiomyopathy. Huang, M., Yang, Z., Li, Y., Lan, H., Cyganek, L., Yuecel, G., Lang, S., Bieback, K., El-Battrawy, I., Zhou, X., Borggrefe, M. & Akin, I. Frontiers in Cardiovascular Medicine 8, 777463 (2022).

Bacteriophage therapy as a treatment option for complex cardiovascular implant infection: The German Heart Center Berlin experience. Tkhilaishvili, T., Potapov, E., Starck, C., Mulzer, J., Falk, V., Trampuz, A. & Schoenrath, F. The Journal of Heart and Lung Transplantation (2022).

Interventional Procedures for Left Ventricular Assist Device-Associated Complications. Lanmueller, P., Eulert-Grehn, J.-J., Unbehaun, A., Klein, C., Hommel, M., Kofler, M., Kempfert, J., Hoermandinger, C., Kaufmann, F., Stawowy, P., Dreysse, S., Mulzer, J., Mueller, M., Falk, V., Schoenrath, F., Potapov, E. & Just, I. A. ASAIO Journal Publish Ahead of Print (2022).

Coronary angiography in acute ischemic stroke patients: frequency and determinants of pathological findings in a multicenter cohort study. Litmeier, S., Meinel, T. R., von Rennenberg, R., Kniepert, J. U., Audebert, H. J., Endres, M., Jung, S., Scheitz, J. F. & Nolte, C. H. J Neurol (2022).   

Conduction disturbances following transcatheter aortic valve implantation: Any room for improvement? Charitos, E. & Kim, W. K. Int J Cardiol (2022).  

Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease. Talmor-Barkan, Y., Bar, N., Shaul, A. A., Shahaf, N., Godneva, A., Bussi, Y., Lotan-Pompan, M., Weinberger, A., Shechter, A., Chezar-Azerrad, C., Arow, Z., Hammer, Y., Chechi, K., Forslund, S. K., Fromentin, S., Dumas, M. E., Ehrlich, S. D., Pedersen, O., Kornowski, R. & Segal, E. Nat Med (2022).  

Nationwide Registry-Based Analysis of Infective Endocarditis Risk After Pulmonary Valve Replacement. Stammnitz, C., Huscher, D., Bauer, U. M. M., Urban, A., Nordmeyer, J., Schubert, S., Photiadis, J., Berger, F., Klaassen, S. & German Competence Network for Congenital Heart Defects, I. J Am Heart Assoc, e022231 (2022).  

Colchicine prevents disease progression in viral myocarditis via modulating the NLRP3 inflammasome in the cardiosplenic axis. Pappritz, K., Lin, J., El-Shafeey, M., Fechner, H., Kuhl, U., Alogna, A., Spillmann, F., Elsanhoury, A., Schulz, R., Tschope, C. & Van Linthout, S. ESC Heart Fail (2022).  

Microbiome and metabolome features of the cardiometabolic disease spectrum. Fromentin, S., Forslund, S. K., Chechi, K., Aron-Wisnewsky, J., Chakaroun, R., Nielsen, T., Tremaroli, V., Ji, B., Prifti, E., Myridakis, A., Chilloux, J., Andrikopoulos, P., Fan, Y., Olanipekun, M. T., Alves, R., Adiouch, S., Bar, N., Talmor-Barkan, Y., Belda, E., Caesar, R. et al. Nat Med (2022).  

Not only lungs: COVID-19 hits platelets as well. Bongiovanni, D., Klug, M., Valgimigli, M. & Bernlochner, I. Eur Heart J (2022).  

The Association of Depression and All-Cause Mortality: Explanatory Factors and the Influence of Gender. Wicke, F. S., Ernst, M., Otten, D., Werner, A., Dreier, M., Brahler, E., Tibubos, A. N., Reiner, I., Michal, M., Wiltink, J., Munzel, T., Lackner, K. J., Pfeiffer, N., Konig, J., Wild, P. S. & Beutel, M. E. J Affect Disord (2022).  

Rodent models for gait network disorders in Parkinson's disease - a translational perspective. Wenger, N., Vogt, A., Skrobot, M., Garulli, E. L., Kabaoglu, B., Salchow-Hommen, C., Schauer, T., Kroneberg, D., Schuhmann, M., Ip, C. W., Harms, C., Endres, M., Isaias, I., Tovote, P. & Blum, R. Exp Neurol, 114011 (2022).   

Evaluation of the spline reconstruction technique for preclinical PET imaging. Vrachliotis, A., Kastis, G. A., Protonotarios, N. E., Fokas, A. S., Nekolla, S. G., Anagnostopoulos, C. D., Costaridou, L. & Gaitanis, A. Comput Methods Programs Biomed 217, 106668 (2022).  

CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes. Stathopoulou, K., Schnittger, J., Raabe, J., Fleischer, F., Mangels, N., Piasecki, A., Findlay, J., Hartmann, K., Krasemann, S., Schlossarek, S., Uebeler, J., Wixler, V., Blake, D. J., Baillie, G. S., Carrier, L., Ehler, E. & Cuello, F. FEBS J (2022).  

Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes. Li, L., Chen, Z., von Scheidt, M., Li, S., Steiner, A., Guldener, U., Koplev, S., Ma, A., Hao, K., Pan, C., Lusis, A. J., Pang, S., Kessler, T., Ermel, R., Sukhavasi, K., Ruusalepp, A., Gagneur, J., Erdmann, J., Kovacic, J. C., Bjorkegren, J. L. M. et al. Basic Res Cardiol 117, 6 (2022).  

