DZHK Paper of the month

Differential interaction of clinical characteristics with key functional parameters in heart failure with preserved ejection fraction — Results of the Aldo-DHF trial. Int J Cardiol. 2013 Nov 30;169(6):408-17 (DZHK-authors: Edelmann, Tschöpe, Herrmann-Lingen, Halle, Hasenfuss,...

Dysfunctional Nitric Oxide Signalling Increases Risk of Myocardial Infarction Nature (2013) doi:10.1038/nature12722 (DZHK-authors: Erdmann, Cor de Wit, Kaiser, Tennstedt, Aherrahrou, Willenborg, Walter, Meitinger, Hengstenberg, Schunkert)

Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy, Am J Human Genetics 93, 67–77, 2013 (DZHK-authors: Berger, Hübner, Kramer, Klaassen)

Inhibition of Microrna-92a Protects against Ischemia-Reperfusion Injury in a Large Animal Model. Circulation (2013) 128:1066-1075 (DZHK-authors: Hinkel, Zeiher, Kupatt, Dimmeler)

Ca2+/Calmodulin-Dependent Protein Kinase Ii and Protein Kinase a Differentially Regulate Sarcoplasmic Reticulum Ca2+ Leak in Human Cardiac Pathology, Circulation 128, 970-981, (2013) (DZHK-authors: Toischer, Hasenfuss, Maier, Sossalla)

Provocation of an Autoimmune Response to Cardiac Voltage-Gated Sodium Channel Nav1.5 Induces Cardiac Conduction Defects in Rats. J Am Coll Cardiol 62, 340-349, (2013) (DZHK-authors: Zitron, Katus, Kaya)

Rescue of Cardiomyopathy through U7snrna-Mediated Exon Skipping in Mybpc3-Targeted Knock-in Mice. EMBO Mol Med. 2013 Jul;5(7):1060-77 (DZHK-authors: Gedicke-Hornung, Behrens-Gawlik, Stimpel, Weinberger, Schlossarek, Braren, Eschenhagen, Mearini, Carrier)

Parthenogenetic stem cells for tissue-engineered heart repair. J Clin Invest. 2013; 123(3):1285–1298 (DZHK-authors: Didié, El-Armouche, Eschenhagen, Schwoerer, Ehmke, ZImmermann)

Effect of Spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: The Aldo-DHF Randomized Controlled Trial. JAMA (2013) 309: 781-791. (DZHK-authors: Edelmann, Wachter, Tschöpe, Herrmann-Lingen, Halle, Hasenfuss)

Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes. EMBO Mol Med. 2013 Mar;5(3):471-81 (DZHK-authors: Soehnlein, Döring, Weber)