Prof. Dr. Jens Fielitz
Contact
Prof. Dr. Jens Fielitz
Ernst-Moritz-Arndt Universität Greifswald
Klinik und Poliklinik für Innere Medizin B
Forschungscluster III
Fleischmannstr. 41
17475 Greifswald
jens.fielitz(at)uni-greifswald.de
Webseite: AG Fielitz
Research Areas: molecular cardiology
Research focus
Jens Fielitz is a DZHK professor for molecular cardiology and muscular proteostasis at the Ernst-Moritz-Arndt University Greifswald. One focus of his studies is the function of the ubiquitin proteasome system (UPS) and its role in different cardiac diseases.
With his translational research group, he focuses on disease mechanisms, which might eventually be useful to develop novel treatment strategies. In particular, he is studying mechanisms of pathological cardiac remodeling and inflammation-dependent skeletal muscle failure.
Recent publications
Busch K, Kny M, Huang N, Klassert TE, Stock M, Hahn A, Graeger S, Todiras M, Schmidt S, Chamling
B, …, Fielitz J. Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy.
(2021) J Cachexia Sarcopenia Muscle 12:1653-1668. PMID: 34472725
Hahn A, Kny M, Pablo-Tortola C, Todiras M, Willenbrock M, Schmidt S, Schmoeckel K, Jorde I,
Nowak M, Jarosch E, …, Fielitz J. Serum amyloid A1 mediates myotube atrophy via Toll-like
receptors. (2020) J Cachexia Sarcopenia Muscle 11:103-119. PMID: 31441598
Li Y, Dörmann N, Brinschwitz B, Kny M, Martin E, Bartels K, Li N, Giri PV, Schwanz S, Boschmann M,
…, Fielitz J. SPSB1-mediated inhibition of TGF-β receptor-II impairs myogenesis in inflammation.
(2023) J Cachexia Sarcopenia Muscle 14:1721-1736. PMID: 37209006
Nowak M, Suenkel B, Porras P, Migotti R, Schmidt F, Kny M, Zhu X, Wanker EE, Dittmar G, Fielitz J,
Sommer T. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. (2019) J Cell Sci
132. PMID: 31391242
Zanders L, Kny M, Hahn A, Schmidt S, Wundersitz S, Todiras M, Lahmann I, Bandyopadhyay A,
Wollersheim T, Kaderali L, Luft FC, Birchmeier C, Weber-Carstens S, Fielitz J. Sepsis induces
interleukin 6, gp130/JAK2/STAT3, and muscle wasting. (2022) J Cachexia Sarcopenia Muscle
13:713-727. PMID: 34821076