Deep breathing couples CSF and venous flow dynamics. Kollmeier, J. M., Gurbuz-Reiss, L., Sahoo, P., Badura, S., Ellebracht, B., Keck, M., Gartner, J., Ludwig, H. C., Frahm, J. & Dreha-Kulaczewski, S. Sci Rep 12, 2568 (2022).  

Neutrophil-Platelet Interactions as Novel Treatment Targets in Cardiovascular Disease. Kaiser, R., Escaig, R., Erber, J. & Nicolai, L. Front Cardiovasc Med 8, 824112 (2021).  

Prognostic Implications of a Second Peak of High-Sensitivity Troponin T After Myocardial Infarction. Hartikainen, T. S., Gossling, A., Sorensen, N. A., Lehmacher, J., Neumann, J. T., Blankenberg, S. & Westermann, D. Front Cardiovasc Med 8, 780198 (2021).  

A novel Troponin I mutation associated with severe restrictive cardiomyopathy-a case report of a 27-year-old woman with fatigue. Gerhardt, T., Monserrat, L., Landmesser, U. & Poller, W. Eur Heart J Case Rep 6, ytac053 (2022).  

Long-Term Effects of Aircraft Noise Exposure on Vascular Oxidative Stress, Endothelial Function and Blood Pressure: No Evidence for Adaptation or Tolerance Development. Frenis, K., Kalinovic, S., Ernst, B. P., Kvandova, M., Al Zuabi, A., Kuntic, M., Oelze, M., Stamm, P., Bayo Jimenez, M. T., Kij, A., Keppeler, K., Klein, V., Strohm, L., Ubbens, H., Daub, S., Hahad, O., Kroller-Schon, S., Schmeisser, M. J., Chlopicki, S., Eckrich, J. et al. Front Mol Biosci 8, 814921 (2021).  

Treatment standards for direct oral anticoagulants in patients with acute ischemic stroke and non-valvular atrial fibrillation: A survey among German stroke units. Fastner, C., Szabo, K., Samartzi, M., Kruska, M., Akin, I., Platten, M., Baumann, S. & Alonso, A. PLoS One 17, e0264122 (2022).  

Muscarinic receptor activation reduces force and arrhythmias in human atria independent of IK,ACh. Petersen, J., Castro, L., Pedersen Bengaard, A. K., Pecha, S., Ismaili, D., Schulz, C., Sahni, J., Steenpass, A., Meier, C., Reichenspurner, H., Jespersen, T., Eschenhagen, T. & Christ, T. J Cardiovasc Pharmacol (2022).  

Distribution and prognostic impact of coronary artery disease and nonischemic cardiomyopathies in patients with electrical storm. Muller, J., Behnes, M., Ellguth, D., Schupp, T., Taton, G., Reiser, L., Engelke, N., Borggrefe, M., Reichelt, T., Bollow, A., Kim, S. H., Barth, C., Weidner, K., Battrawy, I. E., Ansari, U., Akin, M., Grosse Meininghaus, D., Mashayekhi, K. & Akin, I. Coron Artery Dis (2022).  

Patient profile and outcomes associated with follow-up in specialty vs. primary care in heart failure. Lindberg, F., Lund, L. H., Benson, L., Schrage, B., Edner, M., Dahlstrom, U., Linde, C., Rosano, G. & Savarese, G. ESC Heart Fail (2022).  

Nitroxyl Donor CXL-1020 Lowers Blood Pressure by Targeting C195 in Cyclic Guanosine-3',5'-Monophosphate-Dependent Protein Kinase I. Kamynina, A., Guttzeit, S., Eaton, P. & Cuello, F. Hypertension, HYPERTENSIONAHA12218756 (2022).  

One-year results following PASCAL-based or MitraClip-based mitral valve transcatheter edge-to-edge repair. Geis, N. A., Schlegel, P., Heckmann, M. B., Katus, H. A., Frey, N., Crespo Lopez, P. & Raake, P. W. J. ESC Heart Fail (2022).  

The role of epigenetic clocks in explaining educational inequalities in mortality: a multi-cohort study and meta-analysis. Fiorito, G., Pedron, S., Ochoa-Rosales, C., McCrory, C., Polidoro, S., Zhang, Y., Dugue, P. A., Ratliff, S., Zhao, W. N., McKay, G. J., Costa, G., Solinas, M. G., Mullan Harris, K., Tumino, R., Grioni, S., Ricceri, F., Panico, S., Brenner, H., Schwettmann, L., Waldenberger, M. et al. J Gerontol A Biol Sci Med Sci (2022).  

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Iron Deficiency and Reduced Muscle Strength in Patients with Acute and Chronic Ischemic Stroke. Scherbakov, N., Sandek, A., Valentova, M., Mayer, A., von Haehling, S., Jankowska, E., Anker, S. D. & Doehner, W. J Clin Med 11 (2022).  

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Association between Duration of Deep Hypothermic Circulatory Arrest and Surgical Outcome in Patients with Acute Type A Aortic Dissection: A Large Retrospective Cohort Study. Salehi Ravesh, M., Friedrich, C., Schoettler, J., Hummitzsch, L., Elke, G., Salem, M., Lutter, G., Puehler, T., Cremer, J. & Haneya, A. J Clin Med 11 (2022).  

Longitudinal association of Apolipoprotein E polymorphism with lipid profile, type 2 diabetes and metabolic syndrome: Results from a 15 year follow-up study. Pitchika, A., Ricardo Paulista Markus, M., Schipf, S., Teumer, A., Van der Auwera, S., Nauck, M., Dorr, M., Felix, S., Jorgen Grabe, H., Volzke, H. & Ittermann, T. Diabetes Res Clin Pract 185, 109778 (2022).  

