DZHK Paper of the month

Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammation. DZHK authors: Carina Mauersberger, Hendrik Sager, Tan An Dang, Laura Lambrecht, Heribert Schunkert, Thorsten Kessler. Nat Cardiovasc Res (2022). doi:...

Targeting myeloid cell coagulation signaling blocks MAP kinase/TGF-beta1 driven fibrotic remodeling in ischemic heart failure. DZHK authors: V. Garlapati, M. Molitor, S. Finger, J. Wild, S. Karbach, T. Münzel, A. Daiber, M. Brandt, T. Gori, S. Tenzer, W. Ruf, P. Wenzel. J Clin...

Lamin A/C-dependent chromatin architecture safeguards naive pluripotency to prevent aberrant cardiovascular cell fate and function. DZHK authors: Yinuo Wang, Julio Cordero, Haojie Shi, Felix Trogisch, Mona Malek Mohammadi, Johannes Backs, Thomas Wieland, Jörg Heineke, Gergana...

NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart.

DZHK authors: Marion Müller, Rose Eghbalian, Karen S. Frese, Jan Haas, Elham Kayvanpour, Farbod Sedaghat-Hamedani, Maximilian K. Lackner, Oguz F. Tugrul, Rewati Tappu, Diana...

Contractile Force of Transplanted Cardiomyocytes Actively Supports Heart Function After Injury

DZHK authors: Tim Stüdemann, Judith Rössinger, Christoph Manthey, Rajiven Srikantharajah, Constantin von Bibra, Aya Shibamiya, Maria Köhne, Thomas Eschenhagen, Florian Weinberger. ...

Smartphone-based screening for atrial fibrillation: a pragmatic randomized clinical trial. DZHK authors: Konstantinos Rizas, Lukas von Stülpnagel, Mathias Klemm, Steffen Massberg. Nature Medicine. DOI: 10.1038/s41591-022-01979-w

Origin and function of activated fibroblast states during zebrafish heart regeneration. DZHK authors: Bo Hu, Sara Lelek, Bastiaan Spanjaard, Hadil El-Sammak, Mariana Guedes Simões, Janita Mintcheva, Hananeh Aliee, Ronny Schäfer, Alexander M. Meyer, Fabian Theis, Didier Y. R....

A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth. DZHK authors: Marco Castro, Toshiya Sugino, Kerstin Wilhelm, Stefan Guenther, André Schneider, Thomas Braun, Holger Gerhardt, Michael Potente, Nature Metabolism, 2022, DOI...

Neuroimmune cardiovascular interfaces control atherosclerosis, DZHK authors: Sarajo K. Mohanta, Donato Santovito, Remco T. A. Megens, Sabine Steffens, Jürgen Bernhagen, Changjun Yin, Christian Weber, Andreas J. R. Habenicht, Nature, 2022

Loss of Endothelial Cytochrome P450 Reductase Induces Vascular Dysfunction in Mice. DZHK authors: Pedro Felipe Malacarne, Corina Ratiu, Niklas Müller, Melina Lopez, Beatrice Pflüger-Müller, Timothy Warwick, James Oo, Mauro Siragusa, Ingrid Fleming, Ralf P. Brandes, Flávia...