Switching in the expression pattern of actin isoforms marks the onset of contractility and distinct mechanodynamic behavior during cardiomyocyte differentiation. Pires, R. H., Dau, T. H., Manu, E., Shree, N. & Otto, O. Physiol Rep 10, e15171 (2022).  

Soluble ST2 Receptor: Biomarker of Left Ventricular Impairment and Functional Status in Patients with Inflammatory Cardiomyopathy. Obradovic, D. M., Buttner, P., Rommel, K. P., Blazek, S., Loncar, G., von Haehling, S., von Roeder, M., Lucke, C., Gutberlet, M., Thiele, H., Lurz, P. & Besler, C. Cells 11 (2022).  

The Role of Oncostatin M and Its Receptor Complexes in Cardiomyocyte Protection, Regeneration, and Failure. Kubin, T., Gajawada, P., Bramlage, P., Hein, S., Berge, B., Cetinkaya, A., Burger, H., Schonburg, M., Schaper, W., Choi, Y. H. & Richter, M. Int J Mol Sci 23 (2022).  

Improving robustness of automatic cardiac function quantification from cine magnetic resonance imaging using synthetic image data. Gheorghita, B. A., Itu, L. M., Sharma, P., Suciu, C., Wetzl, J., Geppert, C., Ali, M. A. A., Lee, A. M., Piechnik, S. K., Neubauer, S., Petersen, S. E., Schulz-Menger, J. & Chitiboi, T. Sci Rep 12, 2391 (2022).  

Iron deficiency is related to low functional outcome in patients at early rehabilitation after acute stroke. Doehner, W., Scherbakov, N., Schellenberg, T., Jankowska, E. A., Scheitz, J. F., von Haehling, S. & Joebges, M. J Cachexia Sarcopenia Muscle (2022).  

Expression and Characterization of Relaxin Family Peptide Receptor 1 Variants. Speck, D., Kleinau, G., Meininghaus, M., Erbe, A., Einfeldt, A., Szczepek, M., Scheerer, P. & Putter, V. Front Pharmacol 12, 826112 (2021).  

Use of hiPSC-Derived Cardiomyocytes to Rule Out Proarrhythmic Effects of Drugs: The Case of Hydroxychloroquine in COVID-19. Sala, L., Leonov, V., Mura, M., Giannetti, F., Khudiakov, A., Moretti, A., Crotti, L., Gnecchi, M. & Schwartz, P. J. Front Physiol 12, 730127 (2021).  

Paracrine Interleukin 6 Induces Cerebral Remodeling at Early Stages After Unilateral Common Carotid Artery Occlusion in Mice. Kuffner, M. T. C., Koch, S. P., Kirchner, M., Mueller, S., Lips, J., An, J., Mertins, P., Dirnagl, U., Endres, M., Boehm-Sturm, P., Harms, C. & Hoffmann, C. J. Front Cardiovasc Med 8, 805095 (2021).  

Stroke events after transcatheter aortic valve implantation: Temporal relationships and affected brain regions. Linder, M., Higgen, F. L., Voigtlander, L., Weimann, J., Ludwig, S., Waldschmidt, L., Focke, C., Bhadra, O., Grundmann, D., Demal, T., von Zastrow, A., Schafer, A., Schirmer, J., Reichenspurner, H., Blankenberg, S., Westermann, D., Schofer, N., Conradi, L., Thomalla, G. & Seiffert, M. Am Heart J (2022).  

The European Registry for Patients with Mechanical Circulatory Support of the European Association for Cardio-Thoracic Surgery: third report. de By, T., Schoenrath, F., Veen, K. M., Mohacsi, P., Stein, J., Alkhamees, K. M. M., Anastasiadis, K., Berhnardt, A., Beyersdorf, F., Caliskan, K., Reineke, D., Damman, K., Fiane, A., Gkouziouta, A., Gollmann-Tepekoylu, C., Finn, G., Hulman, M., Iacovoni, A., Loforte, A., Merkely, B. et al. Eur J Cardiothorac Surg (2022).  

Impact of prenatal and childhood adversity effects around World War II on multimorbidity: results from the KORA-Age study. Arshadipour, A., Thorand, B., Linkohr, B., Rospleszcz, S., Ladwig, K. H., Heier, M. & Peters, A. BMC Geriatr 22, 115 (2022).  

Target and non-target vessel related events at 10 years post percutaneous coronary intervention. Coughlan, J. J., Aytekin, A., Xhepa, E., Cassese, S., Joner, M., Koch, T., Wiebe, J., Lenz, T., Rheude, T., Pellegrini, C., Gewalt, S., Ibrahim, T., Laugwitz, K. L., Schunkert, H., Kastrati, A. & Kufner, S. Clin Res Cardiol (2022).  

Ticagrelor after Acute Coronary Syndrome: One For All or Part of Personalized Medicine? Akin, I. & Nienaber, C. A. Lancet Reg Health Eur 14, 100309 (2022).  

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Serum Calcification Propensity and Calcification of the Abdominal Aorta in Patients With Primary Aldosteronism. Kantauskaite, M., Bolten, K., Boschheidgen, M., Schmidt, C., Kolb, T., Eckardt, K. U., Pasch, A., Schimmoller, L., Rump, L. C., Voelkl, J. & Stegbauer, J. Front Cardiovasc Med 9, 771096 (2022).  

Functional improvement following direct interventional leaflet repair of severe tricuspid regurgitation. Volz, M. J., Hoerbrand, I., Konstandin, M. H., Mereles, D., Weiss, C., Warnecke, G., Frey, N., Aurich, M. & Raake, P. W. ESC Heart Fail (2022).  

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Feasibility and preliminary efficacy of perioperative interventions in patients undergoing coronary artery bypass grafting: the randomized controlled I-COPE trial. Sadlonova, M., Nagel, J., Becker, S., Neumann, S., Staab, J., Meyer, T., Celano, C. M., Amonoo, H. L., Fangauf, S. V., Herrmann-Lingen, C., Kutschka, I. & Friedrich, M. Eur J Cardiothorac Surg (2022).  

Thyroid Function and the Risk of Prediabetes and Type 2 Diabetes. Roa Duenas, O. H., Van der Burgh, A. C., Ittermann, T., Ligthart, S., Ikram, M. A., Peeters, R. & Chaker, L. J Clin Endocrinol Metab (2022).  

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Targeted proteomics improves cardiovascular risk prediction in secondary prevention. Nurmohamed, N. S., Belo Pereira, J. P., Hoogeveen, R. M., Kroon, J., Kraaijenhof, J. M., Waissi, F., Timmerman, N., Bom, M. J., Hoefer, I. E., Knaapen, P., Catapano, A. L., Koenig, W., de Kleijn, D., Visseren, F. L. J., Levin, E., Stroes, E. S. G. & Group, U.-S. S. Eur Heart J (2022).  

Prognostic impact of secondary prevention after coronary artery bypass grafting-insights from the TiCAB trial. Heer, T., von Scheidt, M., Boening, A., Heyken, C., Gusmini, F., de Waha, A., Kuna, C., Fach, A., Grothusen, C., Oberhoffer, M., Knosalla, C., Walther, T., Danner, B. C., Misfeld, M., Wimmer-Greinecker, G., Siepe, M., Grubitzsch, H., Joost, A., Schaefer, A., Conradi, L. et al. Eur J Cardiothorac Surg (2022).  

MRI-Detected Brain Lesions and Cognitive Function in Atrial Fibrillation Patients Undergoing Left Atrial Catheter Ablation in the Randomized AXAFA-AFNET 5 Trial. Hausler, K. G., Eichner, F. A., Heuschmann, P. U., Fiebach, J. B., Engelhorn, T., Blank, B., Callans, D., Elvan, A., Grimaldi, M., Hansen, J., Hindricks, G., Al-Khalidi, H. R., Mont, L., Nielsen, J. C., Piccini, J. P., Schotten, U., Themistoclakis, S., Vijgen, J., Di Biase, L. & Kirchhof, P. Circulation (2022).  

Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture-prone atherosclerotic plaques. Edsfeldt, A., Swart, M., Singh, P., Dib, L., Sun, J., Cole, J. E., Park, I., Al-Sharify, D., Persson, A., Nitulescu, M., Das Neves Borges, P., Kassiteridi, C., Goddard, M. E., Lee, R., Volkov, P., Orho-Melander, M., Maegdefessel, L., Nilsson, J., Udalova, I., Goncalves, I. et al. Eur Heart J (2022).  

J wave syndromes in patients with spinal and bulbar muscular atrophy. Steinmetz, K., Rudic, B., Borggrefe, M., Muller, K., Siebert, R., Rottbauer, W., Ludolph, A., Buckert, D. & Rosenbohm, A. J Neurol (2022).  

Birth weight and heart failure: hindsight as an exact science? Fonseca, G., Garfias-Veitl, T. & von Haehling, S. Eur J Prev Cardiol (2022).  

Myogenic Vasoconstriction Requires Canonical Gq/11 Signaling of the Angiotensin II Type 1 Receptor. Cui, Y., Kassmann, M., Nickel, S., Zhang, C., Alenina, N., Anistan, Y. M., Schleifenbaum, J., Bader, M., Welsh, D. G., Huang, Y. & Gollasch, M. J Am Heart Assoc 11, e022070 (2022).  

Teleproctoring for Training in Structural Heart Interventions: Initial Real-World Experience During the COVID-19 Pandemic. Beyhoff, N., Zhu, M., Zanders, L., Leistner, D. M., Nobles, A., Schroeder, M., Barbieri, F., Landmesser, U. & Reinthaler, M. J Am Heart Assoc 11, e023757 (2022).  

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Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement. Sun, X., Hao, Y., Sebastian Kiekenap, J. F., Emeis, J., Steitz, M., Breitenstein-Attach, A., Berger, F. & Schmitt, B. J Vis Exp (2022).  

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Different Rates of Bioprosthetic Aortic Valve Failure With Perimount and Trifecta Bioprostheses. Lange, R., Alalawi, Z., Voss, S., Boehm, J., Krane, M. & Vitanova, K. Front Cardiovasc Med 8, 822893 (2021).  

Phosphodiesterases S-sulfhydration contributes to human skeletal muscle function. Vellecco, V., Panza, E., Bibli, S. I., Casillo, G. M., Raucci, F., Manzo, O. L., Smimmo, M., Villani, R., Cavezza, M. R., Fleming, I., d'Emmanuele di Villa Bianca, R., Maione, F., Cirino, G. & Bucci, M. Pharmacol Res 177, 106108 (2022).  

Stable patients with suspected myocardial ischemia: comparison of machine-learning computed tomography-based fractional flow reserve and stress perfusion cardiovascular magnetic resonance imaging to detect myocardial ischemia. Lossnitzer, D., Klenantz, S., Andre, F., Goerich, J., Schoepf, U. J., Pazzo, K. L., Sommer, A., Brado, M., Guckel, F., Sokiranski, R., Becher, T., Akin, I., Buss, S. J. & Baumann, S. BMC Cardiovasc Disord 22, 34 (2022).  

Generation of a CRISPR/Cas edited human induced pluripotent stem cell line DHMi005-A-1 carrying a patient-specific disease-causing point mutation in the TBX5 gene. Lahm, H., Heinrich, P., Zierler, E., Dzilic, E., Neb, I., Luzius, T., Doppler, S. A., Schneider, S., Lange, R., Krane, M. & Dressen, M. Stem Cell Res 60, 102691 (2022).  

Case Report: Cytomegalovirus Reactivation and Pericarditis Following ChAdOx1 nCoV-19 Vaccination Against SARS-CoV-2. Pluss, M., Mese, K., Kowallick, J. T., Schuster, A., Tampe, D. & Tampe, B. Front Immunol 12, 784145 (2021).  

Effects of sacubitril/valsartan versus valsartan on renal function in patients with and without diabetes and heart failure with preserved ejection fraction: insights from PARAGON-HF. Peikert, A., Vaduganathan, M., Mc Causland, F., Claggett, B. L., Chatur, S., Packer, M., Pfeffer, M. A., Zannad, F., Lefkowitz, M. P., Pieske, B., Dungen, H. D., McMurray, J. J. V. & Solomon, S. D. Eur J Heart Fail (2022).  

Early risk stratification in patients with cardiogenic shock irrespective of the underlying cause - the Cardiogenic Shock Score. Beer, B. N., Jentzer, J. C., Weimann, J., Dabboura, S., Yan, I., Sundermeyer, J., Kirchhof, P., Blankenberg, S., Schrage, B. & Westermann, D. Eur J Heart Fail (2022).  

Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels. S, O. B., Holmes, A. P., Johnson, D. M., Kabir, S. N., C, O. S., M, O. R., Avezzu, A., Reyat, J. S., Hall, A. W., Apicella, C., Ellinor, P. T., Niederer, S., Tucker, N. R., Fabritz, L., Kirchhof, P. & Pavlovic, D. J Mol Cell Cardiol 166, 23-35 (2022).  

Impact of thyroid dysfunction on short-term outcomes and long-term mortality in patients with pulmonary embolism. Pohl, K. R., Hobohm, L., Krieg, V. J., Sentler, C., Rogge, N. I. J., Steimke, L., Ebner, M., Lerchbaumer, M., Hasenfuss, G., Konstantinides, S., Lankeit, M. & Keller, K. Thromb Res 211, 70-78 (2022).  

Web of Science's Citation Median Metrics Overcome the Major Constraints of the Journal Impact Factor. Daugherty, A., Hegele, R. A., Lu, H. S., Mackman, N., Rader, D. J. & Weber, C. Arterioscler Thromb Vasc Biol, ATVBAHA122317426 (2022).  

Interactions Between Atrial Fibrillation and Natriuretic Peptide in Predicting Heart Failure Hospitalization or Cardiovascular Death. Brady, P. F., Chua, W., Nehaj, F., Connolly, D. L., Khashaba, A., Purmah, Y. J. V., Ul-Qamar, M. J., Thomas, M. R., Varma, C., Schnabel, R. B., Zeller, T., Fabritz, L. & Kirchhof, P. F. J Am Heart Assoc 11, e022833 (2022).  

Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators. Wesseler, F., Riege, D., Puthanveedu, M., Halver, J., Muller, E., Bertrand, J., Antonchick, A. P., Sievers, S., Waldmann, H. & Schade, D. J Med Chem (2022).  

Diffusion-Weighted Imaging and Fluid-Attenuated Inversion Recovery Quantification to Predict Diffusion-Weighted Imaging-Fluid-Attenuated Inversion Recovery Mismatch Status in Ischemic Stroke With Unknown Onset. Scheldeman, L., Wouters, A., Dupont, P., Christensen, S., Boutitie, F., Cheng, B., Ebinger, M., Endres, M., Fiebach, J. B., Gerloff, C., Muir, K. W., Nighoghossian, N., Pedraza, S., Simonsen, C. Z., Thijs, V., Thomalla, G. & Lemmens, R. Stroke, STROKEAHA121036871 (2022).  

A quantitative RT-PCR protocol to adapt and quantify RBM20-dependent exon splicing of targets at the human locus. Rebs, S., Buchwald, T. A. & Streckfuss-Bomeke, K. STAR Protoc 3, 101117 (2022).  

Successfully implemented artificial intelligence and machine learning applications in cardiology: State-of-the-art review. Van den Eynde, J., Lachmann, M., Laugwitz, K. L., Manlhiot, C. & Kutty, S. Trends Cardiovasc Med (2022).  

Prediction of risk for bleeding, myocardial infarction and mortality after percutaneous coronary intervention in patients with acute coronary syndromes. Ndrepepa, G., Neumann, F. J., Menichelli, M., Richardt, G., Cassese, S., Xhepa, E., Kufner, S., Lahu, S., Aytekin, A., Sager, H. B., Joner, M., Ibrahim, T., Muller, A., Fusaro, M., Hapfelmeier, A., Laugwitz, K. L., Schunkert, H., Kastrati, A. & Kasel, M. Coron Artery Dis (2022).  

Mental Health-Related Risk Factors and Interventions in Patients with Heart Failure. A Position Paper endorsed by the European Association of Preventive Cardiology (EAPC). Ladwig, K. H., Baghai, T. C., Doyle, F., Hamer, M., Herrmann-Lingen, C., Kunschitz, E., Lemogne, C., Beresnevaite, M., Compare, A., von Kanel, R., Sager, H. B. & Kop, W. J. Eur J Prev Cardiol (2022).  

Improved Quantification of Cell Density in the Arterial Wall-A Novel Nucleus Splitting Approach Applied to 3D Two-Photon Laser-Scanning Microscopy. van der Laan, K. W. F., Reesink, K. D., van der Bruggen, M. M., Jaminon, A. M. G., Schurgers, L. J., Megens, R. T. A., Huberts, W., Delhaas, T. & Spronck, B. Front Physiol 12, 814434 (2021).  

Tailoring Cardiac Synthetic Transcriptional Modulation Towards Precision Medicine. Schoger, E., Lelek, S., Panakova, D. & Zelarayan, L. C. Front Cardiovasc Med 8, 783072 (2021).  

Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration. Rivard, L., Friberg, L., Conen, D., Healey, J. S., Berge, T., Boriani, G., Brandes, A., Calkins, H., Camm, A. J., Yee Chen, L., Lluis Clua Espuny, J., Collins, R., Connolly, S., Dagres, N., Elkind, M. S. V., Engdahl, J., Field, T. S., Gersh, B. J., Glotzer, T. V., Hankey, G. J. et al. Circulation 145, 392-409 (2022).  

Coronary Artery Disease in Patients Presenting With Acute Ischemic Stroke or Transient Ischemic Attack and Elevated Troponin Levels. Kruska, M., Kolb, A., Fastner, C., Mildenberger, I., Hetjens, S., Kittel, M., Bail, K., Behnes, M., Akin, I., Borggrefe, M., Szabo, K. & Baumann, S. Front Neurol 12, 781553 (2021).  

Single-cell transcription profiles in Bloom syndrome patients link BLM deficiency with altered condensin complex expression signatures. Gonenc, II, Wolff, A., Schmidt, J., Zibat, A., Muller, C., Cyganek, L., Argyriou, L., Raschle, M., Yigit, G. & Wollnik, B. Hum Mol Genet (2022).  

Muscle Mass and Inflammation in Older Adults: Impact of the Metabolic Syndrome. Buchmann, N., Fielitz, J., Spira, D., Konig, M., Norman, K., Pawelec, G., Goldeck, D., Demuth, I. & Steinhagen-Thiessen, E. Gerontology, 1-10 (2022).



Cigarette smoke augments CSF3 expression in neutrophils to compromise alveolar-capillary barrier function during influenza infection. McGrath, J. J. C., Vanderstocken, G., Dvorkin-Gheva, A., Cass, S. P., Afkhami, S., Fantauzzi, M. F., Thayaparan, D., Reihani, A., Wang, P., Beaulieu, A., Shen, P., Morissette, M., Jimenez-Saiz, R., Revill, S. D., Tabuchi, A., Zabini, D., Lee, W. L., Richards, C. D., Miller, M. S., Ask, K. et al. Eur Respir J 60 (2022).  

Access Route and Clinical Outcomes After Ticagrelor Versus Prasugrel in Patients With Acute Coronary Syndrome Undergoing Invasive Treatment Strategy. Hemetsberger, R., Richardt, G., Lahu, S., Valina, C., Menichelli, M., Abdelghani, M., Wohrle, J., Toelg, R., Witzenbichler, B., Mankerious, N., Liebetrau, C., Bernlochner, I., Hamm, C. W., Allali, A., Joner, M., Fusaro, M., Xhepa, E., Hapfelmeier, A., Kufner, S., Sager, H. B. et al. Cardiovasc Revasc Med 41, 122-128 (2022).  


Redox Regulatory Changes of Circadian Rhythm by the Environmental Risk Factors Traffic Noise and Air Pollution. Daiber, A., Frenis, K., Kuntic, M., Li, H., Wolf, E., Kilgallen, A. B., Lecour, S., Van Laake, L. W., Schulz, R., Hahad, O. & Munzel, T. Antioxid Redox Signal (2022).

Association of thyroid function with insulin resistance: data from two population-based studies. Spira, D., Buchmann, N., Dorr, M., Markus, M. R. P., Nauck, M., Schipf, S., Spranger, J., Demuth, I., Steinhagen-Thiessen, E., Volzke, H. & Ittermann, T. Eur Thyroid J 11 (2022).  

Detection and analysis of cerebral aneurysms based on X-ray rotational angiography - the CADA 2020 challenge. Ivantsits, M., Goubergrits, L., Kuhnigk, J. M., Huellebrand, M., Bruening, J., Kossen, T., Pfahringer, B., Schaller, J., Spuler, A., Kuehne, T., Jia, Y., Li, X., Shit, S., Menze, B., Su, Z., Ma, J., Nie, Z., Jain, K., Liu, Y., Lin, Y. et al. Med Image Anal 77, 102333 (2022).  

Pulsed-field ablation combined with ultrahigh-density mapping in patients undergoing catheter ablation for atrial fibrillation: Practical and electrophysiological considerations. Gunawardene, M. A., Schaeffer, B. N., Jularic, M., Eickholt, C., Maurer, T., Akbulak, R. O., Flindt, M., Anwar, O., Pape, U. F., Maasberg, S., Gessler, N., Hartmann, J. & Willems, S. J Cardiovasc Electrophysiol 33, 345-356 (2022).

Circulating Interleukin-6 Levels and Incident Ischemic Stroke: A Systematic Review and Meta-analysis of Prospective Studies. Papadopoulos, A., Palaiopanos, K., Bjorkbacka, H., Peters, A., de Lemos, J. A., Seshadri, S., Dichgans, M. & Georgakis, M. K. Neurology 98, e1002-e1012 (2022).

Right atriotomy closure with modified ventricular assist device ring. Lanmuller, P., Eulert-Grehn, J. J., Starck, C., Falk, V. & Potapov, E. J Card Surg (2022).  

Evaluation of systemic inflammation in response to remote ischemic preconditioning in patients undergoing transcatheter aortic valve replacement (TAVR). Zhang, K., Troeger, W., Kuhn, M., Wiedemann, S., Ibrahim, K., Pfluecke, C., Sveric, K. M., Winzer, R., Fedders, D., Ruf, T. F., Strasser, R. H., Linke, A., Quick, S. & Heidrich, F. M. Rev Cardiovasc Med 23, 20 (2022).  

Human-Device Interaction in the Life Science Laboratory. Soldner, R., Rheinlander, S., Meyer, T., Olszowy, M. & Austerjost, J. Adv Biochem Eng Biotechnol (2022).  

HFA-PEFF score: prognosis in patients with preserved ejection fraction after transcatheter aortic valve implantation. Seoudy, H., von Eberstein, M., Frank, J., Thomann, M., Puehler, T., Lutter, G., Lutz, M., Bramlage, P., Frey, N., Saad, M. & Frank, D. ESC Heart Fail (2022).  

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Effects of Alirocumab on Triglyceride Metabolism: A Fat-Tolerance Test and Nuclear Magnetic Resonance Spectroscopy Study. Metzner, T., Leitner, D. R., Mellitzer, K., Beck, A., Sourij, H., Stojakovic, T., Reishofer, G., Marz, W., Landmesser, U., Scharnagl, H., Toplak, H. & Silbernagel, G. Biomedicines 10 (2022).  

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Hybrid Surgery for Severe Mitral Valve Calcification: Limitations and Caveats for an Open Transcatheter Approach. Bagaev, E., Ali, A., Saha, S., Sadoni, S., Orban, M., Naebauer, M., Mehilli, J., Massberg, S., Oberbach, A. & Hagl, C. Medicina (Kaunas) 58 (2022).  

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Does Age Matter? Pulmonary Endarterectomy in the Elderly Patient with CTEPH. Wiedenroth, C. B., Bandorski, D., Ariobi, K., Ghofrani, H. A., Lankeit, M., Liebetrau, C., Pruefer, D., Mayer, E., Kriechbaum, S. D. & Guth, S. Thorac Cardiovasc Surg (2022).  

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Multi-organ assessment in mainly non-hospitalized individuals after SARS-CoV-2 infection: The Hamburg City Health Study COVID programme. Petersen, E. L., Gossling, A., Adam, G., Aepfelbacher, M., Behrendt, C. A., Cavus, E., Cheng, B., Fischer, N., Gallinat, J., Kuhn, S., Gerloff, C., Koch-Gromus, U., Harter, M., Hanning, U., Huber, T. B., Kluge, S., Knobloch, J. K., Kuta, P., Schmidt-Lauber, C., Lutgehetmann, M. et al. Eur Heart J (2022).  

Polygenic Risk Scores for Predicting Adverse Outcomes After Coronary Revascularization. Aittokallio, J., Kauko, A., Vaura, F., Salomaa, V., Kiviniemi, T., FinnGen, Schnabel, R. B. & Niiranen, T. Am J Cardiol (2022).  

Effects of whole-body MRI on outpatient health service costs: a general-population prospective cohort study in Mecklenburg-Vorpommern, Germany. Schmidt, C. O., Sierocinski, E., Baumeister, S., Hegenscheid, K., Volzke, H. & Chenot, J. F. BMJ Open 12, e056572 (2022).  

Cap analysis of gene expression reveals alternative promoter usage in a rat model of hypertension. Dahale, S., Ruiz-Orera, J., Silhavy, J., Hubner, N., van Heesch, S., Pravenec, M. & Atanur, S. S. Life Sci Alliance 5 (2022).  

Travelling with heart failure: risk assessment and practical recommendations. von Haehling, S., Birner, C., Dworatzek, E., Frantz, S., Hellenkamp, K., Israel, C. W., Kempf, T., Klein, H. H., Knosalla, C., Laufs, U., Raake, P., Wachter, R. & Hasenfuss, G. Nat Rev Cardiol (2022).  

Comparison of feasibility and results of frailty assessment methods prior to left ventricular assist device implantation. Roehrich, L., Sundermann, S. H., Just, I. A., Kopp Fernandes, L., Stein, J., Solowjowa, N., Mulzer, J., Mueller, M., Hummel, M., Knierim, J., Potapov, E., Falk, V. & Schoenrath, F. ESC Heart Fail (2022).  

The Gutenberg health study: a five-year prospective analysis of psychosocial working conditions using COPSOQ (Copenhagen psychosocial Questoinnaire) and ERI (effort-reward imbalance). Nuebling, M., Hegewald, J., Starke, K. R., Lincke, H. J., Jankowiak, S., Liebers, F., Latza, U., Letzel, S., Riechmann-Wolf, M., Gianicolo, E., Beutel, M., Pfeiffer, N., Lackner, K., Munzel, T., Wild, P. S. & Seidler, A. BMC Public Health 22, 24 (2022).  

Management of patients with mitral regurgitation ineligible for standard therapy undergoing TMVI screening. Ludwig, S., Sedighian, R., Weimann, J., Koell, B., Waldschmidt, L., Schafer, A., Seiffert, M., Westermann, D., Reichenspurner, H., Blankenberg, S., Schofer, N., Lubos, E., Conradi, L. & Kalbacher, D. EuroIntervention (2022).  

A Novel Transcatheter Heart Valve for an Overcrowded TAVR Market: What Should We Focus On? Lange, R. & Vitanova, K. JACC Cardiovasc Interv 15, 105-106 (2022).  

Evidence-based cardiovascular magnetic resonance cost-effectiveness calculator for the detection of significant coronary artery disease. Pandya, A., Yu, Y. J., Ge, Y., Nagel, E., Kwong, R. Y., Bakar, R. A., Grizzard, J. D., Merkler, A. E., Ntusi, N., Petersen, S. E., Rashedi, N., Schwitter, J., Selvanayagam, J. B., White, J. A., Carr, J., Raman, S. V., Simonetti, O. P., Bucciarelli-Ducci, C., Sierra-Galan, L. M., Ferrari, V. A. et al. J Cardiovasc Magn Reson 24, 1 (2022).  

Cell cycle defects underlie childhood-onset cardiomyopathy associated with Noonan syndrome. Meier, A. B., Raj Murthi, S., Rawat, H., Toepfer, C. N., Santamaria, G., Schmid, M., Mastantuono, E., Schwarzmayr, T., Berutti, R., Cleuziou, J., Ewert, P., Gorlach, A., Klingel, K., Laugwitz, K. L., Seidman, C. E., Seidman, J. G., Moretti, A. & Wolf, C. M. iScience 25, 103596 (2022).  

Left atrial strain predicts exercise capacity in heart failure independently of left ventricular ejection fraction. Maffeis, C., Rossi, A., Cannata, L., Zocco, C., Belyavskiy, E., Radhakrishnan, A. K., Feuerstein, A., Morris, D. A., Pieske-Kraigher, E., Pieske, B., Edelmann, F. & Temporelli, P. L. ESC Heart Fail (2022).  

Association of circulating MR-proADM with all-cause and cardiovascular mortality in the general population: Results from the KORA F4 cohort study. Gar, C., Thorand, B., Herder, C., Sujana, C., Heier, M., Meisinger, C., Peters, A., Koenig, W., Rathmann, W., Roden, M., Stumvoll, M., Maalmi, H., Meitinger, T., Then, H., Seissler, J. & Then, C. PLoS One 17, e0262330 (2022).  

Pathophysiological pathways related to high plasma growth differentiation factor 15 concentrations in patients with heart failure. Ceelen, D., Voors, A. A., Tromp, J., van Veldhuisen, D. J., Dickstein, K., de Boer, R. A., Lang, C. C., Anker, S. D., Ng, L. L., Metra, M., Ponikowski, P. & Figarska, S. M. Eur J Heart Fail (2022).  

Early benefit with empagliflozin in heart failure with preserved ejection fraction: insights from the EMPEROR-Preserved trial. Butler, J., Siddiqi, T. J., Filippatos, G., Ferreira, J. P., Pocock, S. J., Zannad, F. & Anker, S. D. Eur J Heart Fail (2022).  

"Precision-CT(O)": CTO-lesions unraveled by multimodality cardiac imaging. Abdelwahed, Y. S., Blum, E., Landmesser, U., Werner, G. S. & Leistner, D. M. Int J Cardiovasc Imaging (2022).  

Implication of proliferation gene biomarkers in pulmonary hypertension. Yan, Y., Jiang, R., Yuan, P., Wen, L., Pang, X. B., Jing, Z. C., He, Y. Y. & Han, Z. Y. Animal Model Exp Med 4, 369-380 (2021). 

Anatomical suitability and off-label use of contemporary transcatheter heart valves. Werner, N., Renker, M., Dorr, O., Bauer, T., Nef, H., Choi, Y. H., Hamm, C. W., Zahn, R. & Kim, W. K. Int J Cardiol 350, 96-103 (2022).  

State-of-the-art: Insights from the Ross Registry. Fujita, B., Aboud, A., Sievers, H. H. & Ensminger, S. JTCVS Tech 10, 396-400 (2021).  

The year in cardiovascular medicine 2021: interventional cardiology. Escaned, J., Jaffer, F. A., Mehilli, J. & Mehran, R. Eur Heart J 43, 377-386 (2022).  

Circulating Interleukin-6 Levels and Incident Ischemic Stroke: A Systematic Review and Meta-analysis of Prospective Studies. Papadopoulos, A., Palaiopanos, K., Bjorkbacka, H., Peters, A., de Lemos, J. A., Seshadri, S., Dichgans, M. & Georgakis, M. K. Neurology (2021).  

Histopathology-Based Deep-Learning Predicts Atherosclerotic Lesions in Intravascular Imaging. Holmberg, O., Lenz, T., Koch, V., Alyagoob, A., Utsch, L., Rank, A., Sabic, E., Seguchi, M., Xhepa, E., Kufner, S., Cassese, S., Kastrati, A., Marr, C., Joner, M. & Nicol, P. Front Cardiovasc Med 8, 779807 (2021).  

PET/MR Technology: Advancement and Challenges. Bogdanovic, B., Solari, E. L., Villagran Asiares, A., McIntosh, L., van Marwick, S., Schachoff, S. & Nekolla, S. G. Semin Nucl Med (2021).  

Remote Speech Analysis in the Evaluation of Hospitalized Patients With Acute Decompensated Heart Failure. Amir, O., Abraham, W. T., Azzam, Z. S., Berger, G., Anker, S. D., Pinney, S. P., Burkhoff, D., Shallom, I. D., Lotan, C. & Edelman, E. R. JACC Heart Fail 10, 41-49 (2022).